Aspirin_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Aspirin perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Aspirin_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CEMIP cell migration inducing protein, hyaluronan binding 0.0707673
SMAD3 SMAD family member 3 0.063579
FOXO1 forkhead box O1 0.0583139
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0488908
BCL2L1 BCL2-like 1 0.0477234
OSMR oncostatin M receptor 0.0467536
DOCK5 dedicator of cytokinesis 5 0.0467512
RIN2 Ras and Rab interactor 2 0.0445645
TRIO trio Rho guanine nucleotide exchange factor 0.0416357
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0397
PLEC plectin 0.038674
MYOF myoferlin 0.0382186
NEK7 NIMA-related kinase 7 0.0379226
NAV2 neuron navigator 2 0.0374929
PRELID2 PRELI domain containing 2 0.0373117
FNDC3B fibronectin type III domain containing 3B 0.0362913
MEF2A myocyte enhancer factor 2A 0.0334404
FLNB filamin B, beta 0.0329616
RICTOR RPTOR independent companion of MTOR, complex 2 0.0324996
CAPRIN2 caprin family member 2 0.0303592
SEPTIN9 septin 9 0.0303489
MTSS1 metastasis suppressor 1 0.0297196
BCAR3 breast cancer anti-estrogen resistance 3 0.0295893
KIAA1217 KIAA1217 0.02917
MSN moesin 0.0284448
MBNL1 muscleblind-like splicing regulator 1 0.0283312
GRB10 growth factor receptor-bound protein 10 0.0282409
PICALM phosphatidylinositol binding clathrin assembly protein 0.0281876
KIF16B kinesin family member 16B 0.0279706
NRIP1 nuclear receptor interacting protein 1 0.0278766
NRG1 neuregulin 1 0.0278071
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0273233
AOPEP aminopeptidase O (putative) 0.0271378
VCL vinculin 0.0269227
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.026469
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0261525
ARHGAP23 Rho GTPase activating protein 23 0.0259125
SLC45A4 solute carrier family 45, member 4 0.0256689
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0244268
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0242459
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0242179
KDM7A lysine (K)-specific demethylase 7A 0.0235554
ANKRD28 ankyrin repeat domain 28 0.0234575
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0233359
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.0231148
BMAL2 basic helix-loop-helix ARNT like 2 0.0225046
LUZP1 leucine zipper protein 1 0.0218756
METTL15 methyltransferase like 15 0.0215402
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.0212465
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0210065
MYH9 myosin, heavy chain 9, non-muscle 0.0210053
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0201489
CD59 CD59 molecule, complement regulatory protein 0.0200044
ARHGAP21 Rho GTPase activating protein 21 0.0199541
SOX13 SRY (sex determining region Y)-box 13 0.0198291
AHNAK AHNAK nucleoprotein 0.0195686
SMYD3 SET and MYND domain containing 3 0.0194859
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0193408
NCEH1 neutral cholesterol ester hydrolase 1 0.0189949
CUL4B cullin 4B 0.0187946
KDM6A lysine (K)-specific demethylase 6A 0.0185041
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0182803
ARHGAP29 Rho GTPase activating protein 29 0.0182439
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0182394
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0181425
CTNND1 catenin (cadherin-associated protein), delta 1 0.0181403
LNPEP leucyl/cystinyl aminopeptidase 0.018081
FNIP1 folliculin interacting protein 1 0.018047
AMOTL1 angiomotin like 1 0.0177019
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 0.0176114
JAG1 jagged 1 0.0175174
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 0.0174962
FRMD5 FERM domain containing 5 0.0174948
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0174561
MACF1 microtubule-actin crosslinking factor 1 0.0173021
ANKH ANKH inorganic pyrophosphate transport regulator 0.0169232
ANO6 anoctamin 6 0.0168101
NCOA3 nuclear receptor coactivator 3 0.0166511
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0165916
PODXL podocalyxin-like 0.0164067
CDKN2A cyclin-dependent kinase inhibitor 2A 0.0163821
RRAS2 related RAS viral (r-ras) oncogene homolog 2 0.0162833
AFAP1 actin filament associated protein 1 0.0162796
DOCK4 dedicator of cytokinesis 4 0.0160126
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0158904
NECTIN1 nectin cell adhesion molecule 1 0.0158082
SH3PXD2A SH3 and PX domains 2A 0.0156254
BRWD3 bromodomain and WD repeat domain containing 3 0.0155117
NDE1 nudE neurodevelopment protein 1 0.0152759
PRKCH protein kinase C, eta 0.0152447
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0151555
EXT1 exostosin glycosyltransferase 1 0.0150366
RAD51B RAD51 paralog B 0.0149313
NLRP1 NLR family, pyrin domain containing 1 0.0148652
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.014799
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0146459
LAMA5 laminin, alpha 5 0.0146203
FOXP1 forkhead box P1 0.0142553
NTSR1 neurotensin receptor 1 (high affinity) 0.0141439
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0141369

decreased expression

Symbol Name Standardized Value
TIMP3 TIMP metallopeptidase inhibitor 3 -0.287403
PTMA prothymosin, alpha -0.129964
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.122877
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.120509
B2M beta-2-microglobulin -0.108241
TPT1 tumor protein, translationally-controlled 1 -0.0997738
TMSB10 thymosin beta 10 -0.0941075
ENO1 enolase 1, (alpha) -0.0868735
RPS6 ribosomal protein S6 -0.0790701
LDHA lactate dehydrogenase A -0.0726073
ANXA1 annexin A1 -0.0716438
TMSB4X thymosin beta 4, X-linked -0.0690948
NDRG1 N-myc downstream regulated 1 -0.069093
RPS8 ribosomal protein S8 -0.0673204
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.067075
S100A10 S100 calcium binding protein A10 -0.0654679
MT2A metallothionein 2A -0.0636955
LMNA lamin A/C -0.062771
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0627655
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0626676
HLA-B major histocompatibility complex, class I, B -0.0620578
POTEF POTE ankyrin domain family, member F -0.0607422
RPS3 ribosomal protein S3 -0.0586426
RPLP1 ribosomal protein, large, P1 -0.0564497
RPLP2 ribosomal protein, large, P2 -0.0560935
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0542264
KRT17 keratin 17, type I -0.0536926
RPS21 ribosomal protein S21 -0.0523935
IFITM3 interferon induced transmembrane protein 3 -0.0511712
STC1 stanniocalcin 1 -0.0507668
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0493256
RPL37 ribosomal protein L37 -0.0490584
PGK1 phosphoglycerate kinase 1 -0.049026
RPS19 ribosomal protein S19 -0.0478692
LOC112694756 uncharaterized LOC112694756 -0.0478669
EZR ezrin -0.0471932
FTL ferritin, light polypeptide -0.0466152
CAV1 caveolin 1, caveolae protein, 22kDa -0.0461601
RPL12 ribosomal protein L12 -0.046134
IGF2 insulin-like growth factor 2 -0.0460971
RPL11 ribosomal protein L11 -0.0457771
GNAS GNAS complex locus -0.045449
RPS13 ribosomal protein S13 -0.0447496
SQSTM1 sequestosome 1 -0.0440926
FTH1 ferritin, heavy polypeptide 1 -0.0437899
RPL37A ribosomal protein L37a -0.043775
RPS24 ribosomal protein S24 -0.0424108
IFITM1 interferon induced transmembrane protein 1 -0.0423057
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0414341
CLU clusterin -0.0411285
RPL8 ribosomal protein L8 -0.0406628
RPS25 ribosomal protein S25 -0.0400475
SQLE squalene epoxidase -0.0399268
HLA-E major histocompatibility complex, class I, E -0.0396318
S100A6 S100 calcium binding protein A6 -0.0394682
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0383354
EIF1 eukaryotic translation initiation factor 1 -0.0382408
RPS12 ribosomal protein S12 -0.0379179
RPS27A ribosomal protein S27a -0.0372248
RPL27A ribosomal protein L27a -0.0369675
S100A2 S100 calcium binding protein A2 -0.0366332
ANXA2 annexin A2 -0.0365079
S100A11 S100 calcium binding protein A11 -0.036502
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0350922
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0344709
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0343859
EMP1 epithelial membrane protein 1 -0.0336009
ALCAM activated leukocyte cell adhesion molecule -0.033283
RPL7A ribosomal protein L7a -0.0326715
PRRC2C proline-rich coiled-coil 2C -0.0326429
DSTN destrin (actin depolymerizing factor) -0.0323025
CANX calnexin -0.0320063
RPLP0 ribosomal protein, large, P0 -0.0319699
RPL36 ribosomal protein L36 -0.0319637
VDAC1 voltage-dependent anion channel 1 -0.0317074
RPL26 ribosomal protein L26 -0.0316042
RPL5 ribosomal protein L5 -0.0315461
NAP1L1 nucleosome assembly protein 1-like 1 -0.03141
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0312658
RPL23 ribosomal protein L23 -0.0312135
RPL19 ribosomal protein L19 -0.0310556
EEF2 eukaryotic translation elongation factor 2 -0.0310168
HLA-A major histocompatibility complex, class I, A -0.0310106
RPS27 ribosomal protein S27 -0.0308286
RPL35A ribosomal protein L35a -0.0307512
RPL34 ribosomal protein L34 -0.0305199
UBC ubiquitin C -0.0295112
DUSP6 dual specificity phosphatase 6 -0.0293925
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.029318
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0289308
CALR calreticulin -0.028827
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0288205
RACK1 receptor for activated C kinase 1 -0.028623
CAVIN1 caveolae associated protein 1 -0.028608
RPL31 ribosomal protein L31 -0.0284596
YBX1 Y box binding protein 1 -0.0284169
TAGLN2 transgelin 2 -0.0283869
RPL30 ribosomal protein L30 -0.0281008
ZMYND8 zinc finger, MYND-type containing 8 -0.0280379
RPL36A ribosomal protein L36a -0.0275813