Aspirin_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Aspirin perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Aspirin_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 0.0544
EFNA5 ephrin-A5 0.0529834
ENOX1 ecto-NOX disulfide-thiol exchanger 1 0.0493399
PDE4B phosphodiesterase 4B, cAMP-specific 0.044172
NBEA neurobeachin 0.0367014
SAMD4A sterile alpha motif domain containing 4A 0.0361481
EGFR epidermal growth factor receptor 0.0360248
CPED1 cadherin-like and PC-esterase domain containing 1 0.0351206
RHOA ras homolog family member A 0.0325483
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0274195
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.02692
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0265985
RHBDD1 rhomboid domain containing 1 0.0264386
ZCCHC7 zinc finger, CCHC domain containing 7 0.0254964
CTIF CBP80/20-dependent translation initiation factor 0.0253124
SMYD3 SET and MYND domain containing 3 0.023597
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0231868
NPAS2 neuronal PAS domain protein 2 0.0219811
ANK2 ankyrin 2, neuronal 0.0216547
FNIP1 folliculin interacting protein 1 0.0212928
EEF2 eukaryotic translation elongation factor 2 0.0211777
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.0206705
PTEN phosphatase and tensin homolog 0.0205027
PYGB phosphorylase, glycogen; brain 0.0204369
PRELID2 PRELI domain containing 2 0.0200616
PMM2 phosphomannomutase 2 0.0195281
LOXL3 lysyl oxidase-like 3 0.0193174
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 0.0183249
TTC28 tetratricopeptide repeat domain 28 0.01759
SEC31A SEC31 homolog A (S. cerevisiae) 0.0175884
ATM ATM serine/threonine kinase 0.0174097
ANKRD36 ankyrin repeat domain 36 0.0171954
PICALM phosphatidylinositol binding clathrin assembly protein 0.0170345
PLXNA1 plexin A1 0.0169388
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 0.0167884
BRWD1 bromodomain and WD repeat domain containing 1 0.0163753
ATP11A ATPase, class VI, type 11A 0.0162112
GANAB glucosidase, alpha; neutral AB 0.0161638
PTPRG protein tyrosine phosphatase, receptor type, G 0.0161588
ACBD6 acyl-CoA binding domain containing 6 0.016063
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0159095
NEBL nebulette 0.0158387
DENND1A DENN/MADD domain containing 1A 0.0157607
LPP LIM domain containing preferred translocation partner in lipoma 0.0156066
CRPPA CDP-L-ribitol pyrophosphorylase A 0.0155817
CLIP1 CAP-GLY domain containing linker protein 1 0.0152705
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0149942
HDLBP high density lipoprotein binding protein 0.0144043
GOLGA3 golgin A3 0.0144029
EPB41 erythrocyte membrane protein band 4.1 0.0143964
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 0.0141713
TBC1D22A TBC1 domain family, member 22A 0.0141659
KLF3 Kruppel-like factor 3 (basic) 0.0141161
GNPDA1 glucosamine-6-phosphate deaminase 1 0.013695
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0136114
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.0135712
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 0.0134858
PDE10A phosphodiesterase 10A 0.0134196
ANKRD17 ankyrin repeat domain 17 0.0132026
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0128625
COX16 COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) 0.012764
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0126596
RFX7 regulatory factor X, 7 0.0126252
GLS2 glutaminase 2 (liver, mitochondrial) 0.0125696
TARBP1 TAR (HIV-1) RNA binding protein 1 0.012453
MBNL2 muscleblind-like splicing regulator 2 0.0123488
TBC1D9B TBC1 domain family, member 9B (with GRAM domain) 0.0123352
PIAS2 protein inhibitor of activated STAT, 2 0.0122854
SBF2 SET binding factor 2 0.0121948
TBC1D32 TBC1 domain family, member 32 0.0120771
TMEM14B transmembrane protein 14B 0.0120242
ENO2 enolase 2 (gamma, neuronal) 0.0120002
ARID1A AT rich interactive domain 1A (SWI-like) 0.0119905
KMT2D lysine (K)-specific methyltransferase 2D 0.0118787
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0118511
ZFYVE28 zinc finger, FYVE domain containing 28 0.0118297
ITGAV integrin, alpha V 0.0117645
SPRED1 sprouty-related, EVH1 domain containing 1 0.0117082
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0117057
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.0116857
EPN2 epsin 2 0.0116835
PATJ PATJ crumbs cell polarity complex component 0.0116654
OSMR oncostatin M receptor 0.0116495
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1 0.011513
TDRD3 tudor domain containing 3 0.0115118
FKBP10 FK506 binding protein 10, 65 kDa 0.0115065
ZNF652 zinc finger protein 652 0.0114857
SMAD3 SMAD family member 3 0.0114778
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0114549
DNHD1 dynein heavy chain domain 1 0.0114426
KIF5C kinesin family member 5C 0.0114362
CLIC4 chloride intracellular channel 4 0.011429
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31) 0.0113799
KDM4C lysine (K)-specific demethylase 4C 0.0113735
GOSR1 golgi SNAP receptor complex member 1 0.0112684
XKR6 XK, Kell blood group complex subunit-related family, member 6 0.0112585
KRIT1 KRIT1, ankyrin repeat containing 0.0111583
KIAA1958 KIAA1958 0.011123
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0111172
PIWIL1 piwi-like RNA-mediated gene silencing 1 0.01101

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.277655
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.109962
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.103519
TPT1 tumor protein, translationally-controlled 1 -0.0885183
EML4 echinoderm microtubule associated protein like 4 -0.0789895
NAMPT nicotinamide phosphoribosyltransferase -0.0787211
RPS6 ribosomal protein S6 -0.07852
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0722629
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0700527
RPS8 ribosomal protein S8 -0.0696781
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0665072
NAP1L1 nucleosome assembly protein 1-like 1 -0.0638471
PKM pyruvate kinase, muscle -0.0618054
PDE4D phosphodiesterase 4D, cAMP-specific -0.0604677
ZNF292 zinc finger protein 292 -0.0600808
KMT2E lysine (K)-specific methyltransferase 2E -0.0590325
B2M beta-2-microglobulin -0.0578616
AHNAK AHNAK nucleoprotein -0.0577253
MKI67 marker of proliferation Ki-67 -0.054593
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0518386
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0516477
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0516419
RPS2 ribosomal protein S2 -0.0516301
RPS19 ribosomal protein S19 -0.0513485
RTN4 reticulon 4 -0.0492983
QKI QKI, KH domain containing, RNA binding -0.0492801
RPL19 ribosomal protein L19 -0.0488453
RPLP1 ribosomal protein, large, P1 -0.0487707
RPL26 ribosomal protein L26 -0.0485336
BMP10 bone morphogenetic protein 10 -0.0466784
RPL36 ribosomal protein L36 -0.0460864
ACTG1 actin gamma 1 -0.0457428
RBM39 RNA binding motif protein 39 -0.0455925
RPL35A ribosomal protein L35a -0.0455
SSBP2 single-stranded DNA binding protein 2 -0.0453625
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0453409
TMSB4X thymosin beta 4, X-linked -0.0446808
ECT2 epithelial cell transforming 2 -0.0439736
RPS25 ribosomal protein S25 -0.0434696
RPL11 ribosomal protein L11 -0.0415361
KDM3A lysine (K)-specific demethylase 3A -0.0404883
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0404494
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0400494
RPL31 ribosomal protein L31 -0.039866
MATR3 matrin 3 -0.0396768
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0394009
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0391165
RPL13A ribosomal protein L13a -0.0389807
RPS3 ribosomal protein S3 -0.0387125
KIF5B kinesin family member 5B -0.0384917
RPL34 ribosomal protein L34 -0.0384896
RPS13 ribosomal protein S13 -0.0373097
ZFAND3 zinc finger, AN1-type domain 3 -0.0370864
CCNL1 cyclin L1 -0.0370637
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0370289
ARL4C ADP-ribosylation factor-like 4C -0.0369991
ADAM10 ADAM metallopeptidase domain 10 -0.0369057
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0367865
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0366546
RPL7A ribosomal protein L7a -0.0365714
RPLP2 ribosomal protein, large, P2 -0.0365582
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0360965
NCKAP1 NCK-associated protein 1 -0.0357552
RPL23 ribosomal protein L23 -0.0354
IFI16 interferon, gamma-inducible protein 16 -0.0353929
PNISR PNN-interacting serine/arginine-rich protein -0.0350358
RPS12 ribosomal protein S12 -0.0346755
FBXO11 F-box protein 11 -0.0340519
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0338648
NF1 neurofibromin 1 -0.0331631
PGK1 phosphoglycerate kinase 1 -0.032704
LOC112694756 uncharaterized LOC112694756 -0.0326379
ELOVL5 ELOVL fatty acid elongase 5 -0.0323568
WAC WW domain containing adaptor with coiled-coil -0.0321957
ANXA1 annexin A1 -0.0321402
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 -0.032076
TMSB10 thymosin beta 10 -0.0318511
RPL37A ribosomal protein L37a -0.0318019
RPL8 ribosomal protein L8 -0.0316797
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0316395
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0309771
EZR ezrin -0.0307408
RPS23 ribosomal protein S23 -0.0307139
RPS27A ribosomal protein S27a -0.0303863
S100A10 S100 calcium binding protein A10 -0.0303529
OSBPL8 oxysterol binding protein-like 8 -0.0303304
BRD2 bromodomain containing 2 -0.0300823
RPL5 ribosomal protein L5 -0.0300499
SMC4 structural maintenance of chromosomes 4 -0.0299992
TXNRD1 thioredoxin reductase 1 -0.0298011
WSB1 WD repeat and SOCS box containing 1 -0.0297691
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0295996
DSTN destrin (actin depolymerizing factor) -0.0292322
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0289734
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0289028
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0288972
CCND1 cyclin D1 -0.0288492
SLMAP sarcolemma associated protein -0.0286417
MYO5C myosin VC -0.0286371
PUM1 pumilio RNA-binding family member 1 -0.028606