Artemether_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Artemether perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Artemether_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DST dystonin 0.0963705
HDAC9 histone deacetylase 9 0.0920291
JMJD1C jumonji domain containing 1C 0.0899742
COL11A1 collagen, type XI, alpha 1 0.0764789
PHIP pleckstrin homology domain interacting protein 0.0745258
TENM3 teneurin transmembrane protein 3 0.0743444
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0720198
PLPP1 phospholipid phosphatase 1 0.0683645
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.066925
LHFPL6 LHFPL tetraspan subfamily member 6 0.0596207
ZEB2 zinc finger E-box binding homeobox 2 0.0548878
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0533502
ANKRD33B ankyrin repeat domain 33B 0.0522818
PGAP1 post-GPI attachment to proteins 1 0.0521403
TSC22D2 TSC22 domain family, member 2 0.0512991
SAMD4A sterile alpha motif domain containing 4A 0.0509284
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0490264
RASAL2 RAS protein activator like 2 0.0468549
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0463499
FAM171B family with sequence similarity 171, member B 0.0457534
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.0450748
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0437028
MYO10 myosin X 0.0427026
MAML2 mastermind-like 2 (Drosophila) 0.0423774
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0420179
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.0419051
PRKD1 protein kinase D1 0.0417748
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0413616
ADAM9 ADAM metallopeptidase domain 9 0.0412684
PEG10 paternally expressed 10 0.0404424
MARCHF6 membrane associated ring-CH-type finger 6 0.0399824
NFIA nuclear factor I/A 0.0395832
FBXO11 F-box protein 11 0.039128
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0391049
FNDC3B fibronectin type III domain containing 3B 0.03904
SPTBN1 spectrin, beta, non-erythrocytic 1 0.038744
CHD1 chromodomain helicase DNA binding protein 1 0.0386722
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0383626
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0381168
COL5A2 collagen, type V, alpha 2 0.0377717
TRIO trio Rho guanine nucleotide exchange factor 0.0376538
CCN2 cellular communication network factor 2 0.0375419
SOX2 SRY (sex determining region Y)-box 2 0.0370948
TMSB4X thymosin beta 4, X-linked 0.0369402
MED13L mediator complex subunit 13-like 0.0364464
CDC73 cell division cycle 73 0.0355225
PDGFC platelet derived growth factor C 0.0353439
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0352951
BIRC6 baculoviral IAP repeat containing 6 0.0352101
PUM2 pumilio RNA-binding family member 2 0.0345534
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0345193
ZFAND3 zinc finger, AN1-type domain 3 0.0339848
ITGAV integrin, alpha V 0.03381
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1 0.0337824
PICALM phosphatidylinositol binding clathrin assembly protein 0.0335908
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0334387
NTM neurotrimin 0.0333688
BTBD3 BTB (POZ) domain containing 3 0.033036
BZW1 basic leucine zipper and W2 domains 1 0.0323299
WSB1 WD repeat and SOCS box containing 1 0.0317504
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0316876
TLK2 tousled-like kinase 2 0.0312256
FNDC3A fibronectin type III domain containing 3A 0.0311722
SSBP2 single-stranded DNA binding protein 2 0.0310697
CHD7 chromodomain helicase DNA binding protein 7 0.0310048
LYST lysosomal trafficking regulator 0.0309774
MACF1 microtubule-actin crosslinking factor 1 0.0309083
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0301167
CANX calnexin 0.0300445
NEK7 NIMA-related kinase 7 0.0297574
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.029747
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.0294569
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0293818
EPB41L5 erythrocyte membrane protein band 4.1 like 5 0.0291111
NCOR2 nuclear receptor corepressor 2 0.0285609
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0284452
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0283301
ATXN2 ataxin 2 0.0280701
PPP4R1 protein phosphatase 4, regulatory subunit 1 0.0280208
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0278995
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0277359
SLC38A2 solute carrier family 38, member 2 0.0275704
TENM2 teneurin transmembrane protein 2 0.0273945
ENAH enabled homolog (Drosophila) 0.0273693
ADGRL3 adhesion G protein-coupled receptor L3 0.0272881
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0272314
PDS5A PDS5 cohesin associated factor A 0.0269044
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0267601
ZSWIM6 zinc finger, SWIM-type containing 6 0.0266984
STRN3 striatin, calmodulin binding protein 3 0.0265275
KPNA6 karyopherin alpha 6 (importin alpha 7) 0.0264324
SYT1 synaptotagmin I 0.0263154
CTTNBP2NL CTTNBP2 N-terminal like 0.0259889
NCKAP1 NCK-associated protein 1 0.0259648
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.025859
MEIS2 Meis homeobox 2 0.025622
THRAP3 thyroid hormone receptor associated protein 3 0.0255021
HMGB2 high mobility group box 2 0.0253241
SHROOM3 shroom family member 3 0.0252907
TBC1D5 TBC1 domain family, member 5 0.025174

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.1907
TMSB10 thymosin beta 10 -0.162061
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.11021
ACTG1 actin gamma 1 -0.0911136
RPLP1 ribosomal protein, large, P1 -0.0909946
RPS16 ribosomal protein S16 -0.0821963
RPL23 ribosomal protein L23 -0.075445
CADM2 cell adhesion molecule 2 -0.0743341
POTEF POTE ankyrin domain family, member F -0.0690456
NAP1L1 nucleosome assembly protein 1-like 1 -0.0681648
RPS27A ribosomal protein S27a -0.0600851
AHNAK AHNAK nucleoprotein -0.0570388
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0560775
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0532317
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0492027
MKI67 marker of proliferation Ki-67 -0.0474123
HMGB1 high mobility group box 1 -0.0472457
RPL35A ribosomal protein L35a -0.0462815
ATP5F1B ATP synthase F1 subunit beta -0.0461454
UBC ubiquitin C -0.0461337
ARHGAP15 Rho GTPase activating protein 15 -0.0444833
RPS2 ribosomal protein S2 -0.0435833
RPS8 ribosomal protein S8 -0.0432703
PTMA prothymosin, alpha -0.0430484
RPS6 ribosomal protein S6 -0.0425833
EEF2 eukaryotic translation elongation factor 2 -0.0402995
RPL5 ribosomal protein L5 -0.0402165
YBX1 Y box binding protein 1 -0.0401072
RPS3 ribosomal protein S3 -0.0386501
RPS19 ribosomal protein S19 -0.0376413
EEF1G eukaryotic translation elongation factor 1 gamma -0.0371906
S100A10 S100 calcium binding protein A10 -0.03699
GNAS GNAS complex locus -0.0367581
RPS12 ribosomal protein S12 -0.03639
CNRIP1 cannabinoid receptor interacting protein 1 -0.0347453
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0344005
RPS29 ribosomal protein S29 -0.0340878
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.033995
RPS13 ribosomal protein S13 -0.0335951
DLG1 discs, large homolog 1 (Drosophila) -0.0332192
PPIG peptidylprolyl isomerase G (cyclophilin G) -0.0330236
MDK midkine (neurite growth-promoting factor 2) -0.0325
RPL12 ribosomal protein L12 -0.0321333
TPT1 tumor protein, translationally-controlled 1 -0.0318419
S100A9 S100 calcium binding protein A9 -0.0317344
RPL18 ribosomal protein L18 -0.031731
RSRC1 arginine/serine-rich coiled-coil 1 -0.0316626
RPL31 ribosomal protein L31 -0.031211
EIF3K eukaryotic translation initiation factor 3, subunit K -0.0311699
PA2G4 proliferation-associated 2G4, 38kDa -0.029944
GPC3 glypican 3 -0.0299079
PDCD5 programmed cell death 5 -0.0294459
RPS17 ribosomal protein S17 -0.0292803
RPL37A ribosomal protein L37a -0.029233
SFPQ splicing factor proline/glutamine-rich -0.0292023
RPL36 ribosomal protein L36 -0.028966
BAZ1A bromodomain adjacent to zinc finger domain, 1A -0.0288485
B2M beta-2-microglobulin -0.0286791
RPL32 ribosomal protein L32 -0.0284352
RPL11 ribosomal protein L11 -0.028425
SERF2 small EDRK-rich factor 2 -0.0283665
ZNF207 zinc finger protein 207 -0.0282851
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0277055
POMP proteasome maturation protein -0.0276082
TAPBP TAP binding protein (tapasin) -0.0274699
RACK1 receptor for activated C kinase 1 -0.0269257
USP22 ubiquitin specific peptidase 22 -0.026814
RPL27 ribosomal protein L27 -0.0267926
PKM pyruvate kinase, muscle -0.0266789
RPL36A ribosomal protein L36a -0.0263739
NUP58 nucleoporin 58 -0.0262896
ACTN4 actinin, alpha 4 -0.0261305
FTL ferritin, light polypeptide -0.0258314
PDE4D phosphodiesterase 4D, cAMP-specific -0.0249693
LDHB lactate dehydrogenase B -0.0244461
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) -0.0244022
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0243646
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0243367
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0243277
H2AZ2 H2A.Z variant histone 2 -0.0242306
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0241229
CENPE centromere protein E, 312kDa -0.024063
RPL19 ribosomal protein L19 -0.0237271
SCAF11 SR-related CTD-associated factor 11 -0.0233293
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 -0.0233282
RPL37 ribosomal protein L37 -0.0231747
SMC4 structural maintenance of chromosomes 4 -0.0231219
PCBP2 poly(rC) binding protein 2 -0.023103
RPL35 ribosomal protein L35 -0.023025
MBIP MAP3K12 binding inhibitory protein 1 -0.0230059
ENO1 enolase 1, (alpha) -0.0228865
KLHL5 kelch-like family member 5 -0.0227796
KMT2E lysine (K)-specific methyltransferase 2E -0.0227726
SET SET nuclear proto-oncogene -0.0227373
ISG15 ISG15 ubiquitin-like modifier -0.0226799
COL1A2 collagen, type I, alpha 2 -0.0224845
HSPB1 heat shock 27kDa protein 1 -0.0224409
VGLL3 vestigial-like family member 3 -0.0224148
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -0.0222436
PDIA4 protein disulfide isomerase family A, member 4 -0.022199