Artemether_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Artemether perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Artemether_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TMSB4X thymosin beta 4, X-linked 0.159088
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.106202
EIF4A2 eukaryotic translation initiation factor 4A2 0.097359
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0812704
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0798574
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0738399
PGK1 phosphoglycerate kinase 1 0.0693042
ECT2 epithelial cell transforming 2 0.066918
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.064925
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0619937
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0581429
DSCAM Down syndrome cell adhesion molecule 0.0517778
ADAM10 ADAM metallopeptidase domain 10 0.0516317
GOLGA4 golgin A4 0.0515238
RBM39 RNA binding motif protein 39 0.050457
TTC3 tetratricopeptide repeat domain 3 0.0492184
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0477534
ENO1 enolase 1, (alpha) 0.0473268
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0467343
PDE4B phosphodiesterase 4B, cAMP-specific 0.0459315
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0449422
KMT2E lysine (K)-specific methyltransferase 2E 0.0428177
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0427739
ZCCHC7 zinc finger, CCHC domain containing 7 0.0427676
QKI QKI, KH domain containing, RNA binding 0.0422195
VCL vinculin 0.0418838
FNDC3B fibronectin type III domain containing 3B 0.0412755
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0412518
JMJD1C jumonji domain containing 1C 0.0406653
CANX calnexin 0.0391171
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0383837
ZFAND3 zinc finger, AN1-type domain 3 0.0383701
COPB1 coatomer protein complex, subunit beta 1 0.0381182
EVI5 ecotropic viral integration site 5 0.0380678
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0355047
PRELID2 PRELI domain containing 2 0.0354883
SEC31A SEC31 homolog A (S. cerevisiae) 0.0354821
LDHA lactate dehydrogenase A 0.0354402
APP amyloid beta (A4) precursor protein 0.0353655
PICALM phosphatidylinositol binding clathrin assembly protein 0.0351895
ZNF608 zinc finger protein 608 0.0351202
SSBP2 single-stranded DNA binding protein 2 0.0347784
ATM ATM serine/threonine kinase 0.0346783
NBAS neuroblastoma amplified sequence 0.0339745
USP9X ubiquitin specific peptidase 9, X-linked 0.033728
ELOVL5 ELOVL fatty acid elongase 5 0.0336076
SAMD4A sterile alpha motif domain containing 4A 0.0335047
NUP58 nucleoporin 58 0.0335002
TJP1 tight junction protein 1 0.0330729
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0330045
ZFC3H1 zinc finger, C3H1-type containing 0.0325417
MYOF myoferlin 0.032102
CPED1 cadherin-like and PC-esterase domain containing 1 0.0319625
LOC112694756 uncharaterized LOC112694756 0.031693
TGFBR3 transforming growth factor, beta receptor III 0.0316795
UBC ubiquitin C 0.031466
INSIG2 insulin induced gene 2 0.0313848
TMEM39A transmembrane protein 39A 0.031318
TOP2B topoisomerase (DNA) II beta 180kDa 0.030901
ASPH aspartate beta-hydroxylase 0.0298225
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0296781
SMYD3 SET and MYND domain containing 3 0.0296752
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0296363
CD47 CD47 molecule 0.0296294
LPP LIM domain containing preferred translocation partner in lipoma 0.0294375
MON2 MON2 homolog (S. cerevisiae) 0.0294017
TNRC6B trinucleotide repeat containing 6B 0.0290231
GDI2 GDP dissociation inhibitor 2 0.0284855
NFIA nuclear factor I/A 0.0282834
ZEB1 zinc finger E-box binding homeobox 1 0.0282643
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0282373
AUH AU RNA binding protein/enoyl-CoA hydratase 0.028213
HELZ helicase with zinc finger 0.028092
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0276144
PLK2 polo-like kinase 2 0.0275216
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0274837
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0272046
TMF1 TATA element modulatory factor 1 0.0270456
EZR ezrin 0.02696
SQSTM1 sequestosome 1 0.0267916
NCKAP1 NCK-associated protein 1 0.0265063
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0263439
EMSY EMSY transcriptional repressor, BRCA2 interacting 0.0261439
OSBPL8 oxysterol binding protein-like 8 0.0261335
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.0260819
HSPA8 heat shock 70kDa protein 8 0.0260467
CAMTA1 calmodulin binding transcription activator 1 0.0257181
CDC73 cell division cycle 73 0.025603
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.0256025
KDM2A lysine (K)-specific demethylase 2A 0.0255038
PDGFC platelet derived growth factor C 0.0254317
NBEA neurobeachin 0.0252676
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0249194
RNF145 ring finger protein 145 0.0248331
CLTC clathrin, heavy chain (Hc) 0.0245885
PCBP2 poly(rC) binding protein 2 0.024476
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0241793
ANXA1 annexin A1 0.0241691
EPS8 epidermal growth factor receptor pathway substrate 8 0.02415
FAM13A family with sequence similarity 13, member A 0.0240803

decreased expression

Symbol Name Standardized Value
RPS6 ribosomal protein S6 -0.128725
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.12813
PTMA prothymosin, alpha -0.125726
RPS8 ribosomal protein S8 -0.123596
PKM pyruvate kinase, muscle -0.117731
RPL35A ribosomal protein L35a -0.117368
TPT1 tumor protein, translationally-controlled 1 -0.114513
RPLP1 ribosomal protein, large, P1 -0.0880142
RPL31 ribosomal protein L31 -0.0756683
RPL23 ribosomal protein L23 -0.075264
RPL34 ribosomal protein L34 -0.0724788
RPS19 ribosomal protein S19 -0.0717501
RPLP2 ribosomal protein, large, P2 -0.0708462
RPL37A ribosomal protein L37a -0.0693311
RPL26 ribosomal protein L26 -0.0646155
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0644528
BMP10 bone morphogenetic protein 10 -0.0613429
RPL9 ribosomal protein L9 -0.0589677
RPS3 ribosomal protein S3 -0.0587886
S100A4 S100 calcium binding protein A4 -0.0579698
S100A9 S100 calcium binding protein A9 -0.0554618
RPL19 ribosomal protein L19 -0.0544659
RPL36 ribosomal protein L36 -0.0525633
RPS25 ribosomal protein S25 -0.0525203
RPL12 ribosomal protein L12 -0.0489459
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0487149
RPS13 ribosomal protein S13 -0.0486617
TMSB10 thymosin beta 10 -0.0482148
RPS29 ribosomal protein S29 -0.0460569
RPS23 ribosomal protein S23 -0.0455164
HSPB1 heat shock 27kDa protein 1 -0.0449817
RPL28 ribosomal protein L28 -0.0445052
RPS21 ribosomal protein S21 -0.0438106
RPS12 ribosomal protein S12 -0.0430352
AHNAK AHNAK nucleoprotein -0.04246
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0424571
EEF1G eukaryotic translation elongation factor 1 gamma -0.0418069
ACTG1 actin gamma 1 -0.0403924
PFN1 profilin 1 -0.0400107
RPL5 ribosomal protein L5 -0.0399366
RPS24 ribosomal protein S24 -0.0399075
RPL27A ribosomal protein L27a -0.0398462
RPS14 ribosomal protein S14 -0.0392655
RPS16 ribosomal protein S16 -0.0384212
FTL ferritin, light polypeptide -0.0374724
ARL4C ADP-ribosylation factor-like 4C -0.0365845
RPS2 ribosomal protein S2 -0.0353374
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0352185
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -0.0351373
HMGA1 high mobility group AT-hook 1 -0.034921
RPL35 ribosomal protein L35 -0.0342652
RACK1 receptor for activated C kinase 1 -0.0336141
S100A6 S100 calcium binding protein A6 -0.0324879
POTEF POTE ankyrin domain family, member F -0.0318296
PRDX2 peroxiredoxin 2 -0.0317642
PABPN1 poly(A) binding protein, nuclear 1 -0.03142
RPS27 ribosomal protein S27 -0.0312102
PTMS parathymosin -0.0310181
HMGB1 high mobility group box 1 -0.0304794
DIAPH3 diaphanous-related formin 3 -0.0301804
RPS17 ribosomal protein S17 -0.030145
RPL30 ribosomal protein L30 -0.0301011
S100A10 S100 calcium binding protein A10 -0.0299207
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0295992
RPL7A ribosomal protein L7a -0.0294969
RPL38 ribosomal protein L38 -0.0290489
RPL32 ribosomal protein L32 -0.0287745
RPS11 ribosomal protein S11 -0.0283322
RPL11 ribosomal protein L11 -0.0279927
TPM4 tropomyosin 4 -0.0278519
RPL8 ribosomal protein L8 -0.0271919
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0271761
RPL18 ribosomal protein L18 -0.026866
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0263515
RPLP0 ribosomal protein, large, P0 -0.0253313
RPS15 ribosomal protein S15 -0.0252849
SMC3 structural maintenance of chromosomes 3 -0.0252833
LDHB lactate dehydrogenase B -0.0252733
RPL13A ribosomal protein L13a -0.0250607
RPS20 ribosomal protein S20 -0.0250311
ASTN2 astrotactin 2 -0.0244144
HLA-B major histocompatibility complex, class I, B -0.0242654
MYL12B myosin, light chain 12B, regulatory -0.0238677
IFI16 interferon, gamma-inducible protein 16 -0.0236114
EBNA1BP2 EBNA1 binding protein 2 -0.0234815
GLI2 GLI family zinc finger 2 -0.0234329
RPS10 ribosomal protein S10 -0.023318
RPL36A ribosomal protein L36a -0.0230445
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0229841
RPS4X ribosomal protein S4, X-linked -0.0225859
HEG1 heart development protein with EGF-like domains 1 -0.0224743
RPS5 ribosomal protein S5 -0.0224179
RPL10A ribosomal protein L10a -0.0222978
SPRY4 sprouty homolog 4 (Drosophila) -0.0222544
RPL27 ribosomal protein L27 -0.0221494
EMP3 epithelial membrane protein 3 -0.0220944
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0220325
PHF14 PHD finger protein 14 -0.0220058
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.021889
NACA nascent polypeptide-associated complex alpha subunit -0.0216978