Aspirin_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Aspirin perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Aspirin_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ZNF292 zinc finger protein 292 0.123981
HDAC9 histone deacetylase 9 0.119863
PDGFC platelet derived growth factor C 0.0873728
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.07162
DST dystonin 0.0709794
COL5A2 collagen, type V, alpha 2 0.0686529
TSC22D2 TSC22 domain family, member 2 0.0675103
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0654794
ZFAND3 zinc finger, AN1-type domain 3 0.0630868
ZEB2 zinc finger E-box binding homeobox 2 0.0606336
YAP1 Yes-associated protein 1 0.0529076
USP3 ubiquitin specific peptidase 3 0.0507983
NCKAP1 NCK-associated protein 1 0.0498671
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0491001
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0480121
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0475591
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.044596
FAM171B family with sequence similarity 171, member B 0.0441925
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0433294
ADAM9 ADAM metallopeptidase domain 9 0.0428815
ATP5F1B ATP synthase F1 subunit beta 0.0422976
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0413981
CDC73 cell division cycle 73 0.0413973
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0407568
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0406049
CORO1C coronin, actin binding protein, 1C 0.0405291
PRTG protogenin 0.0399075
SLC38A2 solute carrier family 38, member 2 0.0396215
MEMO1 mediator of cell motility 1 0.0391952
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0385901
FIGN fidgetin 0.0382608
WDR43 WD repeat domain 43 0.0382072
METAP2 methionyl aminopeptidase 2 0.0376464
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 0.0371795
MEF2A myocyte enhancer factor 2A 0.0355455
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0354515
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0349353
THBS1 thrombospondin 1 0.0347691
ITGAV integrin, alpha V 0.0347411
OSBPL9 oxysterol binding protein-like 9 0.0341848
FBXO11 F-box protein 11 0.0341674
UBE3A ubiquitin protein ligase E3A 0.0341448
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) 0.0335763
JMJD1C jumonji domain containing 1C 0.0313148
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0308849
MDFIC MyoD family inhibitor domain containing 0.0307711
USP25 ubiquitin specific peptidase 25 0.0304112
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.0302292
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0300151
BCLAF1 BCL2-associated transcription factor 1 0.0290803
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0288243
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0286711
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0286081
ZNF608 zinc finger protein 608 0.028215
CUL3 cullin 3 0.0281069
MATR3 matrin 3 0.0275904
RTN4 reticulon 4 0.0275418
TOX thymocyte selection-associated high mobility group box 0.0272333
PCBP2 poly(rC) binding protein 2 0.0266662
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 0.0266029
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 0.0265702
CRY1 cryptochrome circadian clock 1 0.0265334
RLF rearranged L-myc fusion 0.0263567
CTPS1 CTP synthase 1 0.026258
PRR16 proline rich 16 0.0261418
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0260873
LHFPL6 LHFPL tetraspan subfamily member 6 0.0260171
TBC1D12 TBC1 domain family, member 12 0.0257937
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0257706
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.0256754
KMT2C lysine (K)-specific methyltransferase 2C 0.0256505
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0255863
RPL3 ribosomal protein L3 0.0255754
PDS5B PDS5 cohesin associated factor B 0.0251922
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0251877
ANK2 ankyrin 2, neuronal 0.0251337
CCT2 chaperonin containing TCP1, subunit 2 (beta) 0.0251095
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0250043
PUM1 pumilio RNA-binding family member 1 0.0249894
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.024736
PICALM phosphatidylinositol binding clathrin assembly protein 0.024585
RYBP RING1 and YY1 binding protein 0.0244586
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 0.0244551
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0239451
AKAP13 A kinase (PRKA) anchor protein 13 0.0238293
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.023811
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0236904
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0236537
GPC4 glypican 4 0.023579
VCL vinculin 0.0235471
IWS1 IWS1 homolog (S. cerevisiae) 0.0233576
TXNRD1 thioredoxin reductase 1 0.0233161
PPP4R1 protein phosphatase 4, regulatory subunit 1 0.0232089
RHEB Ras homolog enriched in brain 0.0231821
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.023181
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0231573
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0230117
DENND4A DENN/MADD domain containing 4A 0.0229102
ADGRL3 adhesion G protein-coupled receptor L3 0.0227137
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0226504

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.23774
PTMA prothymosin, alpha -0.143991
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.120479
GPC3 glypican 3 -0.116834
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.108688
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0965905
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0949359
CADM2 cell adhesion molecule 2 -0.0816171
TMSB10 thymosin beta 10 -0.0768495
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0767357
RPS16 ribosomal protein S16 -0.0681422
PCDH9 protocadherin 9 -0.0653164
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0630601
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0617996
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0601397
RPS8 ribosomal protein S8 -0.0551631
PCLO piccolo presynaptic cytomatrix protein -0.0536937
SPAG9 sperm associated antigen 9 -0.0523392
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0520601
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0516537
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0512909
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0512384
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0509585
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0498454
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.049707
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0496205
TPR translocated promoter region, nuclear basket protein -0.0493911
WSB1 WD repeat and SOCS box containing 1 -0.0482651
RPL35A ribosomal protein L35a -0.0473251
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.046866
COL11A1 collagen, type XI, alpha 1 -0.0465038
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0464874
SRP54 signal recognition particle 54kDa -0.0451602
CEP350 centrosomal protein 350kDa -0.0451601
COL1A2 collagen, type I, alpha 2 -0.0450142
MEIS2 Meis homeobox 2 -0.0439285
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0419417
GNAS GNAS complex locus -0.0410747
TTC28 tetratricopeptide repeat domain 28 -0.0408331
SNX6 sorting nexin 6 -0.0400496
TPT1 tumor protein, translationally-controlled 1 -0.0396853
LRRC4C leucine rich repeat containing 4C -0.0393966
NPAS3 neuronal PAS domain protein 3 -0.0393536
RPL37 ribosomal protein L37 -0.0393331
KPNB1 karyopherin (importin) beta 1 -0.0390351
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 -0.0389703
TAS2R14 taste receptor, type 2, member 14 -0.038189
RPL34 ribosomal protein L34 -0.0381492
CSMD3 CUB and Sushi multiple domains 3 -0.0378397
RPS19 ribosomal protein S19 -0.0374926
ACTG1 actin gamma 1 -0.0369209
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0363295
PHIP pleckstrin homology domain interacting protein -0.0362765
RPLP1 ribosomal protein, large, P1 -0.0357488
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0349155
MKI67 marker of proliferation Ki-67 -0.0344964
BIRC6 baculoviral IAP repeat containing 6 -0.0336205
CALR calreticulin -0.0333723
CAVIN1 caveolae associated protein 1 -0.0333451
PPIG peptidylprolyl isomerase G (cyclophilin G) -0.033335
BMPR1A bone morphogenetic protein receptor, type IA -0.0328571
ENO1 enolase 1, (alpha) -0.0326233
KTN1 kinectin 1 (kinesin receptor) -0.0319527
RPS3 ribosomal protein S3 -0.0311628
NTM neurotrimin -0.0310931
B2M beta-2-microglobulin -0.0304579
RAB31 RAB31, member RAS oncogene family -0.0302632
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0302094
ISG15 ISG15 ubiquitin-like modifier -0.0296889
NACA nascent polypeptide-associated complex alpha subunit -0.0296837
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0295403
RIGI RNA sensor RIG-I -0.029328
PRKD1 protein kinase D1 -0.029186
NFIA nuclear factor I/A -0.0290985
SREBF2 sterol regulatory element binding transcription factor 2 -0.0286955
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0286241
ADNP activity-dependent neuroprotector homeobox -0.0284265
RPS29 ribosomal protein S29 -0.0281766
RAB6A RAB6A, member RAS oncogene family -0.0281214
RABGAP1L RAB GTPase activating protein 1-like -0.0280027
CUX1 cut-like homeobox 1 -0.0279373
FTL ferritin, light polypeptide -0.0278836
NF1 neurofibromin 1 -0.0276712
DCAF7 DDB1 and CUL4 associated factor 7 -0.0276059
RPLP2 ribosomal protein, large, P2 -0.0273893
PGK1 phosphoglycerate kinase 1 -0.0273883
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0272632
RAB2A RAB2A, member RAS oncogene family -0.0269353
LOC102724023 ES1 protein homolog, mitochondrial -0.0268922
RPL37A ribosomal protein L37a -0.0268459
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0268304
NSD3 nuclear receptor binding SET domain protein 3 -0.0266829
FBXO17 F-box protein 17 -0.0265036
CENPF centromere protein F, 350/400kDa -0.0263963
TPM4 tropomyosin 4 -0.0262965
SFRP4 secreted frizzled-related protein 4 -0.0262066
DDIT4 DNA-damage-inducible transcript 4 -0.0257789
RPL31 ribosomal protein L31 -0.025523
BPTF bromodomain PHD finger transcription factor -0.0254789
RPS24 ribosomal protein S24 -0.0252811