Asciminib_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Asciminib perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Asciminib_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0250114
SAMD4A sterile alpha motif domain containing 4A 0.0235455
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0198362
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0176167
IGFBP3 insulin-like growth factor binding protein 3 0.0174139
CD109 CD109 molecule 0.0158914
GDA guanine deaminase 0.0148341
ATP13A3 ATPase type 13A3 0.0148236
PTEN phosphatase and tensin homolog 0.0141449
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0134689
NEK7 NIMA-related kinase 7 0.0129118
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0125565
ZEB2 zinc finger E-box binding homeobox 2 0.0123262
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0119926
NUP58 nucleoporin 58 0.0114925
RNF145 ring finger protein 145 0.0100775
STC2 stanniocalcin 2 0.00963348
NPAS2 neuronal PAS domain protein 2 0.00954932
TSC22D2 TSC22 domain family, member 2 0.00927395
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.00886456
MSN moesin 0.00871304
TGFBR1 transforming growth factor, beta receptor 1 0.00865951
COPA coatomer protein complex, subunit alpha 0.00864106
ERRFI1 ERBB receptor feedback inhibitor 1 0.00803965
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.00784054
KDM6A lysine (K)-specific demethylase 6A 0.00761739
NBAS neuroblastoma amplified sequence 0.00752836
LAMA1 laminin, alpha 1 0.00751047
ANXA5 annexin A5 0.00749751
RLIM ring finger protein, LIM domain interacting 0.00732056
AGFG1 ArfGAP with FG repeats 1 0.00678957
CCNL1 cyclin L1 0.00654485
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.00646612
AVL9 AVL9 homolog (S. cerevisiase) 0.0064154
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0063064
UBA6 ubiquitin-like modifier activating enzyme 6 0.00609726
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0060899
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.00599683
ARHGAP29 Rho GTPase activating protein 29 0.00599006
WDR43 WD repeat domain 43 0.00594107
CDK17 cyclin-dependent kinase 17 0.00588997
SEC23A Sec23 homolog A (S. cerevisiae) 0.00587429
BDNF brain-derived neurotrophic factor 0.00586801
ITPRID2 ITPR interacting domain containing 2 0.00583938
ADAM9 ADAM metallopeptidase domain 9 0.00565076
CHD1 chromodomain helicase DNA binding protein 1 0.00561356
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 0.00556263
MAT2A methionine adenosyltransferase II, alpha 0.00554891
FAM219A family with sequence similarity 219, member A 0.00554157
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.00553976
PDLIM5 PDZ and LIM domain 5 0.00550394
MYOF myoferlin 0.00548154
USP3 ubiquitin specific peptidase 3 0.0054592
NGLY1 N-glycanase 1 0.0054565
HEATR1 HEAT repeat containing 1 0.00536026
MCL1 myeloid cell leukemia 1 0.00530531
PICALM phosphatidylinositol binding clathrin assembly protein 0.00522805
NOCT nocturnin 0.00517541
TRIO trio Rho guanine nucleotide exchange factor 0.00517509
MEMO1 mediator of cell motility 1 0.00514915
RRAS2 related RAS viral (r-ras) oncogene homolog 2 0.00507209
PIAS2 protein inhibitor of activated STAT, 2 0.00503937
FAR1 fatty acyl CoA reductase 1 0.00502717
ECT2 epithelial cell transforming 2 0.00502682
FNIP1 folliculin interacting protein 1 0.00500993
AFDN afadin, adherens junction formation factor 0.00496739
CRY1 cryptochrome circadian clock 1 0.00484039
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 0.00482723
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 0.00480266
ZFC3H1 zinc finger, C3H1-type containing 0.00479463
CTSC cathepsin C 0.00478003
TMEM39A transmembrane protein 39A 0.00477588
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.00469186
ARRDC3 arrestin domain containing 3 0.00464959
IL1RAP interleukin 1 receptor accessory protein 0.00463103
SPTLC1 serine palmitoyltransferase, long chain base subunit 1 0.0046298
PRRC1 proline-rich coiled-coil 1 0.004615
ZBTB43 zinc finger and BTB domain containing 43 0.00446405
MARCHF1 membrane associated ring-CH-type finger 1 0.00442534
SUCO SUN domain containing ossification factor 0.00441738
MTCL1 microtubule crosslinking factor 1 0.00439432
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.00438434
SLC35F5 solute carrier family 35, member F5 0.00436776
ACVR1 activin A receptor, type I 0.00432892
BMAL2 basic helix-loop-helix ARNT like 2 0.00430861
SMAD4 SMAD family member 4 0.00430267
YEATS2 YEATS domain containing 2 0.00427621
CD274 CD274 molecule 0.004275
ADAM17 ADAM metallopeptidase domain 17 0.00423276
HELZ helicase with zinc finger 0.00422681
RBM12 RNA binding motif protein 12 0.00421417
ANKRD36 ankyrin repeat domain 36 0.00415934
CENPC centromere protein C 0.00414283
SESTD1 SEC14 and spectrin domains 1 0.00408531
CASC3 cancer susceptibility candidate 3 0.00405191
ZC3H12C zinc finger CCCH-type containing 12C 0.00399697
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.00399403
BIRC2 baculoviral IAP repeat containing 2 0.00398919
NIPA1 non imprinted in Prader-Willi/Angelman syndrome 1 0.00398463
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.00396116

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.231082
PDE4D phosphodiesterase 4D, cAMP-specific -0.182461
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.165022
VIM vimentin -0.130054
PTMA prothymosin, alpha -0.127968
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.118589
TMSB10 thymosin beta 10 -0.116925
TPT1 tumor protein, translationally-controlled 1 -0.107756
RPS6 ribosomal protein S6 -0.0885793
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0879365
RPLP1 ribosomal protein, large, P1 -0.0819105
FTL ferritin, light polypeptide -0.0747641
RPS8 ribosomal protein S8 -0.0730603
PDE10A phosphodiesterase 10A -0.0709895
RPS27A ribosomal protein S27a -0.0684172
RPS24 ribosomal protein S24 -0.0645581
RPL31 ribosomal protein L31 -0.063418
RPL37A ribosomal protein L37a -0.0621651
RPL26 ribosomal protein L26 -0.0618646
ASPH aspartate beta-hydroxylase -0.060377
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0587328
RPL12 ribosomal protein L12 -0.0572593
RPL23 ribosomal protein L23 -0.0558391
TM4SF1 transmembrane 4 L six family member 1 -0.0549071
COL5A2 collagen, type V, alpha 2 -0.0537511
NALF1 NALCN channel auxiliary factor 1 -0.0535918
FN1 fibronectin 1 -0.0531346
NAP1L1 nucleosome assembly protein 1-like 1 -0.0529164
RPL35A ribosomal protein L35a -0.0525187
RPS12 ribosomal protein S12 -0.0524669
RPL19 ribosomal protein L19 -0.0513388
RPS19 ribosomal protein S19 -0.0507276
RPS23 ribosomal protein S23 -0.0497233
UBC ubiquitin C -0.0484847
PSD3 pleckstrin and Sec7 domain containing 3 -0.0459058
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0457041
RPL34 ribosomal protein L34 -0.045527
RPL9 ribosomal protein L9 -0.0449631
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0448482
RPS3 ribosomal protein S3 -0.0446233
RPLP2 ribosomal protein, large, P2 -0.0438092
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0437494
SMYD3 SET and MYND domain containing 3 -0.0433755
RPL36A ribosomal protein L36a -0.0431189
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0430414
ACTG1 actin gamma 1 -0.0430368
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0422678
EEF2 eukaryotic translation elongation factor 2 -0.0419866
RPL7A ribosomal protein L7a -0.0417341
S100A10 S100 calcium binding protein A10 -0.0412183
ENO1 enolase 1, (alpha) -0.0410797
EIF1 eukaryotic translation initiation factor 1 -0.0400731
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0399881
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0399735
TXNRD1 thioredoxin reductase 1 -0.0398717
RPS29 ribosomal protein S29 -0.0398269
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0391908
BASP1 brain abundant, membrane attached signal protein 1 -0.0389904
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.038808
RPL11 ribosomal protein L11 -0.0384995
B2M beta-2-microglobulin -0.0382853
CANX calnexin -0.0380785
RPS25 ribosomal protein S25 -0.0361875
RPLP0 ribosomal protein, large, P0 -0.0361631
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0361472
GNAS GNAS complex locus -0.0360344
RPS13 ribosomal protein S13 -0.0358269
RPL37 ribosomal protein L37 -0.0353056
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0351467
MAML3 mastermind-like 3 (Drosophila) -0.0349121
S100A6 S100 calcium binding protein A6 -0.0343721
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0342702
PRKN parkin RBR E3 ubiquitin protein ligase -0.0341757
GRAMD1B GRAM domain containing 1B -0.0339453
RPL38 ribosomal protein L38 -0.0338852
SRGN serglycin -0.0338385
RPS16 ribosomal protein S16 -0.033806
RPS4X ribosomal protein S4, X-linked -0.0334989
RACK1 receptor for activated C kinase 1 -0.0332758
RPS27 ribosomal protein S27 -0.0332667
TFPI2 tissue factor pathway inhibitor 2 -0.0326684
RPS21 ribosomal protein S21 -0.0323718
RPL36 ribosomal protein L36 -0.0318174
RPL13A ribosomal protein L13a -0.031606
HLA-B major histocompatibility complex, class I, B -0.0315651
RPS14 ribosomal protein S14 -0.0315221
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0313494
PKM pyruvate kinase, muscle -0.0294792
COL4A5 collagen, type IV, alpha 5 -0.0293865
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0289681
RPS17 ribosomal protein S17 -0.0284611
LDHA lactate dehydrogenase A -0.0283611
CDH13 cadherin 13 -0.0281236
RPL5 ribosomal protein L5 -0.0276456
RPL32 ribosomal protein L32 -0.0276431
SH3KBP1 SH3-domain kinase binding protein 1 -0.0276399
PRRC2C proline-rich coiled-coil 2C -0.0270312
TBXT T-box transcription factor T -0.0269919
RPL35 ribosomal protein L35 -0.0264655
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.026378