Artesunate_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Artesunate perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Artesunate_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FMN1 formin 1 0.109668
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.079405
ITPRID2 ITPR interacting domain containing 2 0.0782053
RPL3 ribosomal protein L3 0.0756912
EEF2 eukaryotic translation elongation factor 2 0.0657525
AKAP12 A kinase (PRKA) anchor protein 12 0.0646609
TPST1 tyrosylprotein sulfotransferase 1 0.0639012
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.0627327
LPIN1 lipin 1 0.0571392
THSD4 thrombospondin, type I, domain containing 4 0.0565949
THBS1 thrombospondin 1 0.0559263
PTEN phosphatase and tensin homolog 0.0557421
KLHL13 kelch-like family member 13 0.0510305
SET SET nuclear proto-oncogene 0.0503082
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0478967
APP amyloid beta (A4) precursor protein 0.0477479
MYH9 myosin, heavy chain 9, non-muscle 0.047257
TLE4 transducin-like enhancer of split 4 0.0471646
DST dystonin 0.0465561
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0464315
ADAR adenosine deaminase, RNA-specific 0.0461085
DSCAM Down syndrome cell adhesion molecule 0.0458682
VEGFA vascular endothelial growth factor A 0.0457967
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.0456624
PSD3 pleckstrin and Sec7 domain containing 3 0.0455159
RNF213 ring finger protein 213 0.0454202
SRRM2 serine/arginine repetitive matrix 2 0.0453341
GLCCI1 glucocorticoid induced 1 0.0437006
PCBP2 poly(rC) binding protein 2 0.0429702
PTPRE protein tyrosine phosphatase, receptor type, E 0.0422208
ARHGAP9 Rho GTPase activating protein 9 0.0421462
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.0419191
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0416439
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0410633
SIK2 salt-inducible kinase 2 0.0409064
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0397747
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0389129
GOLGA4 golgin A4 0.0387089
PTPRK protein tyrosine phosphatase, receptor type, K 0.0382717
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0379372
TRIO trio Rho guanine nucleotide exchange factor 0.0377067
AOPEP aminopeptidase O (putative) 0.0373159
BPTF bromodomain PHD finger transcription factor 0.0371712
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 0.0347358
ANTXR1 anthrax toxin receptor 1 0.0341317
NALF1 NALCN channel auxiliary factor 1 0.033877
AMOTL1 angiomotin like 1 0.0334249
MYO6 myosin VI 0.033313
TENM4 teneurin transmembrane protein 4 0.0320619
ZFC3H1 zinc finger, C3H1-type containing 0.0320578
PALLD palladin, cytoskeletal associated protein 0.031849
RET ret proto-oncogene 0.0315439
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0311116
COPA coatomer protein complex, subunit alpha 0.0308543
GPATCH8 G patch domain containing 8 0.0306889
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0305648
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0304925
ZMIZ1 zinc finger, MIZ-type containing 1 0.0303764
RIGI RNA sensor RIG-I 0.030347
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0301851
TPM4 tropomyosin 4 0.0299763
CUL1 cullin 1 0.0297714
MEIS2 Meis homeobox 2 0.0296506
BICD1 bicaudal D homolog 1 (Drosophila) 0.0295793
GNG2 guanine nucleotide binding protein (G protein), gamma 2 0.029511
MCL1 myeloid cell leukemia 1 0.0293801
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0292898
APLP2 amyloid beta (A4) precursor-like protein 2 0.0290165
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0287549
PRRC2C proline-rich coiled-coil 2C 0.0285388
RPL4 ribosomal protein L4 0.0284111
HSPA8 heat shock 70kDa protein 8 0.0283265
CANX calnexin 0.0281222
CSDE1 cold shock domain containing E1, RNA-binding 0.0280874
TPR translocated promoter region, nuclear basket protein 0.0280335
LDHA lactate dehydrogenase A 0.0277107
PLAT plasminogen activator, tissue 0.0276771
LIMCH1 LIM and calponin homology domains 1 0.0276556
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0271512
ANKRD17 ankyrin repeat domain 17 0.027034
RBM6 RNA binding motif protein 6 0.026696
DPH6 diphthamine biosynthesis 6 0.0263358
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0261196
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0260934
COL6A1 collagen, type VI, alpha 1 0.0260467
RSL1D1 ribosomal L1 domain containing 1 0.0258816
FLNA filamin A, alpha 0.025472
COL4A2 collagen, type IV, alpha 2 0.0253951
PDE10A phosphodiesterase 10A 0.0248189
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0248116
BRD2 bromodomain containing 2 0.0245824
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0245314
CPNE1 copine I 0.0245131
NRP1 neuropilin 1 0.0242158
ARID5B AT rich interactive domain 5B (MRF1-like) 0.0241109
NES nestin 0.0240236
VCL vinculin 0.0239004
CCDC57 coiled-coil domain containing 57 0.0237138
COL4A1 collagen, type IV, alpha 1 0.0235614
PRRC2B proline-rich coiled-coil 2B 0.0235567

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.174754
LSAMP limbic system-associated membrane protein -0.132089
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0842779
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0675566
NRG1 neuregulin 1 -0.0672749
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0672362
VIM vimentin -0.0587903
NREP neuronal regeneration related protein -0.0563487
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0506477
PTMA prothymosin, alpha -0.0462038
FNDC3B fibronectin type III domain containing 3B -0.0433391
GPC5 glypican 5 -0.0421073
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0409709
EXT1 exostosin glycosyltransferase 1 -0.0406772
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0405465
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0399358
DTNA dystrobrevin, alpha -0.0395474
RPS6 ribosomal protein S6 -0.0390729
FAM13A family with sequence similarity 13, member A -0.0387575
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0372583
KMT2E lysine (K)-specific methyltransferase 2E -0.0366393
WDR45B WD repeat domain 45B -0.0361164
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0344079
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0331972
FRMD4A FERM domain containing 4A -0.0323258
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0320416
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0317582
ACTG1 actin gamma 1 -0.0312254
RACK1 receptor for activated C kinase 1 -0.0311006
RPL34 ribosomal protein L34 -0.0308564
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0300781
RPL38 ribosomal protein L38 -0.0295221
MAML2 mastermind-like 2 (Drosophila) -0.0285073
CD36 CD36 molecule (thrombospondin receptor) -0.0283517
RPL31 ribosomal protein L31 -0.026308
RPLP1 ribosomal protein, large, P1 -0.0261134
RPS25 ribosomal protein S25 -0.0261006
RPS12 ribosomal protein S12 -0.0254442
PKM pyruvate kinase, muscle -0.0253859
RPS24 ribosomal protein S24 -0.0252847
CSMD3 CUB and Sushi multiple domains 3 -0.025038
SPAG16 sperm associated antigen 16 -0.0250244
NDRG1 N-myc downstream regulated 1 -0.024986
DIAPH2 diaphanous-related formin 2 -0.0243254
NPEPPS aminopeptidase puromycin sensitive -0.0240393
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0236569
RPL19 ribosomal protein L19 -0.0228082
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0226234
KMT2A lysine (K)-specific methyltransferase 2A -0.0221778
MAPK10 mitogen-activated protein kinase 10 -0.0221385
UNC5C unc-5 homolog C (C. elegans) -0.0219615
LRRC7 leucine rich repeat containing 7 -0.0215482
RYBP RING1 and YY1 binding protein -0.0212949
IER3 immediate early response 3 -0.021237
PDIA3 protein disulfide isomerase family A, member 3 -0.0211778
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0211111
EIF3E eukaryotic translation initiation factor 3, subunit E -0.0209493
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0209254
RPS8 ribosomal protein S8 -0.0208772
GMDS GDP-mannose 4,6-dehydratase -0.0206978
CADM2 cell adhesion molecule 2 -0.0206954
CUX1 cut-like homeobox 1 -0.0203946
SCLT1 sodium channel and clathrin linker 1 -0.020064
MBNL2 muscleblind-like splicing regulator 2 -0.0199688
RPS23 ribosomal protein S23 -0.0198374
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0195647
RPS19 ribosomal protein S19 -0.0194979
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 -0.0191239
CA12 carbonic anhydrase XII -0.0190761
SNAPC3 small nuclear RNA activating complex, polypeptide 3, 50kDa -0.0189911
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 -0.0188858
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0187988
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0187065
SOX5 SRY (sex determining region Y)-box 5 -0.0186617
BCAS3 breast carcinoma amplified sequence 3 -0.0185737
QKI QKI, KH domain containing, RNA binding -0.0184283
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0184237
RPS5 ribosomal protein S5 -0.0184042
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0183146
PRR11 proline rich 11 -0.0181619
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0181229
RAP1B RAP1B, member of RAS oncogene family -0.0179702
ZNF804A zinc finger protein 804A -0.0177592
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.017716
PHF20 PHD finger protein 20 -0.0176903
ANGPTL4 angiopoietin-like 4 -0.0176636
DENND4A DENN/MADD domain containing 4A -0.0176137
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0175962
SOS1 son of sevenless homolog 1 (Drosophila) -0.0174301
EGFR epidermal growth factor receptor -0.0172437
CDH13 cadherin 13 -0.0172081
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0171722
RPS27 ribosomal protein S27 -0.0171433
SBF2 SET binding factor 2 -0.0171257
SMYD3 SET and MYND domain containing 3 -0.0167072
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0167032
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0166274
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0165572
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0164721
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.016347