Aspirin_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Aspirin perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Aspirin_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TENT5A terminal nucleotidyltransferase 5A 0.046637
MEIS2 Meis homeobox 2 0.0463172
VCL vinculin 0.0386206
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0356696
ITPRID2 ITPR interacting domain containing 2 0.0330517
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0325935
PSD3 pleckstrin and Sec7 domain containing 3 0.0320741
VMP1 vacuole membrane protein 1 0.0314176
ARID5B AT rich interactive domain 5B (MRF1-like) 0.0291797
ZSWIM6 zinc finger, SWIM-type containing 6 0.0272881
MBNL2 muscleblind-like splicing regulator 2 0.026614
VEGFA vascular endothelial growth factor A 0.0258959
SRP54 signal recognition particle 54kDa 0.02267
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0224218
RB1CC1 RB1-inducible coiled-coil 1 0.0219943
DSCAM Down syndrome cell adhesion molecule 0.0215545
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.020682
ZNF292 zinc finger protein 292 0.0204283
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0200613
CD46 CD46 molecule, complement regulatory protein 0.019687
STC1 stanniocalcin 1 0.0194849
FNDC3A fibronectin type III domain containing 3A 0.0194829
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0193618
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0192997
DDB2 damage-specific DNA binding protein 2, 48kDa 0.0187745
GSK3B glycogen synthase kinase 3 beta 0.018518
PRPF8 pre-mRNA processing factor 8 0.0184715
TBC1D22A TBC1 domain family, member 22A 0.016845
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 0.0165266
EIF4B eukaryotic translation initiation factor 4B 0.0165096
DISP1 dispatched homolog 1 (Drosophila) 0.0164968
TLE4 transducin-like enhancer of split 4 0.0164587
AHR aryl hydrocarbon receptor 0.0164428
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0159655
BLTP1 bridge-like lipid transfer protein family member 1 0.0159612
ADAM20 ADAM metallopeptidase domain 20 0.015841
TPST1 tyrosylprotein sulfotransferase 1 0.0158162
DIAPH3 diaphanous-related formin 3 0.0157258
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 0.0154658
METTL15 methyltransferase like 15 0.0154025
GLCCI1 glucocorticoid induced 1 0.0153814
RFC3 replication factor C (activator 1) 3, 38kDa 0.0153301
NGLY1 N-glycanase 1 0.0153284
SNX14 sorting nexin 14 0.0149455
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0148878
WDR49 WD repeat domain 49 0.0147251
PLAT plasminogen activator, tissue 0.0146603
NRIP1 nuclear receptor interacting protein 1 0.0145656
MBD5 methyl-CpG binding domain protein 5 0.0145317
CNOT1 CCR4-NOT transcription complex, subunit 1 0.014243
CEP152 centrosomal protein 152kDa 0.0141364
CASC3 cancer susceptibility candidate 3 0.0140894
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0139903
NBAS neuroblastoma amplified sequence 0.0136982
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0136225
CENPF centromere protein F, 350/400kDa 0.0135305
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0134742
COG6 component of oligomeric golgi complex 6 0.0134701
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0131445
FN1 fibronectin 1 0.0131173
UBE3C ubiquitin protein ligase E3C 0.0129882
N4BP2L2 NEDD4 binding protein 2-like 2 0.0128716
AVL9 AVL9 homolog (S. cerevisiase) 0.0128271
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0128256
CEP192 centrosomal protein 192kDa 0.0127579
OGA O-GlcNAcase 0.0127302
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 0.0126259
ETNK1 ethanolamine kinase 1 0.0124562
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.01243
ZZZ3 zinc finger, ZZ-type containing 3 0.0123589
KIAA1217 KIAA1217 0.0123258
ZNF638 zinc finger protein 638 0.0122016
FER fer (fps/fes related) tyrosine kinase 0.0121844
WWTR1 WW domain containing transcription regulator 1 0.0121048
CBX5 chromobox homolog 5 0.0120083
SEC14L1 SEC14-like 1 (S. cerevisiae) 0.0119601
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0118923
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0118464
IL6ST interleukin 6 signal transducer 0.0118104
SECISBP2 SECIS binding protein 2 0.0117447
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 0.0117129
KAT6B K(lysine) acetyltransferase 6B 0.0117046
ZMAT3 zinc finger, matrin-type 3 0.0116734
RBMS1 RNA binding motif, single stranded interacting protein 1 0.0115678
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0115476
USPL1 ubiquitin specific peptidase like 1 0.0115314
PCF11 PCF11 cleavage and polyadenylation factor subunit 0.0114972
ARHGAP26 Rho GTPase activating protein 26 0.0114847
PCTP phosphatidylcholine transfer protein 0.0114681
USP33 ubiquitin specific peptidase 33 0.0114037
RUNX1 runt-related transcription factor 1 0.0113848
GOLPH3L golgi phosphoprotein 3-like 0.0113795
LYSMD3 LysM, putative peptidoglycan-binding, domain containing 3 0.0113342
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 0.0112513
BCL2L13 BCL2-like 13 (apoptosis facilitator) 0.0112164
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) 0.0112159
ASTL astacin-like metallo-endopeptidase (M12 family) 0.0111607
KAT7 K(lysine) acetyltransferase 7 0.0111305
SNU13 small nuclear ribonucleoprotein 13 0.0111026
ELP3 elongator acetyltransferase complex subunit 3 0.0110915

decreased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.320366
IGF2 insulin-like growth factor 2 -0.170528
NRG1 neuregulin 1 -0.168376
LSAMP limbic system-associated membrane protein -0.165034
PTMA prothymosin, alpha -0.157507
NALF1 NALCN channel auxiliary factor 1 -0.136429
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.134427
VIM vimentin -0.106563
RPS6 ribosomal protein S6 -0.102466
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0995947
RPL23 ribosomal protein L23 -0.0968279
AKAP12 A kinase (PRKA) anchor protein 12 -0.0896183
RPLP1 ribosomal protein, large, P1 -0.083664
ACTG1 actin gamma 1 -0.0763677
SYT1 synaptotagmin I -0.0736865
TPT1 tumor protein, translationally-controlled 1 -0.0736829
RPL35A ribosomal protein L35a -0.0724645
TRIO trio Rho guanine nucleotide exchange factor -0.0717665
COL1A1 collagen, type I, alpha 1 -0.0712514
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0706539
THSD4 thrombospondin, type I, domain containing 4 -0.0694148
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0643822
TMSB10 thymosin beta 10 -0.0642324
LPIN1 lipin 1 -0.063471
EXT1 exostosin glycosyltransferase 1 -0.0629638
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0614435
RPL38 ribosomal protein L38 -0.0573749
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0573248
RPL19 ribosomal protein L19 -0.0564339
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0544768
TRIB2 tribbles pseudokinase 2 -0.0520049
MAP1B microtubule-associated protein 1B -0.052
RPS24 ribosomal protein S24 -0.0519292
COL3A1 collagen, type III, alpha 1 -0.0517989
FTL ferritin, light polypeptide -0.0517627
B2M beta-2-microglobulin -0.0514271
FMN1 formin 1 -0.0503305
KPNB1 karyopherin (importin) beta 1 -0.0503292
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0488399
RPS12 ribosomal protein S12 -0.0486072
BCAS3 breast carcinoma amplified sequence 3 -0.0472131
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0467519
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0459415
CUX1 cut-like homeobox 1 -0.0455849
RPL34 ribosomal protein L34 -0.0451822
CADM2 cell adhesion molecule 2 -0.0441549
HIP1 huntingtin interacting protein 1 -0.043488
PTPRD protein tyrosine phosphatase, receptor type, D -0.0431653
ZNF804A zinc finger protein 804A -0.0429657
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0414054
NAP1L1 nucleosome assembly protein 1-like 1 -0.0410988
RPL26 ribosomal protein L26 -0.040861
RPS3 ribosomal protein S3 -0.0408175
RPL36 ribosomal protein L36 -0.040058
MSI2 musashi RNA-binding protein 2 -0.0398025
PARD3 par-3 family cell polarity regulator -0.0396805
IER3 immediate early response 3 -0.0391031
AHNAK AHNAK nucleoprotein -0.0386866
EIF1 eukaryotic translation initiation factor 1 -0.0381868
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0377544
H3-3B H3.3 histone B -0.0363997
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 -0.0357201
SP100 SP100 nuclear antigen -0.0356511
BPTF bromodomain PHD finger transcription factor -0.0355664
RPS27 ribosomal protein S27 -0.0353955
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0352984
CCND1 cyclin D1 -0.0352425
GNAS GNAS complex locus -0.0349239
DNAH14 dynein, axonemal, heavy chain 14 -0.034802
RPL12 ribosomal protein L12 -0.0342269
EIF5B eukaryotic translation initiation factor 5B -0.034225
RPS17 ribosomal protein S17 -0.0340156
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0336247
COL4A5 collagen, type IV, alpha 5 -0.0335986
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0335967
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0332927
RPL31 ribosomal protein L31 -0.0332443
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0328682
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0324427
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0324136
BICD1 bicaudal D homolog 1 (Drosophila) -0.0323117
MEF2A myocyte enhancer factor 2A -0.0320782
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0320117
TPM4 tropomyosin 4 -0.0319909
RPS25 ribosomal protein S25 -0.0315083
RPL32 ribosomal protein L32 -0.0312985
RPL37A ribosomal protein L37a -0.031204
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0311459
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0310222
CRH corticotropin releasing hormone -0.0309726
PRKCA protein kinase C, alpha -0.0304419
CALR calreticulin -0.0301674
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0299132
RPS14 ribosomal protein S14 -0.0298578
IFI16 interferon, gamma-inducible protein 16 -0.0295949
RPL7A ribosomal protein L7a -0.0294637
RPS19 ribosomal protein S19 -0.0293308
PTPRK protein tyrosine phosphatase, receptor type, K -0.0292042
GREM2 gremlin 2, DAN family BMP antagonist -0.0288318
RPL37 ribosomal protein L37 -0.0285931