| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Asciminib perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Asciminib_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.178032 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0975371 |
| CDH13 | cadherin 13 | 0.0877416 |
| FN1 | fibronectin 1 | 0.0726683 |
| COL5A1 | collagen, type V, alpha 1 | 0.0713827 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | 0.0661697 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0556372 |
| FBN1 | fibrillin 1 | 0.0551227 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0542736 |
| MYOF | myoferlin | 0.0517849 |
| THBS2 | thrombospondin 2 | 0.0508237 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0500187 |
| OGA | O-GlcNAcase | 0.0498699 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0496457 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0480731 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0449449 |
| TMSB4X | thymosin beta 4, X-linked | 0.0442421 |
| FSTL1 | follistatin-like 1 | 0.0430687 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0406054 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0399323 |
| DST | dystonin | 0.0398843 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0398743 |
| COL3A1 | collagen, type III, alpha 1 | 0.0397234 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0394018 |
| PGK1 | phosphoglycerate kinase 1 | 0.0386948 |
| APP | amyloid beta (A4) precursor protein | 0.0386128 |
| TPM4 | tropomyosin 4 | 0.0378212 |
| ATP13A3 | ATPase type 13A3 | 0.0362989 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0357991 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0355382 |
| RTN4 | reticulon 4 | 0.0353278 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0344023 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0332451 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0331932 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.0329342 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0328683 |
| CAVIN1 | caveolae associated protein 1 | 0.032444 |
| XPO1 | exportin 1 | 0.0322777 |
| LOXL2 | lysyl oxidase-like 2 | 0.0322708 |
| CCNY | cyclin Y | 0.0319231 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0310894 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | 0.030946 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0306436 |
| LCOR | ligand dependent nuclear receptor corepressor | 0.0302828 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0300928 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0299571 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0297562 |
| FMNL2 | formin-like 2 | 0.0294597 |
| NEK7 | NIMA-related kinase 7 | 0.0293916 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0293903 |
| TAOK1 | TAO kinase 1 | 0.0291247 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0289313 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0288818 |
| HELZ | helicase with zinc finger | 0.0288289 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0286725 |
| NCKAP1 | NCK-associated protein 1 | 0.0284017 |
| CDC42EP3 | CDC42 effector protein (Rho GTPase binding) 3 | 0.0283126 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0281659 |
| SLC39A11 | solute carrier family 39, member 11 | 0.0280771 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0277021 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.027672 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0275357 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0275334 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0274096 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0273719 |
| FAM107B | family with sequence similarity 107, member B | 0.0271662 |
| DENND1A | DENN/MADD domain containing 1A | 0.0269768 |
| MAP1B | microtubule-associated protein 1B | 0.0269663 |
| ATP2C1 | ATPase, Ca++ transporting, type 2C, member 1 | 0.0269537 |
| XPO6 | exportin 6 | 0.0269363 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0266806 |
| AHNAK | AHNAK nucleoprotein | 0.0266508 |
| G3BP1 | GTPase activating protein (SH3 domain) binding protein 1 | 0.0265967 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0264778 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.026072 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0258858 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0258007 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0257797 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0255696 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.0254798 |
| CLTC | clathrin, heavy chain (Hc) | 0.0251945 |
| CYTH3 | cytohesin 3 | 0.0250651 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0249282 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0249155 |
| QKI | QKI, KH domain containing, RNA binding | 0.0246127 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0246027 |
| DKK3 | dickkopf WNT signaling pathway inhibitor 3 | 0.0245431 |
| CDK6 | cyclin-dependent kinase 6 | 0.0244351 |
| MSN | moesin | 0.0243029 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0240313 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | 0.023881 |
| ANKRD11 | ankyrin repeat domain 11 | 0.023879 |
| COPA | coatomer protein complex, subunit alpha | 0.0238635 |
| MSI2 | musashi RNA-binding protein 2 | 0.0238323 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | 0.0237304 |
| TPM1 | tropomyosin 1 (alpha) | 0.023608 |
| AUTS2 | autism susceptibility candidate 2 | 0.0233018 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0232579 |
| SLC8A1 | solute carrier family 8 (sodium/calcium exchanger), member 1 | 0.0231617 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0229782 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.211591 |
| TMSB10 | thymosin beta 10 | -0.166939 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.147966 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0911489 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0858468 |
| MT2A | metallothionein 2A | -0.085147 |
| UBC | ubiquitin C | -0.0686543 |
| NDRG1 | N-myc downstream regulated 1 | -0.0653658 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0538298 |
| CD44 | CD44 molecule (Indian blood group) | -0.0532068 |
| MYADM | myeloid-associated differentiation marker | -0.047164 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0448744 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0437284 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0429531 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0404667 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0358249 |
| S100A6 | S100 calcium binding protein A6 | -0.0352884 |
| LOX | lysyl oxidase | -0.0344093 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0334462 |
| VIM | vimentin | -0.0331908 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0331644 |
| RPS6 | ribosomal protein S6 | -0.0302567 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0300878 |
| STC1 | stanniocalcin 1 | -0.0299719 |
| RPL23 | ribosomal protein L23 | -0.0295636 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0294199 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.028163 |
| RPL28 | ribosomal protein L28 | -0.0278335 |
| S100A10 | S100 calcium binding protein A10 | -0.0277628 |
| FTL | ferritin, light polypeptide | -0.0259777 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.025235 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0251365 |
| MX2 | MX dynamin-like GTPase 2 | -0.0249201 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0242959 |
| C1D | C1D nuclear receptor corepressor | -0.0242836 |
| OPTN | optineurin | -0.0240419 |
| RPS27A | ribosomal protein S27a | -0.0236513 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0236491 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0232273 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0220504 |
| PKM | pyruvate kinase, muscle | -0.0220469 |
| EHBP1 | EH domain binding protein 1 | -0.0219581 |
| BSG | basigin (Ok blood group) | -0.0211397 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0211129 |
| TAPBP | TAP binding protein (tapasin) | -0.0211114 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0204056 |
| SP100 | SP100 nuclear antigen | -0.0203751 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.020299 |
| PRELID2 | PRELI domain containing 2 | -0.0201336 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.019912 |
| RPLP1 | ribosomal protein, large, P1 | -0.0199087 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | -0.0197135 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0191586 |
| UBXN4 | UBX domain protein 4 | -0.0189557 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0189222 |
| TGFB1 | transforming growth factor, beta 1 | -0.0187963 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.01868 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0185493 |
| RPL34 | ribosomal protein L34 | -0.0184236 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0180914 |
| SON | SON DNA binding protein | -0.0176355 |
| EGR1 | early growth response 1 | -0.0173278 |
| LAMA5 | laminin, alpha 5 | -0.0172847 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0169609 |
| RACK1 | receptor for activated C kinase 1 | -0.0167996 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | -0.0163435 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0162801 |
| RPS15 | ribosomal protein S15 | -0.016277 |
| GLIS3 | GLIS family zinc finger 3 | -0.0162539 |
| RPL31 | ribosomal protein L31 | -0.0161732 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | -0.0158514 |
| DPYSL2 | dihydropyrimidinase-like 2 | -0.015842 |
| MNT | MAX network transcriptional repressor | -0.0158113 |
| TBCA | tubulin folding cofactor A | -0.0156178 |
| TRIM56 | tripartite motif containing 56 | -0.0155698 |
| RPLP2 | ribosomal protein, large, P2 | -0.0153271 |
| NRP1 | neuropilin 1 | -0.0153245 |
| RPS27 | ribosomal protein S27 | -0.0153005 |
| PLAT | plasminogen activator, tissue | -0.015268 |
| RPS8 | ribosomal protein S8 | -0.0150463 |
| RPS19 | ribosomal protein S19 | -0.014998 |
| JMJD1C | jumonji domain containing 1C | -0.014992 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -0.0149654 |
| OSBPL8 | oxysterol binding protein-like 8 | -0.0149447 |
| SAMHD1 | SAM domain and HD domain 1 | -0.0148216 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0147728 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0147531 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0147488 |
| MT1X | metallothionein 1X | -0.0146925 |
| HERC5 | HECT and RLD domain containing E3 ubiquitin protein ligase 5 | -0.0146568 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.0145675 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -0.0145473 |
| BCAR1 | breast cancer anti-estrogen resistance 1 | -0.0145097 |
| RPL12 | ribosomal protein L12 | -0.0144426 |
| RPS5 | ribosomal protein S5 | -0.014355 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0143362 |
| MRC2 | mannose receptor, C type 2 | -0.014173 |
| EPSTI1 | epithelial stromal interaction 1 (breast) | -0.0141059 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.0140472 |
| RPL36 | ribosomal protein L36 | -0.0139464 |
