Aspirin_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Aspirin perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Aspirin_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.0974494
FN1 fibronectin 1 0.0816843
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0743461
MCL1 myeloid cell leukemia 1 0.0624401
GDA guanine deaminase 0.0613403
COL4A6 collagen, type IV, alpha 6 0.05336
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0485002
DST dystonin 0.0482897
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0466395
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0462169
DNER delta/notch-like EGF repeat containing 0.0452951
LIMCH1 LIM and calponin homology domains 1 0.0435195
EFNA5 ephrin-A5 0.0419537
NPAS2 neuronal PAS domain protein 2 0.0404461
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.037513
SAMD4A sterile alpha motif domain containing 4A 0.037498
SMOC1 SPARC related modular calcium binding 1 0.0368561
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0340519
DOCK5 dedicator of cytokinesis 5 0.0338284
MAML3 mastermind-like 3 (Drosophila) 0.0330442
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0330119
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.031496
PTEN phosphatase and tensin homolog 0.0313776
STC1 stanniocalcin 1 0.029608
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0287495
PCBP3 poly(rC) binding protein 3 0.0287226
FNDC3A fibronectin type III domain containing 3A 0.0286112
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0270002
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0265846
FNDC3B fibronectin type III domain containing 3B 0.0259192
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0252452
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0250121
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0244752
CHL1 cell adhesion molecule L1-like 0.0243547
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.024203
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0229349
COL4A5 collagen, type IV, alpha 5 0.0228348
DPYD dihydropyrimidine dehydrogenase 0.0227502
AUTS2 autism susceptibility candidate 2 0.0227348
PDE10A phosphodiesterase 10A 0.0226267
COPA coatomer protein complex, subunit alpha 0.0219255
ADGRD1 adhesion G protein-coupled receptor D1 0.0215179
RTN1 reticulon 1 0.0207161
PDLIM5 PDZ and LIM domain 5 0.0204909
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0200737
DOCK4 dedicator of cytokinesis 4 0.020009
ITPRID2 ITPR interacting domain containing 2 0.0198803
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0197236
PBX1 pre-B-cell leukemia homeobox 1 0.0196202
MSN moesin 0.0193028
MON2 MON2 homolog (S. cerevisiae) 0.0192735
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0190526
FNIP1 folliculin interacting protein 1 0.0187768
PDE7B phosphodiesterase 7B 0.0183756
PSD3 pleckstrin and Sec7 domain containing 3 0.0180783
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0177515
SDK1 sidekick cell adhesion molecule 1 0.0174615
AKAP13 A kinase (PRKA) anchor protein 13 0.0172418
ZCCHC7 zinc finger, CCHC domain containing 7 0.0169821
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0168127
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0167413
CUX1 cut-like homeobox 1 0.0163917
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0162842
N4BP2L2 NEDD4 binding protein 2-like 2 0.016283
EGR1 early growth response 1 0.0162773
THSD4 thrombospondin, type I, domain containing 4 0.0162533
SETX senataxin 0.0160123
MYPN myopalladin 0.0157418
TMX4 thioredoxin-related transmembrane protein 4 0.0156214
LAMA5 laminin, alpha 5 0.0155902
NBEAL1 neurobeachin-like 1 0.0154568
MAML2 mastermind-like 2 (Drosophila) 0.0153716
MFF mitochondrial fission factor 0.0152826
HDAC4 histone deacetylase 4 0.0152048
IL6 interleukin 6 0.0150134
DHRSX dehydrogenase/reductase (SDR family) X-linked 0.014895
MYOF myoferlin 0.0146521
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0145745
WARS1 tryptophanyl-tRNA synthetase 1 0.0145187
SDCCAG8 serologically defined colon cancer antigen 8 0.014502
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.0143949
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 0.0142455
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.0141616
CTNND2 catenin (cadherin-associated protein), delta 2 0.0141359
ANKRD36 ankyrin repeat domain 36 0.0140269
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0139638
GLIS3 GLIS family zinc finger 3 0.013682
ESYT2 extended synaptotagmin-like protein 2 0.0133946
FAM219A family with sequence similarity 219, member A 0.0132039
SLC38A2 solute carrier family 38, member 2 0.0131834
AVL9 AVL9 homolog (S. cerevisiase) 0.0129621
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0128557
CUL4A cullin 4A 0.0127787
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0127199
ZEB2 zinc finger E-box binding homeobox 2 0.0125758
LAMB1 laminin, beta 1 0.0124268
GIGYF2 GRB10 interacting GYF protein 2 0.0123964
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 0.0123788
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D 0.0123667
ATM ATM serine/threonine kinase 0.0123443

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.14647
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.134413
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.110217
TMSB10 thymosin beta 10 -0.110088
PTMA prothymosin, alpha -0.102633
NAMPT nicotinamide phosphoribosyltransferase -0.0964539
RPLP1 ribosomal protein, large, P1 -0.0955569
TPT1 tumor protein, translationally-controlled 1 -0.0952194
FTL ferritin, light polypeptide -0.0926464
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0840672
RPS6 ribosomal protein S6 -0.0829931
NAP1L1 nucleosome assembly protein 1-like 1 -0.0808244
TXNRD1 thioredoxin reductase 1 -0.0797963
RPS24 ribosomal protein S24 -0.0782816
ASPH aspartate beta-hydroxylase -0.0780573
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0757236
RPS8 ribosomal protein S8 -0.0724923
RPL26 ribosomal protein L26 -0.0693524
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0683373
RPL23 ribosomal protein L23 -0.0681036
RPL12 ribosomal protein L12 -0.0644802
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0628408
RPL35A ribosomal protein L35a -0.0615066
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0602506
RPS12 ribosomal protein S12 -0.0586212
RPS19 ribosomal protein S19 -0.0574878
EIF1 eukaryotic translation initiation factor 1 -0.0572179
RPL37A ribosomal protein L37a -0.0567164
PDE4D phosphodiesterase 4D, cAMP-specific -0.0552748
RPL19 ribosomal protein L19 -0.0552465
RPLP0 ribosomal protein, large, P0 -0.0516897
RPL31 ribosomal protein L31 -0.0504866
RPS27A ribosomal protein S27a -0.0492333
RPL11 ribosomal protein L11 -0.0478127
VIM vimentin -0.0473484
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0472866
RPS4X ribosomal protein S4, X-linked -0.046424
RPL34 ribosomal protein L34 -0.045669
BZW1 basic leucine zipper and W2 domains 1 -0.0448465
B2M beta-2-microglobulin -0.0448109
TM4SF1 transmembrane 4 L six family member 1 -0.044642
TFPI2 tissue factor pathway inhibitor 2 -0.0440844
RPS3 ribosomal protein S3 -0.0437191
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0433654
RPL9 ribosomal protein L9 -0.043227
GNAS GNAS complex locus -0.0427181
ENO1 enolase 1, (alpha) -0.0424111
RPS27 ribosomal protein S27 -0.0415585
SPAG9 sperm associated antigen 9 -0.0415204
RPLP2 ribosomal protein, large, P2 -0.0412604
RPS21 ribosomal protein S21 -0.0407593
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0406885
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0406281
RACK1 receptor for activated C kinase 1 -0.0404949
RPL38 ribosomal protein L38 -0.0403752
RPL37 ribosomal protein L37 -0.0402835
TNPO1 transportin 1 -0.0402439
ACTG1 actin gamma 1 -0.0397046
RPL35 ribosomal protein L35 -0.0394862
RPL13A ribosomal protein L13a -0.0390534
RPL36 ribosomal protein L36 -0.03882
RPS23 ribosomal protein S23 -0.0375875
RPL7A ribosomal protein L7a -0.0372507
NALF1 NALCN channel auxiliary factor 1 -0.0372076
RPL36A ribosomal protein L36a -0.0369245
RPS16 ribosomal protein S16 -0.0367388
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0366709
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0366337
LDHA lactate dehydrogenase A -0.0365834
S100A10 S100 calcium binding protein A10 -0.0363335
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0361712
RPL5 ribosomal protein L5 -0.0356018
PRRC2C proline-rich coiled-coil 2C -0.0344764
EZR ezrin -0.0341
LOC112694756 uncharaterized LOC112694756 -0.0335513
RPS14 ribosomal protein S14 -0.0334941
PRDX1 peroxiredoxin 1 -0.0323349
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.032318
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0318814
ANXA2 annexin A2 -0.0315232
RTN4 reticulon 4 -0.0314043
RPS29 ribosomal protein S29 -0.0309845
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0308526
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0305879
RPS2 ribosomal protein S2 -0.0305376
PGK1 phosphoglycerate kinase 1 -0.0302409
SRGN serglycin -0.0298552
RPS17 ribosomal protein S17 -0.0297662
RPL32 ribosomal protein L32 -0.0291949
MATR3 matrin 3 -0.0287543
SQSTM1 sequestosome 1 -0.028483
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0282788
BASP1 brain abundant, membrane attached signal protein 1 -0.0279507
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.0276159
YBX1 Y box binding protein 1 -0.0274192
RPL4 ribosomal protein L4 -0.0273159
RBM39 RNA binding motif protein 39 -0.0272908
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0272055
SMYD3 SET and MYND domain containing 3 -0.0268855
SERBP1 SERPINE1 mRNA binding protein 1 -0.026594