| Dataset | KEGG Pathways 2026 |
| Category | structural or functional annotations |
| Type | pathway |
| Description | A chronic respiratory disease manifested as difficulty breathing due to the narrowing of bronchial passageways.|Tendency of the smooth muscle of the tracheobronchial tree to contract more intensely in response to a given stimulus than it does in the response seen in normal individuals. This condition is present in virtually all symptomatic patients with asthma. The most prominent manifestation of this smooth muscle contraction is a decrease in airway caliber that can be readily measured in the pulmonary function laboratory.|A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).|A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors resulting in recurring periods of wheezing (a whistling sound while breathing), chest tightness, shortness of breath, mucus production and coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, excercise, stress, reflux disease, medications, foods and emotional anxiety. (Experimental Factor Ontology, EFO_0000270) |
| External Link | https://www.kegg.jp/entry/hsa05310 |
| Similar Terms | |
| Downloads & Tools |
30 proteins participating in the Asthma pathway from the KEGG Pathways 2026 dataset.
| Symbol | Name |
|---|---|
| CCL11 | chemokine (C-C motif) ligand 11 |
| CD40 | CD40 molecule, TNF receptor superfamily member 5 |
| CD40LG | CD40 ligand |
| EPX | eosinophil peroxidase |
| FCER1A | Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide |
| FCER1G | Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide |
| HLA-DMA | major histocompatibility complex, class II, DM alpha |
| HLA-DMB | major histocompatibility complex, class II, DM beta |
| HLA-DOA | major histocompatibility complex, class II, DO alpha |
| HLA-DOB | major histocompatibility complex, class II, DO beta |
| HLA-DPA1 | major histocompatibility complex, class II, DP alpha 1 |
| HLA-DQA1 | major histocompatibility complex, class II, DQ alpha 1 |
| HLA-DQA2 | major histocompatibility complex, class II, DQ alpha 2 |
| HLA-DQB2 | major histocompatibility complex, class II, DQ beta 2 |
| HLA-DRA | major histocompatibility complex, class II, DR alpha |
| HLA-DRB1 | major histocompatibility complex, class II, DR beta 1 |
| HLA-DRB3 | major histocompatibility complex, class II, DR beta 3 |
| HLA-DRB4 | major histocompatibility complex, class II, DR beta 4 |
| HLA-DRB5 | major histocompatibility complex, class II, DR beta 5 |
| IL10 | interleukin 10 |
| IL13 | interleukin 13 |
| IL3 | interleukin 3 |
| IL4 | interleukin 4 |
| IL5 | interleukin 5 |
| IL9 | interleukin 9 |
| LOC102724971 | putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 |
| MS4A2 | membrane-spanning 4-domains, subfamily A, member 2 |
| PLPPR3 | phospholipid phosphatase related 3 |
| RNASE3 | ribonuclease, RNase A family, 3 |
| TNF | tumor necrosis factor |
