Asciminib_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Asciminib perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Asciminib_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.147106
FN1 fibronectin 1 0.125158
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0978184
MYH9 myosin, heavy chain 9, non-muscle 0.0755637
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.074143
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0665007
TMSB4X thymosin beta 4, X-linked 0.0644761
CCNL1 cyclin L1 0.0637002
FXR1 fragile X mental retardation, autosomal homolog 1 0.0636435
SDC4 syndecan 4 0.0561257
PCBP2 poly(rC) binding protein 2 0.0556372
TPM3 tropomyosin 3 0.054204
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0541302
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0538651
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0538463
HSPA8 heat shock 70kDa protein 8 0.052801
NAMPT nicotinamide phosphoribosyltransferase 0.0516615
CALR calreticulin 0.0501434
ADAM9 ADAM metallopeptidase domain 9 0.0460324
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0449099
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0445933
ELL2 elongation factor, RNA polymerase II, 2 0.0444962
BHLHE40 basic helix-loop-helix family, member e40 0.0435767
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0427945
TSC22D2 TSC22 domain family, member 2 0.0424547
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0420208
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0412497
LDHA lactate dehydrogenase A 0.0409297
RAD21 RAD21 homolog (S. pombe) 0.040326
PAPOLA poly(A) polymerase alpha 0.0399063
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0398692
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0395695
DSCAM Down syndrome cell adhesion molecule 0.0393858
EIF4A2 eukaryotic translation initiation factor 4A2 0.0392553
IRF6 interferon regulatory factor 6 0.0389905
MSN moesin 0.0385442
VEGFA vascular endothelial growth factor A 0.03745
PEG10 paternally expressed 10 0.0371773
PTK2 protein tyrosine kinase 2 0.0370714
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0369971
ANXA5 annexin A5 0.0369395
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0365492
ASPH aspartate beta-hydroxylase 0.0365012
KDM3A lysine (K)-specific demethylase 3A 0.0350504
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0350016
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0347644
APP amyloid beta (A4) precursor protein 0.0345942
KRT8 keratin 8, type II 0.0342557
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0336567
USP3 ubiquitin specific peptidase 3 0.033607
MSMO1 methylsterol monooxygenase 1 0.0335647
DDIT4 DNA-damage-inducible transcript 4 0.033562
EEF2 eukaryotic translation elongation factor 2 0.032371
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0322458
DUSP10 dual specificity phosphatase 10 0.0322366
RNF145 ring finger protein 145 0.0319103
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0318171
MATR3 matrin 3 0.0314484
RAD23B RAD23 homolog B (S. cerevisiae) 0.0313118
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0309598
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.030258
NUP58 nucleoporin 58 0.0300612
SPAG9 sperm associated antigen 9 0.0296136
RPL4 ribosomal protein L4 0.0295779
MYO6 myosin VI 0.029469
SET SET nuclear proto-oncogene 0.0294451
PPARD peroxisome proliferator-activated receptor delta 0.0292471
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0285792
PLAU plasminogen activator, urokinase 0.0285217
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0279821
MTMR3 myotubularin related protein 3 0.0275649
RYBP RING1 and YY1 binding protein 0.0275487
KDM6A lysine (K)-specific demethylase 6A 0.0273718
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0270214
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0268801
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0264949
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0264864
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0261985
SFPQ splicing factor proline/glutamine-rich 0.0260955
CDC73 cell division cycle 73 0.0260831
ATP13A3 ATPase type 13A3 0.0259238
AFDN afadin, adherens junction formation factor 0.0257325
PLEC plectin 0.0256883
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0255015
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0253651
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.02514
G3BP2 GTPase activating protein (SH3 domain) binding protein 2 0.0250613
MCL1 myeloid cell leukemia 1 0.025014
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0249366
WDR43 WD repeat domain 43 0.0248961
SRSF5 serine/arginine-rich splicing factor 5 0.0245989
ABI1 abl-interactor 1 0.0245877
BRD2 bromodomain containing 2 0.0245102
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0242848
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0239533
TFRC transferrin receptor 0.0238627
YTHDC1 YTH domain containing 1 0.023821
CANX calnexin 0.0238022
HDGF hepatoma-derived growth factor 0.0237821
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.023506

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.325062
FTL ferritin, light polypeptide -0.21914
TMSB10 thymosin beta 10 -0.135784
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.131851
ACTG1 actin gamma 1 -0.101898
NDRG1 N-myc downstream regulated 1 -0.0948336
PTMA prothymosin, alpha -0.0943253
TPT1 tumor protein, translationally-controlled 1 -0.0862994
S100A6 S100 calcium binding protein A6 -0.0855505
IFI27 interferon, alpha-inducible protein 27 -0.0831998
S100A10 S100 calcium binding protein A10 -0.0711792
RPL34 ribosomal protein L34 -0.0701344
RPLP1 ribosomal protein, large, P1 -0.0644932
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0607532
RPL35A ribosomal protein L35a -0.0570213
ISG15 ISG15 ubiquitin-like modifier -0.0568941
IFI6 interferon, alpha-inducible protein 6 -0.0566717
RPS19 ribosomal protein S19 -0.0525523
IFITM3 interferon induced transmembrane protein 3 -0.0505812
EFNA5 ephrin-A5 -0.0482049
RPLP2 ribosomal protein, large, P2 -0.047855
IGFBP3 insulin-like growth factor binding protein 3 -0.0473956
RPS8 ribosomal protein S8 -0.0467079
RPS6 ribosomal protein S6 -0.0465275
MT2A metallothionein 2A -0.0458586
RPL8 ribosomal protein L8 -0.0455748
LIMCH1 LIM and calponin homology domains 1 -0.0455546
TM4SF1 transmembrane 4 L six family member 1 -0.0453373
IFITM1 interferon induced transmembrane protein 1 -0.0450011
RPL23 ribosomal protein L23 -0.0437624
RPS23 ribosomal protein S23 -0.0425802
CSTB cystatin B (stefin B) -0.0422883
LY6E lymphocyte antigen 6 complex, locus E -0.0419101
IFI16 interferon, gamma-inducible protein 16 -0.0417575
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0410531
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0402143
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0400001
FBXO32 F-box protein 32 -0.0399942
HMGA1 high mobility group AT-hook 1 -0.0397083
FTH1 ferritin, heavy polypeptide 1 -0.0379357
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0370727
EIF1 eukaryotic translation initiation factor 1 -0.0370392
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0367876
RPS29 ribosomal protein S29 -0.0364162
RPL28 ribosomal protein L28 -0.0358919
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0354832
S100A9 S100 calcium binding protein A9 -0.0352787
RPS25 ribosomal protein S25 -0.0342551
EXT1 exostosin glycosyltransferase 1 -0.0338661
RPL12 ribosomal protein L12 -0.0335737
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0335076
C15ORF48 chromosome 15 open reading frame 48 -0.0335001
GNAS GNAS complex locus -0.0333832
ZBTB20 zinc finger and BTB domain containing 20 -0.0333645
RPS27 ribosomal protein S27 -0.032921
RPL36 ribosomal protein L36 -0.032295
RPL32 ribosomal protein L32 -0.0319343
WSB1 WD repeat and SOCS box containing 1 -0.0317868
LMO7 LIM domain 7 -0.0315294
MDK midkine (neurite growth-promoting factor 2) -0.031526
SOX4 SRY (sex determining region Y)-box 4 -0.0313163
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0309565
RPS13 ribosomal protein S13 -0.0305635
CD2AP CD2-associated protein -0.0302996
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -0.0302591
RPS14 ribosomal protein S14 -0.0302141
LPP LIM domain containing preferred translocation partner in lipoma -0.0301385
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0301242
NPEPPS aminopeptidase puromycin sensitive -0.0300232
GOLGA4 golgin A4 -0.0295053
MX2 MX dynamin-like GTPase 2 -0.0293275
ITCH itchy E3 ubiquitin protein ligase -0.0284619
H1-0 H1.0 linker histone -0.028237
MAP1B microtubule-associated protein 1B -0.0278555
SACK1A scaffolding CK1 anchoring protein A -0.0277978
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.0275298
RPL19 ribosomal protein L19 -0.0275165
BASP1 brain abundant, membrane attached signal protein 1 -0.026974
RRBP1 ribosome binding protein 1 -0.0268695
RPL31 ribosomal protein L31 -0.0265322
RPS15 ribosomal protein S15 -0.0263484
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0261348
TMEM263 transmembrane protein 263 -0.0257868
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0256169
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0255609
RPL9 ribosomal protein L9 -0.0252544
RPL37 ribosomal protein L37 -0.0252074
RNF213 ring finger protein 213 -0.0250207
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0248788
RPS21 ribosomal protein S21 -0.0245909
MCTP2 multiple C2 domains, transmembrane 2 -0.0245689
RPS27A ribosomal protein S27a -0.0242083
RPS5 ribosomal protein S5 -0.0241172
DLG1 discs, large homolog 1 (Drosophila) -0.0236403
TMEM123 transmembrane protein 123 -0.0234975
ATXN1 ataxin 1 -0.0233218
KRT19 keratin 19, type I -0.0231671
RPL35 ribosomal protein L35 -0.0230137
CDCP1 CUB domain containing protein 1 -0.0227257
GOLGB1 golgin B1 -0.0226712