Artesunate_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Artesunate perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Artesunate_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.299343
MYH9 myosin, heavy chain 9, non-muscle 0.174046
IGFBP3 insulin-like growth factor binding protein 3 0.124428
ERRFI1 ERBB receptor feedback inhibitor 1 0.11917
LDHA lactate dehydrogenase A 0.113501
FLNA filamin A, alpha 0.0982885
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0923436
VEGFA vascular endothelial growth factor A 0.0814909
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0748228
RPL3 ribosomal protein L3 0.0736131
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0690746
APLP2 amyloid beta (A4) precursor-like protein 2 0.0671787
DPYSL2 dihydropyrimidinase-like 2 0.0670531
PCBP2 poly(rC) binding protein 2 0.0605842
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0570712
APP amyloid beta (A4) precursor protein 0.056684
ARRDC3 arrestin domain containing 3 0.0562499
NCOR2 nuclear receptor corepressor 2 0.0509616
HDAC9 histone deacetylase 9 0.0493998
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0490765
ENO1 enolase 1, (alpha) 0.0484853
TPM3 tropomyosin 3 0.0481775
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0466034
CANX calnexin 0.0451832
ERBIN erbb2 interacting protein 0.0422791
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0419625
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0396345
PLEC plectin 0.0394248
ACTN1 actinin, alpha 1 0.0377017
IGFBP5 insulin-like growth factor binding protein 5 0.0374117
MSN moesin 0.0368946
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0365263
SRRM2 serine/arginine repetitive matrix 2 0.0363344
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0352121
DDIT4 DNA-damage-inducible transcript 4 0.0352042
HSPA8 heat shock 70kDa protein 8 0.0350642
MANF mesencephalic astrocyte-derived neurotrophic factor 0.0347672
CD99 CD99 molecule 0.0344262
SLC39A14 solute carrier family 39 (zinc transporter), member 14 0.0343522
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0340605
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0339459
ESYT2 extended synaptotagmin-like protein 2 0.0337649
KTN1 kinectin 1 (kinesin receptor) 0.0335005
RBM25 RNA binding motif protein 25 0.0334709
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0332161
AKAP12 A kinase (PRKA) anchor protein 12 0.0331499
RRBP1 ribosome binding protein 1 0.0329561
NDRG1 N-myc downstream regulated 1 0.0328685
COL6A1 collagen, type VI, alpha 1 0.0327153
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0324137
RPL13A ribosomal protein L13a 0.0322502
WAC WW domain containing adaptor with coiled-coil 0.0319224
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0312281
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0311546
MKI67 marker of proliferation Ki-67 0.0308736
COPA coatomer protein complex, subunit alpha 0.0305688
MAP1B microtubule-associated protein 1B 0.0304905
TPM2 tropomyosin 2 (beta) 0.0302712
SON SON DNA binding protein 0.0302486
ANKRD36C ankyrin repeat domain 36C 0.0301386
CTNND1 catenin (cadherin-associated protein), delta 1 0.0300899
SHB Src homology 2 domain containing adaptor protein B 0.030043
RPS4X ribosomal protein S4, X-linked 0.0299762
MCL1 myeloid cell leukemia 1 0.0290899
ZNF638 zinc finger protein 638 0.0287196
HSPA1B heat shock 70kDa protein 1B 0.0286925
RIGI RNA sensor RIG-I 0.0281356
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0281076
ZNF395 zinc finger protein 395 0.0280444
RPL37 ribosomal protein L37 0.0279781
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0275579
TRRAP transformation/transcription domain-associated protein 0.0271359
TNRC6A trinucleotide repeat containing 6A 0.0271279
GOLGB1 golgin B1 0.0270809
IQGAP1 IQ motif containing GTPase activating protein 1 0.0267606
CPNE1 copine I 0.0266572
YBX1 Y box binding protein 1 0.0265356
KLC1 kinesin light chain 1 0.0261846
YEATS2 YEATS domain containing 2 0.0255092
RRM2 ribonucleotide reductase M2 0.0254908
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 0.0252898
RSAD2 radical S-adenosyl methionine domain containing 2 0.0248987
ALK anaplastic lymphoma receptor tyrosine kinase 0.024878
PDIA3 protein disulfide isomerase family A, member 3 0.024863
TNIP1 TNFAIP3 interacting protein 1 0.0248443
HYOU1 hypoxia up-regulated 1 0.0246054
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0245649
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0244839
VEZT vezatin, adherens junctions transmembrane protein 0.0243695
SET SET nuclear proto-oncogene 0.02423
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 0.0238933
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive) 0.023718
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.023682
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0236717
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0234388
CARS1 cysteinyl-tRNA synthetase 1 0.0231177
JUN jun proto-oncogene 0.023063
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0229984
FOSL1 FOS-like antigen 1 0.022916
MACF1 microtubule-actin crosslinking factor 1 0.0228668

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.210519
TIMP3 TIMP metallopeptidase inhibitor 3 -0.141269
TMSB10 thymosin beta 10 -0.117994
VIM vimentin -0.106706
LOX lysyl oxidase -0.10104
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0758995
COL1A2 collagen, type I, alpha 2 -0.0650588
TENT5A terminal nucleotidyltransferase 5A -0.0634805
F3 coagulation factor III (thromboplastin, tissue factor) -0.0607134
CDH13 cadherin 13 -0.0595979
FN1 fibronectin 1 -0.0587627
TNS3 tensin 3 -0.0586741
RAI14 retinoic acid induced 14 -0.0585913
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0585439
ELL2 elongation factor, RNA polymerase II, 2 -0.0581341
PSD3 pleckstrin and Sec7 domain containing 3 -0.0581128
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0552629
HLA-C major histocompatibility complex, class I, C -0.0551792
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0535123
ZMYND8 zinc finger, MYND-type containing 8 -0.0530118
GLIS3 GLIS family zinc finger 3 -0.0529393
PGK1 phosphoglycerate kinase 1 -0.0528602
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0508169
COL6A2 collagen, type VI, alpha 2 -0.0506705
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0506321
ATP13A3 ATPase type 13A3 -0.0504249
TPST1 tyrosylprotein sulfotransferase 1 -0.049774
VCL vinculin -0.0486059
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0479611
CA12 carbonic anhydrase XII -0.0474908
AHNAK AHNAK nucleoprotein -0.0461685
SPDYA speedy/RINGO cell cycle regulator family member A -0.0458169
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0455318
MARCHF6 membrane associated ring-CH-type finger 6 -0.0449805
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0444091
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0432231
COL1A1 collagen, type I, alpha 1 -0.0432053
CALU calumenin -0.0429775
HM13 histocompatibility (minor) 13 -0.0417528
CAV1 caveolin 1, caveolae protein, 22kDa -0.0416102
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0409597
TTC3 tetratricopeptide repeat domain 3 -0.0409161
TGFBI transforming growth factor, beta-induced, 68kDa -0.0391413
COG5 component of oligomeric golgi complex 5 -0.038969
UBE2H ubiquitin-conjugating enzyme E2H -0.0381462
IL6 interleukin 6 -0.038064
HIP1 huntingtin interacting protein 1 -0.0364646
MT2A metallothionein 2A -0.0358308
SOD2 superoxide dismutase 2, mitochondrial -0.0353996
KAZN kazrin, periplakin interacting protein -0.0352719
DNAH11 dynein, axonemal, heavy chain 11 -0.0350784
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0346949
SOX5 SRY (sex determining region Y)-box 5 -0.0340205
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.033876
TFPI2 tissue factor pathway inhibitor 2 -0.0337815
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0337269
FBXO11 F-box protein 11 -0.0333429
HLA-B major histocompatibility complex, class I, B -0.0332303
TRIO trio Rho guanine nucleotide exchange factor -0.0331869
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0324613
CLIP2 CAP-GLY domain containing linker protein 2 -0.0320491
AUTS2 autism susceptibility candidate 2 -0.0318138
S100A6 S100 calcium binding protein A6 -0.031698
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0312902
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0311445
AFF4 AF4/FMR2 family, member 4 -0.0300932
CLIC4 chloride intracellular channel 4 -0.0298597
RASAL2 RAS protein activator like 2 -0.0295099
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0293398
TMEM165 transmembrane protein 165 -0.0287762
PID1 phosphotyrosine interaction domain containing 1 -0.0287688
PRRC1 proline-rich coiled-coil 1 -0.0287431
KMT2C lysine (K)-specific methyltransferase 2C -0.0280697
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.027884
SH3RF3 SH3 domain containing ring finger 3 -0.0278572
GPR173 G protein-coupled receptor 173 -0.027478
BIRC6 baculoviral IAP repeat containing 6 -0.0274596
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0271822
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0270386
AGO3 argonaute RISC catalytic component 3 -0.0265593
NAMPT nicotinamide phosphoribosyltransferase -0.0264593
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase -0.0264547
TAS2R14 taste receptor, type 2, member 14 -0.0263953
WSB1 WD repeat and SOCS box containing 1 -0.0263674
FAM13A family with sequence similarity 13, member A -0.0258434
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0256121
GOLM2 golgi membrane protein 2 -0.0255734
PDIA5 protein disulfide isomerase family A, member 5 -0.0254919
PHF21A PHD finger protein 21A -0.0250196
IL6ST interleukin 6 signal transducer -0.0249286
RPL31 ribosomal protein L31 -0.0249171
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0243917
LYST lysosomal trafficking regulator -0.0243813
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.0240686
CCM2 cerebral cavernous malformation 2 -0.023916
TRA2A transformer 2 alpha homolog (Drosophila) -0.0232355
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.023036
RYK receptor-like tyrosine kinase -0.0230159
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0229837
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0229738