Aspirin_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Aspirin perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Aspirin_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.12432
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.083664
FAT1 FAT atypical cadherin 1 0.0805726
PTBP3 polypyrimidine tract binding protein 3 0.0802159
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0789499
ABHD2 abhydrolase domain containing 2 0.0667237
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0665671
IFNGR1 interferon gamma receptor 1 0.0619132
RHOBTB3 Rho-related BTB domain containing 3 0.0592256
TXNIP thioredoxin interacting protein 0.0580804
STK24 serine/threonine kinase 24 0.0577729
TSC22D1 TSC22 domain family, member 1 0.0568449
SRRM2 serine/arginine repetitive matrix 2 0.0503589
N4BP2L2 NEDD4 binding protein 2-like 2 0.0495186
C6ORF132 chromosome 6 open reading frame 132 0.0484746
LIMA1 LIM domain and actin binding 1 0.0476197
NRIP1 nuclear receptor interacting protein 1 0.0466053
MACC1 metastasis associated in colon cancer 1 0.0465935
RNF149 ring finger protein 149 0.0459177
RNF43 ring finger protein 43 0.0457765
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0450739
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0433159
SPRED1 sprouty-related, EVH1 domain containing 1 0.0429766
PDZD8 PDZ domain containing 8 0.0404993
YAP1 Yes-associated protein 1 0.0397531
FTH1 ferritin, heavy polypeptide 1 0.03811
IL20RA interleukin 20 receptor, alpha 0.0375247
B2M beta-2-microglobulin 0.0357174
CTNND1 catenin (cadherin-associated protein), delta 1 0.0354387
KMT2E lysine (K)-specific methyltransferase 2E 0.0348045
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0343246
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.032269
ZFP36L1 ZFP36 ring finger protein-like 1 0.0309314
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0304608
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0299908
AKAP13 A kinase (PRKA) anchor protein 13 0.0289644
POTEF POTE ankyrin domain family, member F 0.0288957
ADAM10 ADAM metallopeptidase domain 10 0.0287541
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0285977
SREBF2 sterol regulatory element binding transcription factor 2 0.0285462
ANXA4 annexin A4 0.028448
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0282586
MICU2 mitochondrial calcium uptake 2 0.0274466
UBE2H ubiquitin-conjugating enzyme E2H 0.0273168
UBC ubiquitin C 0.0272306
CDCP1 CUB domain containing protein 1 0.0266223
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0262081
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0259276
ARHGAP5 Rho GTPase activating protein 5 0.0258099
ARGLU1 arginine and glutamate rich 1 0.0251489
LCN2 lipocalin 2 0.0250089
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.0246417
RBM33 RNA binding motif protein 33 0.0243779
VEGFA vascular endothelial growth factor A 0.0243736
SH3RF1 SH3 domain containing ring finger 1 0.0241861
ZNF148 zinc finger protein 148 0.0240867
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0239669
FNIP1 folliculin interacting protein 1 0.0237978
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0237495
SMAD3 SMAD family member 3 0.0233267
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0230084
ASPH aspartate beta-hydroxylase 0.0229332
TPM3 tropomyosin 3 0.0225266
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0219409
DIAPH1 diaphanous-related formin 1 0.0219285
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0215068
KLF3 Kruppel-like factor 3 (basic) 0.0212895
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0211603
ZDHHC20 zinc finger, DHHC-type containing 20 0.0211412
PLS1 plastin 1 0.0209622
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 0.0209139
BCL2L1 BCL2-like 1 0.0208718
PIAS1 protein inhibitor of activated STAT, 1 0.0207874
UBL3 ubiquitin-like 3 0.0206849
TM9SF3 transmembrane 9 superfamily member 3 0.0206542
TJP2 tight junction protein 2 0.0206107
SP3 Sp3 transcription factor 0.0204039
OARD1 O-acyl-ADP-ribose deacylase 1 0.0202723
BAZ2A bromodomain adjacent to zinc finger domain, 2A 0.0202373
B3GNT5 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 0.0200909
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31) 0.0198729
MAP7 microtubule-associated protein 7 0.0193024
DSCAM Down syndrome cell adhesion molecule 0.0192487
RAD23B RAD23 homolog B (S. cerevisiae) 0.0191858
PGK1 phosphoglycerate kinase 1 0.0191758
MKRN1 makorin ring finger protein 1 0.0190291
SERINC5 serine incorporator 5 0.0190118
CD46 CD46 molecule, complement regulatory protein 0.0190036
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.0189024
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 0.0187423
LDHA lactate dehydrogenase A 0.0184939
MYH9 myosin, heavy chain 9, non-muscle 0.018453
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0184214
RBM26 RNA binding motif protein 26 0.0184009
RPS8 ribosomal protein S8 0.0181126
NCKAP5 NCK-associated protein 5 0.0180409
CCDC6 coiled-coil domain containing 6 0.0180013
RPS6 ribosomal protein S6 0.017921
EPHB2 EPH receptor B2 0.0177989
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0175903

decreased expression

Symbol Name Standardized Value
SQSTM1 sequestosome 1 -0.151655
TPT1 tumor protein, translationally-controlled 1 -0.146321
INTS6 integrator complex subunit 6 -0.139658
STAT1 signal transducer and activator of transcription 1, 91kDa -0.139205
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.132626
RIGI RNA sensor RIG-I -0.128914
RNF213 ring finger protein 213 -0.128118
LMO7 LIM domain 7 -0.125039
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.114798
GMDS GDP-mannose 4,6-dehydratase -0.110075
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -0.109448
EZR ezrin -0.101525
SP100 SP100 nuclear antigen -0.0996114
ANXA2 annexin A2 -0.0951826
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0895677
BTBD9 BTB (POZ) domain containing 9 -0.0876951
RRBP1 ribosome binding protein 1 -0.0860232
GCLC glutamate-cysteine ligase, catalytic subunit -0.077937
NPSR1 neuropeptide S receptor 1 -0.0748827
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0735122
XAF1 XIAP associated factor 1 -0.0707365
TRIO trio Rho guanine nucleotide exchange factor -0.0629274
MX2 MX dynamin-like GTPase 2 -0.0624959
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0609567
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0608829
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0594654
VCL vinculin -0.0591541
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0580599
IGF1R insulin-like growth factor 1 receptor -0.0567231
PLSCR1 phospholipid scramblase 1 -0.0555305
IRF1 interferon regulatory factor 1 -0.055124
MUC20 mucin 20, cell surface associated -0.0545125
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.0533302
TJP1 tight junction protein 1 -0.0516147
JUN jun proto-oncogene -0.0513357
ANKRD10 ankyrin repeat domain 10 -0.0496605
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0479711
PTMA prothymosin, alpha -0.0466214
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0454439
PLSCR2 phospholipid scramblase 2 -0.0453908
RAB7A RAB7A, member RAS oncogene family -0.045202
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0448837
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.0446994
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa -0.0446662
TSHZ2 teashirt zinc finger homeobox 2 -0.0443172
SPAG9 sperm associated antigen 9 -0.0436769
ADIPOR2 adiponectin receptor 2 -0.0436521
MX1 MX dynamin-like GTPase 1 -0.0430176
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0430067
H1-0 H1.0 linker histone -0.0415425
CANX calnexin -0.0413366
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 -0.0409395
MBNL2 muscleblind-like splicing regulator 2 -0.0408952
UGDH UDP-glucose 6-dehydrogenase -0.0398722
AHNAK AHNAK nucleoprotein -0.039736
NCOA7 nuclear receptor coactivator 7 -0.0387884
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0385252
NDRG1 N-myc downstream regulated 1 -0.0382829
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0370092
CSTPP1 centriolar satellite-associated tubulin polyglutamylase complex regulator 1 -0.0368829
FNDC3B fibronectin type III domain containing 3B -0.0366937
BLZF1 basic leucine zipper nuclear factor 1 -0.0360404
RABGAP1L RAB GTPase activating protein 1-like -0.0355563
ITPKC inositol-trisphosphate 3-kinase C -0.0353998
POF1B premature ovarian failure, 1B -0.0352899
LOC102724023 ES1 protein homolog, mitochondrial -0.0348931
EPSTI1 epithelial stromal interaction 1 (breast) -0.0341596
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0340578
HDLBP high density lipoprotein binding protein -0.0338663
FBXO39 F-box protein 39 -0.0335831
EGR1 early growth response 1 -0.0334
ARHGAP26 Rho GTPase activating protein 26 -0.0331917
CALR calreticulin -0.0331077
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0331015
PRKCA protein kinase C, alpha -0.0325454
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.032323
EXT1 exostosin glycosyltransferase 1 -0.0322843
TUFT1 tuftelin 1 -0.0322073
ARF4 ADP-ribosylation factor 4 -0.0320543
NABP1 nucleic acid binding protein 1 -0.031498
STS steroid sulfatase (microsomal), isozyme S -0.0312395
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0312206
LAMB3 laminin, beta 3 -0.0308474
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0302537
TFRC transferrin receptor -0.030119
HM13 histocompatibility (minor) 13 -0.0295447
MBD5 methyl-CpG binding domain protein 5 -0.0294703
MORF4L2 mortality factor 4 like 2 -0.0293453
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.029132
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0290511
ANXA1 annexin A1 -0.0289674
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.0287477
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0286447
RBM39 RNA binding motif protein 39 -0.0285035
DDIT3 DNA-damage-inducible transcript 3 -0.0284286
WSB1 WD repeat and SOCS box containing 1 -0.028316
IFIH1 interferon induced with helicase C domain 1 -0.0283089
DIS3 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease -0.0282457
LARP4B La ribonucleoprotein domain family, member 4B -0.0281674
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.0281548