Artemether_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Artemether perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Artemether_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ATP13A3 ATPase type 13A3 0.106711
COL6A3 collagen, type VI, alpha 3 0.096265
AKAP12 A kinase (PRKA) anchor protein 12 0.0898007
MYH9 myosin, heavy chain 9, non-muscle 0.0884317
CDH13 cadherin 13 0.0727263
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0722055
TRIO trio Rho guanine nucleotide exchange factor 0.0692534
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0684068
NAMPT nicotinamide phosphoribosyltransferase 0.0680117
VIM vimentin 0.0661237
FAM13A family with sequence similarity 13, member A 0.0612976
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0608192
SPTBN1 spectrin, beta, non-erythrocytic 1 0.056941
UBA6 ubiquitin-like modifier activating enzyme 6 0.0549286
SOD2 superoxide dismutase 2, mitochondrial 0.0548673
RAB8B RAB8B, member RAS oncogene family 0.0536712
RBM39 RNA binding motif protein 39 0.0528901
CD44 CD44 molecule (Indian blood group) 0.0528541
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0520788
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0515794
CLINT1 clathrin interactor 1 0.0508882
STC1 stanniocalcin 1 0.0502345
FMNL2 formin-like 2 0.0497685
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0484067
MATR3 matrin 3 0.0474513
SND1 staphylococcal nuclease and tudor domain containing 1 0.0473627
UGCG UDP-glucose ceramide glucosyltransferase 0.0470491
RNF216 ring finger protein 216 0.0469417
HELZ helicase with zinc finger 0.0467591
GOLGA4 golgin A4 0.0464651
TNIP1 TNFAIP3 interacting protein 1 0.0440154
ANXA2 annexin A2 0.0430291
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0424228
SEPTIN2 septin 2 0.0422455
HOOK2 hook microtubule-tethering protein 2 0.0421611
GRB10 growth factor receptor-bound protein 10 0.0412534
SUCO SUN domain containing ossification factor 0.0411783
ELL2 elongation factor, RNA polymerase II, 2 0.0407365
ANLN anillin, actin binding protein 0.0403725
INSIG2 insulin induced gene 2 0.0398425
ERRFI1 ERBB receptor feedback inhibitor 1 0.0390546
COPB1 coatomer protein complex, subunit beta 1 0.0387552
CXCL8 chemokine (C-X-C motif) ligand 8 0.0387111
SRP54 signal recognition particle 54kDa 0.038418
CANX calnexin 0.0383381
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 0.0382192
FNDC3B fibronectin type III domain containing 3B 0.0379283
ANXA5 annexin A5 0.0376226
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0372167
JMJD1C jumonji domain containing 1C 0.0368143
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0359845
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0357333
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0353654
BACE2 beta-site APP-cleaving enzyme 2 0.0347769
SEC24A SEC24 family member A 0.0345189
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0342648
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0339394
NCOR1 nuclear receptor corepressor 1 0.0337097
AKAP13 A kinase (PRKA) anchor protein 13 0.0332954
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0331135
PRELID2 PRELI domain containing 2 0.0330012
COL3A1 collagen, type III, alpha 1 0.0329991
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0326283
WDR41 WD repeat domain 41 0.0325456
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0322658
RAB2A RAB2A, member RAS oncogene family 0.032156
UBC ubiquitin C 0.0319944
RSRC2 arginine/serine-rich coiled-coil 2 0.0319752
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0316971
COG5 component of oligomeric golgi complex 5 0.0316925
HMGB2 high mobility group box 2 0.0315208
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0311422
CTNND1 catenin (cadherin-associated protein), delta 1 0.0309355
OSBPL9 oxysterol binding protein-like 9 0.0308831
FNBP1L formin binding protein 1-like 0.03069
NAV2 neuron navigator 2 0.0299677
ARRDC3 arrestin domain containing 3 0.0298213
OGA O-GlcNAcase 0.0297509
TENT5A terminal nucleotidyltransferase 5A 0.0295601
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0295132
IL6ST interleukin 6 signal transducer 0.0289931
AKAP9 A kinase (PRKA) anchor protein 9 0.028963
SOCS5 suppressor of cytokine signaling 5 0.0282955
RND3 Rho family GTPase 3 0.0281939
VCL vinculin 0.0279753
AVL9 AVL9 homolog (S. cerevisiase) 0.0277392
PGK1 phosphoglycerate kinase 1 0.0276981
LOX lysyl oxidase 0.0275793
SKIC3 SKI3 subunit of superkiller complex 0.0275485
SQSTM1 sequestosome 1 0.0275476
RAI14 retinoic acid induced 14 0.0273868
MT2A metallothionein 2A 0.0272074
AUH AU RNA binding protein/enoyl-CoA hydratase 0.0270847
TMEM39A transmembrane protein 39A 0.0269471
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.026841
STK4 serine/threonine kinase 4 0.0267808
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14 0.0267451
ZNF654 zinc finger protein 654 0.0264697
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0264473
APP amyloid beta (A4) precursor protein 0.0263376

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.324394
TGFBI transforming growth factor, beta-induced, 68kDa -0.130489
PSD3 pleckstrin and Sec7 domain containing 3 -0.0988846
IGFBP3 insulin-like growth factor binding protein 3 -0.0944306
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0786443
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0758293
POTEF POTE ankyrin domain family, member F -0.0708573
FN1 fibronectin 1 -0.0698689
HMGA2 high mobility group AT-hook 2 -0.064407
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0607245
PKM pyruvate kinase, muscle -0.0584043
FTL ferritin, light polypeptide -0.0571689
CCNI cyclin I -0.0513924
COL6A1 collagen, type VI, alpha 1 -0.0500543
EGR1 early growth response 1 -0.048866
PDE4D phosphodiesterase 4D, cAMP-specific -0.048697
LDHA lactate dehydrogenase A -0.0484832
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0467673
COL1A1 collagen, type I, alpha 1 -0.0463554
VEGFA vascular endothelial growth factor A -0.0461031
TUBB tubulin, beta class I -0.0434866
TNS3 tensin 3 -0.0431059
IL6 interleukin 6 -0.0427378
SLC38A2 solute carrier family 38, member 2 -0.0363281
ACTG1 actin gamma 1 -0.0358536
HMGB1 high mobility group box 1 -0.0353889
RPLP1 ribosomal protein, large, P1 -0.0346199
DPYD dihydropyrimidine dehydrogenase -0.0335571
TNNC1 troponin C type 1 (slow) -0.0334999
RUNX1 runt-related transcription factor 1 -0.0330192
CD99 CD99 molecule -0.0329278
MAP1B microtubule-associated protein 1B -0.0322088
DDX50 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 -0.031763
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.0312418
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0311765
SIK3 SIK family kinase 3 -0.030904
SEPTIN7 septin 7 -0.0302127
ELP4 elongator acetyltransferase complex subunit 4 -0.0300673
RRBP1 ribosome binding protein 1 -0.029909
KIZ kizuna centrosomal protein -0.0296315
RPL23 ribosomal protein L23 -0.029466
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0294505
FUS FUS RNA binding protein -0.0280389
MBD5 methyl-CpG binding domain protein 5 -0.0280308
F3 coagulation factor III (thromboplastin, tissue factor) -0.0278049
EFHD2 EF-hand domain family, member D2 -0.0277663
PTPRG protein tyrosine phosphatase, receptor type, G -0.0273804
CHD9 chromodomain helicase DNA binding protein 9 -0.027188
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0271643
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.026894
C2CD2 C2 calcium-dependent domain containing 2 -0.0268744
NCOR2 nuclear receptor corepressor 2 -0.0267638
SF3B3 splicing factor 3b, subunit 3, 130kDa -0.0267572
MAML2 mastermind-like 2 (Drosophila) -0.0266879
CCND1 cyclin D1 -0.0266815
RPL28 ribosomal protein L28 -0.0266339
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0265849
H3-3B H3.3 histone B -0.0264565
WWOX WW domain containing oxidoreductase -0.0264126
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0259763
PIAS1 protein inhibitor of activated STAT, 1 -0.0258319
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0254766
RNF11 ring finger protein 11 -0.0251731
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0250057
NDRG1 N-myc downstream regulated 1 -0.0249003
RIGI RNA sensor RIG-I -0.0248492
SREBF2 sterol regulatory element binding transcription factor 2 -0.0248448
RAD51B RAD51 paralog B -0.0247474
NSD1 nuclear receptor binding SET domain protein 1 -0.0247158
RSPRY1 ring finger and SPRY domain containing 1 -0.0247044
PRSS23 protease, serine, 23 -0.0245927
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0245796
NALF1 NALCN channel auxiliary factor 1 -0.0245661
FHIT fragile histidine triad -0.0245252
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 -0.0239895
VGLL4 vestigial-like family member 4 -0.0239745
NPAS2 neuronal PAS domain protein 2 -0.0237104
GFPT2 glutamine-fructose-6-phosphate transaminase 2 -0.0235971
CCDC57 coiled-coil domain containing 57 -0.0234241
NAV1 neuron navigator 1 -0.0232184
ECE1 endothelin converting enzyme 1 -0.0229873
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0229849
GSE1 Gse1 coiled-coil protein -0.022967
CST3 cystatin C -0.022889
AFF3 AF4/FMR2 family, member 3 -0.0228878
CDK14 cyclin-dependent kinase 14 -0.0228871
NCOA7 nuclear receptor coactivator 7 -0.0225803
RPS14 ribosomal protein S14 -0.022243
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0222324
ZRANB2 zinc finger, RAN-binding domain containing 2 -0.0221296
LPP LIM domain containing preferred translocation partner in lipoma -0.0221286
NFIX nuclear factor I/X (CCAAT-binding transcription factor) -0.0219644
GUK1 guanylate kinase 1 -0.0218102
ERCC6L2 excision repair cross-complementation group 6-like 2 -0.021726
RPL32 ribosomal protein L32 -0.0217196
YY1 YY1 transcription factor -0.0216858
VDAC1 voltage-dependent anion channel 1 -0.021537
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) -0.0215077
TNRC6B trinucleotide repeat containing 6B -0.0214994
FAM234A family with sequence similarity 234 member A -0.0214188