Aspirin_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Aspirin perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Aspirin_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.139542
TXNRD1 thioredoxin reductase 1 0.134155
GRAMD1B GRAM domain containing 1B 0.0902134
OSMR oncostatin M receptor 0.0754912
THSD4 thrombospondin, type I, domain containing 4 0.063832
ERRFI1 ERBB receptor feedback inhibitor 1 0.0603647
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0603397
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0490989
MKI67 marker of proliferation Ki-67 0.0485649
ADAR adenosine deaminase, RNA-specific 0.0459999
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0437639
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0429703
TRIO trio Rho guanine nucleotide exchange factor 0.0414517
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0390483
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0385719
BMAL2 basic helix-loop-helix ARNT like 2 0.036363
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0360125
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0359537
CDK17 cyclin-dependent kinase 17 0.0345625
SMAD3 SMAD family member 3 0.032541
STC1 stanniocalcin 1 0.0300259
SENP6 SUMO1/sentrin specific peptidase 6 0.0290092
EML4 echinoderm microtubule associated protein like 4 0.028584
RNF145 ring finger protein 145 0.0283975
CTTNBP2NL CTTNBP2 N-terminal like 0.027656
ELL2 elongation factor, RNA polymerase II, 2 0.0274837
VCL vinculin 0.0268898
BIRC2 baculoviral IAP repeat containing 2 0.026796
MMP12 matrix metallopeptidase 12 0.0259619
CCDC91 coiled-coil domain containing 91 0.0255589
RASAL2 RAS protein activator like 2 0.0254344
RAD51B RAD51 paralog B 0.0248052
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0247199
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0241703
TMEM41B transmembrane protein 41B 0.0238107
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0234309
CENPF centromere protein F, 350/400kDa 0.0233752
TBC1D5 TBC1 domain family, member 5 0.0229986
BICD1 bicaudal D homolog 1 (Drosophila) 0.0225048
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.0221944
CDCP1 CUB domain containing protein 1 0.0219942
ZNF292 zinc finger protein 292 0.021972
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0218314
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.0216731
BHLHE40 basic helix-loop-helix family, member e40 0.0215786
PNPT1 polyribonucleotide nucleotidyltransferase 1 0.0212178
RAB10 RAB10, member RAS oncogene family 0.0211138
RTN4 reticulon 4 0.0209794
ANKRD12 ankyrin repeat domain 12 0.0207585
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0206121
BCAR3 breast cancer anti-estrogen resistance 3 0.0205165
KRT18 keratin 18, type I 0.020497
TCIM transcriptional and immune response regulator 0.020347
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.0202221
SINHCAF SIN3-HDAC complex associated factor 0.0201722
EXOC6B exocyst complex component 6B 0.0199368
EHBP1 EH domain binding protein 1 0.019549
RUSC2 RUN and SH3 domain containing 2 0.0195098
RAI1 retinoic acid induced 1 0.0194748
PUM2 pumilio RNA-binding family member 2 0.0194515
DNMBP dynamin binding protein 0.0193522
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0191275
LATS2 large tumor suppressor kinase 2 0.0189796
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 0.0186054
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0185016
BZW1 basic leucine zipper and W2 domains 1 0.0184985
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0183247
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0182806
MARCHF4 membrane associated ring-CH-type finger 4 0.0181228
SNX9 sorting nexin 9 0.0179257
KCTD20 potassium channel tetramerization domain containing 20 0.0178035
TGIF1 TGFB-induced factor homeobox 1 0.0176028
ADGRG6 adhesion G protein-coupled receptor G6 0.0175887
RNF169 ring finger protein 169 0.0174392
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0172714
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0172109
ANKRD36B ankyrin repeat domain 36B 0.0172056
TRIM56 tripartite motif containing 56 0.0170711
ATP9B ATPase, class II, type 9B 0.0170533
FHL2 four and a half LIM domains 2 0.0169942
PALM2AKAP2 PALM2 and AKAP2 fusion 0.016923
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0167953
PLSCR1 phospholipid scramblase 1 0.0167409
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.016562
NFE2L2 nuclear factor, erythroid 2-like 2 0.0164362
FGD6 FYVE, RhoGEF and PH domain containing 6 0.0163039
ANKRD28 ankyrin repeat domain 28 0.0162653
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0162211
EXOC4 exocyst complex component 4 0.0160923
ADAM17 ADAM metallopeptidase domain 17 0.0160306
CARMIL1 capping protein regulator and myosin 1 linker 1 0.0159927
SPRED2 sprouty-related, EVH1 domain containing 2 0.0158215
BUB1 BUB1 mitotic checkpoint serine/threonine kinase 0.0157851
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0157117
MYSM1 Myb-like, SWIRM and MPN domains 1 0.0156674
KCMF1 potassium channel modulatory factor 1 0.0155716
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase 0.0155688
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3 0.015566
SBF2 SET binding factor 2 0.0155526
MIS18BP1 MIS18 binding protein 1 0.0154705

decreased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.182837
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.104333
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.103534
PTMA prothymosin, alpha -0.10101
ZCCHC7 zinc finger, CCHC domain containing 7 -0.081042
UBC ubiquitin C -0.0800392
PCBP2 poly(rC) binding protein 2 -0.0768625
TMSB10 thymosin beta 10 -0.0754776
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.072824
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0706226
RPL23 ribosomal protein L23 -0.0651326
TFPI2 tissue factor pathway inhibitor 2 -0.0646376
MCL1 myeloid cell leukemia 1 -0.0636407
RPS3 ribosomal protein S3 -0.0636407
RPS8 ribosomal protein S8 -0.0612021
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0580829
YBX3 Y box binding protein 3 -0.0571063
RPL37A ribosomal protein L37a -0.0555871
RPS27A ribosomal protein S27a -0.0554775
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0539558
AEBP2 AE binding protein 2 -0.0536396
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0510483
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0501271
VIM vimentin -0.0488776
ENO1 enolase 1, (alpha) -0.0487573
RPS12 ribosomal protein S12 -0.0450811
PKM pyruvate kinase, muscle -0.0447698
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0435668
BRD2 bromodomain containing 2 -0.0435213
NAP1L1 nucleosome assembly protein 1-like 1 -0.0431869
RBM39 RNA binding motif protein 39 -0.0405015
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0401872
TPM2 tropomyosin 2 (beta) -0.0397824
POTEF POTE ankyrin domain family, member F -0.0395276
CALR calreticulin -0.039051
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0389842
YBX1 Y box binding protein 1 -0.038522
INTS6 integrator complex subunit 6 -0.0384785
SFPQ splicing factor proline/glutamine-rich -0.0384739
NIPBL Nipped-B homolog (Drosophila) -0.0380105
RPLP1 ribosomal protein, large, P1 -0.0361726
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0360159
AFF3 AF4/FMR2 family, member 3 -0.0353793
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0347933
GOLGA4 golgin A4 -0.0345239
PRELID2 PRELI domain containing 2 -0.0342953
SPDYA speedy/RINGO cell cycle regulator family member A -0.0338767
RPS19 ribosomal protein S19 -0.0338753
CANX calnexin -0.033854
PDIA6 protein disulfide isomerase family A, member 6 -0.0337004
SET SET nuclear proto-oncogene -0.0333989
KTN1 kinectin 1 (kinesin receptor) -0.0325405
RPL36 ribosomal protein L36 -0.0316526
RPS29 ribosomal protein S29 -0.0316441
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0315961
RPL37 ribosomal protein L37 -0.0314638
RPL12 ribosomal protein L12 -0.0314582
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0313736
EEF2 eukaryotic translation elongation factor 2 -0.030678
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0299594
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0298493
TRA2A transformer 2 alpha homolog (Drosophila) -0.0297199
RAB1A RAB1A, member RAS oncogene family -0.0295998
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0291206
RPS10 ribosomal protein S10 -0.0285853
RPL5 ribosomal protein L5 -0.0284556
EEF1G eukaryotic translation elongation factor 1 gamma -0.0283246
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0281601
RPL28 ribosomal protein L28 -0.0280679
RPS27 ribosomal protein S27 -0.0280335
NOP58 NOP58 ribonucleoprotein -0.0280153
COPA coatomer protein complex, subunit alpha -0.0280081
RPL26 ribosomal protein L26 -0.02662
PFN1 profilin 1 -0.026528
VCP valosin containing protein -0.0264665
RPL35A ribosomal protein L35a -0.026119
TPM3 tropomyosin 3 -0.0259791
PDIA4 protein disulfide isomerase family A, member 4 -0.0259623
PDIA3 protein disulfide isomerase family A, member 3 -0.0256707
NDRG1 N-myc downstream regulated 1 -0.0254584
RPL8 ribosomal protein L8 -0.0253189
RPL31 ribosomal protein L31 -0.0251951
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0251913
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0251264
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0250574
ATXN1 ataxin 1 -0.0248606
MORF4L2 mortality factor 4 like 2 -0.0245918
TOP1 topoisomerase (DNA) I -0.0245191
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0243158
PDLIM5 PDZ and LIM domain 5 -0.0242201
WNK1 WNK lysine deficient protein kinase 1 -0.0239721
PRH1 proline-rich protein HaeIII subfamily 1 -0.0238987
LRRC23 leucine rich repeat containing 23 -0.0238116
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0237096
RPLP2 ribosomal protein, large, P2 -0.0236609
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 -0.0236482
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 -0.0235216
AKAP9 A kinase (PRKA) anchor protein 9 -0.0233859
RPS21 ribosomal protein S21 -0.023349
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.022925