Arthritis Gene Set

Dataset DISEASES Curated Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description Arthritis (from Greek arthro-, joint + -itis, inflammation; plural: arthritides) is a form of joint disorder that involves inflammation of one or more joints. (Experimental Factor Ontology, EFO_0005856)
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Genes

88 genes involed in the disease Arthritis from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.

Symbol Name Standardized Value
IL6ST interleukin 6 signal transducer 5.0
LACC1 laccase (multicopper oxidoreductase) domain containing 1 5.0
RBPJ recombination signal binding protein for immunoglobulin kappa J region 5.0
CARD14 caspase recruitment domain family, member 14 5.0
CD5 CD5 molecule 5.0
CD2 CD2 molecule 5.0
MCF2L MCF.2 cell line derived transforming sequence-like 5.0
DOT1L DOT1-like histone H3K79 methyltransferase 5.0
PTPRC protein tyrosine phosphatase, receptor type, C 5.0
IRAK1 interleukin-1 receptor-associated kinase 1 5.0
BLK BLK proto-oncogene, Src family tyrosine kinase 5.0
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 5.0
IL2RA interleukin 2 receptor, alpha 5.0
IL2RB interleukin 2 receptor, beta 5.0
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 5.0
IL6R interleukin 6 receptor 5.0
TRAF3IP2 TRAF3 interacting protein 2 5.0
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 5.0
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 5.0
REL v-rel avian reticuloendotheliosis viral oncogene homolog 5.0
TLE3 transducin-like enhancer of split 3 5.0
IRF5 interferon regulatory factor 5 5.0
FAS Fas cell surface death receptor 5.0
C5 complement component 5 5.0
GDF5 growth differentiation factor 5 5.0
GATA3 GATA binding protein 3 5.0
KIF5A kinesin family member 5A 5.0
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 5.0
RCAN1 regulator of calcineurin 1 5.0
STAT4 signal transducer and activator of transcription 4 5.0
RUNX1 runt-related transcription factor 1 5.0
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) 5.0
IL2 interleukin 2 5.0
IRF8 interferon regulatory factor 8 5.0
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 5.0
CCR6 chemokine (C-C motif) receptor 6 5.0
CD40 CD40 molecule, TNF receptor superfamily member 5 5.0
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32) 5.0
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 5.0
PRKCQ protein kinase C, theta 5.0
IL6 interleukin 6 5.0
CCN6 cellular communication network factor 6 5.0
ASTN2 astrotactin 2 5.0
CD58 CD58 molecule 5.0
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 5.0
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 5.0
SPRED2 sprouty-related, EVH1 domain containing 2 5.0
IL13 interleukin 13 5.0
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) 5.0
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 5.0
TNF tumor necrosis factor 5.0
ANKRD55 ankyrin repeat domain 55 5.0
TAGAP T-cell activation RhoGTPase activating protein 5.0
AFF3 AF4/FMR2 family, member 3 5.0
IL21 interleukin 21 5.0
HLA-B major histocompatibility complex, class I, B 5.0
HLA-A major histocompatibility complex, class I, A 5.0
HLA-G major histocompatibility complex, class I, G 5.0
CD247 CD247 molecule 5.0
CD28 CD28 molecule 5.0
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 5.0
NCOA3 nuclear receptor coactivator 3 5.0
CTLA4 cytotoxic T-lymphocyte-associated protein 4 5.0
UBE2L3 ubiquitin-conjugating enzyme E2L 3 5.0
PXK PX domain containing serine/threonine kinase 5.0
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 5.0
TRAF1 TNF receptor-associated factor 1 5.0
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase 5.0
IL23R interleukin 23 receptor 5.0
ARID5B AT rich interactive domain 5B (MRF1-like) 5.0
PRDM1 PR domain containing 1, with ZNF domain 5.0
IKZF3 IKAROS family zinc finger 3 (Aiolos) 5.0
ZFP36L1 ZFP36 ring finger protein-like 1 5.0
PADI4 peptidyl arginine deiminase, type IV 5.0
PTPN2 protein tyrosine phosphatase, non-receptor type 2 5.0
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 5.0
CCL21 chemokine (C-C motif) ligand 21 5.0
COL11A1 collagen, type XI, alpha 1 5.0
IL12B interleukin 12B 5.0
PIP4K2C phosphatidylinositol-5-phosphate 4-kinase, type II, gamma 5.0
POU3F1 POU class 3 homeobox 1 5.0
HLA-C major histocompatibility complex, class I, C 5.0
TYK2 tyrosine kinase 2 5.0
SAA1 serum amyloid A1 4.0
SAA2 serum amyloid A2 4.0
HPRT1 hypoxanthine phosphoribosyltransferase 1 4.0
PRPS1 phosphoribosyl pyrophosphate synthetase 1 4.0
TTR transthyretin 3.0