Aspirin_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Aspirin perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Aspirin_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SOD2 superoxide dismutase 2, mitochondrial 0.0831348
VEGFA vascular endothelial growth factor A 0.0813052
NAV2 neuron navigator 2 0.0631917
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0577933
NAMPT nicotinamide phosphoribosyltransferase 0.0482011
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0468317
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0396551
MSN moesin 0.0370413
PDE10A phosphodiesterase 10A 0.0310804
TRIO trio Rho guanine nucleotide exchange factor 0.030053
MYOF myoferlin 0.0298026
FNIP1 folliculin interacting protein 1 0.0293394
NDRG1 N-myc downstream regulated 1 0.0279317
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.0262414
SDK1 sidekick cell adhesion molecule 1 0.0249381
CADM1 cell adhesion molecule 1 0.0246953
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0244602
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0243796
UBA6 ubiquitin-like modifier activating enzyme 6 0.0236443
ELL2 elongation factor, RNA polymerase II, 2 0.0233423
BACE2 beta-site APP-cleaving enzyme 2 0.0228243
FNDC3B fibronectin type III domain containing 3B 0.0217645
ARRDC3 arrestin domain containing 3 0.0217515
YEATS2 YEATS domain containing 2 0.0213804
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0213378
ESYT2 extended synaptotagmin-like protein 2 0.0203855
FMNL2 formin-like 2 0.020314
ARF4 ADP-ribosylation factor 4 0.019366
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0183143
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0182646
ZMIZ1 zinc finger, MIZ-type containing 1 0.0175753
BHLHE40 basic helix-loop-helix family, member e40 0.0174684
PRELID2 PRELI domain containing 2 0.017361
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 0.0165574
CEP250 centrosomal protein 250kDa 0.0164924
FAM219A family with sequence similarity 219, member A 0.0164057
JMJD1C jumonji domain containing 1C 0.0162143
NOTCH2 notch 2 0.0155456
GOLGA4 golgin A4 0.0153377
MMP12 matrix metallopeptidase 12 0.0153358
ZNF292 zinc finger protein 292 0.0151895
TIMP2 TIMP metallopeptidase inhibitor 2 0.0149771
SEPTIN9 septin 9 0.0148104
CDK19 cyclin-dependent kinase 19 0.0147299
ANKRD36 ankyrin repeat domain 36 0.0146442
BCLAF1 BCL2-associated transcription factor 1 0.0145293
CCNL1 cyclin L1 0.0142227
COL8A1 collagen, type VIII, alpha 1 0.0142071
FAM13A family with sequence similarity 13, member A 0.0141309
DTNA dystrobrevin, alpha 0.0140783
DOCK5 dedicator of cytokinesis 5 0.0140678
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0140553
PGM3 phosphoglucomutase 3 0.0139959
NGLY1 N-glycanase 1 0.0138433
ZNF654 zinc finger protein 654 0.0137813
HELZ helicase with zinc finger 0.0137656
AMPD3 adenosine monophosphate deaminase 3 0.0134722
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0132569
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 0.0132038
ADM adrenomedullin 0.0130042
RUNX1 runt-related transcription factor 1 0.0129483
PCBP3 poly(rC) binding protein 3 0.0127705
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0127271
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.012705
ARFGEF3 ARFGEF family member 3 0.0126872
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0125696
CREBRF CREB3 regulatory factor 0.0125586
MXI1 MAX interactor 1, dimerization protein 0.0122723
ZHX2 zinc fingers and homeoboxes 2 0.0121344
MYH9 myosin, heavy chain 9, non-muscle 0.0121013
TPM3 tropomyosin 3 0.0119077
VAC14 Vac14 homolog (S. cerevisiae) 0.0117718
ATP13A3 ATPase type 13A3 0.0117353
FTH1 ferritin, heavy polypeptide 1 0.0116573
KDM2A lysine (K)-specific demethylase 2A 0.0115961
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0114664
RB1CC1 RB1-inducible coiled-coil 1 0.0113342
FRMPD4 FERM and PDZ domain containing 4 0.0113078
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.0112433
PPARD peroxisome proliferator-activated receptor delta 0.0111171
MIDEAS mitotic deacetylase associated SANT domain protein 0.0110421
ABTB3 ankyrin repeat and BTB domain containing 3 0.010955
EGLN1 egl-9 family hypoxia-inducible factor 1 0.010804
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0106934
PIAS2 protein inhibitor of activated STAT, 2 0.0106117
FLNB filamin B, beta 0.0105322
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.0105027
TENT5A terminal nucleotidyltransferase 5A 0.0104153
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae) 0.0104094
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0102892
SMC5 structural maintenance of chromosomes 5 0.0102325
EPHA6 EPH receptor A6 0.0102238
AXL AXL receptor tyrosine kinase 0.0101555
FBXL4 F-box and leucine-rich repeat protein 4 0.00999082
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.00995215
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.00994699
CD109 CD109 molecule 0.00993178
RPL3 ribosomal protein L3 0.00988016
FYN FYN proto-oncogene, Src family tyrosine kinase 0.00987746
C1D C1D nuclear receptor corepressor 0.00987343

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.241585
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.177436
HLA-B major histocompatibility complex, class I, B -0.131459
MARCKS myristoylated alanine-rich protein kinase C substrate -0.122288
BICC1 BicC family RNA binding protein 1 -0.120619
GLIS3 GLIS family zinc finger 3 -0.110617
TMSB10 thymosin beta 10 -0.105433
FTL ferritin, light polypeptide -0.104811
TPT1 tumor protein, translationally-controlled 1 -0.093579
VCL vinculin -0.0928229
IER3 immediate early response 3 -0.0917536
FRMD4A FERM domain containing 4A -0.0851492
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.082753
EXT1 exostosin glycosyltransferase 1 -0.0715025
RPS6 ribosomal protein S6 -0.069878
FN1 fibronectin 1 -0.0635044
B2M beta-2-microglobulin -0.0597516
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0596045
MT2A metallothionein 2A -0.0587233
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.058388
PGK1 phosphoglycerate kinase 1 -0.0569033
RPS24 ribosomal protein S24 -0.0539006
ANXA2 annexin A2 -0.0536026
EIF1 eukaryotic translation initiation factor 1 -0.0527313
NAP1L1 nucleosome assembly protein 1-like 1 -0.0523464
ZFAND3 zinc finger, AN1-type domain 3 -0.0519809
HMGA2 high mobility group AT-hook 2 -0.050753
RPLP1 ribosomal protein, large, P1 -0.0503974
RPL23 ribosomal protein L23 -0.0499438
HLA-A major histocompatibility complex, class I, A -0.0493041
RPS8 ribosomal protein S8 -0.0492094
AHNAK AHNAK nucleoprotein -0.0482593
THBS1 thrombospondin 1 -0.0471496
RPS12 ribosomal protein S12 -0.0464489
HLA-E major histocompatibility complex, class I, E -0.045747
RPL19 ribosomal protein L19 -0.0449995
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0440421
PTMA prothymosin, alpha -0.0432165
RPLP2 ribosomal protein, large, P2 -0.0429474
RPL35A ribosomal protein L35a -0.042532
RPL12 ribosomal protein L12 -0.0422977
IGFBP3 insulin-like growth factor binding protein 3 -0.0415961
SLC38A2 solute carrier family 38, member 2 -0.0409189
RPS3 ribosomal protein S3 -0.0409163
SLC38A1 solute carrier family 38, member 1 -0.0397207
RPL37A ribosomal protein L37a -0.0395507
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0392983
QKI QKI, KH domain containing, RNA binding -0.0390435
KYNU kynureninase -0.0388081
NABP1 nucleic acid binding protein 1 -0.0383818
RPS4X ribosomal protein S4, X-linked -0.0383597
RPL26 ribosomal protein L26 -0.0381178
RPL36A ribosomal protein L36a -0.0380404
LOC112694756 uncharaterized LOC112694756 -0.0379213
ACTG1 actin gamma 1 -0.0378084
PALLD palladin, cytoskeletal associated protein -0.0365364
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0360101
RPL11 ribosomal protein L11 -0.0351954
PTPRK protein tyrosine phosphatase, receptor type, K -0.035154
LDHA lactate dehydrogenase A -0.0346093
RIGI RNA sensor RIG-I -0.0342274
RPL32 ribosomal protein L32 -0.0339409
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0338291
RPS19 ribosomal protein S19 -0.0337891
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0332327
GNAS GNAS complex locus -0.0328662
SMAD3 SMAD family member 3 -0.0324521
RPL36 ribosomal protein L36 -0.0323447
IFITM3 interferon induced transmembrane protein 3 -0.0321779
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0321434
RPL31 ribosomal protein L31 -0.0320379
RACK1 receptor for activated C kinase 1 -0.0319508
TGFBI transforming growth factor, beta-induced, 68kDa -0.0313321
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0309534
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0308551
RPS23 ribosomal protein S23 -0.0307833
WSB1 WD repeat and SOCS box containing 1 -0.0307377
TUBB tubulin, beta class I -0.0307053
HDAC9 histone deacetylase 9 -0.030361
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0298081
AKAP12 A kinase (PRKA) anchor protein 12 -0.0294554
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0291647
DEK DEK proto-oncogene -0.0291442
NAV1 neuron navigator 1 -0.0290982
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0287306
IGFBP7 insulin-like growth factor binding protein 7 -0.0284529
RPS14 ribosomal protein S14 -0.0283969
COL6A3 collagen, type VI, alpha 3 -0.0281706
ZBTB38 zinc finger and BTB domain containing 38 -0.0281042
EGR1 early growth response 1 -0.0278822
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0276701
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0275958
DST dystonin -0.0275864
RPS27A ribosomal protein S27a -0.0275592
COL1A2 collagen, type I, alpha 2 -0.0275181
RPS13 ribosomal protein S13 -0.0274613
CANX calnexin -0.0270829
RNF213 ring finger protein 213 -0.0266859
NCOA7 nuclear receptor coactivator 7 -0.0266698
IFI16 interferon, gamma-inducible protein 16 -0.026449