| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Asciminib perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Asciminib_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0978961 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0891308 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0677079 |
| CCNL1 | cyclin L1 | 0.0652854 |
| PCBP2 | poly(rC) binding protein 2 | 0.0515756 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0403082 |
| CPOX | coproporphyrinogen oxidase | 0.0394347 |
| TMEM41B | transmembrane protein 41B | 0.038158 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | 0.0375038 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0339335 |
| CLDND1 | claudin domain containing 1 | 0.0338137 |
| GJA1 | gap junction protein, alpha 1, 43kDa | 0.0324283 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.032092 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0320645 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0317687 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | 0.0300653 |
| RRM2 | ribonucleotide reductase M2 | 0.0284236 |
| GASK1B | golgi associated kinase 1B | 0.0272757 |
| NEK7 | NIMA-related kinase 7 | 0.0270931 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0270874 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0270077 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0267597 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0264653 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0260131 |
| ATP2C1 | ATPase, Ca++ transporting, type 2C, member 1 | 0.0254797 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.0253278 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0249626 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0247779 |
| HLA-A | major histocompatibility complex, class I, A | 0.0247386 |
| ETNK1 | ethanolamine kinase 1 | 0.0246893 |
| TSC22D2 | TSC22 domain family, member 2 | 0.02468 |
| WDR43 | WD repeat domain 43 | 0.0243279 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0241979 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0234899 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0231387 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0226735 |
| NCKAP1 | NCK-associated protein 1 | 0.0219384 |
| ZBTB11 | zinc finger and BTB domain containing 11 | 0.0217764 |
| ECT2 | epithelial cell transforming 2 | 0.0216548 |
| CASC3 | cancer susceptibility candidate 3 | 0.0211972 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0210135 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0209603 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.020917 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0203797 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.0202979 |
| TNPO1 | transportin 1 | 0.0198383 |
| CEP192 | centrosomal protein 192kDa | 0.0198334 |
| CXADR | coxsackie virus and adenovirus receptor | 0.0196957 |
| CAND1 | cullin-associated and neddylation-dissociated 1 | 0.0194708 |
| PLK2 | polo-like kinase 2 | 0.0192902 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0191105 |
| TMEM39A | transmembrane protein 39A | 0.0187221 |
| ARRDC3 | arrestin domain containing 3 | 0.0186776 |
| IPO7 | importin 7 | 0.0185379 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0185093 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | 0.0183844 |
| RPL3 | ribosomal protein L3 | 0.0183782 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0181194 |
| TCP1 | t-complex 1 | 0.01796 |
| TPM3 | tropomyosin 3 | 0.0179131 |
| LRP6 | low density lipoprotein receptor-related protein 6 | 0.0178842 |
| ELP2 | elongator acetyltransferase complex subunit 2 | 0.0177928 |
| FAR1 | fatty acyl CoA reductase 1 | 0.0177669 |
| HEATR1 | HEAT repeat containing 1 | 0.017712 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0177115 |
| NUP58 | nucleoporin 58 | 0.0173907 |
| PRKAR1A | protein kinase, cAMP-dependent, regulatory, type I, alpha | 0.0173472 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0172969 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0171487 |
| ARL8B | ADP-ribosylation factor-like 8B | 0.0170855 |
| PER1 | period circadian clock 1 | 0.0169148 |
| RIMKLB | ribosomal modification protein rimK-like family member B | 0.016816 |
| PRKCI | protein kinase C, iota | 0.016653 |
| RPS6KB1 | ribosomal protein S6 kinase, 70kDa, polypeptide 1 | 0.0166066 |
| RPL4 | ribosomal protein L4 | 0.0165218 |
| MATR3 | matrin 3 | 0.0165143 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0164928 |
| HSPA4 | heat shock 70kDa protein 4 | 0.0163765 |
| RPS12 | ribosomal protein S12 | 0.0163342 |
| SSRP1 | structure specific recognition protein 1 | 0.015988 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0158297 |
| WIPF2 | WAS/WASL interacting protein family, member 2 | 0.0156623 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0156421 |
| SP3 | Sp3 transcription factor | 0.0155785 |
| PCMTD1 | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 | 0.0155695 |
| EIF5AL1 | eukaryotic translation initiation factor 5A-like 1 | 0.0155633 |
| GDI2 | GDP dissociation inhibitor 2 | 0.0153961 |
| PEG10 | paternally expressed 10 | 0.0152827 |
| ANXA1 | annexin A1 | 0.0151635 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0148593 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.0146282 |
| GABARAPL1 | GABA(A) receptor-associated protein like 1 | 0.0145581 |
| POLR2B | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa | 0.0145383 |
| CEP70 | centrosomal protein 70kDa | 0.0144931 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.014448 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0142988 |
| PPP4R1 | protein phosphatase 4, regulatory subunit 1 | 0.0141927 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0141264 |
| CEP95 | centrosomal protein 95kDa | 0.014074 |
| UBP1 | upstream binding protein 1 (LBP-1a) | 0.0139988 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NLGN1 | neuroligin 1 | -0.264362 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.21749 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.186619 |
| PCDH7 | protocadherin 7 | -0.101919 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0958897 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0950476 |
| EHBP1 | EH domain binding protein 1 | -0.0937977 |
| HMGA2 | high mobility group AT-hook 2 | -0.0863446 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.065448 |
| TMSB10 | thymosin beta 10 | -0.0631929 |
| MMP12 | matrix metallopeptidase 12 | -0.0597254 |
| DST | dystonin | -0.0587215 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0552619 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0552399 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0519641 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0509756 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0504347 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.0501712 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0499235 |
| ACTG1 | actin gamma 1 | -0.0487683 |
| AHNAK | AHNAK nucleoprotein | -0.0484915 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0482885 |
| PTMA | prothymosin, alpha | -0.0469647 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0448335 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0446289 |
| NHSL1 | NHS-like 1 | -0.0435191 |
| FTL | ferritin, light polypeptide | -0.0430326 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0429293 |
| ZNF804A | zinc finger protein 804A | -0.0422317 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0419907 |
| EDARADD | EDAR-associated death domain | -0.0410276 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0409521 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.04 |
| CMIP | c-Maf inducing protein | -0.0398627 |
| EXOC4 | exocyst complex component 4 | -0.0395271 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0394936 |
| RASAL2 | RAS protein activator like 2 | -0.0394636 |
| CUX1 | cut-like homeobox 1 | -0.0391249 |
| BPTF | bromodomain PHD finger transcription factor | -0.03786 |
| H1-0 | H1.0 linker histone | -0.0364058 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0362387 |
| RPS6 | ribosomal protein S6 | -0.0362254 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | -0.0355412 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0345711 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0344971 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0342661 |
| HMGA1 | high mobility group AT-hook 1 | -0.0335944 |
| VIM | vimentin | -0.033431 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0333034 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0331164 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0326957 |
| DTNA | dystrobrevin, alpha | -0.0324427 |
| NEBL | nebulette | -0.0321305 |
| RPL23 | ribosomal protein L23 | -0.0320261 |
| RNF213 | ring finger protein 213 | -0.0316712 |
| YAP1 | Yes-associated protein 1 | -0.0315274 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.030332 |
| MAP1B | microtubule-associated protein 1B | -0.0302776 |
| RAD51B | RAD51 paralog B | -0.029978 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0295138 |
| CDH12 | cadherin 12, type 2 (N-cadherin 2) | -0.0294704 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0292448 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0291965 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0291504 |
| RPL35A | ribosomal protein L35a | -0.0289351 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0286612 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0285733 |
| ETV6 | ets variant 6 | -0.0285149 |
| HMGB1 | high mobility group box 1 | -0.0284887 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | -0.0279615 |
| L3MBTL4 | l(3)mbt-like 4 (Drosophila) | -0.0278331 |
| EGR1 | early growth response 1 | -0.0278149 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0277848 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0275032 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0274784 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.0272577 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0270872 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0270702 |
| RPS19 | ribosomal protein S19 | -0.0270491 |
| RPL34 | ribosomal protein L34 | -0.0270004 |
| PARD3 | par-3 family cell polarity regulator | -0.0269952 |
| INTS6 | integrator complex subunit 6 | -0.0268702 |
| JMJD1C | jumonji domain containing 1C | -0.0266147 |
| CCND1 | cyclin D1 | -0.0256848 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0256632 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0254585 |
| CCDC88A | coiled-coil domain containing 88A | -0.0253475 |
| RPL19 | ribosomal protein L19 | -0.0252599 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0252009 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | -0.0251408 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.024689 |
| COMMD10 | COMM domain containing 10 | -0.0246249 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.0246242 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0245498 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0245363 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.0244416 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0243265 |
| SPATS2 | spermatogenesis associated, serine-rich 2 | -0.0243146 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0239064 |
| PCNP | PEST proteolytic signal containing nuclear protein | -0.0238159 |
