Aspirin_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Aspirin perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Aspirin_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
BHLHE40 basic helix-loop-helix family, member e40 0.0212732
TM4SF1 transmembrane 4 L six family member 1 0.0182461
SMAD3 SMAD family member 3 0.0168843
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0150105
SOD2 superoxide dismutase 2, mitochondrial 0.00974739
DPYSL3 dihydropyrimidinase-like 3 0.00947502
RASA2 RAS p21 protein activator 2 0.00863255
NAV2 neuron navigator 2 0.00861278
CTNND1 catenin (cadherin-associated protein), delta 1 0.00860045
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.00840479
ESYT2 extended synaptotagmin-like protein 2 0.00827583
MAPK8 mitogen-activated protein kinase 8 0.00801345
ZFC3H1 zinc finger, C3H1-type containing 0.00777658
PARP14 poly (ADP-ribose) polymerase family, member 14 0.00773905
CAMTA1 calmodulin binding transcription activator 1 0.00773521
MTSS1 metastasis suppressor 1 0.00772896
OGA O-GlcNAcase 0.00771397
PLEC plectin 0.00750142
SENP5 SUMO1/sentrin specific peptidase 5 0.00738342
KDM7A lysine (K)-specific demethylase 7A 0.00736386
KAZN kazrin, periplakin interacting protein 0.00721924
PRELID2 PRELI domain containing 2 0.00717419
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme 0.00698686
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.00661302
TNIP1 TNFAIP3 interacting protein 1 0.00642906
WWTR1 WW domain containing transcription regulator 1 0.00622636
TMEM39A transmembrane protein 39A 0.00596758
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.00587164
EHBP1L1 EH domain binding protein 1-like 1 0.00578336
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.00574964
HSPA8 heat shock 70kDa protein 8 0.00573863
NRIP1 nuclear receptor interacting protein 1 0.00569606
ZSWIM6 zinc finger, SWIM-type containing 6 0.0056505
PSME4 proteasome (prosome, macropain) activator subunit 4 0.00563286
ZNF451 zinc finger protein 451 0.00561071
CEP95 centrosomal protein 95kDa 0.0054624
RSRP1 arginine/serine-rich protein 1 0.00545675
SPAG9 sperm associated antigen 9 0.00537144
SNX14 sorting nexin 14 0.00528627
FAM107B family with sequence similarity 107, member B 0.00523326
ERRFI1 ERBB receptor feedback inhibitor 1 0.00517567
TPST1 tyrosylprotein sulfotransferase 1 0.00514436
CHD1 chromodomain helicase DNA binding protein 1 0.00510389
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0051015
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.00502781
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.00499689
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.0048596
ELOVL5 ELOVL fatty acid elongase 5 0.00483454
PMM2 phosphomannomutase 2 0.00482324
VEGFA vascular endothelial growth factor A 0.00478919
DSCAM Down syndrome cell adhesion molecule 0.00476661
CKAP5 cytoskeleton associated protein 5 0.00475728
ICE1 interactor of little elongation complex ELL subunit 1 0.00475272
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.00469814
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.00465582
GPR107 G protein-coupled receptor 107 0.00462974
NKTR natural killer cell triggering receptor 0.00459579
TLCD2 TLC domain containing 2 0.00457989
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) 0.00454689
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1 0.00451926
MYO19 myosin XIX 0.00451742
TMF1 TATA element modulatory factor 1 0.00451679
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.00444608
SUCO SUN domain containing ossification factor 0.00439672
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.00436718
APAF1 apoptotic peptidase activating factor 1 0.00431205
SCAF8 SR-related CTD-associated factor 8 0.00430779
RAB7A RAB7A, member RAS oncogene family 0.00429171
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) 0.00426427
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 0.00425965
ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4 0.00424607
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.00421863
USP47 ubiquitin specific peptidase 47 0.0042086
MTMR14 myotubularin related protein 14 0.00420559
DDB1 damage-specific DNA binding protein 1, 127kDa 0.00419782
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.00419397
MYSM1 Myb-like, SWIRM and MPN domains 1 0.00409914
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 0.00406601
CUL4B cullin 4B 0.00405612
ANKRD36 ankyrin repeat domain 36 0.0040456
VMP1 vacuole membrane protein 1 0.00403965
ADAM19 ADAM metallopeptidase domain 19 0.00397715
PDIA5 protein disulfide isomerase family A, member 5 0.00392554
RINT1 RAD50 interactor 1 0.00392396
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.0038896
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis) 0.00385293
SPTBN1 spectrin, beta, non-erythrocytic 1 0.00385199
COG6 component of oligomeric golgi complex 6 0.00381095
ZCCHC17 zinc finger, CCHC domain containing 17 0.00380925
PHRF1 PHD and ring finger domains 1 0.00378691
PUM2 pumilio RNA-binding family member 2 0.00378084
HPCAL1 hippocalcin-like 1 0.00376279
NPC1 Niemann-Pick disease, type C1 0.00376153
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.00375817
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.00374645
TRIM22 tripartite motif containing 22 0.00374011
KIAA1217 KIAA1217 0.00370466
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) 0.00369241
STX1A syntaxin 1A (brain) 0.00369157
SGMS1 sphingomyelin synthase 1 0.00367953

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.310893
VIM vimentin -0.200609
FN1 fibronectin 1 -0.167118
COL1A1 collagen, type I, alpha 1 -0.129702
NDRG1 N-myc downstream regulated 1 -0.128756
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.119661
COL1A2 collagen, type I, alpha 2 -0.118529
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0843575
TMSB10 thymosin beta 10 -0.0840008
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0833161
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0831419
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0817504
CDH13 cadherin 13 -0.0775849
COL6A3 collagen, type VI, alpha 3 -0.0775341
TGFBI transforming growth factor, beta-induced, 68kDa -0.0678614
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0651541
TPM4 tropomyosin 4 -0.0629007
PSD3 pleckstrin and Sec7 domain containing 3 -0.0574145
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0559331
CALR calreticulin -0.04653
ENO1 enolase 1, (alpha) -0.0463797
MT2A metallothionein 2A -0.0432193
VCAN versican -0.0427809
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.04118
FBN1 fibrillin 1 -0.0411212
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0393277
CANX calnexin -0.0385154
F3 coagulation factor III (thromboplastin, tissue factor) -0.0355309
DPYD dihydropyrimidine dehydrogenase -0.0353765
ASPH aspartate beta-hydroxylase -0.0334195
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0333827
RPS6 ribosomal protein S6 -0.0332796
CALD1 caldesmon 1 -0.0330648
RPS8 ribosomal protein S8 -0.0325134
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0323221
FTL ferritin, light polypeptide -0.0322499
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0316917
ZBTB20 zinc finger and BTB domain containing 20 -0.030699
ACTG1 actin gamma 1 -0.030097
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.030057
MAP1B microtubule-associated protein 1B -0.0298649
LOX lysyl oxidase -0.029707
COL6A1 collagen, type VI, alpha 1 -0.02834
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0277363
LGALS1 lectin, galactoside-binding, soluble, 1 -0.027025
LDHA lactate dehydrogenase A -0.0269969
POSTN periostin, osteoblast specific factor -0.0267238
COL5A1 collagen, type V, alpha 1 -0.0257148
S100A9 S100 calcium binding protein A9 -0.0256158
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0255516
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0249018
PTMA prothymosin, alpha -0.0243925
TRPS1 trichorhinophalangeal syndrome I -0.0240637
RPL35A ribosomal protein L35a -0.0238776
B2M beta-2-microglobulin -0.0238208
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0237955
FOXP1 forkhead box P1 -0.0236091
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0234928
PTK2 protein tyrosine kinase 2 -0.0231098
NAMPT nicotinamide phosphoribosyltransferase -0.0227784
RPL8 ribosomal protein L8 -0.0225235
TRAM1 translocation associated membrane protein 1 -0.0222106
MTDH metadherin -0.022139
IL6ST interleukin 6 signal transducer -0.0220218
HLA-B major histocompatibility complex, class I, B -0.0216169
RPS19 ribosomal protein S19 -0.0215735
RRBP1 ribosome binding protein 1 -0.0215089
INHBA inhibin, beta A -0.0213544
POTEF POTE ankyrin domain family, member F -0.0209598
COL6A2 collagen, type VI, alpha 2 -0.0209457
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0208631
GARS1 glycyl-tRNA synthetase 1 -0.0208278
LOXL2 lysyl oxidase-like 2 -0.0205766
PFN1 profilin 1 -0.0205424
S100A6 S100 calcium binding protein A6 -0.0203059
NALF1 NALCN channel auxiliary factor 1 -0.020029
LMAN1 lectin, mannose-binding, 1 -0.0199149
PKM pyruvate kinase, muscle -0.0197617
IER3 immediate early response 3 -0.0195209
TPM1 tropomyosin 1 (alpha) -0.0193814
TPM2 tropomyosin 2 (beta) -0.0192366
DSTN destrin (actin depolymerizing factor) -0.0190797
PDIA3 protein disulfide isomerase family A, member 3 -0.0190468
MAP4 microtubule-associated protein 4 -0.0187923
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0187316
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0182143
SLC38A2 solute carrier family 38, member 2 -0.018146
YBX1 Y box binding protein 1 -0.0180095
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.017772
SEPTIN7 septin 7 -0.0177363
COL3A1 collagen, type III, alpha 1 -0.0176726
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0176546
MYADM myeloid-associated differentiation marker -0.0175832
RPL28 ribosomal protein L28 -0.0175058
TMSB4X thymosin beta 4, X-linked -0.0172259
CLMP CXADR-like membrane protein -0.0171459
IFI6 interferon, alpha-inducible protein 6 -0.0171031
S100A10 S100 calcium binding protein A10 -0.0169913
EEF2 eukaryotic translation elongation factor 2 -0.0168899
IL6 interleukin 6 -0.0166758