Artesunate_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Artesunate perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Artesunate_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LDHA lactate dehydrogenase A 0.210243
MCL1 myeloid cell leukemia 1 0.170417
CXCL8 chemokine (C-X-C motif) ligand 8 0.142837
LAMA4 laminin, alpha 4 0.10326
KRT18 keratin 18, type I 0.101696
ASPH aspartate beta-hydroxylase 0.0999786
SLTM SAFB-like, transcription modulator 0.0933964
THSD4 thrombospondin, type I, domain containing 4 0.0918837
MT2A metallothionein 2A 0.0898085
LAMC2 laminin, gamma 2 0.0863357
ENO1 enolase 1, (alpha) 0.0776598
GRAMD1B GRAM domain containing 1B 0.0766635
LMO7 LIM domain 7 0.0765606
CEMIP cell migration inducing protein, hyaluronan binding 0.0735282
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0734431
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0706711
ERRFI1 ERBB receptor feedback inhibitor 1 0.0687952
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0674003
AREG amphiregulin 0.0665266
MYOF myoferlin 0.0661577
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) 0.063064
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0595635
RPL3 ribosomal protein L3 0.0585788
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.0551172
SAMD4A sterile alpha motif domain containing 4A 0.0520928
APLP2 amyloid beta (A4) precursor-like protein 2 0.051776
BCAR3 breast cancer anti-estrogen resistance 3 0.0495791
PDLIM5 PDZ and LIM domain 5 0.0493491
MSN moesin 0.0478309
SCEL sciellin 0.0477582
SRRM2 serine/arginine repetitive matrix 2 0.0463792
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0456004
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0455234
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0452095
AKAP12 A kinase (PRKA) anchor protein 12 0.0446603
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0438972
PM20D1 peptidase M20 domain containing 1 0.0431749
STC1 stanniocalcin 1 0.0431179
MYH9 myosin, heavy chain 9, non-muscle 0.042965
MAGEA4 melanoma antigen family A4 0.0426226
HSPA8 heat shock 70kDa protein 8 0.0418993
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.041792
PKM pyruvate kinase, muscle 0.0415151
SMAD3 SMAD family member 3 0.0404991
EXT1 exostosin glycosyltransferase 1 0.0402158
TPM4 tropomyosin 4 0.0391491
TPM3 tropomyosin 3 0.0391228
PCBP2 poly(rC) binding protein 2 0.0389697
NSUN6 NOP2/Sun domain family, member 6 0.0387416
VCL vinculin 0.0375165
LAMB3 laminin, beta 3 0.0372499
BLZF1 basic leucine zipper nuclear factor 1 0.0361244
EGR1 early growth response 1 0.0358116
PLEC plectin 0.035748
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0350769
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0346233
EZR ezrin 0.0345592
AKAP13 A kinase (PRKA) anchor protein 13 0.0342373
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.0341523
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0338555
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0338317
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0335139
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0334363
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0331673
BZW1 basic leucine zipper and W2 domains 1 0.0318988
RPS3 ribosomal protein S3 0.0315238
FLNA filamin A, alpha 0.0314311
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0314025
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0313252
DSCAM Down syndrome cell adhesion molecule 0.0311133
SMYD3 SET and MYND domain containing 3 0.0305625
MPRIP myosin phosphatase Rho interacting protein 0.0296105
APP amyloid beta (A4) precursor protein 0.0295914
RPS4X ribosomal protein S4, X-linked 0.0295573
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0294898
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0286185
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0285509
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.027805
IGFBP3 insulin-like growth factor binding protein 3 0.0277007
ACTN1 actinin, alpha 1 0.0268147
MYO1E myosin IE 0.0267485
B2M beta-2-microglobulin 0.0267456
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0267396
BRD2 bromodomain containing 2 0.0266899
PLS3 plastin 3 0.0265737
DUSP5 dual specificity phosphatase 5 0.0264822
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0262122
SRSF5 serine/arginine-rich splicing factor 5 0.0262101
KRT7 keratin 7, type II 0.026009
PRDX1 peroxiredoxin 1 0.0260005
CAV2 caveolin 2 0.0259563
LPP LIM domain containing preferred translocation partner in lipoma 0.0258965
FAT1 FAT atypical cadherin 1 0.0257112
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 0.0256124
DIAPH1 diaphanous-related formin 1 0.0253769
CMIP c-Maf inducing protein 0.0252288
ADAR adenosine deaminase, RNA-specific 0.025222
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0249975
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0249884
DOCK1 dedicator of cytokinesis 1 0.024814

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0838348
TMEM165 transmembrane protein 165 -0.0712761
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.065988
H1-0 H1.0 linker histone -0.0586672
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0581993
LRP1B low density lipoprotein receptor-related protein 1B -0.0579888
CAMTA1 calmodulin binding transcription activator 1 -0.0529301
NAMPT nicotinamide phosphoribosyltransferase -0.0520718
PTMA prothymosin, alpha -0.0505061
BRWD1 bromodomain and WD repeat domain containing 1 -0.0502081
SEC31A SEC31 homolog A (S. cerevisiae) -0.0483905
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0479979
KMT2E lysine (K)-specific methyltransferase 2E -0.0479974
ZMYND8 zinc finger, MYND-type containing 8 -0.0466326
NGLY1 N-glycanase 1 -0.0463594
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0461682
NDRG1 N-myc downstream regulated 1 -0.046031
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0454731
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.045188
AKR1C1 aldo-keto reductase family 1, member C1 -0.0441022
WASF2 WAS protein family, member 2 -0.0437863
FTH1 ferritin, heavy polypeptide 1 -0.0434699
ANKRD10 ankyrin repeat domain 10 -0.0418219
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0413594
BRWD3 bromodomain and WD repeat domain containing 3 -0.0412252
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0411459
KDM3A lysine (K)-specific demethylase 3A -0.0394901
FAM13A family with sequence similarity 13, member A -0.0394197
WDR45B WD repeat domain 45B -0.038981
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0374596
KCMF1 potassium channel modulatory factor 1 -0.0374434
ABLIM1 actin binding LIM protein 1 -0.037016
SEPTIN2 septin 2 -0.0367821
ZC3H11A zinc finger CCCH-type containing 11A -0.0367795
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0361304
TPT1 tumor protein, translationally-controlled 1 -0.0348764
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0336198
UVRAG UV radiation resistance associated -0.0322445
SPAG9 sperm associated antigen 9 -0.0318203
TOP1 topoisomerase (DNA) I -0.0318001
RAB1A RAB1A, member RAS oncogene family -0.0316823
MARF1 meiosis regulator and mRNA stability factor 1 -0.0313523
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0307859
KDM5B lysine (K)-specific demethylase 5B -0.0296645
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0295173
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 -0.0295118
RNF145 ring finger protein 145 -0.0292871
RAP1B RAP1B, member of RAS oncogene family -0.0289275
BHLHE40 basic helix-loop-helix family, member e40 -0.0288712
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0283168
SUCO SUN domain containing ossification factor -0.0279743
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0279293
SEC24D SEC24 family member D -0.0279009
KMT2A lysine (K)-specific methyltransferase 2A -0.0277364
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0276645
SRP54 signal recognition particle 54kDa -0.0275561
RPS24 ribosomal protein S24 -0.0273218
USP34 ubiquitin specific peptidase 34 -0.02732
OGA O-GlcNAcase -0.0271075
BIRC6 baculoviral IAP repeat containing 6 -0.0267029
CAMK2D calcium/calmodulin-dependent protein kinase II delta -0.0262277
NDE1 nudE neurodevelopment protein 1 -0.0259906
HELZ helicase with zinc finger -0.0257705
PDE8A phosphodiesterase 8A -0.0255617
AGO2 argonaute RISC catalytic component 2 -0.0254921
TPD52 tumor protein D52 -0.0253549
AHNAK AHNAK nucleoprotein -0.0251211
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0249796
PUM2 pumilio RNA-binding family member 2 -0.0248704
HOOK2 hook microtubule-tethering protein 2 -0.0247262
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0246698
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 -0.0246624
MXI1 MAX interactor 1, dimerization protein -0.0246378
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 -0.0245515
MGAT4C MGAT4 family, member C -0.0245419
KDM2A lysine (K)-specific demethylase 2A -0.0244003
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0240873
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0233284
PDIA3 protein disulfide isomerase family A, member 3 -0.0228218
PATJ PATJ crumbs cell polarity complex component -0.0226641
RPL34 ribosomal protein L34 -0.0226192
ARHGAP5 Rho GTPase activating protein 5 -0.022489
TPTEP2-CSNK1E TPTEP2-CSNK1E readthrough -0.0224763
SBF2 SET binding factor 2 -0.0224639
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0224186
NIPBL Nipped-B homolog (Drosophila) -0.0221811
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0221349
USP9X ubiquitin specific peptidase 9, X-linked -0.0220234
NCOA3 nuclear receptor coactivator 3 -0.0219445
RIN2 Ras and Rab interactor 2 -0.0218915
FNIP1 folliculin interacting protein 1 -0.0218592
NF1 neurofibromin 1 -0.0218565
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0218137
ATG7 autophagy related 7 -0.0217538
TENT5A terminal nucleotidyltransferase 5A -0.0217482
AGR2 anterior gradient 2 -0.0217396
RNMT RNA (guanine-7-) methyltransferase -0.0212704
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0211853
TRPM7 transient receptor potential cation channel, subfamily M, member 7 -0.0211684
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.021041