| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Asciminib perturbation in COLO 205 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Asciminib_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FNDC3B | fibronectin type III domain containing 3B | 0.0656621 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0566253 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0498742 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0478548 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0472884 |
| TXNIP | thioredoxin interacting protein | 0.0467688 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0436812 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0397718 |
| UBR2 | ubiquitin protein ligase E3 component n-recognin 2 | 0.0360657 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0354973 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.03547 |
| VEGFA | vascular endothelial growth factor A | 0.0341228 |
| COG6 | component of oligomeric golgi complex 6 | 0.0325969 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0321415 |
| RNF149 | ring finger protein 149 | 0.031021 |
| INTS6 | integrator complex subunit 6 | 0.0307304 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0295092 |
| AREG | amphiregulin | 0.0290721 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0287543 |
| PLSCR2 | phospholipid scramblase 2 | 0.0287041 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0278086 |
| TM4SF19 | transmembrane 4 L six family member 19 | 0.027069 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0268717 |
| HELZ | helicase with zinc finger | 0.0264227 |
| KIF16B | kinesin family member 16B | 0.0252421 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.025066 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0250645 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0246338 |
| USPL1 | ubiquitin specific peptidase like 1 | 0.0238471 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0237596 |
| PADI1 | peptidyl arginine deiminase, type I | 0.0236479 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0234455 |
| MCL1 | myeloid cell leukemia 1 | 0.0231749 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0231726 |
| GOLGA2 | golgin A2 | 0.0229954 |
| PCBP2 | poly(rC) binding protein 2 | 0.0220502 |
| DIS3 | DIS3 exosome endoribonuclease and 3'-5' exoribonuclease | 0.0218694 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.021604 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0214716 |
| ZNF451 | zinc finger protein 451 | 0.0211584 |
| HPCAL1 | hippocalcin-like 1 | 0.0203993 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0202889 |
| HBS1L | HBS1-like translational GTPase | 0.0202754 |
| B3GNT5 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 | 0.0202248 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.0198334 |
| ARRDC3 | arrestin domain containing 3 | 0.0196728 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.019628 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0195474 |
| PKM | pyruvate kinase, muscle | 0.0193466 |
| PFKP | phosphofructokinase, platelet | 0.0190825 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0188864 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | 0.0187582 |
| SMAD3 | SMAD family member 3 | 0.0185589 |
| COG5 | component of oligomeric golgi complex 5 | 0.0185429 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0182976 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0181829 |
| GOSR2 | golgi SNAP receptor complex member 2 | 0.017956 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0174807 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0174415 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0174111 |
| MATR3 | matrin 3 | 0.0173798 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0172362 |
| EIF2AK3 | eukaryotic translation initiation factor 2-alpha kinase 3 | 0.0171737 |
| BRD4 | bromodomain containing 4 | 0.0171165 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0168915 |
| EREG | epiregulin | 0.0167099 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.0166691 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | 0.0166493 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0166191 |
| KHDC4 | KH domain containing 4, pre-mRNA splicing factor | 0.016587 |
| VMP1 | vacuole membrane protein 1 | 0.0162497 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | 0.0160923 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0159237 |
| GPR107 | G protein-coupled receptor 107 | 0.0159155 |
| NDEL1 | nudE neurodevelopment protein 1-like 1 | 0.0156648 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0153998 |
| RNF145 | ring finger protein 145 | 0.0153263 |
| PGK1 | phosphoglycerate kinase 1 | 0.0152484 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0151881 |
| COPA | coatomer protein complex, subunit alpha | 0.0150513 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0150202 |
| RAB6A | RAB6A, member RAS oncogene family | 0.014963 |
| SUCO | SUN domain containing ossification factor | 0.0147667 |
| BRD2 | bromodomain containing 2 | 0.0147113 |
| PDXDC1 | pyridoxal-dependent decarboxylase domain containing 1 | 0.0146188 |
| FNIP1 | folliculin interacting protein 1 | 0.0145933 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0145603 |
| RCOR1 | REST corepressor 1 | 0.0145258 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0145092 |
| PTEN | phosphatase and tensin homolog | 0.014462 |
| PRSS22 | protease, serine, 22 | 0.0143426 |
| ENO1 | enolase 1, (alpha) | 0.0143402 |
| RPRD2 | regulation of nuclear pre-mRNA domain containing 2 | 0.0142723 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | 0.0141498 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0140151 |
| ZNF160 | zinc finger protein 160 | 0.0140085 |
| CANX | calnexin | 0.0139798 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0139283 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0139277 |
| TNRC6A | trinucleotide repeat containing 6A | 0.0139169 |
| Symbol | Name | Standardized Value |
|---|---|---|
| EPSTI1 | epithelial stromal interaction 1 (breast) | -0.213169 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.167592 |
| LMO7 | LIM domain 7 | -0.13455 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.128841 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.120203 |
| RUNX1 | runt-related transcription factor 1 | -0.119529 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.104109 |
| SPATA13 | spermatogenesis associated 13 | -0.10149 |
| EPHB2 | EPH receptor B2 | -0.0969899 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | -0.0956058 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0934123 |
| RIGI | RNA sensor RIG-I | -0.0933734 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0865631 |
| PLSCR1 | phospholipid scramblase 1 | -0.0839905 |
| MX2 | MX dynamin-like GTPase 2 | -0.0832876 |
| XAF1 | XIAP associated factor 1 | -0.082447 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0823012 |
| B2M | beta-2-microglobulin | -0.0788809 |
| PTMA | prothymosin, alpha | -0.0781872 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -0.0768984 |
| MX1 | MX dynamin-like GTPase 1 | -0.0760023 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0754457 |
| RRBP1 | ribosome binding protein 1 | -0.0746384 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0741671 |
| RNF213 | ring finger protein 213 | -0.0724744 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0723593 |
| HLA-B | major histocompatibility complex, class I, B | -0.0712398 |
| TMC5 | transmembrane channel-like 5 | -0.0703492 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.070252 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0692333 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0688381 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0677886 |
| LCN2 | lipocalin 2 | -0.0676251 |
| H1-0 | H1.0 linker histone | -0.0639682 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | -0.0630829 |
| SQSTM1 | sequestosome 1 | -0.0623962 |
| FOXP1 | forkhead box P1 | -0.062023 |
| SP100 | SP100 nuclear antigen | -0.0615111 |
| MACC1 | metastasis associated in colon cancer 1 | -0.0611029 |
| MYO1E | myosin IE | -0.0597735 |
| ATP11A | ATPase, class VI, type 11A | -0.0558976 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0558547 |
| NCKAP5 | NCK-associated protein 5 | -0.0552758 |
| ITGA6 | integrin, alpha 6 | -0.0542346 |
| JUN | jun proto-oncogene | -0.0542056 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0540439 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0525416 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.05068 |
| MECOM | MDS1 and EVI1 complex locus | -0.0504795 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0497479 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0478342 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.047279 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0463916 |
| OAS1 | 2'-5'-oligoadenylate synthetase 1, 40/46kDa | -0.0461166 |
| RPL7L1 | ribosomal protein L7-like 1 | -0.0457974 |
| KIAA1217 | KIAA1217 | -0.0450451 |
| MEIS2 | Meis homeobox 2 | -0.0450155 |
| PMP22 | peripheral myelin protein 22 | -0.0437194 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0435279 |
| IRF1 | interferon regulatory factor 1 | -0.0433692 |
| ETV6 | ets variant 6 | -0.0430753 |
| PERP | PERP, TP53 apoptosis effector | -0.042114 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.0418364 |
| HDAC4 | histone deacetylase 4 | -0.041801 |
| MPHOSPH8 | M-phase phosphoprotein 8 | -0.0416548 |
| TMEM62 | transmembrane protein 62 | -0.0410358 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0410129 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | -0.0405721 |
| C6ORF132 | chromosome 6 open reading frame 132 | -0.039962 |
| TRIM2 | tripartite motif containing 2 | -0.0397235 |
| HLA-C | major histocompatibility complex, class I, C | -0.0395604 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0393337 |
| HLA-E | major histocompatibility complex, class I, E | -0.0391543 |
| FMN1 | formin 1 | -0.0390897 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0388216 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0387329 |
| ARHGEF38 | Rho guanine nucleotide exchange factor (GEF) 38 | -0.038053 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0377664 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0371993 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0371471 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.0368845 |
| PARP9 | poly (ADP-ribose) polymerase family, member 9 | -0.0368203 |
| EZR | ezrin | -0.035119 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0350925 |
| ABLIM1 | actin binding LIM protein 1 | -0.0346259 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0343381 |
| BRCA2 | breast cancer 2, early onset | -0.0341872 |
| MKI67 | marker of proliferation Ki-67 | -0.0338846 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0334115 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0334007 |
| UGGT2 | UDP-glucose glycoprotein glucosyltransferase 2 | -0.0330765 |
| ABHD2 | abhydrolase domain containing 2 | -0.0330685 |
| PATJ | PATJ crumbs cell polarity complex component | -0.033057 |
| VCL | vinculin | -0.0329676 |
| SLC2A12 | solute carrier family 2 (facilitated glucose transporter), member 12 | -0.032936 |
| ELOF1 | elongation factor 1 homolog (S. cerevisiae) | -0.0328262 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.0327496 |
| MSI2 | musashi RNA-binding protein 2 | -0.0327041 |
| ATP10B | ATPase, class V, type 10B | -0.0321384 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0320939 |
