Artesunate_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Artesunate perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Artesunate_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ASPH aspartate beta-hydroxylase 0.103058
MYH9 myosin, heavy chain 9, non-muscle 0.0934518
EXT1 exostosin glycosyltransferase 1 0.0848367
APLP2 amyloid beta (A4) precursor-like protein 2 0.0841808
TMEM156 transmembrane protein 156 0.0670192
VEGFA vascular endothelial growth factor A 0.0631525
SMAD3 SMAD family member 3 0.0587491
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0580799
VCL vinculin 0.0535057
SEPTIN9 septin 9 0.0525484
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0502961
NRP1 neuropilin 1 0.0502469
SVIL supervillin 0.0485449
NTN4 netrin 4 0.0476382
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0427385
MCL1 myeloid cell leukemia 1 0.0404979
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0400094
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.039119
RPL3 ribosomal protein L3 0.0390569
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0384967
GLUL glutamate-ammonia ligase 0.0373089
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0368427
ERRFI1 ERBB receptor feedback inhibitor 1 0.036358
LTBP1 latent transforming growth factor beta binding protein 1 0.0360225
TPM3 tropomyosin 3 0.0336929
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0332635
FLNA filamin A, alpha 0.0332025
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0317445
GLIS3 GLIS family zinc finger 3 0.0312938
ADAR adenosine deaminase, RNA-specific 0.0307804
TXNRD1 thioredoxin reductase 1 0.0304164
HIPK2 homeodomain interacting protein kinase 2 0.0300891
SPRED2 sprouty-related, EVH1 domain containing 2 0.0300606
PELO pelota homolog (Drosophila) 0.0298124
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.029251
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0284303
LDHA lactate dehydrogenase A 0.0282184
VCAN versican 0.027423
MAP1B microtubule-associated protein 1B 0.0270668
SRRM2 serine/arginine repetitive matrix 2 0.0269065
OSMR oncostatin M receptor 0.0265653
DUSP5 dual specificity phosphatase 5 0.0262046
ZSWIM6 zinc finger, SWIM-type containing 6 0.0257871
PDLIM5 PDZ and LIM domain 5 0.0257716
HSPA8 heat shock 70kDa protein 8 0.0257023
TOP1 topoisomerase (DNA) I 0.0256339
APP amyloid beta (A4) precursor protein 0.0255919
RUNX2 runt-related transcription factor 2 0.0253457
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0253185
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0250142
WWTR1 WW domain containing transcription regulator 1 0.02497
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0249386
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.024309
RICTOR RPTOR independent companion of MTOR, complex 2 0.0242915
NPTN neuroplastin 0.0234911
COPA coatomer protein complex, subunit alpha 0.0231957
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0229909
AKAP12 A kinase (PRKA) anchor protein 12 0.0226299
NPAS2 neuronal PAS domain protein 2 0.0225208
TSPYL2 TSPY-like 2 0.0221737
GPATCH2L G patch domain containing 2-like 0.0219579
SHB Src homology 2 domain containing adaptor protein B 0.021875
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0216672
MYO10 myosin X 0.0216558
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0212714
MSN moesin 0.0212626
SRSF5 serine/arginine-rich splicing factor 5 0.0212626
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0212345
BICC1 BicC family RNA binding protein 1 0.0209005
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0208808
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0207969
FHL2 four and a half LIM domains 2 0.0207714
PLEC plectin 0.0206013
NUMA1 nuclear mitotic apparatus protein 1 0.0204915
MACF1 microtubule-actin crosslinking factor 1 0.0204369
EEF2 eukaryotic translation elongation factor 2 0.0200999
ATXN1 ataxin 1 0.0199366
SAMD4A sterile alpha motif domain containing 4A 0.0197459
MAP3K9 mitogen-activated protein kinase kinase kinase 9 0.0197005
LAMA4 laminin, alpha 4 0.0195853
NCOR2 nuclear receptor corepressor 2 0.0194893
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.0194483
ENAH enabled homolog (Drosophila) 0.019295
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0191367
RDH10 retinol dehydrogenase 10 (all-trans) 0.0189775
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.018807
RAB10 RAB10, member RAS oncogene family 0.0187804
YBX3 Y box binding protein 3 0.0187599
KSR1 kinase suppressor of ras 1 0.0186372
SSH1 slingshot protein phosphatase 1 0.0185699
ERBIN erbb2 interacting protein 0.0184923
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0184378
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0181721
MLPH melanophilin 0.0179835
ETV3 ets variant 3 0.0179703
ADORA2B adenosine A2b receptor 0.0175495
SGMS2 sphingomyelin synthase 2 0.0173442
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.017293
IL6ST interleukin 6 signal transducer 0.0171684
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0171079

decreased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.199091
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.173207
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.159055
PTMA prothymosin, alpha -0.138101
SQSTM1 sequestosome 1 -0.126138
TMSB10 thymosin beta 10 -0.102004
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0897662
TPT1 tumor protein, translationally-controlled 1 -0.0853486
HLA-B major histocompatibility complex, class I, B -0.081381
S100A6 S100 calcium binding protein A6 -0.0742233
FTL ferritin, light polypeptide -0.070537
FN1 fibronectin 1 -0.0689719
NRG1 neuregulin 1 -0.0682789
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0674444
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0638438
TMSB4X thymosin beta 4, X-linked -0.0578399
VIM vimentin -0.0539488
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0505546
SOX4 SRY (sex determining region Y)-box 4 -0.0493078
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0488512
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0482932
TMEM165 transmembrane protein 165 -0.0479431
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0467464
B2M beta-2-microglobulin -0.0457111
IER3 immediate early response 3 -0.0452926
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0451671
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0450299
ACTG1 actin gamma 1 -0.0448463
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0438363
ZMYND8 zinc finger, MYND-type containing 8 -0.0437224
RPL35A ribosomal protein L35a -0.043475
ITGA1 integrin, alpha 1 -0.0423904
RPL31 ribosomal protein L31 -0.0421804
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0417311
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0413106
HMGA2 high mobility group AT-hook 2 -0.0403193
HILPDA hypoxia inducible lipid droplet-associated -0.0403171
RPL26 ribosomal protein L26 -0.0371113
RPS6 ribosomal protein S6 -0.0369554
RAI14 retinoic acid induced 14 -0.0366956
RPS29 ribosomal protein S29 -0.0359502
RPS8 ribosomal protein S8 -0.0353057
RPS24 ribosomal protein S24 -0.035293
TFPI2 tissue factor pathway inhibitor 2 -0.0344597
TAS2R14 taste receptor, type 2, member 14 -0.0341258
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0340175
LCORL ligand dependent nuclear receptor corepressor-like -0.0339869
RPL34 ribosomal protein L34 -0.0316582
GNAS GNAS complex locus -0.0308724
PDIA3 protein disulfide isomerase family A, member 3 -0.0307351
NDRG1 N-myc downstream regulated 1 -0.0304147
KDM3A lysine (K)-specific demethylase 3A -0.0304079
IRAK3 interleukin-1 receptor-associated kinase 3 -0.0301226
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0295987
RPL38 ribosomal protein L38 -0.0295393
HMGA1 high mobility group AT-hook 1 -0.0294296
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.029234
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0284264
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0284214
LOC102724023 ES1 protein homolog, mitochondrial -0.0283796
TMEM263 transmembrane protein 263 -0.0283471
RACK1 receptor for activated C kinase 1 -0.0282493
IFI27 interferon, alpha-inducible protein 27 -0.0270721
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0270436
RPS27A ribosomal protein S27a -0.0266394
FTH1 ferritin, heavy polypeptide 1 -0.0265847
KDM5B lysine (K)-specific demethylase 5B -0.026265
MTDH metadherin -0.0262366
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.025634
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0253838
KPNB1 karyopherin (importin) beta 1 -0.0251704
RPLP1 ribosomal protein, large, P1 -0.0251501
RPS25 ribosomal protein S25 -0.0250022
RPL37A ribosomal protein L37a -0.0246906
SPAG9 sperm associated antigen 9 -0.0246197
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0244207
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0243016
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0239134
RPL36 ribosomal protein L36 -0.0236917
CADM1 cell adhesion molecule 1 -0.0235796
DENND4C DENN/MADD domain containing 4C -0.0232825
RPS21 ribosomal protein S21 -0.0228446
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0227992
NPEPPS aminopeptidase puromycin sensitive -0.0225614
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0222946
SOD2 superoxide dismutase 2, mitochondrial -0.0222052
OSBPL8 oxysterol binding protein-like 8 -0.0220366
RPLP2 ribosomal protein, large, P2 -0.0219481
WDR45B WD repeat domain 45B -0.0216423
S100A10 S100 calcium binding protein A10 -0.0214799
RTN3 reticulon 3 -0.0212871
PLIN2 perilipin 2 -0.0212603
SPDYA speedy/RINGO cell cycle regulator family member A -0.0212166
ZCCHC7 zinc finger, CCHC domain containing 7 -0.021179
FAM20C family with sequence similarity 20, member C -0.0211745
SLC38A1 solute carrier family 38, member 1 -0.02104
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0208984
CENPF centromere protein F, 350/400kDa -0.0208539
RPL30 ribosomal protein L30 -0.0205826
CEP350 centrosomal protein 350kDa -0.0205788