Artemether_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Artemether perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Artemether_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.222548
CANX calnexin 0.178126
NAMPT nicotinamide phosphoribosyltransferase 0.098383
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0955481
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0955177
CXCL8 chemokine (C-X-C motif) ligand 8 0.0915085
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.088567
AHR aryl hydrocarbon receptor 0.0861277
TPR translocated promoter region, nuclear basket protein 0.0836958
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.083214
SOD2 superoxide dismutase 2, mitochondrial 0.0801148
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0703698
BIRC6 baculoviral IAP repeat containing 6 0.0689995
FNDC3B fibronectin type III domain containing 3B 0.0686326
MYH9 myosin, heavy chain 9, non-muscle 0.0674411
CD109 CD109 molecule 0.066468
PGK1 phosphoglycerate kinase 1 0.06634
COPA coatomer protein complex, subunit alpha 0.0661099
FAM13A family with sequence similarity 13, member A 0.0657331
SEC23A Sec23 homolog A (S. cerevisiae) 0.0653886
TRIO trio Rho guanine nucleotide exchange factor 0.0635525
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.058407
SUCO SUN domain containing ossification factor 0.0580699
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0566837
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0534178
SEC31A SEC31 homolog A (S. cerevisiae) 0.0533685
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0530422
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0514765
TMSB4X thymosin beta 4, X-linked 0.0514372
ZC3H11A zinc finger CCCH-type containing 11A 0.0460943
PRRC2C proline-rich coiled-coil 2C 0.0459413
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0456714
TTC3 tetratricopeptide repeat domain 3 0.0453021
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0450861
CALU calumenin 0.0444974
BZW1 basic leucine zipper and W2 domains 1 0.0442247
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0441893
APLP2 amyloid beta (A4) precursor-like protein 2 0.0433156
AFDN afadin, adherens junction formation factor 0.0428313
PLIN2 perilipin 2 0.0427094
GOLGA4 golgin A4 0.0425722
APP amyloid beta (A4) precursor protein 0.0418699
RICTOR RPTOR independent companion of MTOR, complex 2 0.0418273
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0410973
ESYT2 extended synaptotagmin-like protein 2 0.0410165
STC2 stanniocalcin 2 0.0408929
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0407513
HILPDA hypoxia inducible lipid droplet-associated 0.0405283
RNF145 ring finger protein 145 0.0403628
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0403149
INSIG2 insulin induced gene 2 0.0400292
CDC73 cell division cycle 73 0.0399122
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.039819
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0396472
ENO1 enolase 1, (alpha) 0.0395465
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0390327
ERRFI1 ERBB receptor feedback inhibitor 1 0.0385722
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0382487
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 0.0381215
HELZ helicase with zinc finger 0.0381212
BASP1 brain abundant, membrane attached signal protein 1 0.0381057
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0380953
OGA O-GlcNAcase 0.0376416
ACBD3 acyl-CoA binding domain containing 3 0.0376123
FBXL5 F-box and leucine-rich repeat protein 5 0.0375861
MARCHF6 membrane associated ring-CH-type finger 6 0.0371811
LOC112694756 uncharaterized LOC112694756 0.0364918
PRELID2 PRELI domain containing 2 0.0363497
GPC6 glypican 6 0.0359119
SNX13 sorting nexin 13 0.0356894
KDM3A lysine (K)-specific demethylase 3A 0.0354145
TXNIP thioredoxin interacting protein 0.0353987
YME1L1 YME1-like 1 ATPase 0.0349737
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0349607
NDRG1 N-myc downstream regulated 1 0.0348266
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0348252
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0348092
TMF1 TATA element modulatory factor 1 0.034583
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0343564
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.0340687
LDHA lactate dehydrogenase A 0.0336811
ANKRD28 ankyrin repeat domain 28 0.0332688
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0330537
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0329843
CTBP2 C-terminal binding protein 2 0.0328711
SQSTM1 sequestosome 1 0.0328017
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0327632
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.032695
CTSA cathepsin A 0.0326733
RB1CC1 RB1-inducible coiled-coil 1 0.0326638
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0325294
CADM1 cell adhesion molecule 1 0.0323705
CEP350 centrosomal protein 350kDa 0.0319005
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0315388
CLTC clathrin, heavy chain (Hc) 0.0315222
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0314284
USP34 ubiquitin specific peptidase 34 0.0313291
VCL vinculin 0.0310579
ANKRD17 ankyrin repeat domain 17 0.030618
LIFR leukemia inhibitory factor receptor alpha 0.0306049

decreased expression

Symbol Name Standardized Value
NRG1 neuregulin 1 -0.168777
HMGA2 high mobility group AT-hook 2 -0.106504
FTL ferritin, light polypeptide -0.102315
TMSB10 thymosin beta 10 -0.101881
MT2A metallothionein 2A -0.0911664
RPLP1 ribosomal protein, large, P1 -0.06817
S100A6 S100 calcium binding protein A6 -0.0571709
IFI27 interferon, alpha-inducible protein 27 -0.0571472
ASPH aspartate beta-hydroxylase -0.0526472
RPS6 ribosomal protein S6 -0.0520405
SYT1 synaptotagmin I -0.0517385
FN1 fibronectin 1 -0.0509337
RPS8 ribosomal protein S8 -0.0498588
RPL35A ribosomal protein L35a -0.0492407
RPL37A ribosomal protein L37a -0.0485009
RPL28 ribosomal protein L28 -0.0472824
PKM pyruvate kinase, muscle -0.0469454
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0460134
RPL26 ribosomal protein L26 -0.0458074
RPL9 ribosomal protein L9 -0.045243
RPL34 ribosomal protein L34 -0.0443232
TPT1 tumor protein, translationally-controlled 1 -0.0438187
RPL23 ribosomal protein L23 -0.0427591
RPS12 ribosomal protein S12 -0.0425579
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0422571
RPL37 ribosomal protein L37 -0.0418773
IFI6 interferon, alpha-inducible protein 6 -0.0402552
RPL36 ribosomal protein L36 -0.0402466
RPS16 ribosomal protein S16 -0.0399382
RPS25 ribosomal protein S25 -0.0398177
RPS19 ribosomal protein S19 -0.0392679
RPS21 ribosomal protein S21 -0.0391351
RPS24 ribosomal protein S24 -0.0374423
RPLP2 ribosomal protein, large, P2 -0.0351813
IER3 immediate early response 3 -0.034969
RPL31 ribosomal protein L31 -0.0344556
RPS29 ribosomal protein S29 -0.0340418
RPL30 ribosomal protein L30 -0.0339147
RPS27 ribosomal protein S27 -0.0335699
TMEM165 transmembrane protein 165 -0.0330475
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0328723
PTMA prothymosin, alpha -0.0327335
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0325516
EGR1 early growth response 1 -0.0320237
NTN4 netrin 4 -0.0315896
HMGA1 high mobility group AT-hook 1 -0.0315427
RPL11 ribosomal protein L11 -0.0308818
RPS20 ribosomal protein S20 -0.0301817
RPL38 ribosomal protein L38 -0.0300518
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0299128
S100A10 S100 calcium binding protein A10 -0.0297863
RNF213 ring finger protein 213 -0.0288808
MAP1B microtubule-associated protein 1B -0.0287696
RPL12 ribosomal protein L12 -0.028562
TSC22D1 TSC22 domain family, member 1 -0.0284224
SP100 SP100 nuclear antigen -0.0275851
IFI44L interferon-induced protein 44-like -0.0270455
ATP5F1E ATP synthase F1 subunit epsilon -0.0264791
GLIS3 GLIS family zinc finger 3 -0.0263755
SEPTIN9 septin 9 -0.0261697
RPL18 ribosomal protein L18 -0.0254755
RPL19 ribosomal protein L19 -0.0249856
S100A9 S100 calcium binding protein A9 -0.0249516
PLSCR1 phospholipid scramblase 1 -0.0249029
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0247141
LOC102724023 ES1 protein homolog, mitochondrial -0.0246511
ACTG1 actin gamma 1 -0.0245253
GNAS GNAS complex locus -0.0239727
NRP1 neuropilin 1 -0.0235309
RPS2 ribosomal protein S2 -0.0231127
RPS11 ribosomal protein S11 -0.0230667
IFI16 interferon, gamma-inducible protein 16 -0.0230141
RPS14 ribosomal protein S14 -0.0226565
ETV1 ets variant 1 -0.022364
MX1 MX dynamin-like GTPase 1 -0.0219207
LMNA lamin A/C -0.0217086
HLA-B major histocompatibility complex, class I, B -0.0216982
RPS5 ribosomal protein S5 -0.0214066
BICD1 bicaudal D homolog 1 (Drosophila) -0.0210632
RPL21 ribosomal protein L21 -0.0207073
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0206038
DNAH5 dynein, axonemal, heavy chain 5 -0.0201319
RPL35 ribosomal protein L35 -0.0199313
RPS23 ribosomal protein S23 -0.0198039
HLA-A major histocompatibility complex, class I, A -0.019643
CCND1 cyclin D1 -0.0196333
RPL8 ribosomal protein L8 -0.0195338
PRH1 proline-rich protein HaeIII subfamily 1 -0.0186493
IFITM3 interferon induced transmembrane protein 3 -0.0184984
RPS15 ribosomal protein S15 -0.0184287
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0182248
RPS3 ribosomal protein S3 -0.018022
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) -0.0180095
RPS17 ribosomal protein S17 -0.0178495
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0177412
MX2 MX dynamin-like GTPase 2 -0.0176564
ANKRD12 ankyrin repeat domain 12 -0.0176114
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0175851
RPS10 ribosomal protein S10 -0.0174668
SOX4 SRY (sex determining region Y)-box 4 -0.0171827