Asthma Gene Set

Dataset DISEASES Experimental Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description A chronic respiratory disease manifested as difficulty breathing due to the narrowing of bronchial passageways.|Tendency of the smooth muscle of the tracheobronchial tree to contract more intensely in response to a given stimulus than it does in the response seen in normal individuals. This condition is present in virtually all symptomatic patients with asthma. The most prominent manifestation of this smooth muscle contraction is a decrease in airway caliber that can be readily measured in the pulmonary function laboratory.|A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).|A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors resulting in recurring periods of wheezing (a whistling sound while breathing), chest tightness, shortness of breath, mucus production and coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, excercise, stress, reflux disease, medications, foods and emotional anxiety. (Experimental Factor Ontology, EFO_0000270)
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Genes

114 genes associated with the disease Asthma in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
IL36R interleukin 36 receptor 1.971
IL33R interleukin 33 receptor 1.971
IL18R1 interleukin 18 receptor 1 1.971
SMAD3 SMAD family member 3 1.94
AAGAB alpha- and gamma-adaptin binding protein 1.94
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5 1.93
IRF1 interferon regulatory factor 1 1.93
IL5 interleukin 5 1.93
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 1.927
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 1.927
LRP1 low density lipoprotein receptor-related protein 1 1.899
TAC3 tachykinin 3 1.899
NEMP1 nuclear envelope integral membrane protein 1 1.899
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2) 1.899
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 1.899
MYO1A myosin IA 1.899
CLEC16A C-type lectin domain family 16, member A 1.895
IL33 interleukin 33 1.867
ING5 inhibitor of growth family, member 5 1.839
DTYMK deoxythymidylate kinase (thymidylate kinase) 1.839
NEU4 sialidase 4 1.839
GAL3ST2 galactose-3-O-sulfotransferase 2 1.839
PDCD1 programmed cell death 1 1.839
D2HGDH D-2-hydroxyglutarate dehydrogenase 1.839
ATG4B autophagy related 4B, cysteine peptidase 1.839
TSLP thymic stromal lymphopoietin 1.827
WDR36 WD repeat domain 36 1.827
HLA-C major histocompatibility complex, class I, C 1.776
HLA-B major histocompatibility complex, class I, B 1.776
ENDOU endonuclease, polyU-specific 1.741
HDAC7 histone deacetylase 7 1.741
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3 1.741
SLC48A1 solute carrier family 48 (heme transporter), member 1 1.741
ZBTB39 zinc finger and BTB domain containing 39 1.69
GPR182 G protein-coupled receptor 182 1.69
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 1.627
TMEM258 transmembrane protein 258 1.576
FADS3 fatty acid desaturase 3 1.576
FADS1 fatty acid desaturase 1 1.576
FADS2 fatty acid desaturase 2 1.576
FEN1 flap structure-specific endonuclease 1 1.576
MYRF myelin regulatory factor 1.576
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 1.491
MUC5B mucin 5B, oligomeric mucus/gel-forming 1.463
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 1.463
RPAP3 RNA polymerase II associated protein 3 1.448
PTPRC protein tyrosine phosphatase, receptor type, C 1.435
ATP6V1G3 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3 1.435
RUNX1 runt-related transcription factor 1 1.431
CCR4 chemokine (C-C motif) receptor 4 1.425
CRTAP cartilage associated protein 1.425
TMPPE transmembrane protein with metallophosphoesterase domain 1.425
GLB1 galactosidase, beta 1 1.425
IL18RAP interleukin 18 receptor accessory protein 1.406
IQCH IQ motif containing H 1.39
SPRY4 sprouty homolog 4 (Drosophila) 1.382
GNPDA1 glucosamine-6-phosphate deaminase 1 1.382
NDFIP1 Nedd4 family interacting protein 1 1.382
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 1.353
IL2RA interleukin 2 receptor, alpha 1.353
RBM17 RNA binding motif protein 17 1.353
IL15RA interleukin 15 receptor, alpha 1.353
RORA RAR-related orphan receptor A 1.326
IL4R interleukin 4 receptor 1.313
IL21R interleukin 21 receptor 1.313
NSMCE1 non-SMC element 1 homolog (S. cerevisiae) 1.313
DAGLA diacylglycerol lipase, alpha 1.275
CD247 CD247 molecule 1.231
CREG1 cellular repressor of E1A-stimulated genes 1 1.231
POU2F1 POU class 2 homeobox 1 1.231
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 1.226
IL2 interleukin 2 1.226
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2 1.226
ADAD1 adenosine deaminase domain containing 1 (testis-specific) 1.226
TFRC transferrin receptor 1.173
LRRC32 leucine rich repeat containing 32 1.112
GATA3 GATA binding protein 3 1.112
EMSY EMSY transcriptional repressor, BRCA2 interacting 1.112
TAF3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa 1.112
IL1R1 interleukin 1 receptor, type I 1.03
COG6 component of oligomeric golgi complex 6 1.017
BEST1 bestrophin 1 1.01
FTH1 ferritin, heavy polypeptide 1 1.01
RAB3IL1 RAB3A interacting protein (rabin3)-like 1 1.01
WDR88 WD repeat domain 88 0.865
SLC7A10 solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10 0.865
LRP3 low density lipoprotein receptor-related protein 3 0.865
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 0.865
RANBP6 RAN binding protein 6 0.862
ZBTB10 zinc finger and BTB domain containing 10 0.777
UGT3A1 UDP glycosyltransferase 3 family, polypeptide A1 0.776
SPEF2 sperm flagellar 2 0.776
CAPSL calcyphosine-like 0.776
IL7R interleukin 7 receptor 0.776
SUOX sulfite oxidase 0.75
ESYT1 extended synaptotagmin-like protein 1 0.75
IKZF4 IKAROS family zinc finger 4 (Eos) 0.75
PMEL premelanosome protein 0.75
RPL41 ribosomal protein L41 0.75
ZC3H10 zinc finger CCCH-type containing 10 0.75
ERBB3 erb-b2 receptor tyrosine kinase 3 0.75
RPS26 ribosomal protein S26 0.75
RAB5B RAB5B, member RAS oncogene family 0.75
PA2G4 proliferation-associated 2G4, 38kDa 0.75
CDK2 cyclin-dependent kinase 2 0.75
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle 0.75
UBAC2 UBA domain containing 2 0.637
TM9SF2 transmembrane 9 superfamily member 2 0.637
PPP2R1B protein phosphatase 2, regulatory subunit A, beta 0.568
BTG4 B-cell translocation gene 4 0.568
SIK2 salt-inducible kinase 2 0.568
LAYN layilin 0.568
MUC6 mucin 6, oligomeric mucus/gel-forming 0.532
ZNF652 zinc finger protein 652 0.532