| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/179340 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in Asimadoline relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PCSK9 | proprotein convertase subtilisin/kexin type 9 | 0.6 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | 0.56 |
| APOB | apolipoprotein B | 0.55 |
| ABTB1 | ankyrin repeat and BTB (POZ) domain containing 1 | 0.55 |
| SLC38A2 | solute carrier family 38, member 2 | 0.53 |
| JAK2 | Janus kinase 2 | 0.52 |
| SPTB | spectrin, beta, erythrocytic | 0.51 |
| SLC1A3 | solute carrier family 1 (glial high affinity glutamate transporter), member 3 | 0.49 |
| PDE9A | phosphodiesterase 9A | 0.49 |
| RNF13 | ring finger protein 13 | 0.49 |
| SOX4 | SRY (sex determining region Y)-box 4 | 0.49 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.49 |
| NDFIP2 | Nedd4 family interacting protein 2 | 0.49 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | 0.48 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.48 |
| SDCBP | syndecan binding protein (syntenin) | 0.47 |
| RETREG1 | reticulophagy regulator 1 | 0.44 |
| BMP4 | bone morphogenetic protein 4 | 0.44 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.43 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.43 |
| MOSPD3 | motile sperm domain containing 3 | 0.43 |
| ZBTB9 | zinc finger and BTB domain containing 9 | 0.42 |
| FAM102A | family with sequence similarity 102, member A | 0.42 |
| LMBRD1 | LMBR1 domain containing 1 | 0.42 |
| NEBL | nebulette | 0.42 |
| TP73 | tumor protein p73 | 0.42 |
| KLHDC8B | kelch domain containing 8B | 0.42 |
| IDI1 | isopentenyl-diphosphate delta isomerase 1 | 0.41 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.41 |
| PHF1 | PHD finger protein 1 | 0.41 |
| ERG28 | ergosterol biosynthesis 28 homolog | 0.4 |
| ELOVL6 | ELOVL fatty acid elongase 6 | 0.39 |
| FAM189B | family with sequence similarity 189, member B | 0.39 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.39 |
| DCAF10 | DDB1 and CUL4 associated factor 10 | 0.38 |
| BDNF | brain-derived neurotrophic factor | 0.38 |
| CSNK1G3 | casein kinase 1, gamma 3 | 0.38 |
| ZCCHC17 | zinc finger, CCHC domain containing 17 | 0.38 |
| TMEM104 | transmembrane protein 104 | 0.38 |
| YAF2 | YY1 associated factor 2 | 0.38 |
| MAP3K12 | mitogen-activated protein kinase kinase kinase 12 | 0.38 |
| SRD5A3 | steroid 5 alpha-reductase 3 | 0.38 |
| MAP3K6 | mitogen-activated protein kinase kinase kinase 6 | 0.37 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | 0.37 |
| MISP3 | MISP family member 3 | 0.36 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | 0.36 |
| TTC31 | tetratricopeptide repeat domain 31 | 0.36 |
| DNAH1 | dynein, axonemal, heavy chain 1 | 0.36 |
| ADCY6 | adenylate cyclase 6 | 0.35 |
| FAM221A | family with sequence similarity 221, member A | 0.35 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.35 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.35 |
| OSCP1 | organic solute carrier partner 1 | 0.35 |
| CCDC102A | coiled-coil domain containing 102A | 0.35 |
| FAR1 | fatty acyl CoA reductase 1 | 0.35 |
| FAM126B | family with sequence similarity 126, member B | 0.34 |
| B9D1 | B9 protein domain 1 | 0.34 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.34 |
| AIF1L | allograft inflammatory factor 1-like | 0.34 |
| ZZZ3 | zinc finger, ZZ-type containing 3 | 0.33 |
| PLPP2 | phospholipid phosphatase 2 | 0.33 |
| KANK2 | KN motif and ankyrin repeat domains 2 | 0.33 |
| GPRC5C | G protein-coupled receptor, class C, group 5, member C | 0.33 |
| TBC1D16 | TBC1 domain family, member 16 | 0.33 |
| MRS2 | MRS2 magnesium transporter | 0.32 |
| NDRG2 | NDRG family member 2 | 0.32 |
| ARHGEF17 | Rho guanine nucleotide exchange factor (GEF) 17 | 0.32 |
| HIST2H2AA3 | histone cluster 2, H2aa3 | 0.32 |
| AGAP2 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 | 0.32 |
| FBXO17 | F-box protein 17 | 0.32 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.32 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | 0.31 |
| CTTNBP2 | cortactin binding protein 2 | 0.31 |
| SERINC1 | serine incorporator 1 | 0.31 |
| JADE2 | jade family PHD finger 2 | 0.31 |
| THEMIS2 | thymocyte selection associated family member 2 | 0.31 |
| PLEKHA3 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3 | 0.31 |
| ARHGAP28 | Rho GTPase activating protein 28 | 0.31 |
| PHLDB1 | pleckstrin homology-like domain, family B, member 1 | 0.31 |
| STARD10 | StAR-related lipid transfer (START) domain containing 10 | 0.31 |
| RASSF2 | Ras association (RalGDS/AF-6) domain family member 2 | 0.31 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.31 |
| ITGB8 | integrin, beta 8 | 0.3 |
| ATG12 | autophagy related 12 | 0.3 |
| PCGF3 | polycomb group ring finger 3 | 0.3 |
| TNS3 | tensin 3 | 0.3 |
| ZCCHC24 | zinc finger, CCHC domain containing 24 | 0.3 |
| TGFBR1 | transforming growth factor, beta receptor 1 | 0.3 |
| DSE | dermatan sulfate epimerase | 0.3 |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) | 0.3 |
| RASGRP2 | RAS guanyl releasing protein 2 (calcium and DAG-regulated) | 0.3 |
| SLX4IP | SLX4 interacting protein | 0.3 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.3 |
| VWA5B2 | von Willebrand factor A domain containing 5B2 | 0.3 |
| RSAD1 | radical S-adenosyl methionine domain containing 1 | 0.3 |
| UBE3D | ubiquitin protein ligase E3D | 0.3 |
| FAN1 | FANCD2/FANCI-associated nuclease 1 | 0.3 |
| ARRB1 | arrestin, beta 1 | 0.29 |
| CEBPZOS | CEBPZ opposite strand | 0.29 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FGG | fibrinogen gamma chain | -5.4 |
| CNTRL | centriolin | -2.56 |
| ITGAM | integrin, alpha M (complement component 3 receptor 3 subunit) | -2.28 |
| ANKRD36 | ankyrin repeat domain 36 | -2.27 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | -2.1 |
| TTN | titin | -1.91 |
| ARHGDIB | Rho GDP dissociation inhibitor (GDI) beta | -1.62 |
| VIM | vimentin | -1.6 |
| CCDC112 | coiled-coil domain containing 112 | -1.42 |
| SMPD1 | sphingomyelin phosphodiesterase 1, acid lysosomal | -1.33 |
| MCM9 | minichromosome maintenance complex component 9 | -1.32 |
| FGA | fibrinogen alpha chain | -1.19 |
| SEMG1 | semenogelin I | -1.18 |
| PCLO | piccolo presynaptic cytomatrix protein | -1.05 |
| KIAA1210 | KIAA1210 | -0.96 |
| HAL | histidine ammonia-lyase | -0.93 |
| ZNRF1 | zinc and ring finger 1, E3 ubiquitin protein ligase | -0.9 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.9 |
| NCKAP1L | NCK-associated protein 1-like | -0.88 |
| DNAH6 | dynein, axonemal, heavy chain 6 | -0.87 |
| RGN | regucalcin | -0.86 |
| MSLN | mesothelin | -0.84 |
| FGB | fibrinogen beta chain | -0.83 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | -0.83 |
| GREB1 | growth regulation by estrogen in breast cancer 1 | -0.79 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | -0.78 |
| NAAA | N-acylethanolamine acid amidase | -0.78 |
| LCP1 | lymphocyte cytosolic protein 1 (L-plastin) | -0.78 |
| TRIM29 | tripartite motif containing 29 | -0.74 |
| WDR20 | WD repeat domain 20 | -0.72 |
| B2M | beta-2-microglobulin | -0.62 |
| CRISPLD2 | cysteine-rich secretory protein LCCL domain containing 2 | -0.62 |
| TMSB10 | thymosin beta 10 | -0.6 |
| ENO1 | enolase 1, (alpha) | -0.56 |
| SLC16A6 | solute carrier family 16, member 6 | -0.55 |
| TOR2A | torsin family 2, member A | -0.54 |
| FOSL1 | FOS-like antigen 1 | -0.54 |
| C7 | complement component 7 | -0.52 |
| ASAH1 | N-acylsphingosine amidohydrolase (acid ceramidase) 1 | -0.48 |
| FDXACB1 | ferredoxin-fold anticodon binding domain containing 1 | -0.48 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.48 |
| ZNF3 | zinc finger protein 3 | -0.48 |
| STX1A | syntaxin 1A (brain) | -0.47 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.46 |
| UPP1 | uridine phosphorylase 1 | -0.45 |
| FOXM1 | forkhead box M1 | -0.44 |
| ZDHHC12 | zinc finger, DHHC-type containing 12 | -0.43 |
| ITGB2 | integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) | -0.43 |
| CORO1A | coronin, actin binding protein, 1A | -0.43 |
| RNF8 | ring finger protein 8, E3 ubiquitin protein ligase | -0.43 |
| WASF3 | WAS protein family, member 3 | -0.41 |
| HOXB9 | homeobox B9 | -0.41 |
| MSANTD2 | Myb/SANT-like DNA-binding domain containing 2 | -0.4 |
| ZDHHC8 | zinc finger, DHHC-type containing 8 | -0.39 |
| FOXRED2 | FAD-dependent oxidoreductase domain containing 2 | -0.39 |
| PES1 | pescadillo ribosomal biogenesis factor 1 | -0.39 |
| ARSD | arylsulfatase D | -0.39 |
| CR2 | complement component (3d/Epstein Barr virus) receptor 2 | -0.39 |
| LRFN4 | leucine rich repeat and fibronectin type III domain containing 4 | -0.38 |
| SESN2 | sestrin 2 | -0.38 |
| NRP1 | neuropilin 1 | -0.38 |
| ODC1 | ornithine decarboxylase 1 | -0.37 |
| OXNAD1 | oxidoreductase NAD-binding domain containing 1 | -0.36 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.36 |
| RWDD2B | RWD domain containing 2B | -0.36 |
| ZNF22 | zinc finger protein 22 | -0.36 |
| NAGS | N-acetylglutamate synthase | -0.36 |
| DNLZ | DNL-type zinc finger | -0.35 |
| CLTCL1 | clathrin, heavy chain-like 1 | -0.35 |
| ZFP36 | ZFP36 ring finger protein | -0.35 |
| FBXL6 | F-box and leucine-rich repeat protein 6 | -0.34 |
| SUMF1 | sulfatase modifying factor 1 | -0.34 |
| STC2 | stanniocalcin 2 | -0.34 |
| TSLIG3C | tRNA splicing ligase complex subunit 3C | -0.33 |
| SDCCAG8 | serologically defined colon cancer antigen 8 | -0.33 |
| UBXN8 | UBX domain protein 8 | -0.33 |
| TNNC2 | troponin C type 2 (fast) | -0.33 |
| MPND | MPN domain containing | -0.33 |
| PET100 | PET100 homolog (S. cerevisiae) | -0.33 |
| MT-CO1 | cytochrome c oxidase subunit I | -0.33 |
| SLC43A2 | solute carrier family 43 (amino acid system L transporter), member 2 | -0.33 |
| NAGA | N-acetylgalactosaminidase, alpha- | -0.33 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.32 |
| TMPO | thymopoietin | -0.32 |
| FMNL1 | formin-like 1 | -0.32 |
| STARD13 | StAR-related lipid transfer (START) domain containing 13 | -0.32 |
| ARMCX5 | armadillo repeat containing, X-linked 5 | -0.31 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.31 |
| ADCY9 | adenylate cyclase 9 | -0.31 |
| EVL | Enah/Vasp-like | -0.31 |
| PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | -0.31 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.31 |
| ZNF200 | zinc finger protein 200 | -0.31 |
| TOMM5 | translocase of outer mitochondrial membrane 5 homolog (yeast) | -0.31 |
| PPT1 | palmitoyl-protein thioesterase 1 | -0.3 |
| GLRX | glutaredoxin (thioltransferase) | -0.3 |
| ITPRIPL1 | inositol 1,4,5-trisphosphate receptor interacting protein-like 1 | -0.3 |
| HLA-B | major histocompatibility complex, class I, B | -0.3 |
| AP1S2 | adaptor-related protein complex 1, sigma 2 subunit | -0.29 |
| CDC20 | cell division cycle 20 | -0.29 |
