Asciminib_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Asciminib perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Asciminib_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.160847
PLAT plasminogen activator, tissue 0.0685852
HELZ helicase with zinc finger 0.0657183
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0575014
PCBP2 poly(rC) binding protein 2 0.0517834
PTMA prothymosin, alpha 0.0511275
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0504849
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0497424
KMT2C lysine (K)-specific methyltransferase 2C 0.0447219
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0417312
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.0383846
POTEF POTE ankyrin domain family, member F 0.0359407
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0347608
ASPH aspartate beta-hydroxylase 0.0345638
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0340362
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.0338355
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0336682
SLMAP sarcolemma associated protein 0.0329543
UBA6 ubiquitin-like modifier activating enzyme 6 0.0327677
ENAH enabled homolog (Drosophila) 0.0322523
MYO6 myosin VI 0.0314187
MEF2A myocyte enhancer factor 2A 0.0314028
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0307793
CRH corticotropin releasing hormone 0.0294714
NUP58 nucleoporin 58 0.0294399
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0289198
FNDC3B fibronectin type III domain containing 3B 0.0287508
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0287304
RPS17 ribosomal protein S17 0.0286209
ZNF148 zinc finger protein 148 0.0285794
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0284749
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0284031
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0281365
RPS3 ribosomal protein S3 0.0279794
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0273172
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0268106
PRRC2C proline-rich coiled-coil 2C 0.0267345
TOP1 topoisomerase (DNA) I 0.0264887
LIMCH1 LIM and calponin homology domains 1 0.0262478
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.0254711
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0253507
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0253443
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.025324
PKM pyruvate kinase, muscle 0.0252923
PHIP pleckstrin homology domain interacting protein 0.0252573
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0252334
SMAD3 SMAD family member 3 0.0251963
ZFP36L1 ZFP36 ring finger protein-like 1 0.0245687
WAC WW domain containing adaptor with coiled-coil 0.0244149
SENP6 SUMO1/sentrin specific peptidase 6 0.0243833
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0242758
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0240795
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0238734
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0238658
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0231461
TRA2A transformer 2 alpha homolog (Drosophila) 0.0231163
FAM13A family with sequence similarity 13, member A 0.0230756
ARRDC3 arrestin domain containing 3 0.0230353
NAMPT nicotinamide phosphoribosyltransferase 0.0228004
SIK3 SIK family kinase 3 0.0227967
RPL27 ribosomal protein L27 0.0227329
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 0.0226553
COPA coatomer protein complex, subunit alpha 0.0224588
PNN pinin, desmosome associated protein 0.0224182
SEC23A Sec23 homolog A (S. cerevisiae) 0.0223464
ARL8B ADP-ribosylation factor-like 8B 0.0223217
VIM vimentin 0.0218989
XPO1 exportin 1 0.0218452
TCP1 t-complex 1 0.0215869
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0215602
KDM6A lysine (K)-specific demethylase 6A 0.021493
ANKRD28 ankyrin repeat domain 28 0.021337
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0212216
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 0.0211912
PPP4R2 protein phosphatase 4, regulatory subunit 2 0.0208768
DCAF7 DDB1 and CUL4 associated factor 7 0.0208646
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0208329
PARD3 par-3 family cell polarity regulator 0.0207658
PGK1 phosphoglycerate kinase 1 0.0206624
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0206502
SET SET nuclear proto-oncogene 0.0205476
UBE2G1 ubiquitin-conjugating enzyme E2G 1 0.0205393
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0205042
TIMP3 TIMP metallopeptidase inhibitor 3 0.0204772
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0203951
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.020374
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0203693
MEMO1 mediator of cell motility 1 0.0203304
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0202431
CCND1 cyclin D1 0.02012
CDH13 cadherin 13 0.0199725
CSDE1 cold shock domain containing E1, RNA-binding 0.01995
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0199293
ADNP activity-dependent neuroprotector homeobox 0.0199013
NUP153 nucleoporin 153kDa 0.0198695
MSI2 musashi RNA-binding protein 2 0.0198002
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0197475
AFF3 AF4/FMR2 family, member 3 0.0196558
CRY1 cryptochrome circadian clock 1 0.0196384
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0196366

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.220668
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.138237
SYT1 synaptotagmin I -0.130403
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.116007
PTPRD protein tyrosine phosphatase, receptor type, D -0.0782523
NCAM2 neural cell adhesion molecule 2 -0.0764495
BPTF bromodomain PHD finger transcription factor -0.0725221
TPST1 tyrosylprotein sulfotransferase 1 -0.0724001
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0687828
FRMD4A FERM domain containing 4A -0.0649251
MEIS2 Meis homeobox 2 -0.0619933
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0613323
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0610902
LSAMP limbic system-associated membrane protein -0.0589933
PLPP1 phospholipid phosphatase 1 -0.0565672
RNF213 ring finger protein 213 -0.0552198
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0532239
VCL vinculin -0.053083
GPC5 glypican 5 -0.0503287
PHF3 PHD finger protein 3 -0.0486753
P4HB prolyl 4-hydroxylase, beta polypeptide -0.04489
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0444276
NRP1 neuropilin 1 -0.0418914
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0416926
CHD9 chromodomain helicase DNA binding protein 9 -0.041029
RIGI RNA sensor RIG-I -0.040999
NRG1 neuregulin 1 -0.0403344
AKAP12 A kinase (PRKA) anchor protein 12 -0.0399082
HAND2 heart and neural crest derivatives expressed 2 -0.0394976
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 -0.0386431
ZBTB20 zinc finger and BTB domain containing 20 -0.038601
RALYL RALY RNA binding protein-like -0.0383502
KLHL13 kelch-like family member 13 -0.0380883
SOS1 son of sevenless homolog 1 (Drosophila) -0.037647
MBD5 methyl-CpG binding domain protein 5 -0.0372479
FMN1 formin 1 -0.036494
SIK2 salt-inducible kinase 2 -0.0364629
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0356039
PDE10A phosphodiesterase 10A -0.0349348
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0344881
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 -0.0340827
MYO9A myosin IXA -0.0331908
GLCCI1 glucocorticoid induced 1 -0.0322966
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0322276
ZC3H11A zinc finger CCCH-type containing 11A -0.0321044
NBEAL1 neurobeachin-like 1 -0.0316792
SP100 SP100 nuclear antigen -0.0307362
CCDC47 coiled-coil domain containing 47 -0.0301389
SMC4 structural maintenance of chromosomes 4 -0.0300213
HDLBP high density lipoprotein binding protein -0.0292974
PTPRK protein tyrosine phosphatase, receptor type, K -0.029152
NDRG1 N-myc downstream regulated 1 -0.0290757
MBNL2 muscleblind-like splicing regulator 2 -0.0289836
CEP95 centrosomal protein 95kDa -0.0289825
MBTD1 mbt domain containing 1 -0.0288146
ARB2A ARB2 cotranscriptional regulator A -0.0287214
TAS2R14 taste receptor, type 2, member 14 -0.0282163
TRPS1 trichorhinophalangeal syndrome I -0.0276647
COL4A5 collagen, type IV, alpha 5 -0.0275743
IFI16 interferon, gamma-inducible protein 16 -0.0275047
NPEPPS aminopeptidase puromycin sensitive -0.0273514
FNDC3A fibronectin type III domain containing 3A -0.0273267
CSNK1A1 casein kinase 1, alpha 1 -0.0272291
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0268789
ANTXR1 anthrax toxin receptor 1 -0.0267398
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0265144
UNC5C unc-5 homolog C (C. elegans) -0.0264108
IRS1 insulin receptor substrate 1 -0.0263325
COL3A1 collagen, type III, alpha 1 -0.026082
FKBP10 FK506 binding protein 10, 65 kDa -0.0259365
ARF1 ADP-ribosylation factor 1 -0.025804
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0257291
SLC38A2 solute carrier family 38, member 2 -0.0256104
SENP5 SUMO1/sentrin specific peptidase 5 -0.025605
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0255459
NF1 neurofibromin 1 -0.025446
THOC2 THO complex 2 -0.0254184
HDX highly divergent homeobox -0.025256
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0252258
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0252205
EXOC4 exocyst complex component 4 -0.0248336
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0247802
NFE2L2 nuclear factor, erythroid 2-like 2 -0.02469
ZNF33B zinc finger protein 33B -0.0246846
DST dystonin -0.0245843
UBE2O ubiquitin-conjugating enzyme E2O -0.0245307
TRIO trio Rho guanine nucleotide exchange factor -0.0243547
CACNB2 calcium channel, voltage-dependent, beta 2 subunit -0.0243356
KCNT2 potassium channel, sodium activated subfamily T, member 2 -0.0243057
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 -0.024233
RBM39 RNA binding motif protein 39 -0.0242168
RAB21 RAB21, member RAS oncogene family -0.0241602
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 -0.023879
FHIT fragile histidine triad -0.0236067
SYNPO2 synaptopodin 2 -0.0235154
ADGRB3 adhesion G protein-coupled receptor B3 -0.0234945
SPAG9 sperm associated antigen 9 -0.0234039
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0231608
DENND4A DENN/MADD domain containing 4A -0.0229535
APTX aprataxin -0.0229089