Asthenozoospermia Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description loss or reduction of the mobility of the spermatozoa, frequently associated with infertility (Mammalian Phenotype Ontology, MP_0002675)
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D053627
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Genes

305 genes/proteins associated with the disease Asthenozoospermia from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
PLAU plasminogen activator, urokinase 2.88009
GSTT1 glutathione S-transferase theta 1 2.88009
IL1B interleukin 1, beta 1.98814
TNF tumor necrosis factor 1.97757
CAT catalase 1.90125
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.8662
SOD1 superoxide dismutase 1, soluble 1.82604
MAPK1 mitogen-activated protein kinase 1 1.81593
CLU clusterin 1.74401
MAPK3 mitogen-activated protein kinase 3 1.73918
ESR1 estrogen receptor 1 1.72968
NOS2 nitric oxide synthase 2, inducible 1.72821
GSTP1 glutathione S-transferase pi 1 1.72758
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.70244
BCL2 B-cell CLL/lymphoma 2 1.68655
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.68316
GGT1 gamma-glutamyltransferase 1 1.67051
JUN jun proto-oncogene 1.65709
FSHB follicle stimulating hormone, beta polypeptide 1.65181
IL6 interleukin 6 1.63944
BAX BCL2-associated X protein 1.63563
BCL2L1 BCL2-like 1 1.63541
TIMP3 TIMP metallopeptidase inhibitor 3 1.63049
CYCS cytochrome c, somatic 1.61828
STAR steroidogenic acute regulatory protein 1.61805
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 1.61389
EGR1 early growth response 1 1.60594
CTSB cathepsin B 1.58398
TGFB1 transforming growth factor, beta 1 1.58137
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.58065
BDNF brain-derived neurotrophic factor 1.56994
CREB1 cAMP responsive element binding protein 1 1.56558
GPX1 glutathione peroxidase 1 1.56361
GSR glutathione reductase 1.55673
CCND1 cyclin D1 1.55059
TP53 tumor protein p53 1.54986
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.53989
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.52061
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 1.52011
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.51105
FOS FBJ murine osteosarcoma viral oncogene homolog 1.50198
ODC1 ornithine decarboxylase 1 1.49736
NUDC nudC nuclear distribution protein 1.49686
KLHL24 kelch-like family member 24 1.49482
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.49096
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 1.48813
ALB albumin 1.48608
MAP2K2 mitogen-activated protein kinase kinase 2 1.48505
BCL2L11 BCL2-like 11 (apoptosis facilitator) 1.48505
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.48454
AR androgen receptor 1.47089
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 1.44845
VEGFA vascular endothelial growth factor A 1.44653
MAPK8 mitogen-activated protein kinase 8 1.44029
SOD2 superoxide dismutase 2, mitochondrial 1.43755
PARP1 poly (ADP-ribose) polymerase 1 1.43347
GSK3B glycogen synthase kinase 3 beta 1.42831
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.41313
GADD45A growth arrest and DNA-damage-inducible, alpha 1.40842
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.40373
DHCR7 7-dehydrocholesterol reductase 1.40064
ICAM1 intercellular adhesion molecule 1 1.39702
COL1A1 collagen, type I, alpha 1 1.39338
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 1.38918
NFE2L2 nuclear factor, erythroid 2-like 2 1.38584
VIM vimentin 1.37958
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 1.37648
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 1.37275
CREBBP CREB binding protein 1.37132
FAS Fas cell surface death receptor 1.36735
PPARG peroxisome proliferator-activated receptor gamma 1.36218
IL2 interleukin 2 1.36161
PAM peptidylglycine alpha-amidating monooxygenase 1.35962
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 1.35618
HSPB1 heat shock 27kDa protein 1 1.35502
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 1.35444
LHB luteinizing hormone beta polypeptide 1.35098
MAPK9 mitogen-activated protein kinase 9 1.34198
FN1 fibronectin 1 1.32577
ACHE acetylcholinesterase (Yt blood group) 1.32458
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 1.32339
WT1 Wilms tumor 1 1.31776
TYMP thymidine phosphorylase 1.31536
CCND2 cyclin D2 1.31327
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 1.30881
UBC ubiquitin C 1.30758
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 1.3036
IGF1R insulin-like growth factor 1 receptor 1.29812
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 1.29626
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.29533
GPI glucose-6-phosphate isomerase 1.2861
PER2 period circadian clock 2 1.27936
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 1.27936
NR1I2 nuclear receptor subfamily 1, group I, member 2 1.27657
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 1.27502
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 1.27471
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4 1.27286
RAF1 Raf-1 proto-oncogene, serine/threonine kinase 1.27224
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 1.27039
ACO2 aconitase 2, mitochondrial 1.26886
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 1.25868
MAP2K1 mitogen-activated protein kinase kinase 1 1.25432
GSN gelsolin 1.25245
HES1 hes family bHLH transcription factor 1 1.25214
LSR lipolysis stimulated lipoprotein receptor 1.25121
HSPA4 heat shock 70kDa protein 4 1.24843
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 1.24338
G6PD glucose-6-phosphate dehydrogenase 1.24307
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.24087
CTTN cortactin 1.24024
GJA1 gap junction protein, alpha 1, 43kDa 1.23868
GOT1 glutamic-oxaloacetic transaminase 1, soluble 1.23712
RPS27 ribosomal protein S27 1.23616
TUBA1B tubulin, alpha 1b 1.23584
RAB14 RAB14, member RAS oncogene family 1.23233
HMGB1 high mobility group box 1 1.23169
MCL1 myeloid cell leukemia 1 1.23074
MPO myeloperoxidase 1.21984
PRDX2 peroxiredoxin 2 1.21887
HMOX1 heme oxygenase 1 1.21855
CDK4 cyclin-dependent kinase 4 1.21501
TH tyrosine hydroxylase 1.21402
AHR aryl hydrocarbon receptor 1.21337
HSPA1A heat shock 70kDa protein 1A 1.21304
NPC2 Niemann-Pick disease, type C2 1.20784
CALR calreticulin 1.20526
ACTA2 actin, alpha 2, smooth muscle, aorta 1.20295
BID BH3 interacting domain death agonist 1.20097
IL4 interleukin 4 1.19835
CSNK1A1 casein kinase 1, alpha 1 1.19542
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 1.19477
CAPG capping protein (actin filament), gelsolin-like 1.19477
RBBP4 retinoblastoma binding protein 4 1.19146
JAK2 Janus kinase 2 1.18948
NINJ1 ninjurin 1 1.18882
TERT telomerase reverse transcriptase 1.18783
GADD45B growth arrest and DNA-damage-inducible, beta 1.1862
BAG1 BCL2-associated athanogene 1.18259
CFLAR CASP8 and FADD-like apoptosis regulator 1.18159
DNMT1 DNA (cytosine-5-)-methyltransferase 1 1.17993
CCND3 cyclin D3 1.17695
IFNG interferon, gamma 1.17235
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 1.17101
GPX3 glutathione peroxidase 3 1.17101
NR2F2 nuclear receptor subfamily 2, group F, member 2 1.16866
SUMO2 small ubiquitin-like modifier 2 1.16766
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase 1.16766
PGR progesterone receptor 1.166
SORD sorbitol dehydrogenase 1.16302
CUTC cutC copper transporter 1.1607
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.15899
TFF1 trefoil factor 1 1.15695
MLF2 myeloid leukemia factor 2 1.15425
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 1.15223
IL10 interleukin 10 1.14989
ATM ATM serine/threonine kinase 1.14747
CCL2 chemokine (C-C motif) ligand 2 1.14644
TIMP1 TIMP metallopeptidase inhibitor 1 1.14644
GATA6 GATA binding protein 6 1.14268
CASP7 caspase 7, apoptosis-related cysteine peptidase 1.14132
FOSL1 FOS-like antigen 1 1.13689
STK38L serine/threonine kinase 38 like 1.13586
MTF2 metal response element binding transcription factor 2 1.13586
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 1.13552
CXCL12 chemokine (C-X-C motif) ligand 12 1.13313
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 1.13279
CST3 cystatin C 1.13245
GFAP glial fibrillary acidic protein 1.12668
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 1.12495
ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa 1.12495
PEX3 peroxisomal biogenesis factor 3 1.12461
PECAM1 platelet/endothelial cell adhesion molecule 1 1.12323
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 1.12254
SOX9 SRY (sex determining region Y)-box 9 1.12117
CCNB1 cyclin B1 1.12082
CTBP1 C-terminal binding protein 1 1.11911
AKT2 v-akt murine thymoma viral oncogene homolog 2 1.11911
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 1.11639
IGFBP3 insulin-like growth factor binding protein 3 1.11606
PPAP2B phosphatidic acid phosphatase type 2B 1.11431
LDHC lactate dehydrogenase C 1.11081
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 1.11011
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 1.10872
PLEKHO1 pleckstrin homology domain containing, family O member 1 1.10872
NQO1 NAD(P)H dehydrogenase, quinone 1 1.10838
ECH1 enoyl CoA hydratase 1, peroxisomal 1.10388
PNISR PNN-interacting serine/arginine-rich protein 1.10388
INTS6 integrator complex subunit 6 1.10388
MR1 major histocompatibility complex, class I-related 1.10353
APP amyloid beta (A4) precursor protein 1.10317
PCNA proliferating cell nuclear antigen 1.10246
GCLC glutamate-cysteine ligase, catalytic subunit 1.10033
MTCH2 mitochondrial carrier 2 1.10033
N4BP2L2 NEDD4 binding protein 2-like 2 1.09892
ESR2 estrogen receptor 2 (ER beta) 1.09822
PTGES prostaglandin E synthase 1.09716
KRT19 keratin 19, type I 1.09576
CTGF connective tissue growth factor 1.09506
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) 1.09401
TPI1 triosephosphate isomerase 1 1.09366
RAB5A RAB5A, member RAS oncogene family 1.0919
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.09047
ADCY9 adenylate cyclase 9 1.08975
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1 1.08975
NIPBL Nipped-B homolog (Drosophila) 1.08975
PLAT plasminogen activator, tissue 1.0894
KLF9 Kruppel-like factor 9 1.0869
E2F5 E2F transcription factor 5, p130-binding 1.08655
NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase) 1.08549
TSHB thyroid stimulating hormone, beta 1.08196
CKB creatine kinase, brain 1.08161
HDAC1 histone deacetylase 1 1.08126
SF3B1 splicing factor 3b, subunit 1, 155kDa 1.08091
GPX7 glutathione peroxidase 7 1.08055
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae) 1.08055
ORM1 orosomucoid 1 1.07804
ERCC1 excision repair cross-complementation group 1 1.07768
CDC14B cell division cycle 14B 1.07732
ALDOA aldolase A, fructose-bisphosphate 1.07518
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 1.07234
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 1.07234
APEH acylaminoacyl-peptide hydrolase 1.07199
DDIT3 DNA-damage-inducible transcript 3 1.07163
MSMO1 methylsterol monooxygenase 1 1.07022
MACF1 microtubule-actin crosslinking factor 1 1.06881
TRIM24 tripartite motif containing 24 1.06771
DDAH2 dimethylarginine dimethylaminohydrolase 2 1.06771
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 1.06552
CLTC clathrin, heavy chain (Hc) 1.06552
NOTCH1 notch 1 1.06442
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 1.06406
HNRNPR heterogeneous nuclear ribonucleoprotein R 1.06333
SYCP2 synaptonemal complex protein 2 1.06333
PHLDA1 pleckstrin homology-like domain, family A, member 1 1.06225
RNPEP arginyl aminopeptidase (aminopeptidase B) 1.06044
FASN fatty acid synthase 1.06008
H1FX H1 histone family, member X 1.05972
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 1.05972
UBE2L3 ubiquitin-conjugating enzyme E2L 3 1.05936
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 1.059
F2R coagulation factor II (thrombin) receptor 1.059
FGFR1 fibroblast growth factor receptor 1 1.059
EGFR epidermal growth factor receptor 1.059
ALAS1 5'-aminolevulinate synthase 1 1.05721
KLK3 kallikrein-related peptidase 3 1.05573
NOP56 NOP56 ribonucleoprotein 1.052
NCOA4 nuclear receptor coactivator 4 1.05163
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1 1.04831
SRSF3 serine/arginine-rich splicing factor 3 1.04831
PTPRO protein tyrosine phosphatase, receptor type, O 1.04831
SULF1 sulfatase 1 1.04831
THRB thyroid hormone receptor, beta 1.04757
PAXBP1 PAX3 and PAX7 binding protein 1 1.04538
PLEKHJ1 pleckstrin homology domain containing, family J member 1 1.04501
PPAT phosphoribosyl pyrophosphate amidotransferase 1.04465
EGF epidermal growth factor 1.04465
RBM39 RNA binding motif protein 39 1.04427
SET SET nuclear proto-oncogene 1.04389
CCNA2 cyclin A2 1.04239
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 1.04088
TRAF4 TNF receptor-associated factor 4 1.04051
GSTA2 glutathione S-transferase alpha 2 1.04051
RPL31 ribosomal protein L31 1.04051
FZD1 frizzled class receptor 1 1.04051
MAPK11 mitogen-activated protein kinase 11 1.04014
PLCB4 phospholipase C, beta 4 1.04014
PDGFRB platelet-derived growth factor receptor, beta polypeptide 1.03752
LGMN legumain 1.03715
GCLM glutamate-cysteine ligase, modifier subunit 1.03678
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 1.03678
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 1.03678
RPL7 ribosomal protein L7 1.03678
GLI2 GLI family zinc finger 2 1.03678
MIR18A microRNA 18a 1.03419
CDK2 cyclin-dependent kinase 2 1.03345
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 1.03046
LDHA lactate dehydrogenase A 1.03009
RGS2 regulator of G-protein signaling 2 1.03009
HTRA2 HtrA serine peptidase 2 1.02971
DLG1 discs, large homolog 1 (Drosophila) 1.02971
TPP1 tripeptidyl peptidase I 1.02971
ATF3 activating transcription factor 3 1.02933
MAPK14 mitogen-activated protein kinase 14 1.02858
CLCN3 chloride channel, voltage-sensitive 3 1.02746
PKM pyruvate kinase, muscle 1.02708
IFITM3 interferon induced transmembrane protein 3 1.02596
APAF1 apoptotic peptidase activating factor 1 1.0241
BCL10 B-cell CLL/lymphoma 10 1.02373
CHMP1A charged multivesicular body protein 1A 1.02336
MIR19A microRNA 19a 1.02299
RARA retinoic acid receptor, alpha 1.02262
TTC3 tetratricopeptide repeat domain 3 1.02262
TBC1D9B TBC1 domain family, member 9B (with GRAM domain) 1.02151
KRT18 keratin 18, type I 1.02114
NT5DC2 5'-nucleotidase domain containing 2 1.01928
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 1.01663
ILK integrin-linked kinase 1.01625
CEL carboxyl ester lipase 1.01474
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 1.01361
BIRC2 baculoviral IAP repeat containing 2 1.01361
GH1 growth hormone 1 1.01249
HPRT1 hypoxanthine phosphoribosyltransferase 1 1.01212
CXCL8 chemokine (C-X-C motif) ligand 8 1.01212
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 1.01174
IER3 immediate early response 3 1.01062