Aspirin_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Aspirin perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

103 genes differentially expressed following the Aspirin_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FMN1 formin 1 0.17139
MATR3 matrin 3 0.169601
EGFR epidermal growth factor receptor 0.150103
NAV2 neuron navigator 2 0.141392
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.141032
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.127889
KMT2C lysine (K)-specific methyltransferase 2C 0.125027
BHLHE40 basic helix-loop-helix family, member e40 0.120546
ENO1 enolase 1, (alpha) 0.118958
GOLGA4 golgin A4 0.114595
ZNF292 zinc finger protein 292 0.113414
EIF1 eukaryotic translation initiation factor 1 0.111442
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.108105
PABPC1 poly(A) binding protein, cytoplasmic 1 0.107349
PDE10A phosphodiesterase 10A 0.103923
BIRC6 baculoviral IAP repeat containing 6 0.0911069
PTMA prothymosin, alpha 0.0896673
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0820073
FNDC3B fibronectin type III domain containing 3B 0.0809932
PCBP2 poly(rC) binding protein 2 0.0805547
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0706806
VCL vinculin 0.0696644
SPAG9 sperm associated antigen 9 0.0639435
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0609738
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0594455
PTK2 protein tyrosine kinase 2 0.0504716
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0489915
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0386388
PGK1 phosphoglycerate kinase 1 0.0319288
MYO1E myosin IE 0.0279554
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0237144
PARD3 par-3 family cell polarity regulator 0.0234301
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0192512
TBC1D22A TBC1 domain family, member 22A 0.0159646
GPC6 glypican 6 0.0159154
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0125228
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0102676
ZFAND3 zinc finger, AN1-type domain 3 0.0093134
TPT1 tumor protein, translationally-controlled 1 0.0083337
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.00695238
ERRFI1 ERBB receptor feedback inhibitor 1 0.00599696
PTPRM protein tyrosine phosphatase, receptor type, M 0.00548149
FAM13A family with sequence similarity 13, member A 0.00230986

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.309758
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.177169
AKAP12 A kinase (PRKA) anchor protein 12 -0.145391
COL5A2 collagen, type V, alpha 2 -0.141051
PKM pyruvate kinase, muscle -0.137401
TMSB10 thymosin beta 10 -0.123472
VIM vimentin -0.115332
RNF213 ring finger protein 213 -0.114203
STC1 stanniocalcin 1 -0.110308
SOD2 superoxide dismutase 2, mitochondrial -0.108859
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.106036
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.105877
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0966458
NAP1L1 nucleosome assembly protein 1-like 1 -0.0964824
ASPH aspartate beta-hydroxylase -0.0947822
HMGA2 high mobility group AT-hook 2 -0.0921129
RIGI RNA sensor RIG-I -0.0865249
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0856896
TAS2R14 taste receptor, type 2, member 14 -0.0829999
CD44 CD44 molecule (Indian blood group) -0.0807925
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0786809
NF1 neurofibromin 1 -0.0780714
OSMR oncostatin M receptor -0.07568
B2M beta-2-microglobulin -0.066602
PRELID2 PRELI domain containing 2 -0.0655
CCNI cyclin I -0.0628252
PDE4D phosphodiesterase 4D, cAMP-specific -0.0617807
SLC38A1 solute carrier family 38, member 1 -0.0594541
MAP1B microtubule-associated protein 1B -0.0572862
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.056578
NAV1 neuron navigator 1 -0.0553696
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0547348
RPS8 ribosomal protein S8 -0.0544894
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0522862
SLC38A2 solute carrier family 38, member 2 -0.050004
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.04857
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0462886
FTH1 ferritin, heavy polypeptide 1 -0.04602
AHNAK AHNAK nucleoprotein -0.0428676
TRIO trio Rho guanine nucleotide exchange factor -0.0425284
MAP4 microtubule-associated protein 4 -0.0410248
LDHA lactate dehydrogenase A -0.0393078
RUNX1 runt-related transcription factor 1 -0.0390589
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0349482
ANXA2 annexin A2 -0.0322786
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0312812
DST dystonin -0.0217594
RPL11 ribosomal protein L11 -0.0217289
CNKSR3 CNKSR family member 3 -0.0197495
ANO6 anoctamin 6 -0.0178535
NDRG1 N-myc downstream regulated 1 -0.0175917
LMO7 LIM domain 7 -0.0172996
IGFBP3 insulin-like growth factor binding protein 3 -0.0171844
NAMPT nicotinamide phosphoribosyltransferase -0.0170295
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0155464
PSD3 pleckstrin and Sec7 domain containing 3 -0.0103119
PRKCA protein kinase C, alpha -0.00689269
JMJD1C jumonji domain containing 1C -0.00299231
DSCAM Down syndrome cell adhesion molecule -0.00197639
JARID2 jumonji, AT rich interactive domain 2 -3.66836E-4