Asciminib_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Asciminib perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Asciminib_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VEGFA vascular endothelial growth factor A 0.0767254
WAC WW domain containing adaptor with coiled-coil 0.0707745
ANKRD11 ankyrin repeat domain 11 0.0707321
RBM39 RNA binding motif protein 39 0.0663475
RNF145 ring finger protein 145 0.0645944
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0642297
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0641495
EREG epiregulin 0.0584007
KRT8 keratin 8, type II 0.0567437
MED13L mediator complex subunit 13-like 0.0557438
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0507903
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0500063
TFG TRK-fused gene 0.0499396
DSCAM Down syndrome cell adhesion molecule 0.0487025
FAM13A family with sequence similarity 13, member A 0.0486501
KDM3A lysine (K)-specific demethylase 3A 0.0476026
KDM6A lysine (K)-specific demethylase 6A 0.0456805
COPA coatomer protein complex, subunit alpha 0.0444041
ZFAND3 zinc finger, AN1-type domain 3 0.044324
EIF4A2 eukaryotic translation initiation factor 4A2 0.043297
GRB10 growth factor receptor-bound protein 10 0.0429621
PICALM phosphatidylinositol binding clathrin assembly protein 0.0429324
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0424043
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0421894
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0413434
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0413397
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0405275
CCNL1 cyclin L1 0.0402731
EPS8 epidermal growth factor receptor pathway substrate 8 0.0400838
PUM1 pumilio RNA-binding family member 1 0.0397394
KMT2E lysine (K)-specific methyltransferase 2E 0.0395322
ZNF292 zinc finger protein 292 0.0394061
FAT1 FAT atypical cadherin 1 0.0392934
USP3 ubiquitin specific peptidase 3 0.0385768
UBA6 ubiquitin-like modifier activating enzyme 6 0.0382684
AHNAK AHNAK nucleoprotein 0.0373354
NUP58 nucleoporin 58 0.0366588
OGA O-GlcNAcase 0.0366311
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0363872
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 0.0359921
SREBF2 sterol regulatory element binding transcription factor 2 0.0354113
PGK1 phosphoglycerate kinase 1 0.0352367
YTHDC1 YTH domain containing 1 0.0350696
XPO1 exportin 1 0.03496
GSK3B glycogen synthase kinase 3 beta 0.0347197
GARS1 glycyl-tRNA synthetase 1 0.0345175
CCNY cyclin Y 0.0342095
RAB1A RAB1A, member RAS oncogene family 0.0341709
TXNIP thioredoxin interacting protein 0.0340891
FUBP1 far upstream element (FUSE) binding protein 1 0.0338911
PUM2 pumilio RNA-binding family member 2 0.033799
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0336486
MACF1 microtubule-actin crosslinking factor 1 0.0326992
PARD3 par-3 family cell polarity regulator 0.0324926
AFDN afadin, adherens junction formation factor 0.0321616
PLAUR plasminogen activator, urokinase receptor 0.0321252
NCKAP1 NCK-associated protein 1 0.0313571
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0312659
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0308013
STRN3 striatin, calmodulin binding protein 3 0.0307859
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0307566
FXR1 fragile X mental retardation, autosomal homolog 1 0.0303409
RREB1 ras responsive element binding protein 1 0.0300346
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0296343
RYBP RING1 and YY1 binding protein 0.0295611
NAMPT nicotinamide phosphoribosyltransferase 0.0295069
APP amyloid beta (A4) precursor protein 0.0294585
HELZ helicase with zinc finger 0.0293305
NEK7 NIMA-related kinase 7 0.0288639
TM9SF3 transmembrane 9 superfamily member 3 0.0285911
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0285738
EWSR1 EWS RNA-binding protein 1 0.0284188
SPPL3 signal peptide peptidase like 3 0.0283732
FNBP1L formin binding protein 1-like 0.0281614
TMSB4X thymosin beta 4, X-linked 0.028075
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0278756
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0278297
RSRC2 arginine/serine-rich coiled-coil 2 0.027699
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0276912
WDR43 WD repeat domain 43 0.0276008
MARCHF6 membrane associated ring-CH-type finger 6 0.0273483
MYO5B myosin VB 0.0273278
MYH9 myosin, heavy chain 9, non-muscle 0.0270982
INSIG1 insulin induced gene 1 0.0270179
ADAM17 ADAM metallopeptidase domain 17 0.0264477
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0261956
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 0.0260465
ERRFI1 ERBB receptor feedback inhibitor 1 0.0260311
HSPA8 heat shock 70kDa protein 8 0.0258659
PCBP2 poly(rC) binding protein 2 0.0257478
PRRC1 proline-rich coiled-coil 1 0.0255916
KCMF1 potassium channel modulatory factor 1 0.0252273
SPAG9 sperm associated antigen 9 0.025182
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 0.0250995
CTNND1 catenin (cadherin-associated protein), delta 1 0.0250604
FDFT1 farnesyl-diphosphate farnesyltransferase 1 0.0246748
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0246725
YME1L1 YME1-like 1 ATPase 0.0246065
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0243191
MORF4L1 mortality factor 4 like 1 0.0242753

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.228197
PTMA prothymosin, alpha -0.162791
TMSB10 thymosin beta 10 -0.151543
RPS6 ribosomal protein S6 -0.0970004
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0802103
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0765617
RPL35A ribosomal protein L35a -0.0748756
RPLP1 ribosomal protein, large, P1 -0.0729266
TPT1 tumor protein, translationally-controlled 1 -0.0719974
RPS8 ribosomal protein S8 -0.0690293
RPL34 ribosomal protein L34 -0.0639435
GMDS GDP-mannose 4,6-dehydratase -0.0612406
FTL ferritin, light polypeptide -0.0600428
S100P S100 calcium binding protein P -0.0583125
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0562799
CEMIP cell migration inducing protein, hyaluronan binding -0.0551617
FTH1 ferritin, heavy polypeptide 1 -0.0548803
RPL12 ribosomal protein L12 -0.0538544
S100A6 S100 calcium binding protein A6 -0.0526087
PTPRK protein tyrosine phosphatase, receptor type, K -0.0523648
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0517054
CADPS Ca++-dependent secretion activator -0.0516919
RPL23 ribosomal protein L23 -0.0504881
RPS19 ribosomal protein S19 -0.0484896
RPL26 ribosomal protein L26 -0.046878
LOC102724023 ES1 protein homolog, mitochondrial -0.0468637
RPL9 ribosomal protein L9 -0.0464707
MUC6 mucin 6, oligomeric mucus/gel-forming -0.0459181
RPLP2 ribosomal protein, large, P2 -0.0452527
S100A10 S100 calcium binding protein A10 -0.0449281
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0447019
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0443479
NPSR1 neuropeptide S receptor 1 -0.0435548
HMGA1 high mobility group AT-hook 1 -0.0426554
RPL31 ribosomal protein L31 -0.0424757
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0414347
RPS25 ribosomal protein S25 -0.0404654
RPS12 ribosomal protein S12 -0.0400848
RPL11 ribosomal protein L11 -0.0397494
S100A9 S100 calcium binding protein A9 -0.0393964
RPL19 ribosomal protein L19 -0.0390811
ITGA6 integrin, alpha 6 -0.038972
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0384049
RPL28 ribosomal protein L28 -0.0377471
AGR2 anterior gradient 2 -0.0369724
NALF1 NALCN channel auxiliary factor 1 -0.0367852
RPS23 ribosomal protein S23 -0.0363578
ALCAM activated leukocyte cell adhesion molecule -0.0363527
RPS3 ribosomal protein S3 -0.0361954
RPLP0 ribosomal protein, large, P0 -0.0358507
GCC2 GRIP and coiled-coil domain containing 2 -0.0354048
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0352475
ASPH aspartate beta-hydroxylase -0.0348699
RPL36 ribosomal protein L36 -0.034556
RPS24 ribosomal protein S24 -0.0345005
ANTXR2 anthrax toxin receptor 2 -0.0337428
RPL37A ribosomal protein L37a -0.0334281
PDE4D phosphodiesterase 4D, cAMP-specific -0.0332005
RPL5 ribosomal protein L5 -0.0331918
RPS27 ribosomal protein S27 -0.0330371
CD44 CD44 molecule (Indian blood group) -0.0325184
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0314218
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0305782
RPS27A ribosomal protein S27a -0.0303645
RPS29 ribosomal protein S29 -0.0300845
RPS14 ribosomal protein S14 -0.0299586
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0299461
ANXA1 annexin A1 -0.0291773
EMP1 epithelial membrane protein 1 -0.0288988
LMNA lamin A/C -0.0287994
RPL8 ribosomal protein L8 -0.028236
RPS16 ribosomal protein S16 -0.0282276
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.027921
EXT1 exostosin glycosyltransferase 1 -0.027858
PTPRR protein tyrosine phosphatase, receptor type, R -0.0278559
RACK1 receptor for activated C kinase 1 -0.0273784
AKAP9 A kinase (PRKA) anchor protein 9 -0.0269085
MBD5 methyl-CpG binding domain protein 5 -0.0258975
GOLGB1 golgin B1 -0.0257194
RPS2 ribosomal protein S2 -0.0252782
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0251584
RPS5 ribosomal protein S5 -0.0251161
RPS13 ribosomal protein S13 -0.0245873
RPL27A ribosomal protein L27a -0.024566
LAMA4 laminin, alpha 4 -0.024289
RPS11 ribosomal protein S11 -0.0239948
EHBP1 EH domain binding protein 1 -0.0233996
RPL7 ribosomal protein L7 -0.0233927
POF1B premature ovarian failure, 1B -0.0232739
TFF3 trefoil factor 3 (intestinal) -0.0231366
LOC112694756 uncharaterized LOC112694756 -0.0229226
ASTN2 astrotactin 2 -0.0227182
RPS17 ribosomal protein S17 -0.0224312
RPL7A ribosomal protein L7a -0.0223797
GDF15 growth differentiation factor 15 -0.0223689
CALB1 calbindin 1, 28kDa -0.0223168
RPL18 ribosomal protein L18 -0.0222846
FOXP1 forkhead box P1 -0.0221531
GPHN gephyrin -0.0220597
BPTF bromodomain PHD finger transcription factor -0.0219246