Artesunate_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Artesunate perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Artesunate_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.235335
C3 complement component 3 0.20335
AKAP12 A kinase (PRKA) anchor protein 12 0.174125
RPL3 ribosomal protein L3 0.124428
LDHA lactate dehydrogenase A 0.091612
APLP2 amyloid beta (A4) precursor-like protein 2 0.0889648
SAMD4A sterile alpha motif domain containing 4A 0.0854198
DSPP dentin sialophosphoprotein 0.0787886
SVIL supervillin 0.0732344
EEF2 eukaryotic translation elongation factor 2 0.0720983
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0677873
TNS1 tensin 1 0.0598357
ERRFI1 ERBB receptor feedback inhibitor 1 0.0542424
MCL1 myeloid cell leukemia 1 0.0530813
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0530808
MYH9 myosin, heavy chain 9, non-muscle 0.0529923
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0495082
VEGFA vascular endothelial growth factor A 0.0471031
RPL13A ribosomal protein L13a 0.0465385
TF transferrin 0.0420146
GRB10 growth factor receptor-bound protein 10 0.0418039
KRT18 keratin 18, type I 0.0416169
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0405312
FAT1 FAT atypical cadherin 1 0.0387994
NDRG1 N-myc downstream regulated 1 0.0363962
FAM107B family with sequence similarity 107, member B 0.0359913
CANX calnexin 0.0357177
PLEC plectin 0.0346849
HSPA8 heat shock 70kDa protein 8 0.0342378
IGFBP1 insulin-like growth factor binding protein 1 0.0338737
FLNA filamin A, alpha 0.0335814
ASPH aspartate beta-hydroxylase 0.0333356
SMAD3 SMAD family member 3 0.0323687
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0316518
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0304643
RPS4X ribosomal protein S4, X-linked 0.0279115
SEPTIN9 septin 9 0.0270124
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0265392
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0264815
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0261268
RPL18A ribosomal protein L18a 0.0261119
HSPA1B heat shock 70kDa protein 1B 0.0260772
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.025742
INSIG2 insulin induced gene 2 0.0251998
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.0250706
TCP1 t-complex 1 0.0245279
FAM13A family with sequence similarity 13, member A 0.023734
ANGPTL2 angiopoietin-like 2 0.022888
RPS4Y1 ribosomal protein S4, Y-linked 1 0.0225151
HSPA1A heat shock 70kDa protein 1A 0.0223979
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0218303
RASA2 RAS p21 protein activator 2 0.0217769
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0210499
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0210362
OPTN optineurin 0.0207847
FAM219A family with sequence similarity 219, member A 0.0207617
NPTN neuroplastin 0.0207052
EEF1G eukaryotic translation elongation factor 1 gamma 0.0204171
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0202184
LMO7 LIM domain 7 0.020212
SET SET nuclear proto-oncogene 0.0201723
DNAH5 dynein, axonemal, heavy chain 5 0.020013
LMCD1 LIM and cysteine-rich domains 1 0.0200062
TMEM181 transmembrane protein 181 0.019696
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 0.0196346
NCOR2 nuclear receptor corepressor 2 0.019512
TPM3 tropomyosin 3 0.0194946
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0193715
YTHDC1 YTH domain containing 1 0.0192919
SHB Src homology 2 domain containing adaptor protein B 0.0192458
KALRN kalirin, RhoGEF kinase 0.0192262
CLTB clathrin, light chain B 0.0191404
ATF3 activating transcription factor 3 0.0185687
ITGA6 integrin, alpha 6 0.0184322
SPATS2L spermatogenesis associated, serine-rich 2-like 0.018279
TNS3 tensin 3 0.0179186
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0176395
PCBP2 poly(rC) binding protein 2 0.0176332
BLCAP bladder cancer associated protein 0.0175745
KRT23 keratin 23, type I 0.0175509
DIAPH1 diaphanous-related formin 1 0.0174509
CEP250 centrosomal protein 250kDa 0.0172992
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.0172463
RPL11 ribosomal protein L11 0.0170915
MACF1 microtubule-actin crosslinking factor 1 0.0170639
BCL2L1 BCL2-like 1 0.0168977
FLNB filamin B, beta 0.0167025
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0166488
AKAP13 A kinase (PRKA) anchor protein 13 0.0165572
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0165377
TPM1 tropomyosin 1 (alpha) 0.0164961
OSBPL10 oxysterol binding protein-like 10 0.0164149
KRT19 keratin 19, type I 0.0161151
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.016025
RIGI RNA sensor RIG-I 0.0159192
CALR calreticulin 0.01588
ZSWIM6 zinc finger, SWIM-type containing 6 0.0157419
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0157215
CTSB cathepsin B 0.015386
CDHR2 cadherin-related family member 2 0.0153772

decreased expression

Symbol Name Standardized Value
APOB apolipoprotein B -0.222667
FN1 fibronectin 1 -0.123112
IGF2 insulin-like growth factor 2 -0.121016
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.108259
FNDC3B fibronectin type III domain containing 3B -0.106308
GPC6 glypican 6 -0.0984061
ELL2 elongation factor, RNA polymerase II, 2 -0.0917809
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0821255
SLC38A2 solute carrier family 38, member 2 -0.0815155
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0793886
ZMYND8 zinc finger, MYND-type containing 8 -0.0778138
LRMDA leucine rich melanocyte differentiation associated -0.0760311
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0736965
MAN1A1 mannosidase, alpha, class 1A, member 1 -0.0710112
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0700204
MAML2 mastermind-like 2 (Drosophila) -0.0675182
EHBP1 EH domain binding protein 1 -0.0643936
GPC3 glypican 3 -0.0632458
TRIM26 tripartite motif containing 26 -0.0615689
FBF1 Fas (TNFRSF6) binding factor 1 -0.0599567
EML4 echinoderm microtubule associated protein like 4 -0.0579269
APOA2 apolipoprotein A-II -0.0560794
TMEM123 transmembrane protein 123 -0.052981
NPAS2 neuronal PAS domain protein 2 -0.0518493
MBNL3 muscleblind-like splicing regulator 3 -0.0507458
SOX5 SRY (sex determining region Y)-box 5 -0.050604
PTPRM protein tyrosine phosphatase, receptor type, M -0.0469661
RPS6 ribosomal protein S6 -0.0459196
RPS24 ribosomal protein S24 -0.0442576
PDGFB platelet-derived growth factor beta polypeptide -0.0439568
H1-0 H1.0 linker histone -0.0430909
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0428081
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0419258
ZBTB20 zinc finger and BTB domain containing 20 -0.0412621
PTBP3 polypyrimidine tract binding protein 3 -0.0402262
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0401926
PTPRK protein tyrosine phosphatase, receptor type, K -0.038181
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.0381297
MT2A metallothionein 2A -0.0367193
RBM39 RNA binding motif protein 39 -0.0365613
STAU1 staufen double-stranded RNA binding protein 1 -0.0363031
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0357836
SLC38A1 solute carrier family 38, member 1 -0.0355736
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0354295
TM4SF1 transmembrane 4 L six family member 1 -0.0349358
LYZ lysozyme -0.0349283
PHF3 PHD finger protein 3 -0.0341711
RPLP1 ribosomal protein, large, P1 -0.0340185
DST dystonin -0.0337086
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0337069
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0331047
FTL ferritin, light polypeptide -0.0326827
MAP1B microtubule-associated protein 1B -0.0312732
NCOA7 nuclear receptor coactivator 7 -0.0310662
PEG10 paternally expressed 10 -0.0306998
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0304935
RPLP2 ribosomal protein, large, P2 -0.030369
RACK1 receptor for activated C kinase 1 -0.030232
CCDC146 coiled-coil domain containing 146 -0.0296493
GSE1 Gse1 coiled-coil protein -0.0295804
GDF15 growth differentiation factor 15 -0.0293068
KMT2E lysine (K)-specific methyltransferase 2E -0.0292471
DENND4A DENN/MADD domain containing 4A -0.0292344
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0292043
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0287825
TPST1 tyrosylprotein sulfotransferase 1 -0.0287514
HMGA1 high mobility group AT-hook 1 -0.0287511
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0286381
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.0285533
NCOR1 nuclear receptor corepressor 1 -0.028436
TPT1 tumor protein, translationally-controlled 1 -0.0283608
FNDC3A fibronectin type III domain containing 3A -0.0279834
RPL34 ribosomal protein L34 -0.0279495
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0279069
PTP4A1 protein tyrosine phosphatase type IVA, member 1 -0.027788
CP ceruloplasmin (ferroxidase) -0.0274828
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0272482
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 -0.0267485
JMJD1C jumonji domain containing 1C -0.0266224
TNRC6B trinucleotide repeat containing 6B -0.0264612
CALD1 caldesmon 1 -0.0261381
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0260174
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0259568
TLK1 tousled-like kinase 1 -0.0258751
DLC1 DLC1 Rho GTPase activating protein -0.0258567
BHLHE40 basic helix-loop-helix family, member e40 -0.0258492
RPS21 ribosomal protein S21 -0.0257869
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0256733
MALT1 MALT1 paracaspase -0.0254459
KIF5B kinesin family member 5B -0.0253229
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0252313
AHR aryl hydrocarbon receptor -0.0250531
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 -0.0249384
MBNL1 muscleblind-like splicing regulator 1 -0.0247469
PTCHD4 patched domain containing 4 -0.0247306
ZFAND3 zinc finger, AN1-type domain 3 -0.0246767
A2M alpha-2-macroglobulin -0.0245659
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0245344
MAP4 microtubule-associated protein 4 -0.0244586
RNF213 ring finger protein 213 -0.0238767