Artemether_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Artemether perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Artemether_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SOD2 superoxide dismutase 2, mitochondrial 0.313981
MYH9 myosin, heavy chain 9, non-muscle 0.16437
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.117289
FN1 fibronectin 1 0.0829652
MSN moesin 0.071113
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0607848
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0522523
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0517858
EEF2 eukaryotic translation elongation factor 2 0.0510761
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0507194
PCBP2 poly(rC) binding protein 2 0.0456175
NAMPT nicotinamide phosphoribosyltransferase 0.0452066
USP9X ubiquitin specific peptidase 9, X-linked 0.0439558
RB1CC1 RB1-inducible coiled-coil 1 0.0438637
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0429768
SPAG9 sperm associated antigen 9 0.0426679
ARRDC3 arrestin domain containing 3 0.0421181
NT5C2 5'-nucleotidase, cytosolic II 0.039654
PGK1 phosphoglycerate kinase 1 0.039271
PDE10A phosphodiesterase 10A 0.0364675
CKAP5 cytoskeleton associated protein 5 0.0347509
TMSB4X thymosin beta 4, X-linked 0.034522
OGA O-GlcNAcase 0.0345056
FNDC3B fibronectin type III domain containing 3B 0.0342801
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0338329
MXI1 MAX interactor 1, dimerization protein 0.033832
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.033552
APP amyloid beta (A4) precursor protein 0.03353
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0321403
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0315096
CADM1 cell adhesion molecule 1 0.0313007
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0300102
ANXA1 annexin A1 0.0296226
JMJD1C jumonji domain containing 1C 0.0291174
MATR3 matrin 3 0.028453
OPTN optineurin 0.0280287
SFTPA2 surfactant protein A2 0.0279915
AKAP13 A kinase (PRKA) anchor protein 13 0.0274967
TSC22D2 TSC22 domain family, member 2 0.0274922
FNIP1 folliculin interacting protein 1 0.0274803
ANLN anillin, actin binding protein 0.027407
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0264326
NAV2 neuron navigator 2 0.0263595
UBA6 ubiquitin-like modifier activating enzyme 6 0.0263519
ADM adrenomedullin 0.0262872
CCNL1 cyclin L1 0.0258898
FLNA filamin A, alpha 0.0252871
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0249551
SDC4 syndecan 4 0.0249551
LAMP2 lysosomal-associated membrane protein 2 0.0248712
AFF4 AF4/FMR2 family, member 4 0.0247632
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0238547
LCORL ligand dependent nuclear receptor corepressor-like 0.023636
GLS2 glutaminase 2 (liver, mitochondrial) 0.0236212
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0235585
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0233775
AHR aryl hydrocarbon receptor 0.0233364
ZNF292 zinc finger protein 292 0.0232767
USP37 ubiquitin specific peptidase 37 0.0229307
WDFY1 WD repeat and FYVE domain containing 1 0.0227626
CDK19 cyclin-dependent kinase 19 0.0226923
APLP2 amyloid beta (A4) precursor-like protein 2 0.0225918
FMNL2 formin-like 2 0.0220565
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.0218512
ATP13A3 ATPase type 13A3 0.0216375
MYOF myoferlin 0.0215396
PCBP3 poly(rC) binding protein 3 0.0212674
PUM2 pumilio RNA-binding family member 2 0.0212124
NGLY1 N-glycanase 1 0.0212072
PHIP pleckstrin homology domain interacting protein 0.0211518
AFDN afadin, adherens junction formation factor 0.0210408
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0209945
SERINC1 serine incorporator 1 0.0209727
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0207291
BCLAF1 BCL2-associated transcription factor 1 0.0206807
MBNL2 muscleblind-like splicing regulator 2 0.0206606
NOTCH2 notch 2 0.020608
IQGAP1 IQ motif containing GTPase activating protein 1 0.0204862
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0204745
HELZ helicase with zinc finger 0.0202792
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0200673
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0200265
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0198608
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 0.019756
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0194247
GAS2L3 growth arrest-specific 2 like 3 0.0192603
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0192198
ZNF654 zinc finger protein 654 0.0191969
KDM3A lysine (K)-specific demethylase 3A 0.0191618
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0189988
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0189521
CANX calnexin 0.018911
ZNF638 zinc finger protein 638 0.0187321
DIAPH3 diaphanous-related formin 3 0.0186671
CENPF centromere protein F, 350/400kDa 0.0186467
PDCD6IP programmed cell death 6 interacting protein 0.0186308
DSCAM Down syndrome cell adhesion molecule 0.0186109
SCAF8 SR-related CTD-associated factor 8 0.0185895
SNX14 sorting nexin 14 0.0180059
XPO1 exportin 1 0.0179548

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.246165
FTL ferritin, light polypeptide -0.154687
TMSB10 thymosin beta 10 -0.141226
IER3 immediate early response 3 -0.128793
HLA-B major histocompatibility complex, class I, B -0.125159
MARCKS myristoylated alanine-rich protein kinase C substrate -0.11421
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.107707
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.107431
GLIS3 GLIS family zinc finger 3 -0.102015
TPT1 tumor protein, translationally-controlled 1 -0.0902904
MT2A metallothionein 2A -0.0845988
AKAP12 A kinase (PRKA) anchor protein 12 -0.0829218
FRMD4A FERM domain containing 4A -0.0775923
IGFBP3 insulin-like growth factor binding protein 3 -0.0758692
RPS6 ribosomal protein S6 -0.0711751
RPL23 ribosomal protein L23 -0.0687731
RPS8 ribosomal protein S8 -0.067539
RPL37A ribosomal protein L37a -0.066869
RPS12 ribosomal protein S12 -0.0652428
RPLP1 ribosomal protein, large, P1 -0.0645686
HMGA2 high mobility group AT-hook 2 -0.0642091
RPLP2 ribosomal protein, large, P2 -0.0639407
RPL35A ribosomal protein L35a -0.057995
RPS19 ribosomal protein S19 -0.0569764
PTMA prothymosin, alpha -0.0519041
RPS24 ribosomal protein S24 -0.0517455
HLA-A major histocompatibility complex, class I, A -0.0498441
RPL36 ribosomal protein L36 -0.0491391
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0485477
RPL12 ribosomal protein L12 -0.0483781
RPL19 ribosomal protein L19 -0.0480941
EXT1 exostosin glycosyltransferase 1 -0.0442792
CDH13 cadherin 13 -0.0442267
NAV1 neuron navigator 1 -0.043757
ZMYND8 zinc finger, MYND-type containing 8 -0.0428397
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0428018
FTH1 ferritin, heavy polypeptide 1 -0.042589
RPS3 ribosomal protein S3 -0.0414577
TGFBI transforming growth factor, beta-induced, 68kDa -0.040473
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0404446
RPS25 ribosomal protein S25 -0.0402762
B2M beta-2-microglobulin -0.0386323
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0383552
S100A9 S100 calcium binding protein A9 -0.0371457
IFITM3 interferon induced transmembrane protein 3 -0.0369232
EGR1 early growth response 1 -0.0366333
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0366171
COL6A3 collagen, type VI, alpha 3 -0.0365707
RPL26 ribosomal protein L26 -0.0363112
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0362333
P4HB prolyl 4-hydroxylase, beta polypeptide -0.035652
RPL9 ribosomal protein L9 -0.0349574
RPL36A ribosomal protein L36a -0.0348671
GNAS GNAS complex locus -0.0344022
VCL vinculin -0.0339835
PTPRK protein tyrosine phosphatase, receptor type, K -0.0335301
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.033435
RAI14 retinoic acid induced 14 -0.0330217
SLC38A1 solute carrier family 38, member 1 -0.032804
RPL35 ribosomal protein L35 -0.0320053
RPL37 ribosomal protein L37 -0.031779
IGFBP7 insulin-like growth factor binding protein 7 -0.0310281
CTSD cathepsin D -0.0308106
RPL34 ribosomal protein L34 -0.0307101
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A -0.0303763
RPS29 ribosomal protein S29 -0.0300971
RPL7A ribosomal protein L7a -0.0300713
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0297869
IFI6 interferon, alpha-inducible protein 6 -0.0295895
RPS4X ribosomal protein S4, X-linked -0.0295405
RPL11 ribosomal protein L11 -0.0295273
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0290637
TMEM132D transmembrane protein 132D -0.0286348
RPL28 ribosomal protein L28 -0.0283659
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0281661
RPS14 ribosomal protein S14 -0.0278475
RPS13 ribosomal protein S13 -0.0276239
MAML2 mastermind-like 2 (Drosophila) -0.0273315
RPS27 ribosomal protein S27 -0.0269636
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0269258
RPS10 ribosomal protein S10 -0.0267948
PKM pyruvate kinase, muscle -0.0267207
RPL39 ribosomal protein L39 -0.026362
SFRP1 secreted frizzled-related protein 1 -0.0261805
BICC1 BicC family RNA binding protein 1 -0.0258775
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0252857
ZBTB20 zinc finger and BTB domain containing 20 -0.0252172
DIAPH2 diaphanous-related formin 2 -0.025206
RRBP1 ribosome binding protein 1 -0.0251555
TPM4 tropomyosin 4 -0.0248766
RNF213 ring finger protein 213 -0.0247899
SLC35F3 solute carrier family 35, member F3 -0.0247085
CLMP CXADR-like membrane protein -0.0245891
RPL5 ribosomal protein L5 -0.0245878
RPS21 ribosomal protein S21 -0.024538
RPL31 ribosomal protein L31 -0.024486
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.024399
SVIL supervillin -0.0243157
AHNAK AHNAK nucleoprotein -0.024158
ASPH aspartate beta-hydroxylase -0.0241039