Aspirin_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Aspirin perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Aspirin_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VEGFA vascular endothelial growth factor A 0.0633504
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0591077
ENO2 enolase 2 (gamma, neuronal) 0.0425025
ZFP36L1 ZFP36 ring finger protein-like 1 0.0385268
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0373877
MRPS6 mitochondrial ribosomal protein S6 0.0362622
RAI14 retinoic acid induced 14 0.033877
NRG1 neuregulin 1 0.0337531
STC2 stanniocalcin 2 0.032719
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0315812
PLIN2 perilipin 2 0.031371
HMGA2 high mobility group AT-hook 2 0.0311729
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0275308
INTS6 integrator complex subunit 6 0.0258276
POTEF POTE ankyrin domain family, member F 0.0252979
ZCCHC7 zinc finger, CCHC domain containing 7 0.0251801
AKAP12 A kinase (PRKA) anchor protein 12 0.0234392
IGFBP3 insulin-like growth factor binding protein 3 0.0234097
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0230027
LIMCH1 LIM and calponin homology domains 1 0.0224365
SRRM2 serine/arginine repetitive matrix 2 0.0223696
HIPK2 homeodomain interacting protein kinase 2 0.022228
ZSWIM6 zinc finger, SWIM-type containing 6 0.0199882
GPC6 glypican 6 0.0199811
MCL1 myeloid cell leukemia 1 0.0198352
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 0.0194957
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0190188
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0189404
ZMIZ1 zinc finger, MIZ-type containing 1 0.0186501
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0186171
TMEM165 transmembrane protein 165 0.017355
AEBP2 AE binding protein 2 0.0170261
CNIH3 cornichon family AMPA receptor auxiliary protein 3 0.0169879
GRB10 growth factor receptor-bound protein 10 0.016946
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0163847
SEPTIN9 septin 9 0.0157546
TENM4 teneurin transmembrane protein 4 0.0149919
ZFYVE16 zinc finger, FYVE domain containing 16 0.0148968
SLC35F3 solute carrier family 35, member F3 0.0143624
HPS3 Hermansky-Pudlak syndrome 3 0.0141003
VCL vinculin 0.0139981
CLIP2 CAP-GLY domain containing linker protein 2 0.0138524
TGM2 transglutaminase 2 0.0138259
PDLIM5 PDZ and LIM domain 5 0.0137114
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0136717
TPM3 tropomyosin 3 0.013617
BRD2 bromodomain containing 2 0.0134376
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0132446
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0130326
CADM1 cell adhesion molecule 1 0.0128091
UBAP2 ubiquitin associated protein 2 0.0127094
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0126978
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 0.0122837
ITCH itchy E3 ubiquitin protein ligase 0.0121154
PALLD palladin, cytoskeletal associated protein 0.0120939
PCNX4 pecanex 4 0.0120647
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.011939
IGF2 insulin-like growth factor 2 0.0119276
CRTAC1 cartilage acidic protein 1 0.011895
MSN moesin 0.0118038
ATN1 atrophin 1 0.0117112
WWTR1 WW domain containing transcription regulator 1 0.0116465
MTSS1 metastasis suppressor 1 0.0115981
CYB5R3 cytochrome b5 reductase 3 0.0114074
EPAS1 endothelial PAS domain protein 1 0.0113427
FBN1 fibrillin 1 0.0113408
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0112599
OXR1 oxidation resistance 1 0.0111733
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0111561
AHRR aryl-hydrocarbon receptor repressor 0.0110858
PRKCA protein kinase C, alpha 0.0110083
KIF16B kinesin family member 16B 0.0108765
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0107956
NOTCH2 notch 2 0.0106256
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4 0.0104477
USP47 ubiquitin specific peptidase 47 0.010304
MYH9 myosin, heavy chain 9, non-muscle 0.010287
SHB Src homology 2 domain containing adaptor protein B 0.0102607
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0101443
TGFB1 transforming growth factor, beta 1 0.0100138
PCBP3 poly(rC) binding protein 3 0.0100113
CCDC138 coiled-coil domain containing 138 0.00999073
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.00972765
VAC14 Vac14 homolog (S. cerevisiae) 0.00964979
TTC19 tetratricopeptide repeat domain 19 0.0096296
TMF1 TATA element modulatory factor 1 0.00957899
FAM219A family with sequence similarity 219, member A 0.00949096
ERRFI1 ERBB receptor feedback inhibitor 1 0.00943763
POU2F2 POU class 2 homeobox 2 0.00943181
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic) 0.00941963
PGM3 phosphoglucomutase 3 0.00940891
DGKH diacylglycerol kinase, eta 0.00935551
HLA-G major histocompatibility complex, class I, G 0.00933042
SF3A1 splicing factor 3a, subunit 1, 120kDa 0.00930898
GOLGB1 golgin B1 0.00928169
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.00926979
CLIC4 chloride intracellular channel 4 0.00925051
CALB2 calbindin 2 0.0091962
GOSR2 golgi SNAP receptor complex member 2 0.00918791
PRPF8 pre-mRNA processing factor 8 0.00911098

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.309447
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.199827
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.169672
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.161136
NAMPT nicotinamide phosphoribosyltransferase -0.159492
SQSTM1 sequestosome 1 -0.121974
MT2A metallothionein 2A -0.102428
CANX calnexin -0.0809299
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0804169
HLA-B major histocompatibility complex, class I, B -0.0793227
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0791747
PTMA prothymosin, alpha -0.0731142
TPT1 tumor protein, translationally-controlled 1 -0.0715855
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0680085
FTL ferritin, light polypeptide -0.0624141
FN1 fibronectin 1 -0.0619369
VIM vimentin -0.0610767
NAP1L1 nucleosome assembly protein 1-like 1 -0.06089
RPL12 ribosomal protein L12 -0.0574027
ASPH aspartate beta-hydroxylase -0.0561045
TMSB10 thymosin beta 10 -0.0545988
RPL26 ribosomal protein L26 -0.0545356
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0530137
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0518144
RBM39 RNA binding motif protein 39 -0.0510455
TXNRD1 thioredoxin reductase 1 -0.0507029
RPL35A ribosomal protein L35a -0.0500274
RPS24 ribosomal protein S24 -0.0499904
RPS6 ribosomal protein S6 -0.048978
PRRC2C proline-rich coiled-coil 2C -0.0483077
RPLP1 ribosomal protein, large, P1 -0.0467347
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0466782
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0458842
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0448549
RPL9 ribosomal protein L9 -0.0444028
RPS12 ribosomal protein S12 -0.04354
S100A6 S100 calcium binding protein A6 -0.0434057
YBX3 Y box binding protein 3 -0.0426579
RPL23 ribosomal protein L23 -0.0421567
RACK1 receptor for activated C kinase 1 -0.0421335
RPS8 ribosomal protein S8 -0.0417776
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0414943
RPL31 ribosomal protein L31 -0.041223
IER3 immediate early response 3 -0.0404188
SEPTIN7 septin 7 -0.0403141
RPL37A ribosomal protein L37a -0.0401626
FNBP1 formin binding protein 1 -0.0400753
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0397949
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0395346
RAD21 RAD21 homolog (S. pombe) -0.0395052
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0394077
RPS19 ribosomal protein S19 -0.0388578
NEK7 NIMA-related kinase 7 -0.0387375
RPS21 ribosomal protein S21 -0.0386255
GNAS GNAS complex locus -0.0384021
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0382699
FOXP1 forkhead box P1 -0.0376312
IFI16 interferon, gamma-inducible protein 16 -0.0374306
RLF rearranged L-myc fusion -0.0373909
RAB1A RAB1A, member RAS oncogene family -0.0370083
TMEM156 transmembrane protein 156 -0.0369556
KDM3A lysine (K)-specific demethylase 3A -0.0366504
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0366341
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0365713
RPL11 ribosomal protein L11 -0.0362169
ARF1 ADP-ribosylation factor 1 -0.0361662
PTK2 protein tyrosine kinase 2 -0.0357145
RPS20 ribosomal protein S20 -0.0355162
B2M beta-2-microglobulin -0.0354858
WDR45B WD repeat domain 45B -0.0351339
LOC112694756 uncharaterized LOC112694756 -0.0349607
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0348846
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0348468
MCTP2 multiple C2 domains, transmembrane 2 -0.0347921
PELO pelota homolog (Drosophila) -0.034765
RPS29 ribosomal protein S29 -0.0345711
RPL38 ribosomal protein L38 -0.0343185
RRBP1 ribosome binding protein 1 -0.0341148
ACTN4 actinin, alpha 4 -0.0338633
RPL19 ribosomal protein L19 -0.0331146
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 -0.0328457
OGA O-GlcNAcase -0.0323545
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0316999
RPL34 ribosomal protein L34 -0.0316355
RPS16 ribosomal protein S16 -0.0314665
ZNF292 zinc finger protein 292 -0.0312863
RPS11 ribosomal protein S11 -0.031258
OSMR oncostatin M receptor -0.031221
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0311853
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0310699
EREG epiregulin -0.0309936
RPS5 ribosomal protein S5 -0.0308779
RPL37 ribosomal protein L37 -0.0308529
MARCHF6 membrane associated ring-CH-type finger 6 -0.0306491
RPL36 ribosomal protein L36 -0.0303338
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0302495
KLHL5 kelch-like family member 5 -0.0301766
ETV1 ets variant 1 -0.0299
TPI1 triosephosphate isomerase 1 -0.0298392
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0298036