Artemether_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Artemether perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Artemether_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0931666
MYH9 myosin, heavy chain 9, non-muscle 0.0703117
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0680003
YBX3 Y box binding protein 3 0.0640589
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0605962
FNDC3B fibronectin type III domain containing 3B 0.0560972
GOLGA4 golgin A4 0.0535557
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0523531
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0516895
PTMA prothymosin, alpha 0.0510456
BASP1 brain abundant, membrane attached signal protein 1 0.0509429
CENPF centromere protein F, 350/400kDa 0.05055
MBNL2 muscleblind-like splicing regulator 2 0.0484818
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0458265
HILPDA hypoxia inducible lipid droplet-associated 0.045696
BIRC3 baculoviral IAP repeat containing 3 0.0450851
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0445554
RNF145 ring finger protein 145 0.0435256
CSNK1A1 casein kinase 1, alpha 1 0.0434379
EIF1 eukaryotic translation initiation factor 1 0.0419558
MSN moesin 0.0417963
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0417564
MACF1 microtubule-actin crosslinking factor 1 0.0417194
ESYT2 extended synaptotagmin-like protein 2 0.0406671
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0406197
WAC WW domain containing adaptor with coiled-coil 0.0405459
ECT2 epithelial cell transforming 2 0.0398534
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0397529
SET SET nuclear proto-oncogene 0.0394047
ENO1 enolase 1, (alpha) 0.0393757
RTN4 reticulon 4 0.0388479
VIM vimentin 0.0388118
LDHA lactate dehydrogenase A 0.0379443
PYGL phosphorylase, glycogen, liver 0.0378529
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0373461
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0369026
KMT2C lysine (K)-specific methyltransferase 2C 0.0363968
MATR3 matrin 3 0.0361776
ERRFI1 ERBB receptor feedback inhibitor 1 0.0355471
GOLGA2 golgin A2 0.0352666
PUM2 pumilio RNA-binding family member 2 0.035187
PBX3 pre-B-cell leukemia homeobox 3 0.0351119
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.035042
TMF1 TATA element modulatory factor 1 0.03498
BZW1 basic leucine zipper and W2 domains 1 0.0348708
ANXA1 annexin A1 0.034654
DST dystonin 0.0346478
GPBP1 GC-rich promoter binding protein 1 0.0342389
AKAP13 A kinase (PRKA) anchor protein 13 0.0341725
TM4SF1 transmembrane 4 L six family member 1 0.0340352
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0336238
CALU calumenin 0.0333382
LOC112694756 uncharaterized LOC112694756 0.0332398
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0326227
GOLGB1 golgin B1 0.0321326
MKI67 marker of proliferation Ki-67 0.0321208
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0317501
RBM25 RNA binding motif protein 25 0.0315339
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0313734
POTEF POTE ankyrin domain family, member F 0.0313599
DOCK4 dedicator of cytokinesis 4 0.0312465
ATXN1 ataxin 1 0.0311253
RSF1 remodeling and spacing factor 1 0.0310581
TRIO trio Rho guanine nucleotide exchange factor 0.0309705
SPAG9 sperm associated antigen 9 0.0307283
PGK1 phosphoglycerate kinase 1 0.0306498
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0305613
XPO1 exportin 1 0.0305019
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0302938
ATP13A3 ATPase type 13A3 0.0301333
ARHGAP21 Rho GTPase activating protein 21 0.0299089
FLNB filamin B, beta 0.0297052
CEP295 centrosomal protein 295kDa 0.0295073
KTN1 kinectin 1 (kinesin receptor) 0.0293911
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0293518
GLG1 golgi glycoprotein 1 0.0293495
CENPE centromere protein E, 312kDa 0.0293385
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0290763
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0290012
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0289273
KDM2A lysine (K)-specific demethylase 2A 0.0285543
CKAP5 cytoskeleton associated protein 5 0.0284693
HSPA8 heat shock 70kDa protein 8 0.0283712
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0282357
ARHGAP12 Rho GTPase activating protein 12 0.0280828
DIAPH1 diaphanous-related formin 1 0.0280365
NUP58 nucleoporin 58 0.0279831
TRA2A transformer 2 alpha homolog (Drosophila) 0.0279033
ACTN1 actinin, alpha 1 0.0276746
UBE3A ubiquitin protein ligase E3A 0.0272116
DSCAM Down syndrome cell adhesion molecule 0.0270261
SEC31A SEC31 homolog A (S. cerevisiae) 0.0269515
PER1 period circadian clock 1 0.0266131
CHD1 chromodomain helicase DNA binding protein 1 0.0266007
QKI QKI, KH domain containing, RNA binding 0.0265403
FXR1 fragile X mental retardation, autosomal homolog 1 0.0265184
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0264555
YAP1 Yes-associated protein 1 0.0263461
AKAP12 A kinase (PRKA) anchor protein 12 0.0262453
RICTOR RPTOR independent companion of MTOR, complex 2 0.0260921

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.0766832
TMSB10 thymosin beta 10 -0.0604289
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0469471
RPL35A ribosomal protein L35a -0.0430879
SMYD3 SET and MYND domain containing 3 -0.0398769
RAD51B RAD51 paralog B -0.0394656
MBD5 methyl-CpG binding domain protein 5 -0.0393646
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0378147
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.0368743
RPLP1 ribosomal protein, large, P1 -0.0366331
RPS8 ribosomal protein S8 -0.0364324
OSMR oncostatin M receptor -0.0360875
FBXL2 F-box and leucine-rich repeat protein 2 -0.0357961
OASL 2'-5'-oligoadenylate synthetase-like -0.0342257
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0336771
RPL36 ribosomal protein L36 -0.0308582
PRH1 proline-rich protein HaeIII subfamily 1 -0.030486
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0299902
IER3 immediate early response 3 -0.0298804
NCEH1 neutral cholesterol ester hydrolase 1 -0.0291924
RPL23 ribosomal protein L23 -0.029149
LRRC49 leucine rich repeat containing 49 -0.0278673
IFIH1 interferon induced with helicase C domain 1 -0.0275735
AOPEP aminopeptidase O (putative) -0.0273198
RPS20 ribosomal protein S20 -0.026746
RPS13 ribosomal protein S13 -0.0251562
NIPBL Nipped-B homolog (Drosophila) -0.0245004
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0244597
IFITM3 interferon induced transmembrane protein 3 -0.024156
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0236952
PARD3 par-3 family cell polarity regulator -0.0236575
RPL19 ribosomal protein L19 -0.023419
RPL37 ribosomal protein L37 -0.0233025
TBL1X transducin (beta)-like 1X-linked -0.0230693
RPL12 ribosomal protein L12 -0.02177
RPLP2 ribosomal protein, large, P2 -0.0217631
PNRC1 proline-rich nuclear receptor coactivator 1 -0.02169
RPL31 ribosomal protein L31 -0.0216152
H3-3B H3.3 histone B -0.0214392
RPS21 ribosomal protein S21 -0.0213508
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0212668
RNF213 ring finger protein 213 -0.0211223
FAM53C family with sequence similarity 53, member C -0.0209342
S100A10 S100 calcium binding protein A10 -0.0209054
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0208721
CCDC91 coiled-coil domain containing 91 -0.020834
FKBP10 FK506 binding protein 10, 65 kDa -0.0208108
WSB1 WD repeat and SOCS box containing 1 -0.0207858
BTBD9 BTB (POZ) domain containing 9 -0.0206165
RPS24 ribosomal protein S24 -0.0205878
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0205134
TLK1 tousled-like kinase 1 -0.0203834
TP53 tumor protein p53 -0.0200785
RPL11 ribosomal protein L11 -0.0200527
GNAS GNAS complex locus -0.0199078
RANBP17 RAN binding protein 17 -0.0197915
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0196437
RPS15 ribosomal protein S15 -0.0195729
RORA RAR-related orphan receptor A -0.0194544
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B -0.0194212
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 -0.0192763
EGR1 early growth response 1 -0.0191724
RIGI RNA sensor RIG-I -0.0190052
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0189849
FTL ferritin, light polypeptide -0.0189448
ZC3H12B zinc finger CCCH-type containing 12B -0.0188806
RPL27A ribosomal protein L27a -0.018777
ERCC8 excision repair cross-complementation group 8 -0.0187403
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme -0.0186694
ETV6 ets variant 6 -0.0186563
MON2 MON2 homolog (S. cerevisiae) -0.018579
HMGA2 high mobility group AT-hook 2 -0.0184728
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0183639
CDC50A cell division cycle 50 P4-ATPase accessory subunit A -0.018271
STXBP1 syntaxin binding protein 1 -0.0182179
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0182144
RPL30 ribosomal protein L30 -0.0181206
RAB1A RAB1A, member RAS oncogene family -0.0181078
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0180863
RPL38 ribosomal protein L38 -0.017797
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.017705
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) -0.0176628
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0176369
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0176158
IGF1R insulin-like growth factor 1 receptor -0.0174694
ISG20 interferon stimulated exonuclease gene 20kDa -0.0173982
ENOSF1 enolase superfamily member 1 -0.0172871
AKAP8L A kinase (PRKA) anchor protein 8-like -0.0171964
E2F3 E2F transcription factor 3 -0.0169453
ZXDC ZXD family zinc finger C -0.0167876
CCND1 cyclin D1 -0.0166627
JPT1 Jupiter microtubule associated homolog 1 -0.0165067
USP12 ubiquitin specific peptidase 12 -0.0164772
RPS28 ribosomal protein S28 -0.0164736
RALGAPB Ral GTPase activating protein, beta subunit (non-catalytic) -0.0164477
RPL28 ribosomal protein L28 -0.0163938
PARK7 parkinson protein 7 -0.0162771
FBXL7 F-box and leucine-rich repeat protein 7 -0.0162711
CCNH cyclin H -0.0160224
CDK12 cyclin-dependent kinase 12 -0.0159452