| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Asciminib perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Asciminib_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.150855 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.133611 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0984793 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0689211 |
| YBX3 | Y box binding protein 3 | 0.067923 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0645089 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0528141 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0480293 |
| OGA | O-GlcNAcase | 0.0462276 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0447929 |
| UBC | ubiquitin C | 0.0444238 |
| CTTN | cortactin | 0.0437617 |
| TPM3 | tropomyosin 3 | 0.0435405 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0418885 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0417588 |
| CEP250 | centrosomal protein 250kDa | 0.0399378 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0398833 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0398337 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0396994 |
| SRPK1 | SRSF protein kinase 1 | 0.0396189 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0394031 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0392904 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0387651 |
| PRELID2 | PRELI domain containing 2 | 0.0379818 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.037341 |
| RRM2 | ribonucleotide reductase M2 | 0.037333 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0373076 |
| VIM | vimentin | 0.0369831 |
| CEP192 | centrosomal protein 192kDa | 0.0367248 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0365456 |
| XPO1 | exportin 1 | 0.0351012 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0349728 |
| RTN4 | reticulon 4 | 0.0346829 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.033853 |
| TMEM165 | transmembrane protein 165 | 0.0336584 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0335208 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.033391 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0328069 |
| APP | amyloid beta (A4) precursor protein | 0.0325779 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0324429 |
| HLA-B | major histocompatibility complex, class I, B | 0.032331 |
| UBE2K | ubiquitin-conjugating enzyme E2K | 0.0323294 |
| BBX | bobby sox homolog (Drosophila) | 0.0321759 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | 0.0317764 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0316101 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0313431 |
| LDHA | lactate dehydrogenase A | 0.0313316 |
| RNF169 | ring finger protein 169 | 0.0311611 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0310977 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0306642 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0300773 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0298021 |
| CTNNBL1 | catenin, beta like 1 | 0.0296247 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0293142 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0289557 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.028484 |
| KHDC4 | KH domain containing 4, pre-mRNA splicing factor | 0.0283709 |
| AHNAK | AHNAK nucleoprotein | 0.0282566 |
| MATR3 | matrin 3 | 0.0275609 |
| WIPF2 | WAS/WASL interacting protein family, member 2 | 0.0275205 |
| TNPO1 | transportin 1 | 0.0271552 |
| EIF2AK3 | eukaryotic translation initiation factor 2-alpha kinase 3 | 0.0271448 |
| WDPCP | WD repeat containing planar cell polarity effector | 0.0271287 |
| MSN | moesin | 0.0266013 |
| KRT18 | keratin 18, type I | 0.0262228 |
| CLTC | clathrin, heavy chain (Hc) | 0.0261734 |
| SBNO1 | strawberry notch homolog 1 (Drosophila) | 0.0257705 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | 0.0256872 |
| CDC5L | cell division cycle 5-like | 0.0256149 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0255757 |
| CPNE1 | copine I | 0.0255234 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0253995 |
| CHD1L | chromodomain helicase DNA binding protein 1-like | 0.0253617 |
| TBK1 | TANK-binding kinase 1 | 0.0252922 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | 0.0252563 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0251367 |
| FMNL2 | formin-like 2 | 0.0249947 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0248864 |
| PLCB4 | phospholipase C, beta 4 | 0.024834 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.024762 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0245591 |
| PFKP | phosphofructokinase, platelet | 0.0244438 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0243371 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0243195 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0242875 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0242536 |
| ENO1 | enolase 1, (alpha) | 0.0240179 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.023952 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0239147 |
| SLC35F5 | solute carrier family 35, member F5 | 0.0239038 |
| POLR2B | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa | 0.0238699 |
| R3HDM2 | R3H domain containing 2 | 0.0236769 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0235645 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0235629 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0234615 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0234488 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | 0.0233658 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.0233467 |
| ANLN | anillin, actin binding protein | 0.0230482 |
| ATP2C1 | ATPase, Ca++ transporting, type 2C, member 1 | 0.0229065 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.194219 |
| EGR1 | early growth response 1 | -0.120375 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0675491 |
| NABP1 | nucleic acid binding protein 1 | -0.0489698 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0485346 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0473761 |
| OSMR | oncostatin M receptor | -0.0470344 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0456917 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.041597 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.041353 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0375135 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0363356 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0336437 |
| POTEF | POTE ankyrin domain family, member F | -0.0323173 |
| SMC4 | structural maintenance of chromosomes 4 | -0.031466 |
| MORF4L2 | mortality factor 4 like 2 | -0.031277 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0311956 |
| ACTG1 | actin gamma 1 | -0.0301935 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.030035 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0291164 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0285366 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | -0.0282111 |
| ADAR | adenosine deaminase, RNA-specific | -0.0281477 |
| REL | v-rel avian reticuloendotheliosis viral oncogene homolog | -0.028003 |
| THOC2 | THO complex 2 | -0.026314 |
| RPL37 | ribosomal protein L37 | -0.0258503 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0252864 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0252586 |
| PLSCR1 | phospholipid scramblase 1 | -0.0246025 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0245824 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0245218 |
| RPL28 | ribosomal protein L28 | -0.0243775 |
| GNAS | GNAS complex locus | -0.0243235 |
| RPS2 | ribosomal protein S2 | -0.0243036 |
| RPL26 | ribosomal protein L26 | -0.024122 |
| RPS27 | ribosomal protein S27 | -0.0241026 |
| SBF2 | SET binding factor 2 | -0.0233792 |
| PMP22 | peripheral myelin protein 22 | -0.0233583 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0231018 |
| RBBP6 | retinoblastoma binding protein 6 | -0.0230813 |
| HELZ2 | helicase with zinc finger 2, transcriptional coactivator | -0.0227501 |
| RPS6 | ribosomal protein S6 | -0.0224929 |
| RPLP1 | ribosomal protein, large, P1 | -0.0223819 |
| RIGI | RNA sensor RIG-I | -0.0223788 |
| RPS25 | ribosomal protein S25 | -0.0223077 |
| TRIP12 | thyroid hormone receptor interactor 12 | -0.0219599 |
| PHC2 | polyhomeotic homolog 2 (Drosophila) | -0.0218095 |
| KMT2D | lysine (K)-specific methyltransferase 2D | -0.0216352 |
| NBEA | neurobeachin | -0.0215943 |
| E2F3 | E2F transcription factor 3 | -0.0215905 |
| CEP128 | centrosomal protein 128kDa | -0.0215052 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.021411 |
| MAP7 | microtubule-associated protein 7 | -0.0211314 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | -0.0210441 |
| AGRN | agrin | -0.0210059 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.020987 |
| TXNRD1 | thioredoxin reductase 1 | -0.020922 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.0206028 |
| C6ORF62 | chromosome 6 open reading frame 62 | -0.0201132 |
| PDE10A | phosphodiesterase 10A | -0.0199981 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0195649 |
| PFN1 | profilin 1 | -0.0194427 |
| RPL34 | ribosomal protein L34 | -0.0193823 |
| STAT2 | signal transducer and activator of transcription 2, 113kDa | -0.0193472 |
| YBX1 | Y box binding protein 1 | -0.0192882 |
| GOLGB1 | golgin B1 | -0.0191369 |
| PTMS | parathymosin | -0.0189284 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | -0.0188214 |
| PHIP | pleckstrin homology domain interacting protein | -0.018672 |
| JUN | jun proto-oncogene | -0.0186541 |
| MIDN | midnolin | -0.0182123 |
| BRD2 | bromodomain containing 2 | -0.018174 |
| HIVEP1 | human immunodeficiency virus type I enhancer binding protein 1 | -0.0181385 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.0181364 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0179722 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0177665 |
| CFAP44 | cilia and flagella associated protein 44 | -0.017726 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | -0.0176702 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0176591 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0176569 |
| ERLEC1 | endoplasmic reticulum lectin 1 | -0.0176455 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0175719 |
| CEP112 | centrosomal protein 112kDa | -0.0173814 |
| RPL5 | ribosomal protein L5 | -0.0173385 |
| HMGA1 | high mobility group AT-hook 1 | -0.0173026 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0172469 |
| PARN | poly(A)-specific ribonuclease | -0.0172439 |
| RPL12 | ribosomal protein L12 | -0.0171756 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | -0.017151 |
| NDRG1 | N-myc downstream regulated 1 | -0.0170914 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0168538 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0168326 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0167906 |
| UGGT2 | UDP-glucose glycoprotein glucosyltransferase 2 | -0.0167777 |
| VMP1 | vacuole membrane protein 1 | -0.0167614 |
| RPL23 | ribosomal protein L23 | -0.0167415 |
| PDSS2 | prenyl (decaprenyl) diphosphate synthase, subunit 2 | -0.016616 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0165472 |
| AP1S3 | adaptor-related protein complex 1, sigma 3 subunit | -0.0165214 |
| FOXP1 | forkhead box P1 | -0.0164659 |
