| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Asciminib perturbation in NCI-H1792 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Asciminib_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NAMPT | nicotinamide phosphoribosyltransferase | 0.115982 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.107019 |
| PCBP2 | poly(rC) binding protein 2 | 0.101738 |
| GOLGA4 | golgin A4 | 0.0860714 |
| FNDC3B | fibronectin type III domain containing 3B | 0.078877 |
| RBM39 | RNA binding motif protein 39 | 0.0780072 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0750947 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0700427 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0684676 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0595699 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0591192 |
| ATP13A3 | ATPase type 13A3 | 0.0585519 |
| SIK3 | SIK family kinase 3 | 0.0583639 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0576881 |
| OGA | O-GlcNAcase | 0.0568618 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0563567 |
| PRRC2C | proline-rich coiled-coil 2C | 0.055592 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0551142 |
| USP3 | ubiquitin specific peptidase 3 | 0.0547276 |
| RNF145 | ring finger protein 145 | 0.0532954 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0532482 |
| EIF3B | eukaryotic translation initiation factor 3, subunit B | 0.0526545 |
| PARD3 | par-3 family cell polarity regulator | 0.0521601 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0510184 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.050845 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0498597 |
| CD44 | CD44 molecule (Indian blood group) | 0.0498083 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0483459 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0477051 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | 0.0472684 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0471991 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0470037 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0458774 |
| SMAD3 | SMAD family member 3 | 0.0444347 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0441854 |
| ABI1 | abl-interactor 1 | 0.0437865 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0417276 |
| SPAG9 | sperm associated antigen 9 | 0.0403981 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0394289 |
| RAB8B | RAB8B, member RAS oncogene family | 0.0382921 |
| MIS18BP1 | MIS18 binding protein 1 | 0.0382332 |
| HELZ | helicase with zinc finger | 0.0381495 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0378546 |
| VMP1 | vacuole membrane protein 1 | 0.0376719 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0374777 |
| COG5 | component of oligomeric golgi complex 5 | 0.0369658 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0367086 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | 0.0358234 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0355474 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.035413 |
| CCNY | cyclin Y | 0.0344219 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0343952 |
| SS18 | synovial sarcoma translocation, chromosome 18 | 0.0343511 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0343108 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0339576 |
| OS9 | osteosarcoma amplified 9, endoplasmic reticulum lectin | 0.033697 |
| COPA | coatomer protein complex, subunit alpha | 0.0329886 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | 0.0329765 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0329161 |
| TOP1 | topoisomerase (DNA) I | 0.0328504 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0327446 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0325066 |
| FAM13A | family with sequence similarity 13, member A | 0.0324302 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0321202 |
| RAP1B | RAP1B, member of RAS oncogene family | 0.032099 |
| ELP2 | elongator acetyltransferase complex subunit 2 | 0.0319242 |
| RBM25 | RNA binding motif protein 25 | 0.0309646 |
| XPO1 | exportin 1 | 0.0306861 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0302794 |
| NEK7 | NIMA-related kinase 7 | 0.0301883 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0295345 |
| CCNL1 | cyclin L1 | 0.0294323 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0293316 |
| CNOT4 | CCR4-NOT transcription complex, subunit 4 | 0.0292601 |
| ZFAND6 | zinc finger, AN1-type domain 6 | 0.0292581 |
| SBF2 | SET binding factor 2 | 0.0292523 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0292314 |
| NBAS | neuroblastoma amplified sequence | 0.0291922 |
| YTHDC1 | YTH domain containing 1 | 0.0291222 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0290135 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0289544 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | 0.0287412 |
| STK38L | serine/threonine kinase 38 like | 0.0287072 |
| MED13L | mediator complex subunit 13-like | 0.028617 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.0283751 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0282992 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0280668 |
| SRP54 | signal recognition particle 54kDa | 0.027928 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0279019 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | 0.0277727 |
| AFTPH | aftiphilin | 0.0277635 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0277028 |
| WDR45B | WD repeat domain 45B | 0.0276824 |
| MARS1 | methionyl-tRNA synthetase 1 | 0.0275581 |
| CDC73 | cell division cycle 73 | 0.0275179 |
| RBM33 | RNA binding motif protein 33 | 0.0274511 |
| USP15 | ubiquitin specific peptidase 15 | 0.0273893 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0272402 |
| SMAD4 | SMAD family member 4 | 0.0271577 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0271089 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CDH13 | cadherin 13 | -0.105068 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.103736 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0999661 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0920356 |
| NRG1 | neuregulin 1 | -0.0919573 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | -0.0916812 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.087756 |
| FN1 | fibronectin 1 | -0.0768471 |
| HMGA2 | high mobility group AT-hook 2 | -0.0680961 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.064647 |
| MTSS1 | metastasis suppressor 1 | -0.0640278 |
| EFNA5 | ephrin-A5 | -0.0578683 |
| STC1 | stanniocalcin 1 | -0.0545835 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.052953 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0508657 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0496642 |
| RAI14 | retinoic acid induced 14 | -0.0494062 |
| MEF2A | myocyte enhancer factor 2A | -0.0489234 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0486379 |
| LOX | lysyl oxidase | -0.0486194 |
| FAM20C | family with sequence similarity 20, member C | -0.0486031 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0459618 |
| NDRG1 | N-myc downstream regulated 1 | -0.0446848 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0435114 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0429726 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0415243 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0410837 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0406433 |
| RAD51B | RAD51 paralog B | -0.0384081 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0383186 |
| GALNT18 | polypeptide N-acetylgalactosaminyltransferase 18 | -0.0379182 |
| FBN1 | fibrillin 1 | -0.0374513 |
| RNF213 | ring finger protein 213 | -0.0342795 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.0341999 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0339614 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0335147 |
| TGFB1 | transforming growth factor, beta 1 | -0.0332801 |
| EGR1 | early growth response 1 | -0.0329577 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0322451 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0322381 |
| OXR1 | oxidation resistance 1 | -0.03189 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0310219 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0309833 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0306746 |
| TMTC1 | transmembrane and tetratricopeptide repeat containing 1 | -0.0306532 |
| ETV6 | ets variant 6 | -0.0302029 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0301071 |
| CA12 | carbonic anhydrase XII | -0.029818 |
| PYGL | phosphorylase, glycogen, liver | -0.0294833 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0294625 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0293023 |
| SEPTIN9 | septin 9 | -0.0285539 |
| EGFR | epidermal growth factor receptor | -0.0282757 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0280111 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0275214 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0273117 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0265908 |
| DST | dystonin | -0.0264535 |
| SUMF1 | sulfatase modifying factor 1 | -0.026429 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0263279 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.025915 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0257251 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0254488 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0254423 |
| DNER | delta/notch-like EGF repeat containing | -0.0245745 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0245576 |
| LOXL2 | lysyl oxidase-like 2 | -0.0244192 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0241104 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0240584 |
| HDAC4 | histone deacetylase 4 | -0.0239944 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0237161 |
| SQSTM1 | sequestosome 1 | -0.0233667 |
| SYNJ2 | synaptojanin 2 | -0.0233204 |
| IER3 | immediate early response 3 | -0.0232949 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | -0.0232744 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0231748 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0226002 |
| CUX1 | cut-like homeobox 1 | -0.0225416 |
| DTNA | dystrobrevin, alpha | -0.022499 |
| WLS | wntless Wnt ligand secretion mediator | -0.0223194 |
| CMIP | c-Maf inducing protein | -0.0222271 |
| VIM | vimentin | -0.022119 |
| GRIK5 | glutamate receptor, ionotropic, kainate 5 | -0.0220827 |
| IL1B | interleukin 1, beta | -0.0220717 |
| AOPEP | aminopeptidase O (putative) | -0.0216676 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0215035 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0214629 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0214237 |
| MECOM | MDS1 and EVI1 complex locus | -0.0213192 |
| ENOSF1 | enolase superfamily member 1 | -0.0212393 |
| BMERB1 | bMERB domain containing 1 | -0.0212374 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | -0.0212262 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0211665 |
| PTPRB | protein tyrosine phosphatase, receptor type, B | -0.0211145 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | -0.0210848 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0210654 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0209959 |
| NAV1 | neuron navigator 1 | -0.020741 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0204295 |
| PDGFA | platelet-derived growth factor alpha polypeptide | -0.0203675 |
