| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Asciminib perturbation in NCI-H596 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Asciminib_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.180414 |
| SPAG9 | sperm associated antigen 9 | 0.168344 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.145545 |
| MT2A | metallothionein 2A | 0.130337 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.109668 |
| NEK7 | NIMA-related kinase 7 | 0.104608 |
| VIM | vimentin | 0.0998052 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0945173 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0930801 |
| NR6A1 | nuclear receptor subfamily 6, group A, member 1 | 0.0911776 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0842904 |
| PKM | pyruvate kinase, muscle | 0.0803296 |
| FN1 | fibronectin 1 | 0.0796508 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0776482 |
| STK39 | serine threonine kinase 39 | 0.0758982 |
| COPA | coatomer protein complex, subunit alpha | 0.0756637 |
| SCFD1 | sec1 family domain containing 1 | 0.0748908 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0742148 |
| SEPTIN7 | septin 7 | 0.0739107 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0730307 |
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 | 0.0707218 |
| RUNX1 | runt-related transcription factor 1 | 0.0691341 |
| RPL12 | ribosomal protein L12 | 0.0643761 |
| ANO6 | anoctamin 6 | 0.0629414 |
| PGK1 | phosphoglycerate kinase 1 | 0.0625191 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0623585 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0604088 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0584561 |
| MEIS2 | Meis homeobox 2 | 0.0577483 |
| ZNF518A | zinc finger protein 518A | 0.0576752 |
| RAB3GAP1 | RAB3 GTPase activating protein subunit 1 (catalytic) | 0.0573907 |
| MLXIP | MLX interacting protein | 0.0571427 |
| ZNF292 | zinc finger protein 292 | 0.0570136 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | 0.0545286 |
| SH3PXD2A | SH3 and PX domains 2A | 0.0543338 |
| FNDC3B | fibronectin type III domain containing 3B | 0.054184 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.0540406 |
| CD44 | CD44 molecule (Indian blood group) | 0.052773 |
| EMP1 | epithelial membrane protein 1 | 0.052707 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0520425 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.051407 |
| ATP13A3 | ATPase type 13A3 | 0.0509428 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0507143 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0501724 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0493091 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0457525 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0445993 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0433898 |
| RPS6 | ribosomal protein S6 | 0.0432301 |
| GOLGA4 | golgin A4 | 0.0416845 |
| RPS12 | ribosomal protein S12 | 0.0412798 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0407616 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0405943 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0401827 |
| TMSB10 | thymosin beta 10 | 0.0400209 |
| H3-3B | H3.3 histone B | 0.0395425 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0395175 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | 0.0394278 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.0379542 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.037656 |
| MYOF | myoferlin | 0.0360681 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0356254 |
| USP34 | ubiquitin specific peptidase 34 | 0.0348454 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0347309 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0338314 |
| SRPK2 | SRSF protein kinase 2 | 0.0325898 |
| FHIT | fragile histidine triad | 0.0322809 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0321355 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0308687 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0307601 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0302552 |
| FMNL2 | formin-like 2 | 0.0279681 |
| GPHN | gephyrin | 0.0273976 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0272427 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0271614 |
| WDR45B | WD repeat domain 45B | 0.0270773 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0252883 |
| FTL | ferritin, light polypeptide | 0.024996 |
| PTK2 | protein tyrosine kinase 2 | 0.0244191 |
| VCL | vinculin | 0.0234574 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.022863 |
| TJP1 | tight junction protein 1 | 0.0228396 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0226981 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0218735 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0214735 |
| LAMB3 | laminin, beta 3 | 0.0211802 |
| FBXO11 | F-box protein 11 | 0.0206067 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0202835 |
| RPL37A | ribosomal protein L37a | 0.0200007 |
| RPL35A | ribosomal protein L35a | 0.019957 |
| SMYD3 | SET and MYND domain containing 3 | 0.0197859 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0191811 |
| MYO1E | myosin IE | 0.0191028 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.0188689 |
| RAB1A | RAB1A, member RAS oncogene family | 0.01865 |
| ENO1 | enolase 1, (alpha) | 0.0182258 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0178714 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0176846 |
| RPLP1 | ribosomal protein, large, P1 | 0.0166279 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0164405 |
| Symbol | Name | Standardized Value |
|---|---|---|
| EFNA5 | ephrin-A5 | -0.140732 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.135327 |
| VMP1 | vacuole membrane protein 1 | -0.113882 |
| RORA | RAR-related orphan receptor A | -0.100918 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.100884 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0976946 |
| ASPH | aspartate beta-hydroxylase | -0.0967826 |
| PDE10A | phosphodiesterase 10A | -0.0965687 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0945022 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.087987 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0809367 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0796825 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0768612 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0678862 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.0656846 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0637364 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0637188 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0631036 |
| RAD51B | RAD51 paralog B | -0.0592122 |
| DTNA | dystrobrevin, alpha | -0.0556398 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0555505 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0533266 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0528486 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | -0.051369 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0513226 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0512123 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0511168 |
| PCBP3 | poly(rC) binding protein 3 | -0.051043 |
| PARD3 | par-3 family cell polarity regulator | -0.0509149 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0507478 |
| STAG2 | stromal antigen 2 | -0.0505534 |
| CDH13 | cadherin 13 | -0.0504705 |
| PRRC2B | proline-rich coiled-coil 2B | -0.0496259 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0494581 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0491721 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0491051 |
| GRIK1 | glutamate receptor, ionotropic, kainate 1 | -0.0482019 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | -0.0478314 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0465175 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0458762 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0458163 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0455252 |
| NSMCE2 | non-SMC element 2, MMS21 homolog (S. cerevisiae) | -0.0454519 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0439394 |
| PRKCA | protein kinase C, alpha | -0.0431995 |
| NHSL1 | NHS-like 1 | -0.0431576 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0430634 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0410862 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0404048 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0393409 |
| MATR3 | matrin 3 | -0.0390164 |
| NF1 | neurofibromin 1 | -0.0389227 |
| ATXN1 | ataxin 1 | -0.0378892 |
| SETD5 | SET domain containing 5 | -0.0374695 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0372922 |
| GPC6 | glypican 6 | -0.0368083 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0362104 |
| GLG1 | golgi glycoprotein 1 | -0.0354397 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0340248 |
| USP15 | ubiquitin specific peptidase 15 | -0.0327882 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0324372 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.032427 |
| DST | dystonin | -0.0324069 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0321415 |
| BPTF | bromodomain PHD finger transcription factor | -0.03136 |
| ACTG1 | actin gamma 1 | -0.0309942 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0300909 |
| NAV2 | neuron navigator 2 | -0.0299981 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0297415 |
| ANKRD11 | ankyrin repeat domain 11 | -0.028427 |
| DSCAM | Down syndrome cell adhesion molecule | -0.028381 |
| MEF2A | myocyte enhancer factor 2A | -0.0279397 |
| MED13L | mediator complex subunit 13-like | -0.0274483 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0259478 |
| HELZ | helicase with zinc finger | -0.0258241 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0252322 |
| MCL1 | myeloid cell leukemia 1 | -0.0250713 |
| EGFR | epidermal growth factor receptor | -0.0247874 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0244549 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0226704 |
| RBM25 | RNA binding motif protein 25 | -0.0222998 |
| TOP1 | topoisomerase (DNA) I | -0.0212681 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0210061 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0201195 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0199061 |
| FAM13A | family with sequence similarity 13, member A | -0.0192356 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | -0.0181765 |
| RPS8 | ribosomal protein S8 | -0.0177479 |
| FBXW7 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase | -0.0176933 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0168549 |
| FNBP1L | formin binding protein 1-like | -0.0164851 |
| PRELID2 | PRELI domain containing 2 | -0.0163639 |
| INTS6 | integrator complex subunit 6 | -0.0159062 |
| SBF2 | SET binding factor 2 | -0.0157668 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | -0.0156625 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0148379 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.014698 |
| PTMA | prothymosin, alpha | -0.014571 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0128302 |
| CANX | calnexin | -0.0126892 |
