| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Asciminib perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Asciminib_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.216454 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.199032 |
| SDC4 | syndecan 4 | 0.139262 |
| VEGFA | vascular endothelial growth factor A | 0.0971188 |
| AFDN | afadin, adherens junction formation factor | 0.093683 |
| TF | transferrin | 0.0841047 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0838413 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0715291 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.070498 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0640234 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0618576 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | 0.0617332 |
| TNS1 | tensin 1 | 0.0596377 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0583402 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0541992 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0535659 |
| PCBP2 | poly(rC) binding protein 2 | 0.0502504 |
| ABCA5 | ATP-binding cassette, sub-family A (ABC1), member 5 | 0.0497729 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0472699 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0465817 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0464812 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0453343 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0452107 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0450576 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.044245 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0411817 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0410786 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.040888 |
| CPE | carboxypeptidase E | 0.0407951 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0406983 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0401641 |
| CRY1 | cryptochrome circadian clock 1 | 0.0387437 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0379762 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0375007 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0370722 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0366025 |
| JAK1 | Janus kinase 1 | 0.0363021 |
| ENO1 | enolase 1, (alpha) | 0.0360157 |
| IQSEC1 | IQ motif and Sec7 domain 1 | 0.0358142 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0350135 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0347814 |
| FLNB | filamin B, beta | 0.0347392 |
| KRT8 | keratin 8, type II | 0.0345417 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0343971 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0329022 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0323612 |
| SUCO | SUN domain containing ossification factor | 0.032143 |
| RPL3 | ribosomal protein L3 | 0.0302799 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0302405 |
| C3 | complement component 3 | 0.0299434 |
| SMAP1 | small ArfGAP 1 | 0.0299189 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.0297479 |
| ANXA5 | annexin A5 | 0.0294492 |
| MTSS1 | metastasis suppressor 1 | 0.0290332 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | 0.0284759 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0284715 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0282205 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0281388 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0280874 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.0280667 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0280136 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0278554 |
| RPL4 | ribosomal protein L4 | 0.0277626 |
| LDHA | lactate dehydrogenase A | 0.0277441 |
| RRAS2 | related RAS viral (r-ras) oncogene homolog 2 | 0.0276007 |
| ARFGEF3 | ARFGEF family member 3 | 0.0275756 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0275273 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0273558 |
| FNIP1 | folliculin interacting protein 1 | 0.0273498 |
| CFB | complement factor B | 0.0270885 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0267495 |
| ITIH2 | inter-alpha-trypsin inhibitor heavy chain 2 | 0.0265407 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0264597 |
| MRTFA | myocardin related transcription factor A | 0.0263917 |
| MAPK8 | mitogen-activated protein kinase 8 | 0.0263343 |
| BRD4 | bromodomain containing 4 | 0.0262022 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0260638 |
| NPTN | neuroplastin | 0.0258713 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0258708 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0258514 |
| KCMF1 | potassium channel modulatory factor 1 | 0.0257819 |
| CUL3 | cullin 3 | 0.0257146 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0256152 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0255618 |
| KIF1B | kinesin family member 1B | 0.0253465 |
| HELZ | helicase with zinc finger | 0.0251917 |
| RYBP | RING1 and YY1 binding protein | 0.0249946 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0249296 |
| CCNY | cyclin Y | 0.0249268 |
| RBM39 | RNA binding motif protein 39 | 0.0248755 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.024681 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0246246 |
| GRK3 | G protein-coupled receptor kinase 3 | 0.0246077 |
| RBM25 | RNA binding motif protein 25 | 0.0245603 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0240439 |
| SLC11A2 | solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 | 0.024021 |
| PDZD8 | PDZ domain containing 8 | 0.0239942 |
| PLEC | plectin | 0.0239941 |
| ASXL1 | additional sex combs like transcriptional regulator 1 | 0.0239841 |
| CYTH1 | cytohesin 1 | 0.0237388 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.251243 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.137114 |
| MT2A | metallothionein 2A | -0.13391 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.123371 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.121685 |
| APOA2 | apolipoprotein A-II | -0.0982923 |
| EHBP1 | EH domain binding protein 1 | -0.0974126 |
| FTL | ferritin, light polypeptide | -0.0812952 |
| IGFBP1 | insulin-like growth factor binding protein 1 | -0.0750981 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0727233 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0710261 |
| RPS6 | ribosomal protein S6 | -0.0683526 |
| APOB | apolipoprotein B | -0.0658772 |
| RPS24 | ribosomal protein S24 | -0.0658626 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0657824 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0626636 |
| RPL35A | ribosomal protein L35a | -0.0612357 |
| TMSB10 | thymosin beta 10 | -0.0565181 |
| RPLP1 | ribosomal protein, large, P1 | -0.054937 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0544206 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0485382 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.046194 |
| GPC6 | glypican 6 | -0.0455757 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0439078 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0433933 |
| RPL34 | ribosomal protein L34 | -0.0408031 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0407042 |
| RPL12 | ribosomal protein L12 | -0.0400523 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0400182 |
| RPL32 | ribosomal protein L32 | -0.0388153 |
| RRBP1 | ribosome binding protein 1 | -0.0372114 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0364994 |
| ATXN1 | ataxin 1 | -0.0364854 |
| CCL20 | chemokine (C-C motif) ligand 20 | -0.0364067 |
| BPTF | bromodomain PHD finger transcription factor | -0.0358493 |
| RPLP2 | ribosomal protein, large, P2 | -0.0353064 |
| RPL9 | ribosomal protein L9 | -0.0352997 |
| APOE | apolipoprotein E | -0.0346556 |
| H1-0 | H1.0 linker histone | -0.0344143 |
| RPL23 | ribosomal protein L23 | -0.0343198 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0340969 |
| RPS29 | ribosomal protein S29 | -0.0340128 |
| PTCHD4 | patched domain containing 4 | -0.0337775 |
| RPL11 | ribosomal protein L11 | -0.0333525 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0331841 |
| RPS23 | ribosomal protein S23 | -0.0330344 |
| RPS19 | ribosomal protein S19 | -0.0326174 |
| FAM135A | family with sequence similarity 135, member A | -0.032347 |
| RPS27A | ribosomal protein S27a | -0.032286 |
| RPS8 | ribosomal protein S8 | -0.0322026 |
| PERP | PERP, TP53 apoptosis effector | -0.0318562 |
| PTMA | prothymosin, alpha | -0.0313992 |
| GNAS | GNAS complex locus | -0.0311445 |
| GPC3 | glypican 3 | -0.0310793 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0309028 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0308487 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0305759 |
| S100A9 | S100 calcium binding protein A9 | -0.0304694 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0303155 |
| TMEM123 | transmembrane protein 123 | -0.0300969 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | -0.0300794 |
| FRMD5 | FERM domain containing 5 | -0.0300054 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0299261 |
| RPLP0 | ribosomal protein, large, P0 | -0.0296451 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | -0.0289189 |
| ARHGAP18 | Rho GTPase activating protein 18 | -0.0287454 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0286433 |
| ITGA1 | integrin, alpha 1 | -0.0284439 |
| RPS16 | ribosomal protein S16 | -0.027708 |
| IER3 | immediate early response 3 | -0.0276652 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0275331 |
| KRT18 | keratin 18, type I | -0.0274539 |
| RNF213 | ring finger protein 213 | -0.0270299 |
| RPS25 | ribosomal protein S25 | -0.0267054 |
| ZFHX3 | zinc finger homeobox 3 | -0.026313 |
| EGR1 | early growth response 1 | -0.026267 |
| RPS21 | ribosomal protein S21 | -0.026207 |
| FOXP1 | forkhead box P1 | -0.0261111 |
| RAPGEF5 | Rap guanine nucleotide exchange factor (GEF) 5 | -0.0257926 |
| ACSS3 | acyl-CoA synthetase short-chain family member 3 | -0.0254768 |
| RPS11 | ribosomal protein S11 | -0.0253983 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0253963 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0252136 |
| TNFSF14 | tumor necrosis factor (ligand) superfamily, member 14 | -0.0249132 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0247175 |
| DNAH17 | dynein, axonemal, heavy chain 17 | -0.024349 |
| CDK6 | cyclin-dependent kinase 6 | -0.0242478 |
| OSBPL10 | oxysterol binding protein-like 10 | -0.0237665 |
| AHSG | alpha-2-HS-glycoprotein | -0.0234256 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.0232163 |
| GOLGB1 | golgin B1 | -0.0230353 |
| GK | glycerol kinase | -0.022944 |
| VIM | vimentin | -0.0229017 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0228765 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0227846 |
| ENAH | enabled homolog (Drosophila) | -0.0227821 |
| RPL31 | ribosomal protein L31 | -0.022084 |
| CTDSPL | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like | -0.0220622 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0219794 |
| RPS5 | ribosomal protein S5 | -0.0212692 |
