Artemether_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Artemether perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Artemether_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EFNA5 ephrin-A5 0.146819
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0858127
GDA guanine deaminase 0.0663177
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0570036
NPAS2 neuronal PAS domain protein 2 0.0557481
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0531675
SAMD4A sterile alpha motif domain containing 4A 0.051032
DOCK4 dedicator of cytokinesis 4 0.0476591
KYNU kynureninase 0.0451575
ASPH aspartate beta-hydroxylase 0.0451497
TRIO trio Rho guanine nucleotide exchange factor 0.0439487
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0437924
MYOF myoferlin 0.043164
LIMCH1 LIM and calponin homology domains 1 0.0424322
DST dystonin 0.0412431
PCBP3 poly(rC) binding protein 3 0.0407445
GRAMD1B GRAM domain containing 1B 0.038695
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0376433
NAMPT nicotinamide phosphoribosyltransferase 0.0375443
PM20D1 peptidase M20 domain containing 1 0.0371948
TGFBR1 transforming growth factor, beta receptor 1 0.0363635
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0361176
FNDC3B fibronectin type III domain containing 3B 0.0349134
NRCAM neuronal cell adhesion molecule 0.0345399
ELL2 elongation factor, RNA polymerase II, 2 0.0340294
NEK7 NIMA-related kinase 7 0.0323035
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0318712
CTSC cathepsin C 0.0310773
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.028841
ZEB2 zinc finger E-box binding homeobox 2 0.0287767
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0286252
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0283306
AVL9 AVL9 homolog (S. cerevisiase) 0.0283035
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0282814
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0277754
OGA O-GlcNAcase 0.02672
COL4A6 collagen, type IV, alpha 6 0.0256914
ARHGAP29 Rho GTPase activating protein 29 0.0256249
BCAR3 breast cancer anti-estrogen resistance 3 0.025567
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0254347
ESYT2 extended synaptotagmin-like protein 2 0.0251628
PTEN phosphatase and tensin homolog 0.0249702
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0230012
CD109 CD109 molecule 0.022439
BDNF brain-derived neurotrophic factor 0.0217948
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0212626
MON2 MON2 homolog (S. cerevisiae) 0.0209196
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0205105
BRWD3 bromodomain and WD repeat domain containing 3 0.0202834
MCL1 myeloid cell leukemia 1 0.0199616
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.019709
FLNB filamin B, beta 0.0194638
USP9X ubiquitin specific peptidase 9, X-linked 0.0193492
ANKRD17 ankyrin repeat domain 17 0.0189491
MFF mitochondrial fission factor 0.0186751
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0184822
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 0.0181961
BIRC6 baculoviral IAP repeat containing 6 0.0181689
COL8A1 collagen, type VIII, alpha 1 0.0180111
MKI67 marker of proliferation Ki-67 0.0178135
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.017801
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0177066
ANKRD28 ankyrin repeat domain 28 0.017703
AKAP13 A kinase (PRKA) anchor protein 13 0.0174319
ERRFI1 ERBB receptor feedback inhibitor 1 0.0173466
ITPRID2 ITPR interacting domain containing 2 0.0171051
EPHA4 EPH receptor A4 0.0169998
ENAH enabled homolog (Drosophila) 0.0169689
MALT1 MALT1 paracaspase 0.0168868
DNER delta/notch-like EGF repeat containing 0.0168356
CENPF centromere protein F, 350/400kDa 0.0166797
COPA coatomer protein complex, subunit alpha 0.0164669
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0163763
ZFC3H1 zinc finger, C3H1-type containing 0.0163308
WWTR1 WW domain containing transcription regulator 1 0.0163099
PDLIM5 PDZ and LIM domain 5 0.0161959
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0161713
CLTC clathrin, heavy chain (Hc) 0.0159628
WDFY2 WD repeat and FYVE domain containing 2 0.0159211
GPC6 glypican 6 0.0158609
AP1S3 adaptor-related protein complex 1, sigma 3 subunit 0.0153832
ZNF638 zinc finger protein 638 0.0153264
MYO10 myosin X 0.0152257
IL1RAP interleukin 1 receptor accessory protein 0.0150626
COG5 component of oligomeric golgi complex 5 0.0149895
WDR26 WD repeat domain 26 0.0148835
MSN moesin 0.0147437
CSNK1A1 casein kinase 1, alpha 1 0.0146654
IGFBP3 insulin-like growth factor binding protein 3 0.0144362
NBAS neuroblastoma amplified sequence 0.0143571
PRKACB protein kinase, cAMP-dependent, catalytic, beta 0.0139064
ATP13A3 ATPase type 13A3 0.0137871
ZNF292 zinc finger protein 292 0.0137336
METTL15 methyltransferase like 15 0.0137003
SDK1 sidekick cell adhesion molecule 1 0.0136205
NGLY1 N-glycanase 1 0.0135279
USP34 ubiquitin specific peptidase 34 0.0135065
CANX calnexin 0.0134148
GSK3B glycogen synthase kinase 3 beta 0.0133628
CUL4B cullin 4B 0.0131542

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.151624
TMSB10 thymosin beta 10 -0.151312
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.147802
VIM vimentin -0.138441
PDE4D phosphodiesterase 4D, cAMP-specific -0.137514
PTMA prothymosin, alpha -0.120988
TPT1 tumor protein, translationally-controlled 1 -0.115081
RPS6 ribosomal protein S6 -0.11338
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.11144
FTL ferritin, light polypeptide -0.109657
RPLP1 ribosomal protein, large, P1 -0.097763
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0915974
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.089571
RPS8 ribosomal protein S8 -0.0793096
RPS19 ribosomal protein S19 -0.0764352
RPL37A ribosomal protein L37a -0.0761548
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0755885
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0745301
RPS12 ribosomal protein S12 -0.0738795
RPL35A ribosomal protein L35a -0.0738435
RPL31 ribosomal protein L31 -0.0663758
RPS24 ribosomal protein S24 -0.0648822
RPL12 ribosomal protein L12 -0.0648558
RPL26 ribosomal protein L26 -0.0628566
NALF1 NALCN channel auxiliary factor 1 -0.0608748
FN1 fibronectin 1 -0.0606329
B2M beta-2-microglobulin -0.059735
RPL19 ribosomal protein L19 -0.0596228
RPL23 ribosomal protein L23 -0.058431
RPS23 ribosomal protein S23 -0.0562295
RPS3 ribosomal protein S3 -0.0542086
RPLP2 ribosomal protein, large, P2 -0.0518067
CDH13 cadherin 13 -0.0517295
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0513211
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0507941
RPL34 ribosomal protein L34 -0.0504949
RPL9 ribosomal protein L9 -0.04815
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.047984
RPL7A ribosomal protein L7a -0.0476861
RPS14 ribosomal protein S14 -0.0470315
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0459212
RPL37 ribosomal protein L37 -0.0451597
RPS29 ribosomal protein S29 -0.0448752
RPS21 ribosomal protein S21 -0.0447994
S100A6 S100 calcium binding protein A6 -0.0445404
PKM pyruvate kinase, muscle -0.0443925
RPS27A ribosomal protein S27a -0.0442864
RPS16 ribosomal protein S16 -0.0440167
RACK1 receptor for activated C kinase 1 -0.0433615
RPLP0 ribosomal protein, large, P0 -0.0425683
RPS27 ribosomal protein S27 -0.0423853
RPL36 ribosomal protein L36 -0.0421903
HLA-A major histocompatibility complex, class I, A -0.0417706
EIF1 eukaryotic translation initiation factor 1 -0.0414727
RPS25 ribosomal protein S25 -0.0414073
RPL36A ribosomal protein L36a -0.0400137
RPS13 ribosomal protein S13 -0.0399712
HLA-B major histocompatibility complex, class I, B -0.0399551
RPL11 ribosomal protein L11 -0.0391436
NAP1L1 nucleosome assembly protein 1-like 1 -0.0385716
ACTG1 actin gamma 1 -0.0377265
S100A10 S100 calcium binding protein A10 -0.0372991
RPS4X ribosomal protein S4, X-linked -0.0370341
RPS17 ribosomal protein S17 -0.0362185
PTPRM protein tyrosine phosphatase, receptor type, M -0.0359077
SMYD3 SET and MYND domain containing 3 -0.0355263
P3H2 prolyl 3-hydroxylase 2 -0.0351665
PDE10A phosphodiesterase 10A -0.0350208
RPL5 ribosomal protein L5 -0.0345741
PRKN parkin RBR E3 ubiquitin protein ligase -0.0338784
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0337074
WARS1 tryptophanyl-tRNA synthetase 1 -0.0332039
RPL35 ribosomal protein L35 -0.0330111
GNAS GNAS complex locus -0.032872
LSAMP limbic system-associated membrane protein -0.0328037
RPL38 ribosomal protein L38 -0.0321349
RPL32 ribosomal protein L32 -0.0317015
LMNA lamin A/C -0.0315515
ENO1 enolase 1, (alpha) -0.0309742
EEF2 eukaryotic translation elongation factor 2 -0.0307089
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0306777
ASTN2 astrotactin 2 -0.030419
RPL13A ribosomal protein L13a -0.0300571
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0297406
CADM2 cell adhesion molecule 2 -0.0286241
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0284211
MT2A metallothionein 2A -0.0280115
RPL8 ribosomal protein L8 -0.0277413
RPL18 ribosomal protein L18 -0.0275853
RPL28 ribosomal protein L28 -0.0274268
ANTXR1 anthrax toxin receptor 1 -0.0272932
RPS5 ribosomal protein S5 -0.0268054
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0260313
RPS11 ribosomal protein S11 -0.0259533
OASL 2'-5'-oligoadenylate synthetase-like -0.0254688
SRGN serglycin -0.0254292
PFN1 profilin 1 -0.0253817
RPS10 ribosomal protein S10 -0.0248324
SOX4 SRY (sex determining region Y)-box 4 -0.0247122
RPL30 ribosomal protein L30 -0.0244366