Aspirin_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Aspirin perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Aspirin_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B 0.0589883
SMAD3 SMAD family member 3 0.0537004
NAV2 neuron navigator 2 0.0492312
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.048877
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0363554
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0348678
ELL2 elongation factor, RNA polymerase II, 2 0.034669
SOD2 superoxide dismutase 2, mitochondrial 0.0342751
ZEB2 zinc finger E-box binding homeobox 2 0.0318645
OGA O-GlcNAcase 0.031417
OSMR oncostatin M receptor 0.0292933
RAB27B RAB27B, member RAS oncogene family 0.0284628
ATP13A3 ATPase type 13A3 0.0279067
RICTOR RPTOR independent companion of MTOR, complex 2 0.0272623
KMT2C lysine (K)-specific methyltransferase 2C 0.026995
CD44 CD44 molecule (Indian blood group) 0.0261469
NPC1 Niemann-Pick disease, type C1 0.0260632
ADD3 adducin 3 (gamma) 0.0258366
BMAL2 basic helix-loop-helix ARNT like 2 0.0249418
SAMD4A sterile alpha motif domain containing 4A 0.0239719
SIK3 SIK family kinase 3 0.0238459
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.023703
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0233658
CTNND1 catenin (cadherin-associated protein), delta 1 0.0232402
BHLHE40 basic helix-loop-helix family, member e40 0.0230765
EFNA5 ephrin-A5 0.0229465
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0228736
AHR aryl hydrocarbon receptor 0.0227057
ARHGAP5 Rho GTPase activating protein 5 0.0225176
DPYSL3 dihydropyrimidinase-like 3 0.0220159
RBM39 RNA binding motif protein 39 0.0216997
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0215421
ZFC3H1 zinc finger, C3H1-type containing 0.0208034
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0207707
RUNX1 runt-related transcription factor 1 0.0207575
AGFG1 ArfGAP with FG repeats 1 0.0199671
PTPRM protein tyrosine phosphatase, receptor type, M 0.019747
WWTR1 WW domain containing transcription regulator 1 0.0197346
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0195043
RUNX2 runt-related transcription factor 2 0.019447
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0191326
CHD1 chromodomain helicase DNA binding protein 1 0.019047
SPRED1 sprouty-related, EVH1 domain containing 1 0.0189585
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0189105
TRIO trio Rho guanine nucleotide exchange factor 0.0186097
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0185239
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 0.0177596
DSCAM Down syndrome cell adhesion molecule 0.0177411
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0174404
FBXL13 F-box and leucine-rich repeat protein 13 0.0171387
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.016724
STK38L serine/threonine kinase 38 like 0.0165422
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 0.0163661
CAB39 calcium binding protein 39 0.0159922
PRELID2 PRELI domain containing 2 0.0159071
PELI1 pellino E3 ubiquitin protein ligase 1 0.0156922
UBA6 ubiquitin-like modifier activating enzyme 6 0.0150833
MYH9 myosin, heavy chain 9, non-muscle 0.0145752
RB1CC1 RB1-inducible coiled-coil 1 0.0145714
MED13L mediator complex subunit 13-like 0.0143044
ARHGAP42 Rho GTPase activating protein 42 0.0142874
CHIC2 cysteine-rich hydrophobic domain 2 0.0139783
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 0.0137629
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 0.0137223
NBAS neuroblastoma amplified sequence 0.0134438
RASA2 RAS p21 protein activator 2 0.0132948
MARCHF6 membrane associated ring-CH-type finger 6 0.0132725
VWDE von Willebrand factor D and EGF domains 0.0132427
DNMBP dynamin binding protein 0.0131559
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.0131521
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0129356
EPS8 epidermal growth factor receptor pathway substrate 8 0.0129274
IL1R1 interleukin 1 receptor, type I 0.0129057
NEK7 NIMA-related kinase 7 0.0128244
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0127462
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0126597
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0124357
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0124
DOCK4 dedicator of cytokinesis 4 0.0123358
SPAG9 sperm associated antigen 9 0.0120672
PHIP pleckstrin homology domain interacting protein 0.0120442
RBMS1 RNA binding motif, single stranded interacting protein 1 0.0120144
TOP2B topoisomerase (DNA) II beta 180kDa 0.0119668
SLTM SAFB-like, transcription modulator 0.0118392
ZEB1 zinc finger E-box binding homeobox 1 0.0117043
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0116998
KLF6 Kruppel-like factor 6 0.0116441
PCNX1 pecanex 1 0.011609
MAPK8 mitogen-activated protein kinase 8 0.0115723
FRS2 fibroblast growth factor receptor substrate 2 0.0115691
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.011564
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0114794
MYOF myoferlin 0.011466
USP47 ubiquitin specific peptidase 47 0.0114077
CDK17 cyclin-dependent kinase 17 0.0113199
ABI1 abl-interactor 1 0.0112417
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) 0.0111847
FAM3C family with sequence similarity 3, member C 0.0111608
OTUD7B OTU deubiquitinase 7B 0.0111191
MAN2A1 mannosidase, alpha, class 2A, member 1 0.0110872

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.180525
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.162491
TMSB10 thymosin beta 10 -0.147729
IGFBP3 insulin-like growth factor binding protein 3 -0.0965194
PDE4D phosphodiesterase 4D, cAMP-specific -0.0869574
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0805646
FTL ferritin, light polypeptide -0.0742013
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0711104
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0698365
P4HB prolyl 4-hydroxylase, beta polypeptide -0.062467
STC1 stanniocalcin 1 -0.0615181
PTMA prothymosin, alpha -0.0597946
FN1 fibronectin 1 -0.0562532
B2M beta-2-microglobulin -0.049433
NRG1 neuregulin 1 -0.0483648
DPYD dihydropyrimidine dehydrogenase -0.0481141
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0480934
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0479499
S100A6 S100 calcium binding protein A6 -0.044687
RPLP1 ribosomal protein, large, P1 -0.0444899
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0413969
RPS19 ribosomal protein S19 -0.040782
CDH13 cadherin 13 -0.0400468
EIF1 eukaryotic translation initiation factor 1 -0.0398954
RPS6 ribosomal protein S6 -0.0385361
RPL35A ribosomal protein L35a -0.0383793
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0382558
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0376642
GRB10 growth factor receptor-bound protein 10 -0.0372574
ZMYND8 zinc finger, MYND-type containing 8 -0.0359379
TPT1 tumor protein, translationally-controlled 1 -0.0353809
EGR1 early growth response 1 -0.0353159
TFPI2 tissue factor pathway inhibitor 2 -0.0352533
RPS8 ribosomal protein S8 -0.0344633
DDIT3 DNA-damage-inducible transcript 3 -0.0344396
RAB1A RAB1A, member RAS oncogene family -0.0343525
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0337079
BASP1 brain abundant, membrane attached signal protein 1 -0.0333313
AKAP12 A kinase (PRKA) anchor protein 12 -0.0329946
CANX calnexin -0.0327552
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.032736
MAML3 mastermind-like 3 (Drosophila) -0.032119
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0321128
LOC102724023 ES1 protein homolog, mitochondrial -0.0318588
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0314531
ENO1 enolase 1, (alpha) -0.0308997
RPL31 ribosomal protein L31 -0.0308057
RPLP2 ribosomal protein, large, P2 -0.030799
RPL36 ribosomal protein L36 -0.030702
NDRG1 N-myc downstream regulated 1 -0.030545
HMGA1 high mobility group AT-hook 1 -0.0303393
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0301566
RPS21 ribosomal protein S21 -0.029736
BTG1 B-cell translocation gene 1, anti-proliferative -0.0296789
LMAN1 lectin, mannose-binding, 1 -0.0293363
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0290935
MT2A metallothionein 2A -0.0289512
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0288946
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0287126
PDIA3 protein disulfide isomerase family A, member 3 -0.0285297
PKM pyruvate kinase, muscle -0.0281681
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0277726
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0277572
CUX1 cut-like homeobox 1 -0.0267162
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0262344
MSRB3 methionine sulfoxide reductase B3 -0.0261604
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0260907
CALU calumenin -0.0260892
MEF2A myocyte enhancer factor 2A -0.0259609
S100A10 S100 calcium binding protein A10 -0.0258079
RPS13 ribosomal protein S13 -0.0258003
RPS12 ribosomal protein S12 -0.0257337
RPL32 ribosomal protein L32 -0.0257337
IER3 immediate early response 3 -0.025355
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0253237
RPL37A ribosomal protein L37a -0.025142
HM13 histocompatibility (minor) 13 -0.0247273
NAP1L1 nucleosome assembly protein 1-like 1 -0.0244566
FTH1 ferritin, heavy polypeptide 1 -0.0242149
RPL34 ribosomal protein L34 -0.0241748
LOX lysyl oxidase -0.024155
RPS29 ribosomal protein S29 -0.0240711
CLMP CXADR-like membrane protein -0.0239467
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0238568
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0237809
RPL11 ribosomal protein L11 -0.023597
TMEM165 transmembrane protein 165 -0.0235707
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0234064
C15ORF48 chromosome 15 open reading frame 48 -0.0233924
IFI6 interferon, alpha-inducible protein 6 -0.0230852
TTC3 tetratricopeptide repeat domain 3 -0.023001
ZNF609 zinc finger protein 609 -0.0228917
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0227832
VDAC1 voltage-dependent anion channel 1 -0.0227404
RPS27 ribosomal protein S27 -0.0226096
MRPS6 mitochondrial ribosomal protein S6 -0.0226051
DIAPH2 diaphanous-related formin 2 -0.0223408
LIMCH1 LIM and calponin homology domains 1 -0.0218371
CDH2 cadherin 2, type 1, N-cadherin (neuronal) -0.0218319
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0218298