Artesunate_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Artesunate perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Artesunate_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PM20D1 peptidase M20 domain containing 1 0.190678
MCL1 myeloid cell leukemia 1 0.155395
RPL3 ribosomal protein L3 0.124534
KYNU kynureninase 0.120898
PDLIM5 PDZ and LIM domain 5 0.118703
LDHA lactate dehydrogenase A 0.116882
MYOF myoferlin 0.100024
COL5A2 collagen, type V, alpha 2 0.0920783
DST dystonin 0.0837528
EEF2 eukaryotic translation elongation factor 2 0.0822252
RPS4X ribosomal protein S4, X-linked 0.0800989
GDA guanine deaminase 0.080002
ASPH aspartate beta-hydroxylase 0.0727903
PCBP2 poly(rC) binding protein 2 0.0695568
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0661035
SAMD4A sterile alpha motif domain containing 4A 0.0658723
APLP2 amyloid beta (A4) precursor-like protein 2 0.0631586
DOCK5 dedicator of cytokinesis 5 0.0622543
COL8A1 collagen, type VIII, alpha 1 0.0585004
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.055886
ZSWIM6 zinc finger, SWIM-type containing 6 0.0554484
VCL vinculin 0.0551687
FLNA filamin A, alpha 0.0537363
SMOC1 SPARC related modular calcium binding 1 0.053224
CD109 CD109 molecule 0.0532149
MSN moesin 0.0529747
SLC39A8 solute carrier family 39 (zinc transporter), member 8 0.05143
P3H2 prolyl 3-hydroxylase 2 0.047859
COL4A6 collagen, type IV, alpha 6 0.0475965
HSPA8 heat shock 70kDa protein 8 0.0467621
NCOR2 nuclear receptor corepressor 2 0.0464206
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0455489
PSD3 pleckstrin and Sec7 domain containing 3 0.0455154
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.045509
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0445568
IGFBP3 insulin-like growth factor binding protein 3 0.0442571
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0440649
CTIF CBP80/20-dependent translation initiation factor 0.0436714
MYH9 myosin, heavy chain 9, non-muscle 0.0431725
FLNB filamin B, beta 0.0430138
INTS6 integrator complex subunit 6 0.0402368
GRAMD1B GRAM domain containing 1B 0.0401988
TPM3 tropomyosin 3 0.0401956
ATXN1 ataxin 1 0.0391252
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0382212
SLC38A2 solute carrier family 38, member 2 0.0382026
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0373251
RPS4Y1 ribosomal protein S4, Y-linked 1 0.0362474
FMNL2 formin-like 2 0.0360027
RPL13A ribosomal protein L13a 0.035674
CANX calnexin 0.034987
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0348344
RAB3B RAB3B, member RAS oncogene family 0.034832
EXT1 exostosin glycosyltransferase 1 0.0346646
SET SET nuclear proto-oncogene 0.0343447
SMAD2 SMAD family member 2 0.0342378
BASP1 brain abundant, membrane attached signal protein 1 0.0336429
AKAP13 A kinase (PRKA) anchor protein 13 0.0335477
COL4A5 collagen, type IV, alpha 5 0.0331983
RPL18A ribosomal protein L18a 0.0330037
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0318293
SRRM2 serine/arginine repetitive matrix 2 0.0317837
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.0306284
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0304816
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0304198
RAD51B RAD51 paralog B 0.0298096
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0296665
EEF1G eukaryotic translation elongation factor 1 gamma 0.0295112
PKM pyruvate kinase, muscle 0.0292827
ERRFI1 ERBB receptor feedback inhibitor 1 0.029135
PTEN phosphatase and tensin homolog 0.0290464
TGFBR1 transforming growth factor, beta receptor 1 0.0286605
TMX4 thioredoxin-related transmembrane protein 4 0.0278966
SH3KBP1 SH3-domain kinase binding protein 1 0.0274287
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit 0.027339
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0272835
OLFML2A olfactomedin-like 2A 0.0271946
PRKN parkin RBR E3 ubiquitin protein ligase 0.0268572
DPYSL2 dihydropyrimidinase-like 2 0.0258631
SMC1A structural maintenance of chromosomes 1A 0.0258053
ITPRID2 ITPR interacting domain containing 2 0.0257005
PRSS23 protease, serine, 23 0.0256229
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.02561
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0254853
MACF1 microtubule-actin crosslinking factor 1 0.0253625
CLU clusterin 0.0251528
GLCCI1 glucocorticoid induced 1 0.0248276
INHBA inhibin, beta A 0.0248015
CREB3L2 cAMP responsive element binding protein 3-like 2 0.0247052
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.023911
BRD2 bromodomain containing 2 0.0238878
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0238728
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0232508
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0230973
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0230126
BMP6 bone morphogenetic protein 6 0.0226697
PDE10A phosphodiesterase 10A 0.022621
MGST1 microsomal glutathione S-transferase 1 0.0225903
SCARA5 scavenger receptor class A, member 5 0.0222247
PDE7B phosphodiesterase 7B 0.0220328

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.1713
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.154319
PDE4D phosphodiesterase 4D, cAMP-specific -0.126111
EFNA5 ephrin-A5 -0.118375
NAMPT nicotinamide phosphoribosyltransferase -0.115607
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.109217
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0906941
VIM vimentin -0.0752676
TPT1 tumor protein, translationally-controlled 1 -0.0729849
TFPI2 tissue factor pathway inhibitor 2 -0.0714369
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0697803
NALF1 NALCN channel auxiliary factor 1 -0.0685294
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0650904
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0641121
TMSB10 thymosin beta 10 -0.0618611
TM4SF1 transmembrane 4 L six family member 1 -0.0610534
RPS24 ribosomal protein S24 -0.058027
PTMA prothymosin, alpha -0.0577981
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0525914
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0502789
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0492766
SMYD3 SET and MYND domain containing 3 -0.048863
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0441586
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0441475
ELL2 elongation factor, RNA polymerase II, 2 -0.0439647
RTN4 reticulon 4 -0.0431806
RPLP1 ribosomal protein, large, P1 -0.041423
SOX4 SRY (sex determining region Y)-box 4 -0.0403728
ADGRD1 adhesion G protein-coupled receptor D1 -0.0386515
KDM3A lysine (K)-specific demethylase 3A -0.0385763
S100A6 S100 calcium binding protein A6 -0.0383257
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0377967
WARS1 tryptophanyl-tRNA synthetase 1 -0.0377923
BMERB1 bMERB domain containing 1 -0.0372967
SLC16A6 solute carrier family 16, member 6 -0.0367501
STC1 stanniocalcin 1 -0.0362267
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0339179
HLA-B major histocompatibility complex, class I, B -0.0339051
VDAC1 voltage-dependent anion channel 1 -0.0336418
SPAG9 sperm associated antigen 9 -0.0327592
RPL36A ribosomal protein L36a -0.0327466
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0316387
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0316063
KMT2E lysine (K)-specific methyltransferase 2E -0.0315258
KPNB1 karyopherin (importin) beta 1 -0.0314652
RPL26 ribosomal protein L26 -0.0310714
ZMYND8 zinc finger, MYND-type containing 8 -0.0309368
CDH13 cadherin 13 -0.0301112
RPL38 ribosomal protein L38 -0.0297517
BHLHE40 basic helix-loop-helix family, member e40 -0.0293483
BTG1 B-cell translocation gene 1, anti-proliferative -0.0290629
NAP1L1 nucleosome assembly protein 1-like 1 -0.0286966
NIBAN1 niban apoptosis regulator 1 -0.0286524
FTL ferritin, light polypeptide -0.02857
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0285
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.028239
NCKAP5 NCK-associated protein 5 -0.0274368
BRWD3 bromodomain and WD repeat domain containing 3 -0.0268032
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0265408
ADGRB3 adhesion G protein-coupled receptor B3 -0.0264196
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 -0.0263402
IER3 immediate early response 3 -0.0261465
RPL34 ribosomal protein L34 -0.0257429
SCN3A sodium channel, voltage gated, type III alpha subunit -0.0256871
ARHGAP5 Rho GTPase activating protein 5 -0.0255693
FOXC1 forkhead box C1 -0.0250411
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -0.0249266
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0243539
LMAN1 lectin, mannose-binding, 1 -0.0240712
WSB1 WD repeat and SOCS box containing 1 -0.0240429
RACK1 receptor for activated C kinase 1 -0.0238805
GARS1 glycyl-tRNA synthetase 1 -0.0236418
OSMR oncostatin M receptor -0.0236216
NPEPPS aminopeptidase puromycin sensitive -0.0234813
SBF2 SET binding factor 2 -0.0234626
CCDC68 coiled-coil domain containing 68 -0.0229792
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0229565
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0227756
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0227685
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -0.0226436
CTNND2 catenin (cadherin-associated protein), delta 2 -0.0226394
PDIA3 protein disulfide isomerase family A, member 3 -0.0226352
RHOB ras homolog family member B -0.022612
FNDC3A fibronectin type III domain containing 3A -0.022603
ZBTB38 zinc finger and BTB domain containing 38 -0.022585
SLC38A1 solute carrier family 38, member 1 -0.0224208
NCOR1 nuclear receptor corepressor 1 -0.022315
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0219935
MAP1B microtubule-associated protein 1B -0.0218
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0217462
DIAPH2 diaphanous-related formin 2 -0.021731
PRRC2C proline-rich coiled-coil 2C -0.0211942
TENT5A terminal nucleotidyltransferase 5A -0.0210569
NBEAL1 neurobeachin-like 1 -0.0210345
S100A10 S100 calcium binding protein A10 -0.0210065
RPS29 ribosomal protein S29 -0.021003
TNPO1 transportin 1 -0.0210027
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0207297
RPL6 ribosomal protein L6 -0.0205837
IARS1 isoleucyl-tRNA synthetase 1 -0.0205664