| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Asciminib perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Asciminib_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GRAMD1B | GRAM domain containing 1B | 0.177319 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.120236 |
| PM20D1 | peptidase M20 domain containing 1 | 0.118398 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.113965 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.101973 |
| TXNRD1 | thioredoxin reductase 1 | 0.101136 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.101103 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.0983864 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.089798 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0741949 |
| FGB | fibrinogen beta chain | 0.0718838 |
| RRM2 | ribonucleotide reductase M2 | 0.0700994 |
| RTN4 | reticulon 4 | 0.0682825 |
| TPM3 | tropomyosin 3 | 0.0651943 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0637817 |
| VIM | vimentin | 0.0621458 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0596087 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0595303 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0589581 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0541997 |
| CALR | calreticulin | 0.0523649 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0518429 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0500895 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | 0.0472973 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0469331 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0456052 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0453817 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0449953 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0431951 |
| FAM168A | family with sequence similarity 168, member A | 0.0431447 |
| WDR43 | WD repeat domain 43 | 0.0430905 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.040914 |
| ANLN | anillin, actin binding protein | 0.0404857 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | 0.0400091 |
| ZNF292 | zinc finger protein 292 | 0.0387165 |
| CANX | calnexin | 0.0385506 |
| RFWD3 | ring finger and WD repeat domain 3 | 0.0383789 |
| RPL4 | ribosomal protein L4 | 0.0383433 |
| MKI67 | marker of proliferation Ki-67 | 0.0382809 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0380598 |
| THBS1 | thrombospondin 1 | 0.0374321 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.0370916 |
| RAD21 | RAD21 homolog (S. pombe) | 0.037063 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0367073 |
| SDC4 | syndecan 4 | 0.0366824 |
| ECT2 | epithelial cell transforming 2 | 0.0366473 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | 0.0365513 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0361876 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0361117 |
| DENND4A | DENN/MADD domain containing 4A | 0.0359954 |
| TPM4 | tropomyosin 4 | 0.0359812 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0355332 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0348204 |
| YBX3 | Y box binding protein 3 | 0.0344402 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0340707 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0334355 |
| USP3 | ubiquitin specific peptidase 3 | 0.0329309 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.032632 |
| ENO1 | enolase 1, (alpha) | 0.0323254 |
| YME1L1 | YME1-like 1 ATPase | 0.032265 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0320736 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0319744 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0319357 |
| TCERG1 | transcription elongation regulator 1 | 0.0318833 |
| TAGLN2 | transgelin 2 | 0.0317394 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0317001 |
| MATR3 | matrin 3 | 0.0316096 |
| POTEF | POTE ankyrin domain family, member F | 0.0314615 |
| CTSL | cathepsin L | 0.0310398 |
| KHDC4 | KH domain containing 4, pre-mRNA splicing factor | 0.0305464 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0300264 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | 0.0298005 |
| CLTC | clathrin, heavy chain (Hc) | 0.0296253 |
| XRCC6 | X-ray repair complementing defective repair in Chinese hamster cells 6 | 0.0294767 |
| SPAG5 | sperm associated antigen 5 | 0.0291811 |
| CENPF | centromere protein F, 350/400kDa | 0.0291576 |
| KLF6 | Kruppel-like factor 6 | 0.0290105 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | 0.028866 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0287226 |
| TSR1 | TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) | 0.0286744 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | 0.0286038 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0285914 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0285621 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0284568 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0281938 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | 0.0281568 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | 0.0281164 |
| OSMR | oncostatin M receptor | 0.0280817 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0280554 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0278244 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0277627 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | 0.0276046 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 | 0.0274824 |
| DNMT1 | DNA (cytosine-5-)-methyltransferase 1 | 0.0272616 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0271543 |
| RBM8A | RNA binding motif protein 8A | 0.0271323 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.027017 |
| ELOVL5 | ELOVL fatty acid elongase 5 | 0.0266793 |
| PFDN2 | prefoldin subunit 2 | 0.0265498 |
| MSMO1 | methylsterol monooxygenase 1 | 0.0265193 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | -0.153557 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.134753 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.119382 |
| FMNL2 | formin-like 2 | -0.0875631 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0721382 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0672778 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0601171 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0574533 |
| FLNB | filamin B, beta | -0.0567492 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0560652 |
| NDRG1 | N-myc downstream regulated 1 | -0.0540014 |
| FTL | ferritin, light polypeptide | -0.0539785 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0535888 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0521881 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0508094 |
| IGF2 | insulin-like growth factor 2 | -0.0506518 |
| EGFR | epidermal growth factor receptor | -0.0485584 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0469133 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0456039 |
| RPS6 | ribosomal protein S6 | -0.0448029 |
| IER3 | immediate early response 3 | -0.044316 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.043992 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0424875 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0423112 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0415412 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0405167 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0404572 |
| RPL35A | ribosomal protein L35a | -0.0398068 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0393169 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.038459 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0383312 |
| S100A6 | S100 calcium binding protein A6 | -0.0380668 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0374107 |
| PARD3 | par-3 family cell polarity regulator | -0.0373971 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0350256 |
| RPL23 | ribosomal protein L23 | -0.0338567 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0337426 |
| TMSB10 | thymosin beta 10 | -0.033223 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0328584 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0328135 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0316488 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0314854 |
| RAD51B | RAD51 paralog B | -0.0312905 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | -0.0307193 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0304476 |
| RPLP1 | ribosomal protein, large, P1 | -0.0303552 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0302024 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.03011 |
| RPL37A | ribosomal protein L37a | -0.0295787 |
| NEBL | nebulette | -0.0294598 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0293775 |
| RBM25 | RNA binding motif protein 25 | -0.0293125 |
| TLK1 | tousled-like kinase 1 | -0.0292542 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.028924 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0285299 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.028248 |
| SQSTM1 | sequestosome 1 | -0.0281989 |
| PYGL | phosphorylase, glycogen, liver | -0.0281834 |
| MYO1E | myosin IE | -0.0279615 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0278124 |
| HLA-A | major histocompatibility complex, class I, A | -0.0274867 |
| KIF13A | kinesin family member 13A | -0.0272799 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0269592 |
| NOP58 | NOP58 ribonucleoprotein | -0.0269556 |
| NUMB | numb homolog (Drosophila) | -0.0265225 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0264809 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0264173 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -0.026393 |
| RPL12 | ribosomal protein L12 | -0.026299 |
| HELZ | helicase with zinc finger | -0.0261916 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0261397 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0260965 |
| EFNA5 | ephrin-A5 | -0.0258445 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0258207 |
| FBXL2 | F-box and leucine-rich repeat protein 2 | -0.0258139 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0254266 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0253476 |
| RPL9 | ribosomal protein L9 | -0.0252085 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0251513 |
| ITSN2 | intersectin 2 | -0.0250021 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0248908 |
| RAP1GAP2 | RAP1 GTPase activating protein 2 | -0.0247384 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0245266 |
| RPL34 | ribosomal protein L34 | -0.0243789 |
| ZNF207 | zinc finger protein 207 | -0.0242978 |
| RBM39 | RNA binding motif protein 39 | -0.0242882 |
| GNAS | GNAS complex locus | -0.0242546 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0242141 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.024088 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0239353 |
| COPA | coatomer protein complex, subunit alpha | -0.0239177 |
| RPL31 | ribosomal protein L31 | -0.0236422 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | -0.0236029 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | -0.0230886 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0227459 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0226081 |
| NF1 | neurofibromin 1 | -0.0225349 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.0224571 |
| DST | dystonin | -0.0224378 |
| KCTD9 | potassium channel tetramerization domain containing 9 | -0.0222291 |
