Asciminib_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Asciminib perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Asciminib_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 0.0827157
SPAG9 sperm associated antigen 9 0.0722676
LAMC2 laminin, gamma 2 0.0709717
NAMPT nicotinamide phosphoribosyltransferase 0.0686138
PGK1 phosphoglycerate kinase 1 0.0669619
GSK3B glycogen synthase kinase 3 beta 0.0648564
LMO7 LIM domain 7 0.0639377
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.059446
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0579224
LAMB3 laminin, beta 3 0.0564902
DSCAM Down syndrome cell adhesion molecule 0.0544255
ANKRD10 ankyrin repeat domain 10 0.0519682
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0488513
TOP1 topoisomerase (DNA) I 0.0463127
PTPRM protein tyrosine phosphatase, receptor type, M 0.0462254
UVRAG UV radiation resistance associated 0.0443442
ELL2 elongation factor, RNA polymerase II, 2 0.0437271
RICTOR RPTOR independent companion of MTOR, complex 2 0.0415303
ASPH aspartate beta-hydroxylase 0.0406238
ANXA5 annexin A5 0.0377913
PCBP2 poly(rC) binding protein 2 0.0358782
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0355857
EIF4A2 eukaryotic translation initiation factor 4A2 0.0354589
ATP13A3 ATPase type 13A3 0.0346469
ADAM9 ADAM metallopeptidase domain 9 0.0343266
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0331244
MYH9 myosin, heavy chain 9, non-muscle 0.0329224
ERRFI1 ERBB receptor feedback inhibitor 1 0.0326461
KDM3A lysine (K)-specific demethylase 3A 0.032567
ADAM17 ADAM metallopeptidase domain 17 0.0325354
ECT2 epithelial cell transforming 2 0.0316549
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0313383
GLS2 glutaminase 2 (liver, mitochondrial) 0.0306441
SLTM SAFB-like, transcription modulator 0.0295885
NUP58 nucleoporin 58 0.0292112
KDM6A lysine (K)-specific demethylase 6A 0.0291846
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0291499
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0286534
DENND4A DENN/MADD domain containing 4A 0.0282729
TPD52 tumor protein D52 0.0278432
SOD2 superoxide dismutase 2, mitochondrial 0.0277757
ARL8B ADP-ribosylation factor-like 8B 0.0275656
SDC4 syndecan 4 0.0273237
PLEC plectin 0.0272795
USP9X ubiquitin specific peptidase 9, X-linked 0.0272158
HOOK2 hook microtubule-tethering protein 2 0.0268859
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0265672
OGA O-GlcNAcase 0.0265576
NCKAP1 NCK-associated protein 1 0.0263863
BZW1 basic leucine zipper and W2 domains 1 0.0260942
RNF145 ring finger protein 145 0.0259387
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0256284
NPTN neuroplastin 0.0248059
USP53 ubiquitin specific peptidase 53 0.024313
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0242575
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0238417
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0238336
CDC73 cell division cycle 73 0.0235794
RAD21 RAD21 homolog (S. pombe) 0.0232445
KRT8 keratin 8, type II 0.0232394
STRN3 striatin, calmodulin binding protein 3 0.0231111
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0225427
ANXA2 annexin A2 0.0223856
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0220001
ZFC3H1 zinc finger, C3H1-type containing 0.0219312
JAK1 Janus kinase 1 0.021859
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0215309
ARRDC3 arrestin domain containing 3 0.0209545
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0208523
NGLY1 N-glycanase 1 0.0208486
MYO5B myosin VB 0.0206186
MKI67 marker of proliferation Ki-67 0.0204105
MATR3 matrin 3 0.0203633
PDLIM5 PDZ and LIM domain 5 0.0203509
RASA2 RAS p21 protein activator 2 0.0202215
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0202065
TES testin LIM domain protein 0.0201761
VEZT vezatin, adherens junctions transmembrane protein 0.0200959
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.0200445
MAP3K4 mitogen-activated protein kinase kinase kinase 4 0.0199127
SUCO SUN domain containing ossification factor 0.0197762
MCL1 myeloid cell leukemia 1 0.0195259
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0195234
PUM2 pumilio RNA-binding family member 2 0.0195053
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0194498
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0193525
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0191807
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0191127
YEATS2 YEATS domain containing 2 0.0185429
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0184615
UBA6 ubiquitin-like modifier activating enzyme 6 0.0183728
APP amyloid beta (A4) precursor protein 0.0183492
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0183035
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.0181107
CASC3 cancer susceptibility candidate 3 0.0180937
CSDE1 cold shock domain containing E1, RNA-binding 0.0180607
PRRC2C proline-rich coiled-coil 2C 0.0179807
FXR1 fragile X mental retardation, autosomal homolog 1 0.0179465
PPTC7 PTC7 protein phosphatase homolog (S. cerevisiae) 0.0178137
FGD6 FYVE, RhoGEF and PH domain containing 6 0.0177528

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.466364
EGFR epidermal growth factor receptor -0.189288
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.161384
MT2A metallothionein 2A -0.107204
NDRG1 N-myc downstream regulated 1 -0.0920697
FTH1 ferritin, heavy polypeptide 1 -0.0904562
PTMA prothymosin, alpha -0.0558775
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0549122
RPLP1 ribosomal protein, large, P1 -0.0548128
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0485156
TMSB10 thymosin beta 10 -0.0479368
S100A10 S100 calcium binding protein A10 -0.0479216
RPS6 ribosomal protein S6 -0.0463682
PDE4D phosphodiesterase 4D, cAMP-specific -0.0449148
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0447122
TPT1 tumor protein, translationally-controlled 1 -0.0444849
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.0437164
FTL ferritin, light polypeptide -0.0431873
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0427653
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0419686
RPS25 ribosomal protein S25 -0.0406888
EGR1 early growth response 1 -0.0388194
PDIA3 protein disulfide isomerase family A, member 3 -0.0353661
ANKRD12 ankyrin repeat domain 12 -0.0336087
RPL35A ribosomal protein L35a -0.0317237
INTS6 integrator complex subunit 6 -0.0315644
RPS8 ribosomal protein S8 -0.0314264
S100P S100 calcium binding protein P -0.03095
TMEM45B transmembrane protein 45B -0.0285697
RPL34 ribosomal protein L34 -0.0273208
RPL31 ribosomal protein L31 -0.0267979
GOLGB1 golgin B1 -0.0267256
GOLGA4 golgin A4 -0.0253191
RPS23 ribosomal protein S23 -0.0252337
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.024768
FRY furry homolog (Drosophila) -0.0237413
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0235364
SEC24D SEC24 family member D -0.0234237
RPS19 ribosomal protein S19 -0.0232816
WASF2 WAS protein family, member 2 -0.0227809
RPS29 ribosomal protein S29 -0.0224832
AKAP9 A kinase (PRKA) anchor protein 9 -0.0222292
THSD4 thrombospondin, type I, domain containing 4 -0.0221052
RPS17 ribosomal protein S17 -0.0220977
BPTF bromodomain PHD finger transcription factor -0.0220916
RPS3 ribosomal protein S3 -0.021743
RPL36 ribosomal protein L36 -0.0216923
RPS12 ribosomal protein S12 -0.0216868
CSTB cystatin B (stefin B) -0.0215485
RAD51B RAD51 paralog B -0.0214995
IER3 immediate early response 3 -0.0214187
HM13 histocompatibility (minor) 13 -0.0210481
ZMYND8 zinc finger, MYND-type containing 8 -0.0208997
RPL37A ribosomal protein L37a -0.0207676
RPS27 ribosomal protein S27 -0.0205886
EFNA5 ephrin-A5 -0.0202981
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0199866
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.019847
STC1 stanniocalcin 1 -0.0196412
RPL19 ribosomal protein L19 -0.0195569
MT1X metallothionein 1X -0.0192089
LOC112694756 uncharaterized LOC112694756 -0.0189886
MRPS6 mitochondrial ribosomal protein S6 -0.0188179
RPL9 ribosomal protein L9 -0.0182961
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0182265
CST3 cystatin C -0.0180756
CEMIP cell migration inducing protein, hyaluronan binding -0.0179083
RPLP2 ribosomal protein, large, P2 -0.0179002
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0178976
RPL11 ribosomal protein L11 -0.0177312
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0176476
CDCP1 CUB domain containing protein 1 -0.0175134
HMGA1 high mobility group AT-hook 1 -0.0174338
RPL8 ribosomal protein L8 -0.0174124
MBD5 methyl-CpG binding domain protein 5 -0.0173894
ANKRD37 ankyrin repeat domain 37 -0.0172728
AGR2 anterior gradient 2 -0.0172437
RIN2 Ras and Rab interactor 2 -0.017157
RPL37 ribosomal protein L37 -0.0170934
S100A6 S100 calcium binding protein A6 -0.0167639
GNAS GNAS complex locus -0.0166238
SCFD1 sec1 family domain containing 1 -0.016547
ACBD3 acyl-CoA binding domain containing 3 -0.0164995
CPE carboxypeptidase E -0.0164777
BLZF1 basic leucine zipper nuclear factor 1 -0.0163108
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0161989
RPS24 ribosomal protein S24 -0.0161984
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0161666
PER2 period circadian clock 2 -0.0161517
RPL28 ribosomal protein L28 -0.0161353
NTSR1 neurotensin receptor 1 (high affinity) -0.0161037
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0160696
GRAMD1B GRAM domain containing 1B -0.0159336
RPL12 ribosomal protein L12 -0.0158591
S100A9 S100 calcium binding protein A9 -0.0156691
TRIM56 tripartite motif containing 56 -0.0156658
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0156493
RPL23 ribosomal protein L23 -0.0155705
CUX1 cut-like homeobox 1 -0.0153599
SUMF1 sulfatase modifying factor 1 -0.0153186