Asciminib_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Asciminib perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Asciminib_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EIF4A2 eukaryotic translation initiation factor 4A2 0.128112
TMSB4X thymosin beta 4, X-linked 0.103311
GOLGA4 golgin A4 0.069516
SQSTM1 sequestosome 1 0.0662215
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0639027
DSCAM Down syndrome cell adhesion molecule 0.0608844
ZNF292 zinc finger protein 292 0.0565159
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0536844
CD47 CD47 molecule 0.0534534
CAMTA1 calmodulin binding transcription activator 1 0.0503169
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0479317
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.043948
ZEB1 zinc finger E-box binding homeobox 1 0.0423769
RPL3 ribosomal protein L3 0.0419344
CRY1 cryptochrome circadian clock 1 0.0419274
TMEM65 transmembrane protein 65 0.0417243
NBAS neuroblastoma amplified sequence 0.0416179
ZFAND3 zinc finger, AN1-type domain 3 0.0415531
PLK2 polo-like kinase 2 0.0406141
EVI5 ecotropic viral integration site 5 0.0406031
GSK3B glycogen synthase kinase 3 beta 0.0400853
RTN4 reticulon 4 0.0395703
SOX6 SRY (sex determining region Y)-box 6 0.039149
ADAM10 ADAM metallopeptidase domain 10 0.0388262
TXNIP thioredoxin interacting protein 0.0387608
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.0385595
NCKAP1 NCK-associated protein 1 0.0382612
PRPF38B pre-mRNA processing factor 38B 0.036099
CCNL1 cyclin L1 0.0352587
COPA coatomer protein complex, subunit alpha 0.0349055
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0348331
XPO1 exportin 1 0.0347261
ZNF644 zinc finger protein 644 0.0342872
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.0342242
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0339405
COG5 component of oligomeric golgi complex 5 0.0335137
ELOVL5 ELOVL fatty acid elongase 5 0.0328649
ECT2 epithelial cell transforming 2 0.0328108
ADAM9 ADAM metallopeptidase domain 9 0.0325535
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0325411
ZNF608 zinc finger protein 608 0.03183
CASC3 cancer susceptibility candidate 3 0.0316275
KDM6A lysine (K)-specific demethylase 6A 0.0312692
KMT2E lysine (K)-specific methyltransferase 2E 0.0309052
VMP1 vacuole membrane protein 1 0.0305851
NUP58 nucleoporin 58 0.0305187
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0304715
WDR43 WD repeat domain 43 0.0303189
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0301901
YAP1 Yes-associated protein 1 0.0299652
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0297957
RBM25 RNA binding motif protein 25 0.0294898
RAD23B RAD23 homolog B (S. cerevisiae) 0.0294718
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0293104
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0286715
RPL4 ribosomal protein L4 0.0285945
PDGFC platelet derived growth factor C 0.0284278
ECPAS Ecm29 proteasome adaptor and scaffold 0.0281325
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0276576
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0275338
SUCO SUN domain containing ossification factor 0.0269006
TM9SF3 transmembrane 9 superfamily member 3 0.0268222
DENND4A DENN/MADD domain containing 4A 0.0265317
PTEN phosphatase and tensin homolog 0.0264605
PTBP2 polypyrimidine tract binding protein 2 0.0264114
SCAF8 SR-related CTD-associated factor 8 0.0260261
BIRC6 baculoviral IAP repeat containing 6 0.0257993
CDC73 cell division cycle 73 0.0257602
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0257572
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0256931
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.025641
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.025618
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0255642
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.0255132
YTHDC1 YTH domain containing 1 0.0255056
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0254439
AMOTL2 angiomotin like 2 0.0253332
CHD1 chromodomain helicase DNA binding protein 1 0.0252883
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0252054
EML4 echinoderm microtubule associated protein like 4 0.0251437
COG6 component of oligomeric golgi complex 6 0.0249707
PUM2 pumilio RNA-binding family member 2 0.0246799
TNRC6B trinucleotide repeat containing 6B 0.0243924
QKI QKI, KH domain containing, RNA binding 0.0241227
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0240685
CEP250 centrosomal protein 250kDa 0.0239126
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.023857
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.0238188
OGA O-GlcNAcase 0.0238142
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0235739
PCBP2 poly(rC) binding protein 2 0.023519
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0234876
NCEH1 neutral cholesterol ester hydrolase 1 0.0233708
SPRED2 sprouty-related, EVH1 domain containing 2 0.0231914
SET SET nuclear proto-oncogene 0.0231676
CEP95 centrosomal protein 95kDa 0.0230728
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0229979
SEC23A Sec23 homolog A (S. cerevisiae) 0.0227693
ANKRD12 ankyrin repeat domain 12 0.0226402
USP9X ubiquitin specific peptidase 9, X-linked 0.0223706

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.26679
PTMA prothymosin, alpha -0.223893
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.129922
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.10701
TPT1 tumor protein, translationally-controlled 1 -0.101265
PDE4D phosphodiesterase 4D, cAMP-specific -0.0991276
FOXP1 forkhead box P1 -0.0974069
RPS6 ribosomal protein S6 -0.0818617
RPS8 ribosomal protein S8 -0.0760817
ACTG1 actin gamma 1 -0.0724138
GLI3 GLI family zinc finger 3 -0.06676
RPL35A ribosomal protein L35a -0.0640418
PKM pyruvate kinase, muscle -0.0622662
RPL34 ribosomal protein L34 -0.0564557
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0504409
RPLP1 ribosomal protein, large, P1 -0.0501722
MYO5C myosin VC -0.0499178
PDE4B phosphodiesterase 4B, cAMP-specific -0.0496281
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0488101
NPAS2 neuronal PAS domain protein 2 -0.0487956
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0474247
RPL9 ribosomal protein L9 -0.0456122
RPS19 ribosomal protein S19 -0.0445398
RPL26 ribosomal protein L26 -0.0440374
TMSB10 thymosin beta 10 -0.043736
RPL31 ribosomal protein L31 -0.042211
RPL36 ribosomal protein L36 -0.0416786
GLI2 GLI family zinc finger 2 -0.041386
S100A6 S100 calcium binding protein A6 -0.0408414
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0402464
RPLP2 ribosomal protein, large, P2 -0.0398598
BMP10 bone morphogenetic protein 10 -0.0393083
RPS25 ribosomal protein S25 -0.0379232
RPL8 ribosomal protein L8 -0.0370078
CCND1 cyclin D1 -0.0365261
RPS29 ribosomal protein S29 -0.0363713
EGFR epidermal growth factor receptor -0.036239
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0351529
RPS21 ribosomal protein S21 -0.0342121
PFN1 profilin 1 -0.0340523
DLG1 discs, large homolog 1 (Drosophila) -0.0340184
RACK1 receptor for activated C kinase 1 -0.033811
RPL7A ribosomal protein L7a -0.0337896
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0337622
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 -0.0335227
S100A10 S100 calcium binding protein A10 -0.0328781
RPL32 ribosomal protein L32 -0.0322726
S100A4 S100 calcium binding protein A4 -0.0322443
RPS23 ribosomal protein S23 -0.0318363
HSPB1 heat shock 27kDa protein 1 -0.0311285
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -0.0310265
RPL19 ribosomal protein L19 -0.0310058
RPL23 ribosomal protein L23 -0.0307352
RPS13 ribosomal protein S13 -0.0306876
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0305251
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -0.0302726
AHNAK AHNAK nucleoprotein -0.030233
NFIA nuclear factor I/A -0.0301356
S100A9 S100 calcium binding protein A9 -0.0299205
RPS16 ribosomal protein S16 -0.0298622
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0296557
IFI16 interferon, gamma-inducible protein 16 -0.029603
HDAC9 histone deacetylase 9 -0.0293091
ARL4C ADP-ribosylation factor-like 4C -0.0286722
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 -0.0285607
RPL11 ribosomal protein L11 -0.0281053
TM4SF1 transmembrane 4 L six family member 1 -0.0277793
DPYD dihydropyrimidine dehydrogenase -0.0277646
PRUNE2 prune homolog 2 (Drosophila) -0.027756
RPL28 ribosomal protein L28 -0.027624
RPLP0 ribosomal protein, large, P0 -0.026
DIAPH3 diaphanous-related formin 3 -0.025403
GSE1 Gse1 coiled-coil protein -0.0252585
EXOC6B exocyst complex component 6B -0.0252441
FTL ferritin, light polypeptide -0.0248005
NAV2 neuron navigator 2 -0.0246133
BABAM2 BRISC and BRCA1 A complex member 2 -0.0245999
RPS15 ribosomal protein S15 -0.0238302
SP100 SP100 nuclear antigen -0.0232741
RPS27 ribosomal protein S27 -0.0229794
RIGI RNA sensor RIG-I -0.0229478
RABGAP1L RAB GTPase activating protein 1-like -0.0228205
BMP2K BMP2 inducible kinase -0.0227777
CEP112 centrosomal protein 112kDa -0.022761
NBEA neurobeachin -0.0227303
PDE7B phosphodiesterase 7B -0.0225173
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.022407
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -0.0223448
CUX1 cut-like homeobox 1 -0.0219355
TUBB tubulin, beta class I -0.0217451
SMYD3 SET and MYND domain containing 3 -0.021733
RPS27A ribosomal protein S27a -0.0216765
HMGB1 high mobility group box 1 -0.0216459
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0215324
FLNB filamin B, beta -0.0212926
RPL37A ribosomal protein L37a -0.021277
HLA-B major histocompatibility complex, class I, B -0.0210868
BPTF bromodomain PHD finger transcription factor -0.0210043
RPS2 ribosomal protein S2 -0.0209079
ANXA1 annexin A1 -0.0207185