Asbestosis Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description A pneumoconiosis caused by inhalation and retention of asbestos fibers. (Human Disease Ontology, DOID_10320)
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Genes

164 genes co-occuring with the disease Asbestosis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
MSLN mesothelin 2.37
CALB2 calbindin 2 2.194
IL1B interleukin 1, beta 2.181
CASP1 caspase 1, apoptosis-related cysteine peptidase 2.128
MUC5B mucin 5B, oligomeric mucus/gel-forming 2.125
NLRP3 NLR family, pyrin domain containing 3 2.111
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1 2.069
TGFB1 transforming growth factor, beta 1 1.993
IL18 interleukin 18 1.988
SFTPC surfactant protein C 1.976
NLRC4 NLR family, CARD domain containing 4 1.927
TNF tumor necrosis factor 1.816
SPP1 secreted phosphoprotein 1 1.779
IL6 interleukin 6 1.767
PYCARD PYD and CARD domain containing 1.751
AIM2 absent in melanoma 2 1.729
CTSB cathepsin B 1.724
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) 1.708
FN1 fibronectin 1 1.677
HMGB1 high mobility group box 1 1.675
CXCL8 chemokine (C-X-C motif) ligand 8 1.674
IL1A interleukin 1, alpha 1.669
TP53 tumor protein p53 1.641
GSTM1 glutathione S-transferase mu 1 1.638
OGG1 8-oxoguanine DNA glycosylase 1.624
MUC1 mucin 1, cell surface associated 1.616
NOX4 NADPH oxidase 4 1.615
NLRP1 NLR family, pyrin domain containing 1 1.612
NF2 neurofibromin 2 (merlin) 1.594
IL13 interleukin 13 1.582
KIF18A kinesin family member 18A 1.561
WT1 Wilms tumor 1 1.536
IFNG interferon, gamma 1.533
CDKN2A cyclin-dependent kinase inhibitor 2A 1.532
KRT5 keratin 5, type II 1.524
SFTPD surfactant protein D 1.509
TXN thioredoxin 1.505
IL10 interleukin 10 1.502
IL1R1 interleukin 1 receptor, type I 1.501
TXNIP thioredoxin interacting protein 1.492
SOD3 superoxide dismutase 3, extracellular 1.482
CD4 CD4 molecule 1.482
CCL2 chemokine (C-C motif) ligand 2 1.479
MARCO macrophage receptor with collagenous structure 1.476
CASP5 caspase 5, apoptosis-related cysteine peptidase 1.465
TERT telomerase reverse transcriptase 1.448
IL5 interleukin 5 1.447
NLRP7 NLR family, pyrin domain containing 7 1.446
IL4 interleukin 4 1.438
PARN poly(A)-specific ribonuclease 1.432
NLRP6 NLR family, pyrin domain containing 6 1.426
FAM13A family with sequence similarity 13, member A 1.421
SFTPA2 surfactant protein A2 1.405
ALB albumin 1.39
NLRP12 NLR family, pyrin domain containing 12 1.371
CD8A CD8a molecule 1.367
PANX1 pannexin 1 1.361
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 1.352
TLR4 toll-like receptor 4 1.35
RTEL1 regulator of telomere elongation helicase 1 1.344
ENOX2 ecto-NOX disulfide-thiol exchanger 2 1.339
ACE angiotensin I converting enzyme 1.336
JUN jun proto-oncogene 1.335
IL33 interleukin 33 1.327
MMP7 matrix metallopeptidase 7 1.324
TOLLIP toll interacting protein 1.315
MMP9 matrix metallopeptidase 9 1.309
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.3
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3 1.297
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) 1.295
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 1.286
MCAT malonyl CoA:ACP acyltransferase (mitochondrial) 1.283
ACO2 aconitase 2, mitochondrial 1.282
BCL2 B-cell CLL/lymphoma 2 1.281
ELMOD2 ELMO/CED-12 domain containing 2 1.28
MEFV Mediterranean fever 1.279
NAIP NLR family, apoptosis inhibitory protein 1.276
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 1.276
NLRP4 NLR family, pyrin domain containing 4 1.276
NLRP10 NLR family, pyrin domain containing 10 1.272
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.267
CRP C-reactive protein, pentraxin-related 1.264
SPPL2C signal peptide peptidase like 2C 1.222
EGFR epidermal growth factor receptor 1.216
PTGER4 prostaglandin E receptor 4 (subtype EP4) 1.213
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) 1.211
IL17A interleukin 17A 1.205
GSTP1 glutathione S-transferase pi 1 1.203
HMOX1 heme oxygenase 1 1.193
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 1.188
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 1.185
DPP9 dipeptidyl-peptidase 9 1.184
CARD8 caspase recruitment domain family, member 8 1.183
CCL3 chemokine (C-C motif) ligand 3 1.179
MCU mitochondrial calcium uniporter 1.173
ATP11A ATPase, class VI, type 11A 1.173
CARD18 caspase recruitment domain family, member 18 1.171
CHIT1 chitinase 1 (chitotriosidase) 1.161
NKX2-1 NK2 homeobox 1 1.155
KCNK6 potassium channel, two pore domain subfamily K, member 6 1.151
SEPTIN7 septin 7 1.151
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.151
MYD88 myeloid differentiation primary response 88 1.15
SFTPA1 surfactant protein A1 1.147
KAZALD1 Kazal-type serine peptidase inhibitor domain 1 1.147
MMP12 matrix metallopeptidase 12 1.144
NOD2 nucleotide-binding oligomerization domain containing 2 1.144
TIMP1 TIMP metallopeptidase inhibitor 1 1.144
CCL5 chemokine (C-C motif) ligand 5 1.142
CTSS cathepsin S 1.141
CIITA class II, major histocompatibility complex, transactivator 1.14
EGF epidermal growth factor 1.139
IL2 interleukin 2 1.136
CYBB cytochrome b-245, beta polypeptide 1.132
CCN2 cellular communication network factor 2 1.131
DKC1 dyskeratosis congenita 1, dyskerin 1.128
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.128
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.128
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.121
GPX3 glutathione peroxidase 3 1.117
MMP2 matrix metallopeptidase 2 1.113
MPO myeloperoxidase 1.105
NLRC5 NLR family, CARD domain containing 5 1.102
NLRX1 NLR family member X1 1.101
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1 1.1
CYCS cytochrome c, somatic 1.1
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 1.099
GSDMD gasdermin D 1.097
TLR2 toll-like receptor 2 1.095
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 1.093
CCL4 chemokine (C-C motif) ligand 4 1.091
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 1.089
IAPP islet amyloid polypeptide 1.085
PDGFA platelet-derived growth factor alpha polypeptide 1.081
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.079
GPX2 glutathione peroxidase 2 1.076
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1.076
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.074
CCL11 chemokine (C-C motif) ligand 11 1.074
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.073
PDPN podoplanin 1.069
FASLG Fas ligand (TNF superfamily, member 6) 1.06
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 1.059
IGF1 insulin-like growth factor 1 (somatomedin C) 1.058
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 1.056
GPX6 glutathione peroxidase 6 1.054
GPX5 glutathione peroxidase 5 1.053
KRAS Kirsten rat sarcoma viral oncogene homolog 1.053
GPX8 glutathione peroxidase 8 (putative) 1.053
TINF2 TERF1 (TRF1)-interacting nuclear factor 2 1.052
GPX7 glutathione peroxidase 7 1.05
IL4I1 interleukin 4 induced 1 1.047
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.046
NAA11 N(alpha)-acetyltransferase 11, NatA catalytic subunit 1.043
PTPRC protein tyrosine phosphatase, receptor type, C 1.033
GREM1 gremlin 1, DAN family BMP antagonist 1.029
TRPM2 transient receptor potential cation channel, subfamily M, member 2 1.019
HPGDS hematopoietic prostaglandin D synthase 1.019
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 1.018
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.01
GCSH glycine cleavage system protein H (aminomethyl carrier) 1.007
COL1A2 collagen, type I, alpha 2 1.002
BCL2L1 BCL2-like 1 1.001
THBD thrombomodulin 1.001