Asciminib_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Asciminib perturbation in HS-578T cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Asciminib_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.178279
COL6A3 collagen, type VI, alpha 3 0.166188
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.133855
MYH9 myosin, heavy chain 9, non-muscle 0.120094
TRIO trio Rho guanine nucleotide exchange factor 0.0774617
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0708967
SPAG9 sperm associated antigen 9 0.0667491
ELL2 elongation factor, RNA polymerase II, 2 0.0531169
ATP13A3 ATPase type 13A3 0.0475249
COL7A1 collagen, type VII, alpha 1 0.0457508
LOX lysyl oxidase 0.0432776
APP amyloid beta (A4) precursor protein 0.0428983
COL4A1 collagen, type IV, alpha 1 0.0422968
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0421057
NAV2 neuron navigator 2 0.0417889
RAD21 RAD21 homolog (S. pombe) 0.0376919
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0360366
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0357477
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0353948
ERRFI1 ERBB receptor feedback inhibitor 1 0.0345898
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0345863
TMSB4X thymosin beta 4, X-linked 0.0344888
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.033613
CLIC4 chloride intracellular channel 4 0.0332177
SQLE squalene epoxidase 0.0331598
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.031564
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.031558
ECT2 epithelial cell transforming 2 0.0312916
MYO10 myosin X 0.0309867
CALR calreticulin 0.0304016
EIF4A2 eukaryotic translation initiation factor 4A2 0.0303707
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0300021
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0294532
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0292859
CALU calumenin 0.0292004
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.029005
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0278779
RRM2 ribonucleotide reductase M2 0.0265683
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 0.0261219
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0254
HSPA8 heat shock 70kDa protein 8 0.0251207
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0243943
OGA O-GlcNAcase 0.0242381
VEGFA vascular endothelial growth factor A 0.0241587
IGFBP7 insulin-like growth factor binding protein 7 0.0238926
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0238842
ARRDC3 arrestin domain containing 3 0.0237213
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.023501
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0233847
SUCO SUN domain containing ossification factor 0.0232652
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0229748
SDC4 syndecan 4 0.0228539
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0226445
CKAP5 cytoskeleton associated protein 5 0.0225541
RASA2 RAS p21 protein activator 2 0.0225178
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0224209
GJA1 gap junction protein, alpha 1, 43kDa 0.0222347
CD109 CD109 molecule 0.0219181
POSTN periostin, osteoblast specific factor 0.021819
CANX calnexin 0.0217121
SERINC3 serine incorporator 3 0.0216907
ANXA5 annexin A5 0.0215766
PLEC plectin 0.0213316
FDFT1 farnesyl-diphosphate farnesyltransferase 1 0.0213157
DENND5A DENN/MADD domain containing 5A 0.021044
MSN moesin 0.0207668
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.0205225
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0205061
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0204989
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0202869
CHD1 chromodomain helicase DNA binding protein 1 0.0202156
UBA6 ubiquitin-like modifier activating enzyme 6 0.0200443
CDC27 cell division cycle 27 0.0197514
ADAM17 ADAM metallopeptidase domain 17 0.0196771
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.019285
ACTN4 actinin, alpha 4 0.0192443
BRD2 bromodomain containing 2 0.0191911
CORO1C coronin, actin binding protein, 1C 0.0191191
ADAM9 ADAM metallopeptidase domain 9 0.0190878
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0189928
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0188833
USP3 ubiquitin specific peptidase 3 0.0188165
RLF rearranged L-myc fusion 0.0187134
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0186498
LOXL2 lysyl oxidase-like 2 0.0185867
TPX2 TPX2, microtubule-associated 0.0184996
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.018407
C1ORF21 chromosome 1 open reading frame 21 0.0183864
KDM2A lysine (K)-specific demethylase 2A 0.0182893
ANLN anillin, actin binding protein 0.0182582
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0181985
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0181733
CENPE centromere protein E, 312kDa 0.0181229
ELOVL5 ELOVL fatty acid elongase 5 0.0178356
SMAD3 SMAD family member 3 0.017464
FAM107B family with sequence similarity 107, member B 0.0172593
YME1L1 YME1-like 1 ATPase 0.0171926
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0171139
AKAP13 A kinase (PRKA) anchor protein 13 0.0170466
MAPK8 mitogen-activated protein kinase 8 0.0169425

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.228502
NDRG1 N-myc downstream regulated 1 -0.178244
COL1A1 collagen, type I, alpha 1 -0.136256
VIM vimentin -0.132057
PSD3 pleckstrin and Sec7 domain containing 3 -0.109466
TMSB10 thymosin beta 10 -0.108982
TIMP3 TIMP metallopeptidase inhibitor 3 -0.100259
MT2A metallothionein 2A -0.0997801
CDH13 cadherin 13 -0.0894277
FTH1 ferritin, heavy polypeptide 1 -0.0880887
IGFBP3 insulin-like growth factor binding protein 3 -0.0854897
RPS8 ribosomal protein S8 -0.081628
FTL ferritin, light polypeptide -0.0795931
RPL35A ribosomal protein L35a -0.0780247
RPS6 ribosomal protein S6 -0.0762166
ZBTB20 zinc finger and BTB domain containing 20 -0.0736372
HMGA2 high mobility group AT-hook 2 -0.0711549
DPYD dihydropyrimidine dehydrogenase -0.0694095
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0665737
TGFBI transforming growth factor, beta-induced, 68kDa -0.0601573
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0579388
PTMA prothymosin, alpha -0.0556113
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.053205
COL1A2 collagen, type I, alpha 2 -0.0518425
TRPS1 trichorhinophalangeal syndrome I -0.0502273
ACTG1 actin gamma 1 -0.0483329
RPL23 ribosomal protein L23 -0.0480805
IL6 interleukin 6 -0.0478782
RPS19 ribosomal protein S19 -0.0453933
FNDC3B fibronectin type III domain containing 3B -0.0452153
EIF1 eukaryotic translation initiation factor 1 -0.0447074
NKAIN3 Na+/K+ transporting ATPase interacting 3 -0.04444
RPL11 ribosomal protein L11 -0.0437382
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0427399
IER3 immediate early response 3 -0.0424563
RPL28 ribosomal protein L28 -0.0418803
RPL26 ribosomal protein L26 -0.0416966
RPLP1 ribosomal protein, large, P1 -0.0411722
S100A9 S100 calcium binding protein A9 -0.0407086
TPT1 tumor protein, translationally-controlled 1 -0.0405275
RPL8 ribosomal protein L8 -0.0403631
RPL12 ribosomal protein L12 -0.039657
CD44 CD44 molecule (Indian blood group) -0.0393117
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0379638
CNTN5 contactin 5 -0.0372389
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0369526
RPS12 ribosomal protein S12 -0.0367213
GLIS3 GLIS family zinc finger 3 -0.035775
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0354546
OXR1 oxidation resistance 1 -0.0347887
F3 coagulation factor III (thromboplastin, tissue factor) -0.0346942
HLA-B major histocompatibility complex, class I, B -0.0343158
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0341753
RPL31 ribosomal protein L31 -0.0338434
RPL19 ribosomal protein L19 -0.0335301
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0331236
S100A10 S100 calcium binding protein A10 -0.0328161
IFI6 interferon, alpha-inducible protein 6 -0.0328
RPL34 ribosomal protein L34 -0.0325142
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0324422
RPS3 ribosomal protein S3 -0.0319342
RPL30 ribosomal protein L30 -0.0317684
S100A6 S100 calcium binding protein A6 -0.0310949
RPL37A ribosomal protein L37a -0.0307436
RACK1 receptor for activated C kinase 1 -0.0304071
NRP1 neuropilin 1 -0.0301912
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0298587
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0297108
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0293902
MTDH metadherin -0.0293747
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0293708
RIGI RNA sensor RIG-I -0.0292396
RPL36 ribosomal protein L36 -0.028698
RPS14 ribosomal protein S14 -0.0284387
RPL9 ribosomal protein L9 -0.0284361
IFITM3 interferon induced transmembrane protein 3 -0.0281158
RPLP2 ribosomal protein, large, P2 -0.028059
RPL5 ribosomal protein L5 -0.0272399
RPS5 ribosomal protein S5 -0.0269696
NALF1 NALCN channel auxiliary factor 1 -0.0269575
RRBP1 ribosome binding protein 1 -0.0261446
RPL7 ribosomal protein L7 -0.0259567
CALD1 caldesmon 1 -0.0259069
ALCAM activated leukocyte cell adhesion molecule -0.025885
EGR1 early growth response 1 -0.0255783
RPS11 ribosomal protein S11 -0.0254647
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0253707
RND3 Rho family GTPase 3 -0.025087
RPLP0 ribosomal protein, large, P0 -0.0248504
PFN1 profilin 1 -0.0245345
RPL37 ribosomal protein L37 -0.0243845
SP100 SP100 nuclear antigen -0.024266
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0241642
RPS25 ribosomal protein S25 -0.0240619
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0240137
ZFPM2 zinc finger protein, FOG family member 2 -0.023677
FBXO32 F-box protein 32 -0.0235566
MAML2 mastermind-like 2 (Drosophila) -0.0234834
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0228669
RPS15 ribosomal protein S15 -0.0226797