| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Asciminib perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Asciminib_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | 0.116013 |
| HLA-B | major histocompatibility complex, class I, B | 0.0911828 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0821543 |
| RPL37A | ribosomal protein L37a | 0.0761548 |
| TMSB4X | thymosin beta 4, X-linked | 0.0712195 |
| RPL35A | ribosomal protein L35a | 0.0656883 |
| RPS8 | ribosomal protein S8 | 0.0624514 |
| RPS3 | ribosomal protein S3 | 0.0579159 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0567649 |
| POTEF | POTE ankyrin domain family, member F | 0.052938 |
| RPS12 | ribosomal protein S12 | 0.0497325 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0495008 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0452529 |
| MCL1 | myeloid cell leukemia 1 | 0.0451962 |
| RPL37 | ribosomal protein L37 | 0.0441259 |
| NUP58 | nucleoporin 58 | 0.0431194 |
| RPS10 | ribosomal protein S10 | 0.0429537 |
| RPL31 | ribosomal protein L31 | 0.0426208 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0424937 |
| RPS23 | ribosomal protein S23 | 0.0421026 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0409908 |
| SPAG9 | sperm associated antigen 9 | 0.0403902 |
| MATR3 | matrin 3 | 0.0397055 |
| WDR43 | WD repeat domain 43 | 0.0395557 |
| SET | SET nuclear proto-oncogene | 0.0395186 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0394781 |
| B2M | beta-2-microglobulin | 0.0382862 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0380579 |
| APP | amyloid beta (A4) precursor protein | 0.0375628 |
| PCBP2 | poly(rC) binding protein 2 | 0.0375191 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0373838 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0360311 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0353869 |
| RPS27A | ribosomal protein S27a | 0.0351175 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0344537 |
| ATP13A3 | ATPase type 13A3 | 0.0342694 |
| RPL38 | ribosomal protein L38 | 0.0342692 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0333001 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0330111 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.032819 |
| OGA | O-GlcNAcase | 0.0325264 |
| GDI2 | GDP dissociation inhibitor 2 | 0.0318993 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0316839 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0314148 |
| RPLP2 | ribosomal protein, large, P2 | 0.0310941 |
| MEMO1 | mediator of cell motility 1 | 0.0309536 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0309437 |
| RPS24 | ribosomal protein S24 | 0.0303617 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0302254 |
| RPL36A | ribosomal protein L36a | 0.0297548 |
| VDAC1 | voltage-dependent anion channel 1 | 0.0296894 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | 0.0295937 |
| IPO7 | importin 7 | 0.0293864 |
| DENND5A | DENN/MADD domain containing 5A | 0.0289192 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0286299 |
| RPS13 | ribosomal protein S13 | 0.028602 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0283688 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.0280253 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.0278609 |
| RPS6 | ribosomal protein S6 | 0.0274539 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0273677 |
| RNF145 | ring finger protein 145 | 0.0270452 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0266807 |
| RPS25 | ribosomal protein S25 | 0.0266428 |
| TPM3 | tropomyosin 3 | 0.0265131 |
| RPL26 | ribosomal protein L26 | 0.0263329 |
| IBTK | inhibitor of Bruton agammaglobulinemia tyrosine kinase | 0.0262155 |
| SPIRE1 | spire-type actin nucleation factor 1 | 0.0259215 |
| HDGF | hepatoma-derived growth factor | 0.0259062 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0247283 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | 0.0244272 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0244208 |
| HBS1L | HBS1-like translational GTPase | 0.0243249 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0242501 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0241551 |
| ECPAS | Ecm29 proteasome adaptor and scaffold | 0.0240422 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0239449 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0239399 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | 0.0239267 |
| CANX | calnexin | 0.023856 |
| CTBP2 | C-terminal binding protein 2 | 0.0238368 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0237494 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0236695 |
| FAR1 | fatty acyl CoA reductase 1 | 0.0235702 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0235258 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0232793 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0232692 |
| USP36 | ubiquitin specific peptidase 36 | 0.0231523 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0230602 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0225887 |
| CCNL1 | cyclin L1 | 0.022541 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0223959 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0222916 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0221524 |
| CNBP | CCHC-type zinc finger, nucleic acid binding protein | 0.021869 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0217675 |
| CAVIN1 | caveolae associated protein 1 | 0.0217464 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0217275 |
| XPO6 | exportin 6 | 0.0216418 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0216307 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | -0.372536 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.271413 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.164635 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.161248 |
| MT1X | metallothionein 1X | -0.141302 |
| TMSB10 | thymosin beta 10 | -0.103935 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0811073 |
| MT1E | metallothionein 1E | -0.0800849 |
| VIM | vimentin | -0.0697863 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0688758 |
| CD44 | CD44 molecule (Indian blood group) | -0.0681327 |
| EMP1 | epithelial membrane protein 1 | -0.0592202 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0587467 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0546817 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0512976 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0503414 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | -0.0478954 |
| CADM2 | cell adhesion molecule 2 | -0.0468142 |
| GCLM | glutamate-cysteine ligase, modifier subunit | -0.0466606 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0458164 |
| ANGPTL4 | angiopoietin-like 4 | -0.0443749 |
| TP63 | tumor protein p63 | -0.0442628 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0430944 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0417358 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0408288 |
| PLSCR1 | phospholipid scramblase 1 | -0.0407774 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.04016 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0388245 |
| KLF6 | Kruppel-like factor 6 | -0.0386516 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0377816 |
| PDE10A | phosphodiesterase 10A | -0.0377287 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0366356 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0358924 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0358381 |
| SMYD3 | SET and MYND domain containing 3 | -0.034309 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0333904 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0333893 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0329464 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | -0.0327297 |
| S100A6 | S100 calcium binding protein A6 | -0.032655 |
| SERPINB9 | serpin peptidase inhibitor, clade B (ovalbumin), member 9 | -0.0322612 |
| RIGI | RNA sensor RIG-I | -0.0320788 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0318253 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | -0.0317227 |
| SPIDR | scaffolding protein involved in DNA repair | -0.03168 |
| PRELID2 | PRELI domain containing 2 | -0.0315629 |
| CFAP299 | cilia and flagella associated protein 299 | -0.0315072 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0306458 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | -0.0298079 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0294529 |
| DST | dystonin | -0.0290931 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.0286527 |
| RAD51B | RAD51 paralog B | -0.0286185 |
| RUNX1 | runt-related transcription factor 1 | -0.0281194 |
| BCKDHB | branched chain keto acid dehydrogenase E1, beta polypeptide | -0.0278802 |
| SVIL | supervillin | -0.0272302 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | -0.0270063 |
| EXOC4 | exocyst complex component 4 | -0.0269157 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0268661 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.0265086 |
| SON | SON DNA binding protein | -0.026079 |
| ACTG1 | actin gamma 1 | -0.0259674 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0258539 |
| H1-0 | H1.0 linker histone | -0.0255356 |
| TPI1 | triosephosphate isomerase 1 | -0.0255326 |
| ZDHHC14 | zinc finger, DHHC-type containing 14 | -0.0252395 |
| DNTTIP1 | deoxynucleotidyltransferase, terminal, interacting protein 1 | -0.0252061 |
| S100A10 | S100 calcium binding protein A10 | -0.0251061 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0246237 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0244663 |
| CENPF | centromere protein F, 350/400kDa | -0.0243483 |
| YBX3 | Y box binding protein 3 | -0.0242055 |
| PRDX1 | peroxiredoxin 1 | -0.0241672 |
| RPS4X | ribosomal protein S4, X-linked | -0.0241431 |
| CMIP | c-Maf inducing protein | -0.0238168 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0237656 |
| SSH2 | slingshot protein phosphatase 2 | -0.0230653 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0229723 |
| VEGFC | vascular endothelial growth factor C | -0.0227745 |
| FOSL1 | FOS-like antigen 1 | -0.0225364 |
| SPRY4 | sprouty homolog 4 (Drosophila) | -0.0224091 |
| ERCC1 | excision repair cross-complementation group 1 | -0.0218397 |
| TNFRSF6B | tumor necrosis factor receptor superfamily, member 6b, decoy | -0.0218341 |
| EREG | epiregulin | -0.0216847 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0216093 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.021379 |
| LHX1 | LIM homeobox 1 | -0.021338 |
| DNER | delta/notch-like EGF repeat containing | -0.0212817 |
| CDK6 | cyclin-dependent kinase 6 | -0.0211058 |
| USP34 | ubiquitin specific peptidase 34 | -0.0210816 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | -0.0207219 |
| JUN | jun proto-oncogene | -0.0205404 |
| ANXA1 | annexin A1 | -0.0204715 |
| SMC4 | structural maintenance of chromosomes 4 | -0.02035 |
| SDCCAG8 | serologically defined colon cancer antigen 8 | -0.01992 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0197949 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0197418 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0195245 |
| KDM4C | lysine (K)-specific demethylase 4C | -0.0193167 |
| EGR1 | early growth response 1 | -0.0187696 |
