Aspirin_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Aspirin perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Aspirin_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0417266
MATR3 matrin 3 0.0404357
ELL2 elongation factor, RNA polymerase II, 2 0.0374843
MACF1 microtubule-actin crosslinking factor 1 0.0319133
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0312049
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0304085
ATP13A3 ATPase type 13A3 0.0293695
PDE10A phosphodiesterase 10A 0.0288324
CDK19 cyclin-dependent kinase 19 0.028513
ERRFI1 ERBB receptor feedback inhibitor 1 0.0278348
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.0276372
CLIP2 CAP-GLY domain containing linker protein 2 0.0250174
SPRED2 sprouty-related, EVH1 domain containing 2 0.0239493
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0227336
CTNND1 catenin (cadherin-associated protein), delta 1 0.021599
TRA2A transformer 2 alpha homolog (Drosophila) 0.0214458
ARHGAP12 Rho GTPase activating protein 12 0.0211626
PEG10 paternally expressed 10 0.0205712
NRXN3 neurexin 3 0.0200132
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0199644
WDR41 WD repeat domain 41 0.0198338
OXSR1 oxidative stress responsive 1 0.0192281
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0191643
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.019127
PNN pinin, desmosome associated protein 0.0190849
EPAS1 endothelial PAS domain protein 1 0.0190412
PRKACB protein kinase, cAMP-dependent, catalytic, beta 0.0189039
WASF2 WAS protein family, member 2 0.018691
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.018627
LEMD3 LEM domain containing 3 0.0185357
SUB1 SUB1 homolog (S. cerevisiae) 0.0183769
SCFD2 sec1 family domain containing 2 0.0182356
SMOC1 SPARC related modular calcium binding 1 0.0181544
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0180418
DCAF6 DDB1 and CUL4 associated factor 6 0.0180412
SLC25A51 solute carrier family 25, member 51 0.0179954
EXOC6B exocyst complex component 6B 0.0176981
TENM1 teneurin transmembrane protein 1 0.0175065
TXNL1 thioredoxin-like 1 0.0175056
ARHGAP35 Rho GTPase activating protein 35 0.0172621
P3H2 prolyl 3-hydroxylase 2 0.0172259
AKAP9 A kinase (PRKA) anchor protein 9 0.0172258
COL1A1 collagen, type I, alpha 1 0.0172136
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0168489
SHB Src homology 2 domain containing adaptor protein B 0.0167864
COPA coatomer protein complex, subunit alpha 0.0167714
IGFBP5 insulin-like growth factor binding protein 5 0.0167158
FBXL7 F-box and leucine-rich repeat protein 7 0.016711
FTH1 ferritin, heavy polypeptide 1 0.0167091
ARID3A AT rich interactive domain 3A (BRIGHT-like) 0.0165235
HERPUD2 HERPUD family member 2 0.0164973
ZFAND6 zinc finger, AN1-type domain 6 0.0163284
PYGL phosphorylase, glycogen, liver 0.0163264
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.0162678
USP37 ubiquitin specific peptidase 37 0.0162676
NBAS neuroblastoma amplified sequence 0.0162598
UBA6 ubiquitin-like modifier activating enzyme 6 0.0161644
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.016146
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.0160704
GMCL1 germ cell-less, spermatogenesis associated 1 0.0159393
GPBP1L1 GC-rich promoter binding protein 1-like 1 0.0159365
FHIT fragile histidine triad 0.0159154
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0158841
AMBRA1 autophagy/beclin-1 regulator 1 0.0158036
NUP214 nucleoporin 214kDa 0.0157851
TRIP12 thyroid hormone receptor interactor 12 0.0157138
HIPK3 homeodomain interacting protein kinase 3 0.0156899
RARA retinoic acid receptor, alpha 0.0156805
NDEL1 nudE neurodevelopment protein 1-like 1 0.0155784
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 0.0155233
POT1 protection of telomeres 1 0.0154213
NPC1 Niemann-Pick disease, type C1 0.0153593
BCL2L1 BCL2-like 1 0.0152947
ZNF146 zinc finger protein 146 0.0152024
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0151122
HPCAL1 hippocalcin-like 1 0.015017
RBM39 RNA binding motif protein 39 0.0149402
TGOLN2 trans-golgi network protein 2 0.0148668
MYO1E myosin IE 0.0146439
KDM5A lysine (K)-specific demethylase 5A 0.0146224
ABI1 abl-interactor 1 0.0145752
UXS1 UDP-glucuronate decarboxylase 1 0.0144956
DDB1 damage-specific DNA binding protein 1, 127kDa 0.0144523
VGF VGF nerve growth factor inducible 0.0144468
TM9SF4 transmembrane 9 superfamily protein member 4 0.0144443
ZFC3H1 zinc finger, C3H1-type containing 0.0143848
FAM168A family with sequence similarity 168, member A 0.0143791
FGF14 fibroblast growth factor 14 0.0143757
DCP2 decapping mRNA 2 0.0143385
GAN gigaxonin 0.0142215
ZSWIM5 zinc finger, SWIM-type containing 5 0.0142131
ANKRD11 ankyrin repeat domain 11 0.0141739
COG6 component of oligomeric golgi complex 6 0.014061
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0139867
KLHL2 kelch-like family member 2 0.0139806
TNXB tenascin XB 0.0139799
FLNB filamin B, beta 0.0139012
VEGFA vascular endothelial growth factor A 0.0138583
GYS1 glycogen synthase 1 (muscle) 0.0138232
MED4 mediator complex subunit 4 0.0138153

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.166985
VIM vimentin -0.158621
TMSB10 thymosin beta 10 -0.152278
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.131474
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.130892
TGFBI transforming growth factor, beta-induced, 68kDa -0.121052
TIMP3 TIMP metallopeptidase inhibitor 3 -0.114707
HLA-B major histocompatibility complex, class I, B -0.109334
FN1 fibronectin 1 -0.107989
IGFBP3 insulin-like growth factor binding protein 3 -0.104092
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.101652
B2M beta-2-microglobulin -0.0814324
FTL ferritin, light polypeptide -0.075494
NAMPT nicotinamide phosphoribosyltransferase -0.0682576
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0637785
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0598232
F3 coagulation factor III (thromboplastin, tissue factor) -0.0570967
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0526813
CALR calreticulin -0.0525096
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0520476
CALD1 caldesmon 1 -0.0512841
HLA-C major histocompatibility complex, class I, C -0.0511748
COL6A3 collagen, type VI, alpha 3 -0.0509496
TPM4 tropomyosin 4 -0.0496658
CALU calumenin -0.0493442
CDH13 cadherin 13 -0.048937
POTEF POTE ankyrin domain family, member F -0.0466912
TPT1 tumor protein, translationally-controlled 1 -0.0450832
TNS3 tensin 3 -0.0450372
PKM pyruvate kinase, muscle -0.0437966
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0432861
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0428378
MT1X metallothionein 1X -0.0425038
GNAS GNAS complex locus -0.040296
CANX calnexin -0.0399666
ACTG1 actin gamma 1 -0.0395157
COL6A1 collagen, type VI, alpha 1 -0.0382301
STC1 stanniocalcin 1 -0.0381812
COL6A2 collagen, type VI, alpha 2 -0.037283
RAI14 retinoic acid induced 14 -0.0365475
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.03608
IL6ST interleukin 6 signal transducer -0.03562
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0354972
CADM1 cell adhesion molecule 1 -0.0348581
ZMYND8 zinc finger, MYND-type containing 8 -0.0346667
KMT2E lysine (K)-specific methyltransferase 2E -0.0339756
LDHA lactate dehydrogenase A -0.0339227
EIF1 eukaryotic translation initiation factor 1 -0.0338688
LPP LIM domain containing preferred translocation partner in lipoma -0.0317708
GLIS3 GLIS family zinc finger 3 -0.0315799
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0312082
COL5A1 collagen, type V, alpha 1 -0.030722
RRBP1 ribosome binding protein 1 -0.0307042
RPL34 ribosomal protein L34 -0.0305151
PSD3 pleckstrin and Sec7 domain containing 3 -0.0297998
CAVIN1 caveolae associated protein 1 -0.0295467
S100A6 S100 calcium binding protein A6 -0.029243
RPL37A ribosomal protein L37a -0.0290894
RPS8 ribosomal protein S8 -0.0290542
PRSS23 protease, serine, 23 -0.028981
PDPK1 3-phosphoinositide dependent protein kinase 1 -0.0289169
LOC112694756 uncharaterized LOC112694756 -0.0289065
HIPK2 homeodomain interacting protein kinase 2 -0.0283858
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0282146
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0280594
ENO1 enolase 1, (alpha) -0.027672
TFPI2 tissue factor pathway inhibitor 2 -0.0266365
DPYD dihydropyrimidine dehydrogenase -0.0261246
ANXA5 annexin A5 -0.0260062
HILPDA hypoxia inducible lipid droplet-associated -0.0259425
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0257474
FBN1 fibrillin 1 -0.0254488
ADM adrenomedullin -0.0253312
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.024961
GRB10 growth factor receptor-bound protein 10 -0.0248898
H3-3B H3.3 histone B -0.0243385
CCNI cyclin I -0.0243143
S100A9 S100 calcium binding protein A9 -0.0242957
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0239689
CAV1 caveolin 1, caveolae protein, 22kDa -0.0238027
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0235869
RAD51B RAD51 paralog B -0.0235097
IL6 interleukin 6 -0.0233739
LOX lysyl oxidase -0.0232962
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0231758
RTN4 reticulon 4 -0.0229033
ATXN1 ataxin 1 -0.0228288
LMNA lamin A/C -0.0228067
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0227507
DST dystonin -0.0226333
PDIA3 protein disulfide isomerase family A, member 3 -0.0224165
WSB1 WD repeat and SOCS box containing 1 -0.0222581
RPL35A ribosomal protein L35a -0.0222323
TUBB tubulin, beta class I -0.0220149
RUNX1 runt-related transcription factor 1 -0.0219464
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0216546
TBC1D5 TBC1 domain family, member 5 -0.0216338
FLNA filamin A, alpha -0.0215821
BBX bobby sox homolog (Drosophila) -0.0212355
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0211459