Asciminib_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Asciminib perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Asciminib_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.0583949
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0522497
NTM neurotrimin 0.0472655
ADGRV1 adhesion G protein-coupled receptor V1 0.0453521
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6 0.0437422
CHD1 chromodomain helicase DNA binding protein 1 0.0423784
PTK2 protein tyrosine kinase 2 0.0419436
USP53 ubiquitin specific peptidase 53 0.0397655
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.038831
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0376432
EMP1 epithelial membrane protein 1 0.0355489
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0327609
TNRC6B trinucleotide repeat containing 6B 0.0327568
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0327009
ZNF292 zinc finger protein 292 0.0326524
COL5A2 collagen, type V, alpha 2 0.0324914
THBS1 thrombospondin 1 0.0318252
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.0312505
RAD21 RAD21 homolog (S. pombe) 0.0307584
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0305849
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 0.0305353
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa 0.0303542
SRP54 signal recognition particle 54kDa 0.0301899
FOXP2 forkhead box P2 0.0298951
ADAM9 ADAM metallopeptidase domain 9 0.0293163
NSUN6 NOP2/Sun domain family, member 6 0.0290868
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0289799
KDM3A lysine (K)-specific demethylase 3A 0.0286904
WSB1 WD repeat and SOCS box containing 1 0.0286068
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.0283728
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0281108
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 0.027683
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0273592
TJP2 tight junction protein 2 0.0265461
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0261173
ZNF451 zinc finger protein 451 0.026048
CDC50A cell division cycle 50 P4-ATPase accessory subunit A 0.0257931
COL3A1 collagen, type III, alpha 1 0.0257838
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.025751
TP53BP2 tumor protein p53 binding protein 2 0.0257487
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0256621
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0256113
CKAP5 cytoskeleton associated protein 5 0.0255154
ANLN anillin, actin binding protein 0.0254827
CORO1C coronin, actin binding protein, 1C 0.0254773
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0254083
RBM39 RNA binding motif protein 39 0.0253766
ACTN4 actinin, alpha 4 0.0251686
HMGB2 high mobility group box 2 0.0250799
PICALM phosphatidylinositol binding clathrin assembly protein 0.0250257
TPR translocated promoter region, nuclear basket protein 0.0250175
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.0244468
MAP4 microtubule-associated protein 4 0.0243153
SQSTM1 sequestosome 1 0.0241738
ZNF385D zinc finger protein 385D 0.0241639
CCDC102B coiled-coil domain containing 102B 0.024056
OSBPL6 oxysterol binding protein-like 6 0.0236433
OPHN1 oligophrenin 1 0.0235238
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.023246
RASSF3 Ras association (RalGDS/AF-6) domain family member 3 0.0231568
MAST2 microtubule associated serine/threonine kinase 2 0.023124
FUBP1 far upstream element (FUSE) binding protein 1 0.0225488
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0224996
AHCTF1 AT hook containing transcription factor 1 0.0224158
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0222688
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0222424
TCP1 t-complex 1 0.0221426
ARHGAP5 Rho GTPase activating protein 5 0.0218747
UBE3C ubiquitin protein ligase E3C 0.0217775
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.0217144
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.021638
FGFR1 fibroblast growth factor receptor 1 0.0215979
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 0.0215774
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0215203
ZNF217 zinc finger protein 217 0.0211448
DEPDC1 DEP domain containing 1 0.0211213
NDFIP1 Nedd4 family interacting protein 1 0.0210169
KDM1A lysine (K)-specific demethylase 1A 0.0209153
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0208173
PHIP pleckstrin homology domain interacting protein 0.0206919
HSPA8 heat shock 70kDa protein 8 0.0203512
LCORL ligand dependent nuclear receptor corepressor-like 0.0203297
HIPK1 homeodomain interacting protein kinase 1 0.0202783
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0202488
ARRDC3 arrestin domain containing 3 0.0201833
PRKCI protein kinase C, iota 0.0201362
ENO1 enolase 1, (alpha) 0.0201023
UBE2H ubiquitin-conjugating enzyme E2H 0.019982
ZEB1 zinc finger E-box binding homeobox 1 0.0199589
MED13 mediator complex subunit 13 0.0198873
ASXL1 additional sex combs like transcriptional regulator 1 0.0197193
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0196781
C1ORF21 chromosome 1 open reading frame 21 0.0196729
AHNAK AHNAK nucleoprotein 0.0196612
RTN3 reticulon 3 0.0195527
THRAP3 thyroid hormone receptor associated protein 3 0.0192902
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0192245
AMBRA1 autophagy/beclin-1 regulator 1 0.0191329
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0191265
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 0.0191202

decreased expression

Symbol Name Standardized Value
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.164727
CADM2 cell adhesion molecule 2 -0.109814
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0874136
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0799579
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -0.0690081
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.066655
COL11A1 collagen, type XI, alpha 1 -0.0656316
TSC22D2 TSC22 domain family, member 2 -0.0638063
ITGAV integrin, alpha V -0.0621185
PCBP2 poly(rC) binding protein 2 -0.0542194
RPLP1 ribosomal protein, large, P1 -0.0521086
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0520764
GPC3 glypican 3 -0.0503475
PEG10 paternally expressed 10 -0.0499033
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0479217
RPS6 ribosomal protein S6 -0.047293
ZFAND3 zinc finger, AN1-type domain 3 -0.0453017
TMSB10 thymosin beta 10 -0.0429228
RPS12 ribosomal protein S12 -0.0428987
RPS16 ribosomal protein S16 -0.0421616
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 -0.0417387
FNDC3A fibronectin type III domain containing 3A -0.0412243
NAMPT nicotinamide phosphoribosyltransferase -0.0394409
ANK2 ankyrin 2, neuronal -0.0390586
RPL23 ribosomal protein L23 -0.0383631
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0380281
P4HB prolyl 4-hydroxylase, beta polypeptide -0.03783
PDE4D phosphodiesterase 4D, cAMP-specific -0.0377265
MED13L mediator complex subunit 13-like -0.0363424
SFRP4 secreted frizzled-related protein 4 -0.0361794
FNDC3B fibronectin type III domain containing 3B -0.035873
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0358424
POTEF POTE ankyrin domain family, member F -0.0354095
SMYD3 SET and MYND domain containing 3 -0.0349373
CDC73 cell division cycle 73 -0.0343742
ZC3H12B zinc finger CCCH-type containing 12B -0.0342498
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0338789
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0334929
RPS3 ribosomal protein S3 -0.0328243
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0326355
RPS2 ribosomal protein S2 -0.0323715
RIGI RNA sensor RIG-I -0.032246
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0313134
GNAS GNAS complex locus -0.0309617
PHF3 PHD finger protein 3 -0.0308639
EEF2 eukaryotic translation elongation factor 2 -0.0306873
VIM vimentin -0.0302098
SCFD1 sec1 family domain containing 1 -0.0297058
PDIA3 protein disulfide isomerase family A, member 3 -0.0295649
PNISR PNN-interacting serine/arginine-rich protein -0.029298
LHFPL6 LHFPL tetraspan subfamily member 6 -0.0289432
MTF2 metal response element binding transcription factor 2 -0.0286303
MARCKS myristoylated alanine-rich protein kinase C substrate -0.028598
OLA1 Obg-like ATPase 1 -0.0285784
FNBP1L formin binding protein 1-like -0.0284929
EXOC4 exocyst complex component 4 -0.0282929
NBEAL1 neurobeachin-like 1 -0.0281834
RPL12 ribosomal protein L12 -0.0281764
RPL31 ribosomal protein L31 -0.0275898
ATP5F1B ATP synthase F1 subunit beta -0.0273584
PFN1 profilin 1 -0.0269125
GARS1 glycyl-tRNA synthetase 1 -0.0266779
PARD3B par-3 family cell polarity regulator beta -0.0265373
PCDH9 protocadherin 9 -0.0265064
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0264608
SOX5 SRY (sex determining region Y)-box 5 -0.0263893
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0263865
RPS27 ribosomal protein S27 -0.0259603
ADGRL3 adhesion G protein-coupled receptor L3 -0.0259034
UPP1 uridine phosphorylase 1 -0.0258743
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0257704
HMGB1 high mobility group box 1 -0.0256852
EXT1 exostosin glycosyltransferase 1 -0.0255654
YBX1 Y box binding protein 1 -0.0255376
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0255319
QKI QKI, KH domain containing, RNA binding -0.0254688
RPL30 ribosomal protein L30 -0.0252665
ARHGAP15 Rho GTPase activating protein 15 -0.025172
RPL37 ribosomal protein L37 -0.0251206
PDIA6 protein disulfide isomerase family A, member 6 -0.0251053
NUP58 nucleoporin 58 -0.0249363
FTL ferritin, light polypeptide -0.0247713
ISG15 ISG15 ubiquitin-like modifier -0.0247344
NALF1 NALCN channel auxiliary factor 1 -0.0244875
PA2G4 proliferation-associated 2G4, 38kDa -0.0242456
CCN2 cellular communication network factor 2 -0.0242353
ATP5F1E ATP synthase F1 subunit epsilon -0.024128
RPL9 ribosomal protein L9 -0.0241116
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0239654
RPL35A ribosomal protein L35a -0.0239468
TMEM165 transmembrane protein 165 -0.0237376
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) -0.0237251
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0235174
DLG1 discs, large homolog 1 (Drosophila) -0.0233349
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.023284
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0232205
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0229989
METAP2 methionyl aminopeptidase 2 -0.0229869
DENND1A DENN/MADD domain containing 1A -0.0229568
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit -0.0228062