| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Asciminib perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Asciminib_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.169271 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.140697 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.129879 |
| GRB10 | growth factor receptor-bound protein 10 | 0.128486 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.106327 |
| B2M | beta-2-microglobulin | 0.0945148 |
| SAR1A | secretion associated, Ras related GTPase 1A | 0.0937155 |
| RAB8B | RAB8B, member RAS oncogene family | 0.0861953 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0847294 |
| ACVR1 | activin A receptor, type I | 0.0779265 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0771035 |
| SPAG9 | sperm associated antigen 9 | 0.0733264 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0730477 |
| ATP13A3 | ATPase type 13A3 | 0.071504 |
| DICER1 | dicer 1, ribonuclease type III | 0.0707377 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0670428 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.0669344 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0645832 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.063978 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0632788 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0583565 |
| RORA | RAR-related orphan receptor A | 0.0583346 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0573542 |
| RTN4 | reticulon 4 | 0.0570619 |
| CCNL1 | cyclin L1 | 0.0550192 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | 0.0547335 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0545119 |
| WDFY2 | WD repeat and FYVE domain containing 2 | 0.0544752 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0504296 |
| PLS3 | plastin 3 | 0.0502041 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0474371 |
| OXR1 | oxidation resistance 1 | 0.0473301 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.045744 |
| SDC4 | syndecan 4 | 0.0456723 |
| FRMD6 | FERM domain containing 6 | 0.0442097 |
| AFAP1 | actin filament associated protein 1 | 0.0439378 |
| USP3 | ubiquitin specific peptidase 3 | 0.0437832 |
| H3-3B | H3.3 histone B | 0.0437746 |
| IFRD1 | interferon-related developmental regulator 1 | 0.0425456 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | 0.0422332 |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | 0.0419748 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0417603 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0416331 |
| PTGES2 | prostaglandin E synthase 2 | 0.0413463 |
| BCL6 | B-cell CLL/lymphoma 6 | 0.0412751 |
| GPC6 | glypican 6 | 0.0407766 |
| IRS2 | insulin receptor substrate 2 | 0.0403306 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0401151 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0400653 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0400218 |
| MLLT3 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 | 0.0399439 |
| RBFOX2 | RNA binding protein, fox-1 homolog (C. elegans) 2 | 0.0393727 |
| MEF2A | myocyte enhancer factor 2A | 0.0392547 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0391344 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | 0.0388818 |
| FYN | FYN proto-oncogene, Src family tyrosine kinase | 0.0385738 |
| MYO10 | myosin X | 0.038243 |
| ARHGAP32 | Rho GTPase activating protein 32 | 0.0377306 |
| ENTPD7 | ectonucleoside triphosphate diphosphohydrolase 7 | 0.0375542 |
| EML4 | echinoderm microtubule associated protein like 4 | 0.0371776 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0368449 |
| NBAS | neuroblastoma amplified sequence | 0.0362301 |
| PTK2 | protein tyrosine kinase 2 | 0.0360917 |
| CDC14A | cell division cycle 14A | 0.0359197 |
| MAN2A1 | mannosidase, alpha, class 2A, member 1 | 0.0358977 |
| EIF3E | eukaryotic translation initiation factor 3, subunit E | 0.0358877 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0358376 |
| ANXA1 | annexin A1 | 0.0358343 |
| FMNL2 | formin-like 2 | 0.0355367 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.0351844 |
| EFNA5 | ephrin-A5 | 0.0350274 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.03475 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0338652 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0333688 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0331442 |
| HM13 | histocompatibility (minor) 13 | 0.0328857 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.0327965 |
| PHACTR4 | phosphatase and actin regulator 4 | 0.0326621 |
| USP12 | ubiquitin specific peptidase 12 | 0.0321188 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0320908 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0319087 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0318859 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0317043 |
| AP1G1 | adaptor-related protein complex 1, gamma 1 subunit | 0.0311887 |
| CARD16 | caspase recruitment domain family, member 16 | 0.0311837 |
| LSAMP | limbic system-associated membrane protein | 0.0311353 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | 0.0311105 |
| NBEA | neurobeachin | 0.030906 |
| RNF24 | ring finger protein 24 | 0.0308122 |
| HELZ | helicase with zinc finger | 0.0306474 |
| VIM | vimentin | 0.0306462 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.030557 |
| SSH2 | slingshot protein phosphatase 2 | 0.0305331 |
| SUCO | SUN domain containing ossification factor | 0.0303772 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0299537 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | 0.0297674 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0297118 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0295805 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.029574 |
| NEK7 | NIMA-related kinase 7 | 0.0292122 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.163219 |
| LMO7 | LIM domain 7 | -0.1338 |
| FN1 | fibronectin 1 | -0.133676 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.125661 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.10928 |
| KRT17 | keratin 17, type I | -0.104222 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0932606 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0802517 |
| IGF2 | insulin-like growth factor 2 | -0.0776867 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0770161 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0734561 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0714773 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0704829 |
| SVIL | supervillin | -0.0697497 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.0693724 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0692848 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0686293 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0673613 |
| EZR | ezrin | -0.0655125 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0643386 |
| ATOSA | atos homolog A | -0.0635876 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0626522 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0611164 |
| ACTG1 | actin gamma 1 | -0.0608247 |
| LAMB3 | laminin, beta 3 | -0.0607743 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0597263 |
| CMIP | c-Maf inducing protein | -0.0595945 |
| TJP1 | tight junction protein 1 | -0.0590872 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0568317 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0552545 |
| ANXA2 | annexin A2 | -0.0537015 |
| MUC16 | mucin 16, cell surface associated | -0.0531107 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0519791 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0509337 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.0493198 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0492805 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0491789 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0475973 |
| CDH13 | cadherin 13 | -0.0474425 |
| FNIP1 | folliculin interacting protein 1 | -0.0468635 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0467696 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0463616 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0463568 |
| NDRG1 | N-myc downstream regulated 1 | -0.0449137 |
| S100A9 | S100 calcium binding protein A9 | -0.0446524 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | -0.0445845 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0436839 |
| PKM | pyruvate kinase, muscle | -0.0404211 |
| KYNU | kynureninase | -0.0402531 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0401692 |
| RUNX1 | runt-related transcription factor 1 | -0.0388653 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | -0.0386959 |
| ARHGEF4 | Rho guanine nucleotide exchange factor (GEF) 4 | -0.038221 |
| MYO1E | myosin IE | -0.0380409 |
| RPS6 | ribosomal protein S6 | -0.0373713 |
| CDK13 | cyclin-dependent kinase 13 | -0.0372886 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0370492 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0370273 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0368412 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.036785 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0361366 |
| POTEF | POTE ankyrin domain family, member F | -0.0355202 |
| DSG2 | desmoglein 2 | -0.0352026 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | -0.0347623 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0342461 |
| CUX1 | cut-like homeobox 1 | -0.0341408 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0340737 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0338648 |
| RPL37 | ribosomal protein L37 | -0.0336914 |
| RAB10 | RAB10, member RAS oncogene family | -0.0336619 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0329718 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0329514 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0325891 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0325443 |
| MXD1 | MAX dimerization protein 1 | -0.0322969 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0317918 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0312791 |
| S100A11 | S100 calcium binding protein A11 | -0.0308015 |
| RPLP0 | ribosomal protein, large, P0 | -0.0307053 |
| WDFY3 | WD repeat and FYVE domain containing 3 | -0.0306698 |
| UBC | ubiquitin C | -0.0302241 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0302134 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0302084 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0301047 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0300801 |
| AFDN | afadin, adherens junction formation factor | -0.0298793 |
| QKI | QKI, KH domain containing, RNA binding | -0.0296536 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -0.0293321 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0292566 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | -0.0287164 |
| SLMAP | sarcolemma associated protein | -0.0286614 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0286502 |
| ABHD17C | abhydrolase domain containing 17C | -0.0285024 |
| RPL11 | ribosomal protein L11 | -0.0284675 |
| TAOK1 | TAO kinase 1 | -0.0283453 |
| HECTD4 | HECT domain containing E3 ubiquitin protein ligase 4 | -0.0281266 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | -0.0279813 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0276258 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | -0.0274961 |
| PRKCSH | protein kinase C substrate 80K-H | -0.0274354 |
